LOCUS       NM_016463               2601 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens CXXC finger protein 5 (CXXC5), transcript variant 2,
            mRNA.
ACCESSION   NM_016463
VERSION     NM_016463.9
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Geng,T., Sun,Q., He,J., Chen,Y., Cheng,W., Shen,J., Liu,B.,
            Zhang,M., Wang,S., Asan,K., Song,M., Gao,Q., Song,Y., Liu,R.,
            Liu,X., Ding,Y., Jing,A., Ye,X., Ren,H., Zeng,K., Zhou,Y.,
            Zhang,B., Ma,S., Liu,W., Liu,S. and Ji,J.
  TITLE     CXXC5 drove inflammation and ovarian cancer proliferation via
            transcriptional activation of ZNF143 and EGR1
  JOURNAL   Cell Signal 119, 111180 (2024)
   PUBMED   38642782
  REMARK    GeneRIF: CXXC5 drove inflammation and ovarian cancer proliferation
            via transcriptional activation of ZNF143 and EGR1.
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Kim,E., Seo,S.H., Hwang,Y., Ryu,Y.C., Kim,H., Lee,K.M., Lee,J.W.,
            Park,K.H. and Choi,K.Y.
  TITLE     Inhibiting the cytosolic function of CXXC5 accelerates diabetic
            wound healing by enhancing angiogenesis and skin repair
  JOURNAL   Exp Mol Med 55 (8), 1770-1782 (2023)
   PUBMED   37524876
  REMARK    GeneRIF: Inhibiting the cytosolic function of CXXC5 accelerates
            diabetic wound healing by enhancing angiogenesis and skin repair.
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Yoon,M., Kim,H., Shin,H., Lee,H., Kang,M.J., Park,S.H., Han,G.,
            Kim,Y. and Choi,K.Y.
  TITLE     Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes
            by restoring Wnt/beta-catenin signaling pathway
  JOURNAL   Pharmacol Res 194, 106836 (2023)
   PUBMED   37355147
  REMARK    GeneRIF: Inhibition of CXXC5 function rescues Alzheimer's disease
            phenotypes by restoring Wnt/beta-catenin signaling pathway.
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Ryu,Y.C., Park,J., Kim,Y.R., Choi,S., Kim,G.U., Kim,E., Hwang,Y.,
            Kim,H., Han,G., Lee,S.H. and Choi,K.Y.
  TITLE     CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
  JOURNAL   Cells 12 (4), 555 (2023)
   PUBMED   36831222
  REMARK    GeneRIF: CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Wang,W., Zhang,Z., Zhao,M., Wang,Y., Ge,Y. and Shan,L.
  TITLE     Zinc-finger protein CXXC5 promotes breast carcinogenesis by
            regulating the TSC1/mTOR signaling pathway
  JOURNAL   J Biol Chem 299 (1), 102812 (2023)
   PUBMED   36539038
  REMARK    GeneRIF: Zinc-finger protein CXXC5 promotes breast carcinogenesis
            by regulating the TSC1/mTOR signaling pathway.
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Pendino,F., Nguyen,E., Jonassen,I., Dysvik,B., Azouz,A.,
            Lanotte,M., Segal-Bendirdjian,E. and Lillehaug,J.R.
  TITLE     Functional involvement of RINF, retinoid-inducible nuclear factor
            (CXXC5), in normal and tumoral human myelopoiesis
  JOURNAL   Blood 113 (14), 3172-3181 (2009)
   PUBMED   19182210
  REMARK    GeneRIF: RINF expression correlates with retinoid-induced
            differentiation of leukemic cells and with cytokine-induced
            myelopoiesis of normal CD34(+) progenitors.
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Andersson,T., Sodersten,E., Duckworth,J.K., Cascante,A., Fritz,N.,
            Sacchetti,P., Cervenka,I., Bryja,V. and Hermanson,O.
  TITLE     CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in
            neural stem cells
  JOURNAL   J Biol Chem 284 (6), 3672-3681 (2009)
   PUBMED   19001364
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024338.1 and BC006428.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016463.8.
            
            Summary: The protein encoded by this gene is a retinoid-inducible
            nuclear protein containing a CXXC-type zinc finger motif. The
            encoded protein is involved in myelopoiesis, is required for DNA
            damage-induced p53 activation, regulates the differentiation of
            C2C12 myoblasts into myocytes, and negatively regulates cutaneous
            wound healing. Several transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All of the variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006428.1, SRR3476690.1037937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302517.8/ ENSP00000302543.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK024338.1         58-69
            13-2601             BC006428.1         1-2589
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..2601
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /note="CXXC finger protein 5"
                     /db_xref="GeneID:51523"
                     /db_xref="HGNC:HGNC:26943"
                     /db_xref="MIM:612752"
     exon            1..497
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1581
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..1626
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /note="retinoid-inducible nuclear factor; WT1-induced
                     Inhibitor of Dishevelled; CXXC finger 5 protein; putative
                     MAPK-activating protein PM08; putative
                     NF-kappa-B-activating protein 102"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 5"
                     /protein_id="NP_057547.5"
                     /db_xref="CCDS:CCDS43370.1"
                     /db_xref="GeneID:51523"
                     /db_xref="HGNC:HGNC:26943"
                     /db_xref="MIM:612752"
                     /translation="MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAA
                     APASVADDTPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESA
                     DKATAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQL
                     TLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINP
                     GLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCE
                     QCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ"
     exon            1582..2601
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="CXXC5"
                     /gene_synonym="CF5; HSPC195; RINF; WID"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggca gaggcggctg agcctgagcg gggatgtaga ggcggcggca gcagaggcgg
       61 cactggcggc aagagcagac gcccgagccg agcgagaaga gcggcagagc cttatcccct
      121 gaagccgggc cccgcgtccc agccctgccc agcccgcgcc cagccatgcg cgccgcctgc
      181 tgagtccggg cgccgcacgc tgagccctcc gcccgcgagc cgcgctcagc tcgggggtga
      241 ttagttgctt tttgttgttt tttaatttgg gccgcgggga gggggaggag gggcaggtgc
      301 tgcaggctcc cccccctccc cgcctcgggc cagccgcggc ggcgcgactc gggctccgga
      361 cccgggcact gctggcggct ggagcggagc gcaccgcggc ggtggtgccc agagcggagc
      421 gcagctccct gccccgcccc tccccctcgg cctcgcggcg acggcggcgg tggcggcttg
      481 gacgactcgg agagccgagt gaagacattt ccacctggac acctgaccat gtgcctgccc
      541 tgagcagcga ggcccaccag gcatctctgt tgtgggcagc agggccaggt cctggtctgt
      601 ggaccctcgg cagttggcag gctccctctg cagtggggtc tgggcctcgg ccccaccatg
      661 tcgagcctcg gcggtggctc ccaggatgcc ggcggcagta gcagcagcag caccaatggc
      721 agcggtggca gtggcagcag tggcccaaag gcaggagcag cagacaagag tgcagtggtg
      781 gctgccgccg caccagcctc agtggcagat gacacaccac cccccgagcg tcggaacaag
      841 agcggtatca tcagtgagcc cctcaacaag agcctgcgcc gctcccgccc gctctcccac
      901 tactcttctt ttggcagcag tggtggtagt ggcggtggca gcatgatggg cggagagtct
      961 gctgacaagg ccactgcggc tgcagccgct gcctccctgt tggccaatgg gcatgacctg
     1021 gcggcggcca tggcggtgga caaaagcaac cctacctcaa agcacaaaag tggtgctgtg
     1081 gccagcctgc tgagcaaggc agagcgggcc acggagctgg cagccgaggg acagctgacg
     1141 ctgcagcagt ttgcgcagtc cacagagatg ctgaagcgcg tggtgcagga gcatctcccg
     1201 ctgatgagcg aggcgggtgc tggcctgcct gacatggagg ctgtggcagg tgccgaagcc
     1261 ctcaatggcc agtccgactt cccctacctg ggcgctttcc ccatcaaccc aggcctcttc
     1321 attatgaccc cggcaggtgt gttcctggcc gagagcgcgc tgcacatggc gggcctggct
     1381 gagtacccca tgcagggaga gctggcctct gccatcagct ccggcaagaa gaagcggaaa
     1441 cgctgcggca tgtgcgcgcc ctgccggcgg cgcatcaact gcgagcagtg cagcagttgt
     1501 aggaatcgaa agactggcca tcagatttgc aaattcagaa aatgtgagga actcaaaaag
     1561 aagccttccg ctgctctgga gaaggtgatg cttccgacgg gagccgcctt ccggtggttt
     1621 cagtgacggc ggcggaaccc aaagctgccc tctccgtgca atgtcactgc tcgtgtggtc
     1681 tccagcaagg gattcgggcg aagacaaacg gatgcacccg tctttagaac caaaaatatt
     1741 ctctcacaga tttcattcct gtttttatat atatattttt tgttgtcgtt ttaacatctc
     1801 cacgtcccta gcataaaaag aaaaagaaaa aaatttaaac tgctttttcg gaagaacaac
     1861 aacaaaaaag aggtaaagac gaatctataa agtaccgaga cttcctgggc aaagaatgga
     1921 caatcagttt ccttcctgtg tcgatgtcga tgttgtctgt gcaggagatg cagtttttgt
     1981 gtagagaatg taaattttct gtaacctttt gaaatctagt tactaataag cactactgta
     2041 atttagcaca gtttaactcc accctcattt aaacttcctt tgattctttc cgaccatgaa
     2101 atagtgcata gtttgcctgg agaatccact cacgttcata aagagaatgt tgatggcgcc
     2161 gtgtagaagc cgctctgtat ccatccacgc gtgcagagct gccagcaggg agctcacaga
     2221 aggggaggga gcaccaggcc agctgagctg cacccacagt cccgagactg ggatccccca
     2281 ccccaacagt gattttggaa aaaaaaatga aagttctgtt cgtttatcca ttgcgatctg
     2341 gggagcccca tctcgatatt tccaatcctg gctacttttc ttagagaaaa taagtccttt
     2401 ttttctggcc ttgctaatgg caacagaaga aagggcttct ttgcgtggtc ccctgctggt
     2461 gggggtgggt ccccaggggg ccccctgcgg cctgggcccc cctgcccacg gccagcttcc
     2521 tgctgatgaa catgctgttt gtattgtttt aggaaaccag gctgttttgt gaataaaacg
     2581 aatgcatgtt tgtgtcacga a
//
