LOCUS       NM_025212               5569 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1,
            mRNA.
ACCESSION   NM_025212
VERSION     NM_025212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5569)
  AUTHORS   Di,C., Liang,J., Wang,Y., Zhao,G. and Zhao,Y.
  TITLE     SPZ1 promotes glioma aggravation via targeting CXXC4
  JOURNAL   J BUON 26 (2), 373-379 (2021)
   PUBMED   34076982
  REMARK    GeneRIF: SPZ1 promotes glioma aggravation via targeting CXXC4.
REFERENCE   2  (bases 1 to 5569)
  AUTHORS   Byun,H.J., Yoon,J.H. and Lee,S.K.
  TITLE     LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes
            CXXC4 and SFRP2 in Gastric Cancer
  JOURNAL   Yonsei Med J 61 (11), 923-934 (2020)
   PUBMED   33107235
  REMARK    GeneRIF: LUCAT1 Epigenetically Downregulates the Tumor Suppressor
            Genes CXXC4 and SFRP2 in Gastric Cancer.
            Erratum:[Yonsei Med J. 2021 Apr;62(4):378. doi:
            10.3349/ymj.2021.62.4.378.. PMID: 33779095]
REFERENCE   3  (bases 1 to 5569)
  AUTHORS   Olofsen,P.A., Fatrai,S., van Strien,P.M.H., Obenauer,J.C., de
            Looper,H.W.J., Hoogenboezem,R.M., Erpelinck-Verschueren,C.A.J.,
            Vermeulen,M.P.W.M., Roovers,O., Haferlach,T., Jansen,J.H.,
            Ghazvini,M., Bindels,E.M.J., Schneider,R.K., de Pater,E.M. and
            Touw,I.P.
  TITLE     Malignant Transformation Involving CXXC4 Mutations Identified in a
            Leukemic Progression Model of Severe Congenital Neutropenia
  JOURNAL   Cell Rep Med 1 (5), 100074 (2020)
   PUBMED   33205068
  REMARK    GeneRIF: Malignant Transformation Involving CXXC4 Mutations
            Identified in a Leukemic Progression Model of Severe Congenital
            Neutropenia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5569)
  AUTHORS   Lu,H., Jin,W., Sun,J., Feng,L., Lan,H., Shen,Q., Ma,Y., Li,J.,
            Yue,Y., Jin,H. and Wang,X.
  TITLE     New tumor suppressor CXXC finger protein 4 inactivates mitogen
            activated protein kinase signaling
  JOURNAL   FEBS Lett 588 (18), 3322-3326 (2014)
   PUBMED   25064842
  REMARK    GeneRIF: EZH2 can activate MAPK signaling by inhibiting CXXC4
            expression.
REFERENCE   5  (bases 1 to 5569)
  AUTHORS   Li,S., Fan,R., Zhao,X.L. and Wang,X.Q.
  TITLE     CXXC4 mRNA levels are associated with clinicopathological
            parameters and survival of myelodysplastic syndrome patients
  JOURNAL   Leuk Res 38 (9), 1072-1078 (2014)
   PUBMED   25085016
  REMARK    GeneRIF: Age of patients and levels of CXXC4 mRNA, hemoglobin, and
            marrow blast associated with survival of Myelodysplastic syndrome
            patients.
REFERENCE   6  (bases 1 to 5569)
  AUTHORS   Lu,H., Sun,J., Wang,F., Feng,L., Ma,Y., Shen,Q., Jiang,Z., Sun,X.,
            Wang,X. and Jin,H.
  TITLE     Enhancer of zeste homolog 2 activates wnt signaling through
            downregulating CXXC finger protein 4
  JOURNAL   Cell Death Dis 4 (8), e776 (2013)
   PUBMED   23949225
  REMARK    GeneRIF: CXXC4 is a novel potential tumor suppressor directly
            regulated by EZH2, and its expression is a significant prognosis
            factor for patients with early stages of gastric cancer.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5569)
  AUTHORS   Ko,M., An,J., Bandukwala,H.S., Chavez,L., Aijo,T., Pastor,W.A.,
            Segal,M.F., Li,H., Koh,K.P., Lahdesmaki,H., Hogan,P.G., Aravind,L.
            and Rao,A.
  TITLE     Modulation of TET2 expression and 5-methylcytosine oxidation by the
            CXXC domain protein IDAX
  JOURNAL   Nature 497 (7447), 122-126 (2013)
   PUBMED   23563267
  REMARK    GeneRIF: IDAX expression results in caspase activation and TET2
            protein downregulation, in a manner that depends on DNA binding
            through the IDAX CXXC domain, suggesting that IDAX recruits TET2 to
            DNA before degradation
REFERENCE   8  (bases 1 to 5569)
  AUTHORS   Nguyen,A.V., Albers,C.G. and Holcombe,R.F.
  TITLE     Differentiation of tubular and villous adenomas based on Wnt
            pathway-related gene expression profiles
  JOURNAL   Int J Mol Med 26 (1), 121-125 (2010)
   PUBMED   20514431
REFERENCE   9  (bases 1 to 5569)
  AUTHORS   Kojima,T., Shimazui,T., Hinotsu,S., Joraku,A., Oikawa,T., Kawai,K.,
            Horie,R., Suzuki,H., Nagashima,R., Yoshikawa,K., Michiue,T.,
            Asashima,M., Akaza,H. and Uchida,K.
  TITLE     Decreased expression of CXXC4 promotes a malignant phenotype in
            renal cell carcinoma by activating Wnt signaling
  JOURNAL   Oncogene 28 (2), 297-305 (2009)
   PUBMED   18931698
  REMARK    GeneRIF: Decreased CXXC4 was associated with kidney cancer
            metastasis, poor survival, beta-catenin translocation, cell
            proliferation, reduced apoptosis in response to cancer drugs, and
            upregulation of genes involed in proliferation, invasion, and cell
            survival.
REFERENCE   10 (bases 1 to 5569)
  AUTHORS   Hino,S., Kishida,S., Michiue,T., Fukui,A., Sakamoto,I., Takada,S.,
            Asashima,M. and Kikuchi,A.
  TITLE     Inhibition of the Wnt signaling pathway by Idax, a novel
            Dvl-binding protein
  JOURNAL   Mol Cell Biol 21 (1), 330-342 (2001)
   PUBMED   11113207
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA804531.1, AC093628.3,
            AK125395.1, CB068467.1 and AA708035.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025212.3.
            
            Summary: This gene encodes a CXXC-type zinc finger
            domain-containing protein that functions as an antagonist of the
            canonical wingless/integrated signaling pathway. The encoded
            protein negatively regulates wingless/integrated signaling through
            interaction with the post synaptic density protein/ Drosophila disc
            large tumor suppressor/ zonula occludens-1 protein domain of
            Dishevelled, a scaffolding protein required for the stabilization
            of the transcriptional co-activator beta-catenin. In addition, the
            CXXC domain of this protein has been shown to bind unmethylated CpG
            dinucleotides, localize to promoters and CpG islands, and interact
            with the catalytic domain of methylcytosine dioxygenase
            ten-eleven-translocation 2, an iron and
            alpha-ketoglutarate-dependent dioxygenase that modifies the
            methylation status of DNA. In humans, a mutation in this gene has
            been associated with development of malignant renal cell carcinoma.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.414910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394767.3/ ENSP00000378248.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               DA804531.1         1-477
            478-1510            AC093628.3         43065-44097         c
            1511-2963           AC093628.3         23235-24687         c
            2964-5201           AK125395.1         798-3035
            5202-5506           CB068467.1         63-367              c
            5507-5569           AA708035.1         17-79               c
FEATURES             Location/Qualifiers
     source          1..5569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..5569
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /note="CXXC finger protein 4"
                     /db_xref="GeneID:80319"
                     /db_xref="HGNC:HGNC:24593"
                     /db_xref="MIM:611645"
     exon            1..194
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /inference="alignment:Splign:2.1.0"
     exon            195..1510
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..1555
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /note="Dvl-binding protein IDAX (inhibition of the Dvl and
                     Axin complex); CXXC finger 4; inhibition of the Dvl and
                     axin complex protein"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 4"
                     /protein_id="NP_079488.2"
                     /db_xref="CCDS:CCDS3665.2"
                     /db_xref="GeneID:80319"
                     /db_xref="HGNC:HGNC:24593"
                     /db_xref="MIM:611645"
                     /translation="MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRS
                     FATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAAATA
                     MLWGSGGGGGGGGGGGGGGGGGGGGGGGGGGGRKSSSAAASSSASSSSAILPAGGGGG
                     GGGGGSRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLK
                     CGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIAN
                     LADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQ
                     ICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF"
     exon            1511..5569
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5546..5551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /note="hexamer: AATAAA"
     polyA_site      5569
                     /gene="CXXC4"
                     /gene_synonym="IDAX"
                     /note="major polyA site"
ORIGIN      
        1 gcacacagcg actggagacg gacggagagc aacgcgctgg gagaggagag accaccgaca
       61 acagacccgc gctctcacac atacactcac actcgactct ttcctctccc cccacctcct
      121 cctccttcca cccccaccac taacaccatc tcctcctcct tctctctgca acaagaaaaa
      181 aaagccattt acagttgtaa cagttggagg ataatgcaaa ggaagacgct gcctgggaat
      241 tcaccgtctg tggaaatgag ccccagagag gaataaagca gccctcacct tgctctcccc
      301 acccgaaccc actttcccca cccgcctcgg cccccacccc aacaccacca tcactccctt
      361 ccctcccccc cacctttccc ccttttccac ccaggtgtcg gaccaggcgg tccccacttc
      421 caccctgcac cccttcttcc ccccctgcac catgaacacc aatgtctgcg tggagcccgg
      481 gccgagcccg gaggccccgg gcttgcccaa ggaaagccac ttgcccgagg gggctctgaa
      541 cagccttgtg gattacaact cggaaatgga gcgctaccgc tcctttgcca cctccttcta
      601 caagaccaac gggggcgcct tcccacaggc ggccaagatc gcgcgcatca ccacccccat
      661 cttccccagc agcgccgccg ccgccgcggc cgccgcgcgc atcggcatgt ccccctggaa
      721 ctgcgacaac gcggccaccg ccgccgccgc caccgccatg ctctggggca gcggcggggg
      781 cgggggcggc ggcggggggg gtggcggcgg cggcggcggc ggcggaggcg ggggcggggg
      841 tggtgggggc ggcaggaaat cctcctccgc cgccgcctcc tcctccgcct cctcctcctc
      901 ggcgatcctc cccgccggcg gtggcggcgg cggcggcggc ggcggcagca ggaccagcat
      961 gcaccaccga aacgactccc agaggctggg gaaagctggc tgcccgccag agccgtcgtt
     1021 gcaaatggca aatactaatt tcctctccac cttatcccct gaacactgca gacctttggc
     1081 gggggaatgc atgaacaagc tcaaatgcgg cgctgctgaa gcagagataa tgaatctccc
     1141 cgagcgcgtg gggacttttt ccgctatccc ggctttaggg ggcatctcat tacctccagg
     1201 ggtcatcgtc atgacagccc ttcactcccc cgcagcagcc tcagcagccg tcacagacag
     1261 tgcgtttcaa attgccaatc tggcagactg cccgcagaat cattcctcct cctcctcgtc
     1321 ctcctcaggg ggagctggcg gagccaaccc agccaagaag aagaggaaaa ggtgtggggt
     1381 ctgcgtgccc tgcaagaggc tcatcaactg tggcgtctgc agcagttgca ggaaccgcaa
     1441 aacgggacac cagatctgca aatttagaaa atgtgaagag ctaaagaaaa aacctggcac
     1501 ttcactagag agaacacctg ttcccagcgc tgaagcattc cgatggttct tttaaagcag
     1561 tagtatatct tattttcaag gcatttggaa atgaagggca aactaatgtc ttgttttaag
     1621 aaactgctta gtccaccact gaagaaaata tccagaaatt attttcattt tatgtatagg
     1681 gctttcttca aaaaaaaaaa aaaagaggaa aagaaaagaa aaagacataa aaataatgtg
     1741 agagcttgga gaattggcca gtctatttac tttcaatacg ctgattcttt ctttgatgta
     1801 atttagctat agtagtgaag ttgttgtcta ttttgaaagt ggctgtaaaa aataagtttg
     1861 ggtaaacccc tgctgtaaaa tcatgtatct ttgcaaagta catatctata cttcattttc
     1921 aaatatatgt gtttcagtac tgtaaactgt acagatagca gcttgtattt tgtgtgttta
     1981 gacacaagga gacaatcatg tctgagcatc tatggagatt aacagtttgt acacaacagt
     2041 atggttctgc aagttaaatc tggagcaata aattttagct ttaactattt tttgccagtg
     2101 gtttagaagc agcaacagca ctggcaccat tttgccatgc atctttccat agagacttga
     2161 tgccaagttt tacaagacta aaagattatg atgcatccac caattacctt cagttttatt
     2221 gttataagag gggaagatgt tatgaaagtt tcaattaatc ttttgagcac tatattagag
     2281 tagtggttat gcacttgcat tgcttacaaa cgagctgtac agaagggtat acctcccaaa
     2341 tacttagtgt agttgacttg tcttgggttg cactgtaagg cagagtactc agagtagttg
     2401 gaaaatgcag aatcagttgt ataatttttt tttataaaaa cggtgttttt taggctaaag
     2461 aataaagtat catatcttag gaggggaaaa tttataactg acattttttc cccagcccaa
     2521 tatgggctgt atacgtttta ttgtttctta atttttttct tattttttct gtaggaaaaa
     2581 atcttaataa aaactacccc aatgttttaa cttcatgtat gatattaaat gggtagtttt
     2641 aacacttgaa tatgttgagg gcttctgcct tgaggcaggg cttgatatat ttttaattta
     2701 caaagaatta aacatattca taaaagtgag gcattttatc tctttttatt ttcttttctc
     2761 atagccaccc agttggacta gtggtcttcc cctggtcctt cagtaaaatg ctccattgct
     2821 gccatttcca ttgttgttac ttgatgcttt cattcctgag aaggcagggc tacagtctct
     2881 ggaatttcat aaatgcatga catacccctc cccccacaac ctacacacaa aggatctaat
     2941 gcttcataga acctgtgcta ccttttcatg ttggagttgg ttttcttatc acagtcaggg
     3001 ttcttaaggc cgtcccatca ggacaaatat ttaccttcca ttttatttct gtttgtccca
     3061 attataaaga ctattttcag tttcaggagt agaacagggt ttagcaaaaa tatgtagagt
     3121 atcaaagtta cctactgcaa ctttttgttc tttgtccact agccaggtga tttaacccac
     3181 taaatccatt agcttgctga aaaatgttag caaagtaaat cacgagaaga aagataattt
     3241 gagaagagaa atggtatggt acaatgaaag aagctgtaaa gattaggaaa gactagtaag
     3301 tgaatatttt taaaaattta gttgtagatt tcaatgggat acgataggac agaaaagatt
     3361 ttttaaaaag cagaaagagt gtttcatggt gaaagtactg ggggagggtg gacaaagcat
     3421 gcacacatgc caatttgaaa atcaagtgtg acttacctca cgtagagtat gaatacatgg
     3481 tccacagtta tggtcaacaa gcgttttcaa gaaaaactca tgatgtgtta cacccatcca
     3541 tatttagaga tgagaattaa atgattacaa gctaaaatgt gctgtatact gtattaattt
     3601 tgagatagct ttctacttga tgtatatttc tttgagggtt tctatctagt tagaatttca
     3661 gcttctgctg tgggaccaat gagagctgta tgagtttttt tttttttttc cttttccatt
     3721 attttatttt ttgttttttg tttaccaatt tgctaattaa ttacaagtaa gtgaaaactt
     3781 actttcacac ttgaatgata agcttgcctt gctctttgga aaatgatgat tgttattaca
     3841 gaagtgaaac aaacttctat tcaggctaca gtaggcatac aataacctaa agatctcata
     3901 gaagtatact gagagtctaa aatacattct agtagtgcat gtcttggtgt gcttttgttt
     3961 gtttgctttc taaaagaact aatgaatctg tatattgtaa actgtggtgt tttacatgtc
     4021 aattcatttt tttaatgaaa gaaaatttgt tgattactga aatgagaaag tgtagctttt
     4081 cattaattct cttatgtttt ttattcttga tattgttctt ttataccacc cactttttaa
     4141 tgtttttggt taaactccat ttatataatg taggatgcat ataaagttct cattggtgat
     4201 gttgaagaaa gagatgactc ttctggcctt tctctagttt tcttcctcat atgtccctgt
     4261 actgagaact tctaaagctt atcattataa acctaaggca gtgatttgaa agtttacatt
     4321 tttcatgatt ttcaaatacc aatgaaatgt aacttttaaa tattcctcac tgtgtgtttt
     4381 atattcactg tcaagaaaat tcagaatgta gattgtgtgg acagctatac acaacttaat
     4441 aattatatat cagataaact gaataaaaaa ctttgtaaga gtggtctacg cacacaggat
     4501 cttgtcctcc ctaggcgtgg atagagagat gccataatct gccagcattt ggggagatca
     4561 tggtaaatac ttgaggcgtt gatacatagt gcagtgagcc aatttccttt tcagttgtca
     4621 ctcagcacca taacatcacg aagaacatca ttaatgcaaa cctctcacta agccttcaga
     4681 ccaaagtggc tttctgatgg actctgcctg tctgtctaca agtggagtca gattcaaagt
     4741 agaaatgtat ccatccttgg gaaagaaaat aggaagtctt cccccactgt aggagtatat
     4801 aaaaatgtct cctggttgct taattcccaa cactcaattt ccttcttcta aacacattta
     4861 taaggagcaa gagatggtgc acttattatg aattaatatt aagcaatcac taaaagaaag
     4921 gaatattctc ttcctttcaa tcagaaaccc tgatatgtaa gttgtgcaat taatgctaaa
     4981 gcatataaag tctttaagct gataagtatc tgtaatcaaa taatgaaaaa aggaaagcag
     5041 ttaaatgaac acactattca gggtcaaata tgttcagcaa aaagccgtag cgggtctttg
     5101 atcatggtta gattcacagt gatatcaaac agttggttct catgtaacag ctaaatgttt
     5161 cagttttttt ttttttatta aatttggcat ttcacactga gatctgtatt cctagtgaat
     5221 aaaagacagc tactatatta ggagggattc cattttcaca attgcaaaac agatatttca
     5281 ggaacatggg ccacaaaatg tactcctttc acagtgttct cctcttctga actgtgcagt
     5341 tatctattaa attttctaat agatatttgt gtaaggtgta tgtatgcttg tgcaattatt
     5401 taaaaaacgg ttttggaaaa cagtgtattt attaaagaaa attacttatg gggcatgtac
     5461 aaaactgtaa aaaaaaaaaa aaagtaaaaa aaatcacatt caatttgccc agtaaagttg
     5521 tttttgtgaa atttctgtgt tgttgaataa aggactttag tactcaaaa
//
