LOCUS       NM_014593               2320 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens CXXC finger protein 1 (CXXC1), transcript variant 2,
            mRNA.
ACCESSION   NM_014593
VERSION     NM_014593.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
  REMARK    GeneRIF: Cfp1 Controls Cardiomyocyte Maturation by Modifying
            Histone H3K4me3 of Structural, Metabolic, and Contractile Related
            Genes.
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Yang,S.C., Park,M., Hong,K.H., La,H., Park,C., Wang,P., Li,G.,
            Chen,Q., Choi,Y., DeMayo,F.J., Lydon,J.P., Skalnik,D.G., Lim,H.J.,
            Hong,S.H., Park,S.H., Kim,Y.S., Kim,H.R. and Song,H.
  TITLE     CFP1 governs uterine epigenetic landscapes to intervene in
            progesterone responses for uterine physiology and suppression of
            endometriosis
  JOURNAL   Nat Commun 14 (1), 3220 (2023)
   PUBMED   37270588
  REMARK    GeneRIF: CFP1 governs uterine epigenetic landscapes to intervene in
            progesterone responses for uterine physiology and suppression of
            endometriosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Yang,L.Q., Hu,H.Y., Han,Y., Tang,Z.Y., Gao,J., Zhou,Q.Y., Liu,Y.X.,
            Chen,H.S., Xu,T.N., Ao,L., Xu,Y., Che,X., Jiang,Y.B., Xu,C.W.,
            Zhang,X.C., Jiang,Y.X., Heger,M., Wang,X.M., Cheng,S.Q. and
            Pan,W.W.
  TITLE     CpG-binding protein CFP1 promotes ovarian cancer cell proliferation
            by regulating BST2 transcription
  JOURNAL   Cancer Gene Ther 29 (12), 1895-1907 (2022)
   PUBMED   35864225
  REMARK    GeneRIF: CpG-binding protein CFP1 promotes ovarian cancer cell
            proliferation by regulating BST2 transcription.
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Yang,Y., Yang,Y., Chan,K. and Couture,J.F.
  TITLE     Analyzing the impact of CFP1 mutational landscape on epigenetic
            signaling
  JOURNAL   FASEB J 35 (8), e21790 (2021)
   PUBMED   34320252
  REMARK    GeneRIF: Analyzing the impact of CFP1 mutational landscape on
            epigenetic signaling.
            Review article
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Lee,J.H., Voo,K.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the DNA binding domain of
            CpG-binding protein
  JOURNAL   J Biol Chem 276 (48), 44669-44676 (2001)
   PUBMED   11572867
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Carlone,D.L. and Skalnik,D.G.
  TITLE     CpG binding protein is crucial for early embryonic development
  JOURNAL   Mol Cell Biol 21 (22), 7601-7606 (2001)
   PUBMED   11604496
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Fujino,T., Hasegawa,M., Shibata,S., Kishimoto,T., Imai,S. and
            Takano,T.
  TITLE     PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain,
            is regulated by proteolysis
  JOURNAL   Biochem Biophys Res Commun 271 (2), 305-310 (2000)
   PUBMED   10799292
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Voo,K.S., Carlone,D.L., Jacobsen,B.M., Flodin,A. and Skalnik,D.G.
  TITLE     Cloning of a mammalian transcriptional activator that binds
            unmethylated CpG motifs and shares a CXXC domain with DNA
            methyltransferase, human trithorax, and methyl-CpG binding domain
            protein 1
  JOURNAL   Mol Cell Biol 20 (6), 2108-2121 (2000)
   PUBMED   10688657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB031069.1.
            
            On Aug 11, 2020 this sequence version replaced NM_014593.3.
            
            Summary: This gene encodes a protein that functions as a
            transcriptional activator that binds specifically to non-methylated
            CpG motifs through its CXXC domain. The protein is a component of
            the SETD1 complex, regulates gene expression and is essential for
            vertebrate development. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the mid-coding region, compared to variant 1,
            resulting in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031069.1, AL136862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285106.11/ ENSP00000285106.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2320              AB031069.1         126-2445
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..2320
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /note="CXXC finger protein 1"
                     /db_xref="GeneID:30827"
                     /db_xref="HGNC:HGNC:24343"
                     /db_xref="MIM:609150"
     exon            1..106
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2074
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DNA-binding protein with PHD finger and CXXC domain; CXXC
                     finger 1 (PHD domain); zinc finger, CpG binding-type
                     containing 1; CpG binding protein; cpG-binding protein;
                     CXXC-type zinc finger protein 1; PHD finger and CXXC
                     domain-containing protein 1"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 1 isoform 2"
                     /protein_id="NP_055408.2"
                     /db_xref="CCDS:CCDS11945.1"
                     /db_xref="GeneID:30827"
                     /db_xref="HGNC:HGNC:24343"
                     /db_xref="MIM:609150"
                     /translation="MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCD
                     NCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEP
                     RDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQ
                     QIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKY
                     FPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATP
                     EPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRRE
                     KKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCS
                     DDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERR
                     FHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAK
                     YESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGC
                     PLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRT
                     AMTNRAGLLALMLHQTIQHDPLTTDLRSSADR"
     exon            107..225
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..326
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..562
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..742
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..769
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1015
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1123
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1308
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1516
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1627
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1677
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1774
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1927
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2320
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="CXXC1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; CFP1; CGBP;
                     hCGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1"
                     /note="major polyA site"
ORIGIN      
        1 agttgtgggc gcctttgcaa ccgcctggga cgccgccgag tggtctgtgc aggttcgcgg
       61 gtcgctggcg ggggtcgtga gggagtgcgc cgggagcgga gatatggagg gagatggttc
      121 agacccagag cctccagatg ccggggagga cagcaagtcc gagaatgggg agaatgcgcc
      181 catctactgc atctgccgca aaccggacat caactgcttc atgatcgggt gtgacaactg
      241 caatgagtgg ttccatgggg actgcatccg gatcactgag aagatggcca aggccatccg
      301 ggagtggtac tgtcgggagt gcagagagaa agaccccaag ctagagattc gctatcggca
      361 caagaagtca cgggagcggg atggcaatga gcgggacagc agtgagcccc gggatgaggg
      421 tggagggcgc aagaggcctg tccctgatcc agacctgcag cgccgggcag ggtcagggac
      481 aggggttggg gccatgcttg ctcggggctc tgcttcgccc cacaaatcct ctccgcagcc
      541 cttggtggcc acacccagcc agcatcacca gcagcagcag cagcagatca aacggtcagc
      601 ccgcatgtgt ggtgagtgtg aggcatgtcg gcgcactgag gactgtggtc actgtgattt
      661 ctgtcgggac atgaagaagt tcgggggccc caacaagatc cggcagaagt gccggctgcg
      721 ccagtgccag ctgcgggccc gggaatcgta caagtacttc ccttcctcgc tctcaccagt
      781 gacgccctca gagtccctgc caaggccccg ccggccactg cccacccaac agcagccaca
      841 gccatcacag aagttagggc gcatccgtga agatgagggg gcagtggcgt catcaacagt
      901 caaggagcct cctgaggcta cagccacacc tgagccactc tcagatgagg acctacctct
      961 ggatcctgac ctgtatcagg acttctgtgc aggggccttt gatgaccatg gcctgccctg
     1021 gatgagcgac acagaagagt ccccattcct ggaccccgcg ctgcggaaga gggcagtgaa
     1081 agtgaagcat gtgaagcgtc gggagaagaa gtctgagaag aagaaggagg agcgatacaa
     1141 gcggcatcgg cagaagcaga agcacaagga taaatggaaa cacccagaga gggctgatgc
     1201 caaggaccct gcgtcactgc cccagtgcct ggggcccggc tgtgtgcgcc ccgcccagcc
     1261 cagctccaag tattgctcag atgactgtgg catgaagctg gcagccaacc gcatctacga
     1321 gatcctcccc cagcgcatcc agcagtggca gcagagccct tgcattgctg aagagcacgg
     1381 caagaagctg ctcgaacgca ttcgccgaga gcagcagagt gcccgcactc gccttcagga
     1441 aatggaacgc cgattccatg agcttgaggc catcattcta cgtgccaagc agcaggctgt
     1501 gcgcgaggat gaggagagca acgagggtga cagtgatgac acagacctgc agatcttctg
     1561 tgtttcctgt gggcacccca tcaacccacg tgttgccttg cgccacatgg agcgctgcta
     1621 cgccaagtat gagagccaga cgtcctttgg gtccatgtac cccacacgca ttgaaggggc
     1681 cacacgactc ttctgtgatg tgtataatcc tcagagcaaa acatactgta agcggctcca
     1741 ggtgctgtgc cccgagcact cacgggaccc caaagtgcca gctgacgagg tatgcgggtg
     1801 cccccttgta cgtgatgtct ttgagctcac gggtgacttc tgccgcctgc ccaagcgcca
     1861 gtgcaatcgc cattactgct gggagaagct gcggcgtgcg gaagtggact tggagcgcgt
     1921 gcgtgtgtgg tacaagctgg acgagctgtt tgagcaggag cgcaatgtgc gcacagccat
     1981 gacaaaccgc gcgggattgc tggccctgat gctgcaccag acgatccagc acgatcccct
     2041 cactaccgac ctgcgctcca gtgccgaccg ctgagcctcc tggcccggac cccttacacc
     2101 ctgcattcca gatgggggag ccgcccggtg cccgtgtgtc cgttcctcca ctcatctgtt
     2161 tctccggttc tccctgtgcc catccaccgg ttgaccgccc atctgccttt atcagaggga
     2221 ctgtccccgt cgacatgttc agtgcctggt ggggctgcgg agtccactca tccttgcctc
     2281 ctctccctgg gttttgttaa taaaattttg aagaaaccaa
//
