LOCUS       NM_006564               1968 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 6 (CXCR6), transcript
            variant 1, mRNA.
ACCESSION   NM_006564
VERSION     NM_006564.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Huang,X., Fei,Y., Qiu,X., Qian,T., Shang,Q., Cui,J., Song,Y.,
            Sheng,S., Xiao,W., Yu,Q., Wang,T. and Wang,X.
  TITLE     MiR-625-5p is a potential therapeutic target in sepsis by
            regulating CXCL16/CXCR6 axis and endothelial barrier
  JOURNAL   Int Immunopharmacol 137, 112508 (2024)
   PUBMED   38889512
  REMARK    GeneRIF: MiR-625-5p is a potential therapeutic target in sepsis by
            regulating CXCL16/CXCR6 axis and endothelial barrier.
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Tooley,K., Jerby,L., Escobar,G., Krovi,S.H., Mangani,D.,
            Dandekar,G., Cheng,H., Madi,A., Goldschmidt,E., Lambden,C.,
            Krishnan,R.K., Rozenblatt-Rosen,O., Regev,A. and Anderson,A.C.
  TITLE     Pan-cancer mapping of single CD8+ T cell profiles reveals a
            TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor
            immunity
  JOURNAL   Cell Rep Med 5 (7), 101640 (2024)
   PUBMED   38959885
  REMARK    GeneRIF: Pan-cancer mapping of single CD8[+] T cell profiles
            reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and
            anti-tumor immunity.
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Uvarova,A.N., Stasevich,E.M., Ustiugova,A.S., Mitkin,N.A.,
            Zheremyan,E.A., Sheetikov,S.A., Zornikova,K.V., Bogolyubova,A.V.,
            Rubtsov,M.A., Kulakovskiy,I.V., Kuprash,D.V., Korneev,K.V. and
            Schwartz,A.M.
  TITLE     rs71327024 Associated with COVID-19 Hospitalization Reduces CXCR6
            Promoter Activity in Human CD4+ T Cells via Disruption of c-Myb
            Binding
  JOURNAL   Int J Mol Sci 24 (18), 13790 (2023)
   PUBMED   37762093
  REMARK    GeneRIF: rs71327024 Associated with COVID-19 Hospitalization
            Reduces CXCR6 Promoter Activity in Human CD4[+] T Cells via
            Disruption of c-Myb Binding.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Fallahi,P., Corrado,A., Di Domenicantonio,A., Frenzilli,G.,
            Antonelli,A. and Ferrari,S.M.
  TITLE     CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes
  JOURNAL   Curr Drug Targets 17 (5), 515-519 (2016)
   PUBMED   25547908
  REMARK    Review article
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Czaja,A.J.
  TITLE     Review article: chemokines as orchestrators of autoimmune hepatitis
            and potential therapeutic targets
  JOURNAL   Aliment Pharmacol Ther 40 (3), 261-279 (2014)
   PUBMED   24890045
  REMARK    Review article
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   La Porta,C.A.
  TITLE     CXCR6: the role of environment in tumor progression. Challenges for
            therapy
  JOURNAL   Stem Cell Rev Rep 8 (4), 1282-1285 (2012)
   PUBMED   22678828
  REMARK    GeneRIF: the present review proposes and discusses the possibility
            to modulate tumor self renewal affecting asymmetric/symmetric cell
            division targeting specific factors such as CXCR6.
            Review article
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Deng,L., Chen,N., Li,Y., Zheng,H. and Lei,Q.
  TITLE     CXCR6/CXCL16 functions as a regulator in metastasis and progression
            of cancer
  JOURNAL   Biochim Biophys Acta 1806 (1), 42-49 (2010)
   PUBMED   20122997
  REMARK    Review article
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Loetscher,M., Amara,A., Oberlin,E., Brass,N., Legler,D.,
            Loetscher,P., D'Apuzzo,M., Meese,E., Rousset,D., Virelizier,J.L.,
            Baggiolini,M., Arenzana-Seisdedos,F. and Moser,B.
  TITLE     TYMSTR, a putative chemokine receptor selectively expressed in
            activated T cells, exhibits HIV-1 coreceptor function
  JOURNAL   Curr Biol 7 (9), 652-660 (1997)
   PUBMED   9285716
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Deng,H.K., Unutmaz,D., KewalRamani,V.N. and Littman,D.R.
  TITLE     Expression cloning of new receptors used by simian and human
            immunodeficiency viruses
  JOURNAL   Nature 388 (6639), 296-300 (1997)
   PUBMED   9230441
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Liao,F., Alkhatib,G., Peden,K.W., Sharma,G., Berger,E.A. and
            Farber,J.M.
  TITLE     STRL33, A novel chemokine receptor-like protein, functions as a
            fusion cofactor for both macrophage-tropic and T cell line-tropic
            HIV-1
  JOURNAL   J Exp Med 185 (11), 2015-2023 (1997)
   PUBMED   9166430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099782.2 and Y13248.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006564.1.
            
            Summary: The protein encoded by this gene is a G protein-coupled
            receptor with seven transmembrane domains that belongs to the CXC
            chemokine receptor family. This family also includes CXCR1, CXCR2,
            CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the
            chemokine receptor gene cluster, is expressed in several T
            lymphocyte subsets and bone marrow stromal cells. The encoded
            protein and its exclusive ligand, chemokine ligand 16 (CCL16), are
            part of a signalling pathway that regulates T lymphocyte migration
            to various peripheral tissues (the liver, spleen red pulp,
            intestine, lungs, and skin) and promotes cell-cell interaction with
            dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also
            controls the localization of resident memory T lymphocytes to
            different compartments of the lung and maintains airway resident
            memory T lymphocytes, which are an important first line of defense
            against respiratory pathogens. The encoded protein serves as an
            entry coreceptor used by HIV-1 and SIV to enter target cells, in
            conjunction with CD4. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13248.1, DN995857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304552.5/ ENSP00000304414.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC099782.2         129389-129405
            18-1968             Y13248.1           1-1951
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1968
                     /gene="CXCR6"
                     /gene_synonym="BONZO; CD186; CDw186; STRL33; TYMSTR"
                     /note="C-X-C motif chemokine receptor 6"
                     /db_xref="GeneID:10663"
                     /db_xref="HGNC:HGNC:16647"
                     /db_xref="MIM:605163"
     exon            1..77
                     /gene="CXCR6"
                     /gene_synonym="BONZO; CD186; CDw186; STRL33; TYMSTR"
                     /inference="alignment:Splign:2.1.0"
     exon            78..1968
                     /gene="CXCR6"
                     /gene_synonym="BONZO; CD186; CDw186; STRL33; TYMSTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1127
                     /gene="CXCR6"
                     /gene_synonym="BONZO; CD186; CDw186; STRL33; TYMSTR"
                     /note="G protein-coupled receptor; G-protein coupled
                     receptor bonzo; G-protein coupled receptor STRL33;
                     chemokine (C-X-C motif) receptor 6"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 6"
                     /protein_id="NP_006555.1"
                     /db_xref="CCDS:CCDS2735.1"
                     /db_xref="GeneID:10663"
                     /db_xref="HGNC:HGNC:16647"
                     /db_xref="MIM:605163"
                     /translation="MAEHDYHEDYGFSSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVC
                     GLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMC
                     KSLLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISL
                     LVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL
                     LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAI
                     AYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKSSEDNSKTFSASHNV
                     EATSMFQL"
     regulatory      1945..1950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR6"
                     /gene_synonym="BONZO; CD186; CDw186; STRL33; TYMSTR"
                     /note="hexamer: AATAAA"
     polyA_site      1968
                     /gene="CXCR6"
                     /gene_synonym="BONZO; CD186; CDw186; STRL33; TYMSTR"
                     /note="major polyA site"
ORIGIN      
        1 acatcacaga agtagaggca gaccttgctt catgagcaag ctcatctctg gaacaaactg
       61 gcaaagcatc tctgctggtg ttcatcagaa cagacaccat ggcagagcat gattaccatg
      121 aagactatgg gttcagcagt ttcaatgaca gcagccagga ggagcatcaa gacttcctgc
      181 agttcagcaa ggtctttctg ccctgcatgt acctggtggt gtttgtctgt ggtctggtgg
      241 ggaactctct ggtgctggtc atatccatct tctaccataa gttgcagagc ctgacggatg
      301 tgttcctggt gaacctaccc ctggctgacc tggtgtttgt ctgcactctg cccttctggg
      361 cctatgcagg catccatgaa tgggtgtttg gccaggtcat gtgcaagagc ctactgggca
      421 tctacactat taacttctac acgtccatgc tcatcctcac ctgcatcact gtggatcgtt
      481 tcattgtagt ggttaaggcc accaaggcct acaaccagca agccaagagg atgacctggg
      541 gcaaggtcac cagcttgctc atctgggtga tatccctgct ggtttccttg ccccaaatta
      601 tctatggcaa tgtctttaat ctcgacaagc tcatatgtgg ttaccatgac gaggcaattt
      661 ccactgtggt tcttgccacc cagatgacac tggggttctt cttgccactg ctcaccatga
      721 ttgtctgcta ttcagtcata atcaaaacac tgcttcatgc tggaggcttc cagaagcaca
      781 gatctctaaa gatcatcttc ctggtgatgg ctgtgttcct gctgacccag atgcccttca
      841 acctcatgaa gttcatccgc agcacacact gggaatacta tgccatgacc agctttcact
      901 acaccatcat ggtgacagag gccatcgcat acctgagggc ctgccttaac cctgtgctct
      961 atgcctttgt cagcctgaag tttcgaaaga acttctggaa acttgtgaag gacattggtt
     1021 gcctccctta ccttggggtc tcacatcaat ggaaatcttc tgaggacaat tccaagactt
     1081 tttctgcctc ccacaatgtg gaggccacca gcatgttcca gttataggcc ttgccagggt
     1141 ttcgagaagc tgctctggaa tttgcaagtc atggctgtgc cctcttgatg tggtgaggca
     1201 ggctttgttt atagcttgcg cattctcatg gagaagttat cagacactct ggctggtttg
     1261 gaatgcttct tctcaggcat gaacatgtac tgttctcttc ttgaacactc atgctgaaag
     1321 cccaagtagg gggtctaaaa tttttaagga ctttccttcc tccatctcca agaatgctga
     1381 aaccaagggg gatgacatgt gactcctatg atctcaggtt ctccttgatt gggactgggg
     1441 ctgaaggttg aagaggtgag cacggccaac aaagctgttg atggtaggtg gcacactggg
     1501 tgcccaagct cagaaggctc ttctgactac tgggcaaaga gtgtagatca gagcagcagt
     1561 gaaaacaagt gctggcacca ccaggcacct cacagaaatg agatcaggct ctgcctcacc
     1621 ttggggcttg acttttgtat aggtagatgt tcagattgct ttgattaatc cagaataact
     1681 agcaccaggg actatgaatg ggcaaaactg aattataaga ggctgataat tccagtggtc
     1741 catggaatgc ttgaaaaatg tgcaaaacag cgtttaagac tgtaatgaat ctaagcagca
     1801 tttctgaagt ggactctttg gtggctttgc attttaaaaa tgaaattttc caatgtctgc
     1861 cacacaaacg tatgtaaatg tatataccca cacacataca cacatatgtc atatattact
     1921 agcatatgag tttcatagct aagaaataaa actgttaaag tctccaaa
//
