LOCUS       NM_001716               4293 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 5 (CXCR5), transcript
            variant 1, mRNA.
ACCESSION   NM_001716
VERSION     NM_001716.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4293)
  AUTHORS   Zhang,Z., Zhang,H., Antonic-Baker,A., Kwan,P., Yan,Y. and Ma,Y.
  TITLE     CXCR5 Regulates Neuronal Polarity Development and Migration in the
            Embryonic Stage via F-Actin Homeostasis and Results in
            Epilepsy-Related Behavior
  JOURNAL   Neurosci Bull 39 (11), 1605-1622 (2023)
   PUBMED   37460877
  REMARK    GeneRIF: CXCR5 Regulates Neuronal Polarity Development and
            Migration in the Embryonic Stage via F-Actin Homeostasis and
            Results in Epilepsy-Related Behavior.
REFERENCE   2  (bases 1 to 4293)
  AUTHORS   Hinrichs,A.C., Kruize,A.A., Lafeber,F.P.J.G., Leavis,H.L. and van
            Roon,J.A.G.
  TITLE     CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary
            Sjogren's Syndrome and Are Enriched in PD-1/ICOS-Expressing
            Effector T Cells
  JOURNAL   Int J Mol Sci 24 (15), 11952 (2023)
   PUBMED   37569326
  REMARK    GeneRIF: CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in
            Primary Sjogren's Syndrome and Are Enriched in PD-1/ICOS-Expressing
            Effector T Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4293)
  AUTHORS   Shi,Y., Chang,C., Xu,L., Jiang,P., Wei,K., Zhao,J., Xu,L., Jin,Y.,
            Zhang,R., Wang,H., Qian,Y., Qin,Y., Ding,Q., Jiang,T., Guo,S.,
            Wang,R. and He,D.
  TITLE     Circulating DNA methylation level of CXCR5 correlates with
            inflammation in patients with rheumatoid arthritis
  JOURNAL   Immun Inflamm Dis 11 (6), e902 (2023)
   PUBMED   37382265
  REMARK    GeneRIF: Circulating DNA methylation level of CXCR5 correlates with
            inflammation in patients with rheumatoid arthritis.
REFERENCE   4  (bases 1 to 4293)
  AUTHORS   Su,Z., Ma,C., Zhao,R., Jiang,Y., Cai,Y., Yong,G., Yang,T. and Xu,X.
  TITLE     Heterogeneity of circulating CXCR5-PD-1hiTph cells in patients of
            type 2 and type 1 diabetes in Chinese population
  JOURNAL   Acta Diabetol 60 (6), 767-776 (2023)
   PUBMED   36879107
  REMARK    GeneRIF: Heterogeneity of circulating CXCR5-PD-1[hi]Tph cells in
            patients of type 2 and type 1 diabetes in Chinese population.
REFERENCE   5  (bases 1 to 4293)
  AUTHORS   Hinrichs,A.C., Kruize,A.A., Leavis,H.L. and van Roon,J.A.G.
  TITLE     In patients with primary Sjogren's syndrome innate-like MAIT cells
            display upregulated IL-7R, IFN-gamma, and IL-21 expression and have
            increased proportions of CCR9 and CXCR5-expressing cells
  JOURNAL   Front Immunol 13, 1017157 (2022)
   PUBMED   36505431
  REMARK    GeneRIF: In patients with primary Sjogren's syndrome innate-like
            MAIT cells display upregulated IL-7R, IFN-gamma, and IL-21
            expression and have increased proportions of CCR9 and
            CXCR5-expressing cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4293)
  AUTHORS   Muller,G. and Lipp,M.
  TITLE     Signal transduction by the chemokine receptor CXCR5: structural
            requirements for G protein activation analyzed by chimeric
            CXCR1/CXCR5 molecules
  JOURNAL   Biol Chem 382 (9), 1387-1397 (2001)
   PUBMED   11688722
  REMARK    GeneRIF: structural requirements for the activation of signal
            transduction pathways by CXCR5
REFERENCE   7  (bases 1 to 4293)
  AUTHORS   Gunn,M.D., Ngo,V.N., Ansel,K.M., Ekland,E.H., Cyster,J.G. and
            Williams,L.T.
  TITLE     A B-cell-homing chemokine made in lymphoid follicles activates
            Burkitt's lymphoma receptor-1
  JOURNAL   Nature 391 (6669), 799-803 (1998)
   PUBMED   9486651
REFERENCE   8  (bases 1 to 4293)
  AUTHORS   Legler,D.F., Loetscher,M., Roos,R.S., Clark-Lewis,I., Baggiolini,M.
            and Moser,B.
  TITLE     B cell-attracting chemokine 1, a human CXC chemokine expressed in
            lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
  JOURNAL   J Exp Med 187 (4), 655-660 (1998)
   PUBMED   9463416
REFERENCE   9  (bases 1 to 4293)
  AUTHORS   Barella,L., Loetscher,M., Tobler,A., Baggiolini,M. and Moser,B.
  TITLE     Sequence variation of a novel heptahelical leucocyte receptor
            through alternative transcript formation
  JOURNAL   Biochem J 309 (Pt 3) (Pt 3), 773-779 (1995)
   PUBMED   7639692
REFERENCE   10 (bases 1 to 4293)
  AUTHORS   Dobner,T., Wolf,I., Emrich,T. and Lipp,M.
  TITLE     Differentiation-specific expression of a novel G protein-coupled
            receptor from Burkitt's lymphoma
  JOURNAL   Eur J Immunol 22 (11), 2795-2799 (1992)
   PUBMED   1425907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291512.1, BC110352.1,
            AW575330.1 and AP004609.1.
            
            On May 17, 2019 this sequence version replaced NM_001716.4.
            
            Summary: This gene encodes a multi-pass membrane protein that
            belongs to the CXC chemokine receptor family. It is expressed in
            mature B-cells and Burkitt's lymphoma. This cytokine receptor binds
            to B-lymphocyte chemoattractant (BLC), and is involved in B-cell
            migration into B-cell follicles of spleen and Peyer patches.
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Aug 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110352.1, X68149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292174.5/ ENSP00000292174.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               AK291512.1         127-660
            535-1109            BC110352.1         575-1149
            1110-1257           AK291512.1         1236-1383
            1258-2768           BC110352.1         1298-2808
            2769-2777           AW575330.1         17-25               c
            2778-4293           AP004609.1         113280-114795
FEATURES             Location/Qualifiers
     source          1..4293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..4293
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /note="C-X-C motif chemokine receptor 5"
                     /db_xref="GeneID:643"
                     /db_xref="HGNC:HGNC:1060"
                     /db_xref="MIM:601613"
     exon            1..101
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1169
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt
                     lymphoma receptor 1, GTP binding protein (chemokine (C-X-C
                     motif) receptor 5); C-X-C chemokine receptor type 5;
                     monocyte-derived receptor 15; CXC-R5; CXCR-5; MDR-15"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 5 isoform 1"
                     /protein_id="NP_001707.1"
                     /db_xref="CCDS:CCDS8402.1"
                     /db_xref="GeneID:643"
                     /db_xref="HGNC:HGNC:1060"
                     /db_xref="MIM:601613"
                     /translation="MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGP
                     LMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVF
                     ILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRH
                     RRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTS
                     RFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYH
                     IVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLS
                     RLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF"
     exon            102..4293
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /note="hexamer: AATAAA"
     polyA_site      2683
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /note="major polyA site"
     regulatory      2744..2749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /note="hexamer: AATAAA"
     polyA_site      2770
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /note="major polyA site"
     polyA_site      2822
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
ORIGIN      
        1 ctctcaacat aagacagtga ccagtctggt gactcacagc cggcacagcc atgaactacc
       61 cgctaacgct ggaaatggac ctcgagaacc tggaggacct gttctgggaa ctggacagat
      121 tggacaacta taacgacacc tccctggtgg aaaatcatct ctgccctgcc acagaggggc
      181 ccctcatggc ctccttcaag gccgtgttcg tgcccgtggc ctacagcctc atcttcctcc
      241 tgggcgtgat cggcaacgtc ctggtgctgg tgatcctgga gcggcaccgg cagacacgca
      301 gttccacgga gaccttcctg ttccacctgg ccgtggccga cctcctgctg gtcttcatct
      361 tgccctttgc cgtggccgag ggctctgtgg gctgggtcct ggggaccttc ctctgcaaaa
      421 ctgtgattgc cctgcacaaa gtcaacttct actgcagcag cctgctcctg gcctgcatcg
      481 ccgtggaccg ctacctggcc attgtccacg ccgtccatgc ctaccgccac cgccgcctcc
      541 tctccatcca catcacctgt gggaccatct ggctggtggg cttcctcctt gccttgccag
      601 agattctctt cgccaaagtc agccaaggcc atcacaacaa ctccctgcca cgttgcacct
      661 tctcccaaga gaaccaagca gaaacgcatg cctggttcac ctcccgattc ctctaccatg
      721 tggcgggatt cctgctgccc atgctggtga tgggctggtg ctacgtgggg gtagtgcaca
      781 ggttgcgcca ggcccagcgg cgccctcagc ggcagaaggc agtcagggtg gccatcctgg
      841 tgacaagcat cttcttcctc tgctggtcac cctaccacat cgtcatcttc ctggacaccc
      901 tggcgaggct gaaggccgtg gacaatacct gcaagctgaa tggctctctc cccgtggcca
      961 tcaccatgtg tgagttcctg ggcctggccc actgctgcct caaccccatg ctctacactt
     1021 tcgccggcgt gaagttccgc agtgacctgt cgcggctcct gacgaagctg ggctgtaccg
     1081 gccctgcctc cctgtgccag ctcttcccta gctggcgcag gagcagtctc tctgagtcag
     1141 agaatgccac ctctctcacc acgttctagg tcccagtgtc cccttttatt gctgcttttc
     1201 cttggggcag gcagtgatgc tggatgctcc ttccaacagg agctgggatc ctaagggctc
     1261 accgtggcta agagtgtcct aggagtatcc tcatttgggg tagctagagg aaccaacccc
     1321 catttctaga acatccctgc cagctcttct gccggccctg gggctaggct ggagcccagg
     1381 gagcggaaag cagctcaaag gcacagtgaa ggctgtcctt acccatctgc acccccctgg
     1441 gctgagagaa cctcacgcac ctcccatcct aatcatccaa tgctcaagaa acaacttcta
     1501 cttctgccct tgccaacgga gagcgcctgc ccctcccaga acacactcca tcagcttagg
     1561 ggctgctgac ctccacagct tcccctctct cctcctgccc acctgtcaaa caaagccaga
     1621 agctgagcac caggggatga gtggaggtta aggctgagga aaggccagct ggcagcagag
     1681 tgtggccttc ggacaactca gtccctaaaa acacagacat tctgccaggc ccccaagcct
     1741 gcagtcatct tgaccaagca ggaagctcag actggttgag ttcaggtagc tgcccctggc
     1801 tctgaccgaa acagcgctgg gtccacccca tgtcaccgga tcctgggtgg tctgcaggca
     1861 gggctgactc taggtgccct tggaggccag ccagtgacct gaggaagcgt gaaggccgag
     1921 aagcaagaaa gaaacccgac agagggaaga aaagagcttt cttcccgaac cccaaggagg
     1981 gagatggatc aatcaaaccc ggcggtcccc tccgccaggc gagatggggt ggggtggaga
     2041 actcctaggg tggctgggtc caggggatgg gaggttgtgg gcattgatgg ggaaggaggc
     2101 tggcttgtcc cctcctcact cccttcccat aagctataga cccgaggaaa ctcagagtcg
     2161 gaacggagaa aggtggactg gaaggggccc gtgggagtca tctcaaccat cccctccgtg
     2221 gcatcacctt aggcagggaa gtgtaagaaa cacactgagg cagggaagtc cccaggcccc
     2281 aggaagccgt gccctgcccc cgtgaggatg tcactcagat ggaaccgcag gaagctgctc
     2341 cgtgcttgtt tgctcacctg gggtgtggga ggcccgtccg gcagttctgg gtgctcccta
     2401 ccacctcccc agcctttgat caggtgggga gtcagggacc cctgcccttg tcccactcaa
     2461 gccaagcagc caagctcctt gggaggcccc actggggaaa taacagctgt ggctcacgtg
     2521 agagtgtctt cacggcagga caacgaggaa gccctaagac gtcccttttt tctctgagta
     2581 tctcctcgca agctgggtaa tcgatggggg agtctgaagc agatgcaaag aggcaagagg
     2641 ctggattttg aattttcttt ttaataaaaa ggcacctata aaacaggtca atacagtaca
     2701 ggcagcacag agacccccgg aacaagccta aaaattgttt caaaataaaa accaagaaga
     2761 tgtcttcaca tattgtattt atatatttat atttatatat atatttatat aatggtacaa
     2821 aatggctggg ggtgtggcca tggatggagg gaagagtagg ctggcctgtg gcgtgggtgg
     2881 gaggagaggg gacggagagg gcactcggcc cgctgcaatc tgacccctct ctcctcaggg
     2941 caggaaacac agagtcagac agtttggggg ggtcttgggc caggggtgga gggctcaagg
     3001 gcacagggcc caggctgagg cagggcgggc aaagcgcctg gcaggatgaa gggcaagtgg
     3061 ccccccaaac acagaggccc tggccatgga ccctgggagg tgaccggggt gagtcagggg
     3121 cctgttgtca gccccagagg aagcgctgga cctggccgat ggtgggccga gaggacagca
     3181 ccaggctggg agaagtgggg cgagttccct ttgtattaca gctgccagtg caagaccagg
     3241 ccctccaggc caggaaggct agggacgggt cctggtagaa gacaccctgt ctagaatggc
     3301 ccttggtcct ggaggtgggg cgcaaaaggc ctcagccagg gaactgccct gccacctccc
     3361 gaggcaggaa aggaagtgag aaaaggagaa gtttttttac tcctggggcc aaagtagggg
     3421 gacaaacacc cagtcgtata tggcttcagc tctgaccaaa ggcggatagg gagctctcct
     3481 gggtaggagc agggagccaa gggggaggca gtggctgtgc ctgggtgggc acagacagat
     3541 ctggtacatg gccctgagcc ctgggcagag ggacaacctt gccggtgagt gggcaggcag
     3601 agaggaggcg gcaggatgct gtttccccga ttccatcctc agggagtgga gactggaggg
     3661 gaggtgcact gactcagatg aactgttctc ccccttcttt gataagaagt aggtggcagc
     3721 agcctctgga aaagtcaggg ccctggaggt tacctggccc agggctacta cagccacagg
     3781 ccccagtggc accatgccac cccttccatg gctccactca agggggccac acagccaccg
     3841 cctcttcctc ctttccttca tcccaaactg ggacaaaaga cttcaagttc tggctaagat
     3901 gtagcagcag cggatgcccg ggcatccaaa gtggaaagcc agggccccgt gtcaccggtg
     3961 tgggcaaaca cacatgcacg tgcacacatg ttctccctga atcactcagc agcagacagg
     4021 ctgccgccct gggggtctca gccctgctag ggctcaccag gtggaagcct aggtggtctg
     4081 acctcagttt aggagtgggt catttacgtc atcttaccat ttggggacga gacaggaatg
     4141 gtatccctta gggacccaga gacactgcaa acagtgggtg gccatgtagg gctgcatgtc
     4201 cctgggtcca ggggaatgga gggagcaata acttgaagaa ggggggaagg gtttctttta
     4261 tccttttttt tttgtgtgac ttctatcaaa aca
//
