LOCUS       NM_003467               1668 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 4 (CXCR4), transcript
            variant 2, mRNA.
ACCESSION   NM_003467
VERSION     NM_003467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Korayem,O.H., Ahmed,A.E., Meabed,M.H., Magdy,D.M. and
            Abdelghany,W.M.
  TITLE     Potential protective association of the AA genotype and a allele of
            CXCR4 rs2228014 polymorphism with COVID-19 severity in adult
            egyptians
  JOURNAL   BMC Infect Dis 24 (1), 1158 (2024)
   PUBMED   39407172
  REMARK    GeneRIF: Potential protective association of the AA genotype and a
            allele of CXCR4 rs2228014 polymorphism with COVID-19 severity in
            adult egyptians.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Xun,J., Ma,Y., Wang,B., Jiang,X., Liu,B., Gao,R., Zhai,Q.,
            Cheng,R., Wu,X., Wu,Y. and Zhang,Q.
  TITLE     RGS1 targeted by miR-191-3p inhibited the stemness properties of
            esophageal cancer cells by suppressing CXCR4/PI3K/AKT signaling
  JOURNAL   Acta Histochem 126 (5-7), 152190 (2024)
   PUBMED   39173233
  REMARK    GeneRIF: RGS1 targeted by miR-191-3p inhibited the stemness
            properties of esophageal cancer cells by suppressing CXCR4/PI3K/AKT
            signaling.
REFERENCE   3  (bases 1 to 1668)
  AUTHORS   Zhang,Y., Zhang,C., Feng,R., Meng,T., Peng,W., Song,J., Ma,W.,
            Xu,W., Chen,X., Chen,J. and Liang,C.
  TITLE     CXCR4 regulates macrophage M1 polarization by altering glycolysis
            to promote prostate fibrosis
  JOURNAL   Cell Commun Signal 22 (1), 456 (2024)
   PUBMED   39327570
  REMARK    GeneRIF: CXCR4 regulates macrophage M1 polarization by altering
            glycolysis to promote prostate fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1668)
  AUTHORS   Sati,S., Huang,J., Kersh,A.E., Jones,P., Ahart,O., Murphy,C.,
            Prouty,S.M., Hedberg,M.L., Jain,V., Gregory,S.G., Leung,D.H.,
            Seykora,J.T., Rosenbach,M. and Leung,T.H.
  TITLE     Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes
            sarcoidosis from other skin granulomatous diseases
  JOURNAL   J Clin Invest 134 (17), e178711 (2024)
   PUBMED   39225100
  REMARK    GeneRIF: Recruitment of CXCR4+ type 1 innate lymphoid cells
            distinguishes sarcoidosis from other skin granulomatous diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1668)
  AUTHORS   Hu,Y., Xu,Z., Zhou,D., Hou,H., Liu,B., Long,H., Hu,W., Tang,Y.,
            Wang,J., Wei,D. and Zhao,Q.
  TITLE     CXCR4 promotes migration, invasion, and epithelial-mesenchymal
            transition of papillary thyroid carcinoma by activating STAT3
            signaling pathway
  JOURNAL   J Cancer Res Ther 20 (4), 1241-1250 (2024)
   PUBMED   39206986
  REMARK    GeneRIF: CXCR4 promotes migration, invasion, and
            epithelial-mesenchymal transition of papillary thyroid carcinoma by
            activating STAT3 signaling pathway.
REFERENCE   6  (bases 1 to 1668)
  AUTHORS   Lu,Z.H., Wang,Z.X., Horuk,R., Hesselgesser,J., Lou,Y.C.,
            Hadley,T.J. and Peiper,S.C.
  TITLE     The promiscuous chemokine binding profile of the Duffy
            antigen/receptor for chemokines is primarily localized to sequences
            in the amino-terminal domain
  JOURNAL   J Biol Chem 270 (44), 26239-26245 (1995)
   PUBMED   7592830
REFERENCE   7  (bases 1 to 1668)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 1668)
  AUTHORS   Nomura,H., Nielsen,B.W. and Matsushima,K.
  TITLE     Molecular cloning of cDNAs encoding a LD78 receptor and putative
            leukocyte chemotactic peptide receptors
  JOURNAL   Int Immunol 5 (10), 1239-1249 (1993)
   PUBMED   7505609
REFERENCE   9  (bases 1 to 1668)
  AUTHORS   Jazin,E.E., Yoo,H., Blomqvist,A.G., Yee,F., Weng,G., Walker,M.W.,
            Salon,J., Larhammar,D. and Wahlestedt,C.
  TITLE     A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its
            human homologue, confers neither NPY binding sites nor NPY
            responsiveness on transfected cells
  JOURNAL   Regul Pept 47 (3), 247-258 (1993)
   PUBMED   8234909
REFERENCE   10 (bases 1 to 1668)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA940702.1 and AF147204.2.
            
            On Aug 31, 2019 this sequence version replaced NM_003467.2.
            
            Summary: This gene encodes a CXC chemokine receptor specific for
            stromal cell-derived factor-1. The protein has 7 transmembrane
            regions and is located on the cell surface. It acts with the CD4
            protein to support HIV entry into cells and is also highly
            expressed in breast cancer cells. Mutations in this gene have been
            associated with WHIM (warts, hypogammaglobulinemia, infections, and
            myelokathexis) syndrome. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 3. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129916.1, BC020968.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241393.4/ ENSP00000241393.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               DA940702.1         32-159
            129-552             DA940702.1         161-584
            553-1668            AF147204.2         772-1887
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.1"
     gene            1..1668
                     /gene="CXCR4"
                     /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3;
                     LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
                     WHIMS; WHIMS1"
                     /note="C-X-C motif chemokine receptor 4"
                     /db_xref="GeneID:7852"
                     /db_xref="HGNC:HGNC:2561"
                     /db_xref="MIM:162643"
     exon            1..104
                     /gene="CXCR4"
                     /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3;
                     LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
                     WHIMS; WHIMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1148
                     /gene="CXCR4"
                     /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3;
                     LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
                     WHIMS; WHIMS1"
                     /note="isoform b is encoded by transcript variant 2;
                     seven-transmembrane-segment receptor, spleen;
                     lipopolysaccharide-associated protein 3; stromal
                     cell-derived factor 1 receptor; CD184 antigen; C-X-C
                     chemokine receptor type 4; neuropeptide Y receptor Y3;
                     fusin; chemokine (C-X-C motif) receptor 4; seven
                     transmembrane helix receptor; SDF-1 receptor;
                     leukocyte-derived seven transmembrane domain receptor;
                     LPS-associated protein 3; neuropeptide Y3 receptor"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 4 isoform b"
                     /protein_id="NP_003458.1"
                     /db_xref="CCDS:CCDS46420.1"
                     /db_xref="GeneID:7852"
                     /db_xref="HGNC:HGNC:2561"
                     /db_xref="MIM:162643"
                     /translation="MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTI
                     YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
                     YFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV
                     WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSC
                     YCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEF
                     ENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKR
                     GGHSSVSTESESSSFHSS"
     exon            105..1668
                     /gene="CXCR4"
                     /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3;
                     LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
                     WHIMS; WHIMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1646..1651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR4"
                     /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3;
                     LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
                     WHIMS; WHIMS1"
                     /note="hexamer: AATAAA"
     polyA_site      1668
                     /gene="CXCR4"
                     /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3;
                     LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
                     WHIMS; WHIMS1"
                     /note="major polyA site"
ORIGIN      
        1 agtttgttgg ctgcggcagc aggtagcaaa gtgacgccga gggcctgagt gctccagtag
       61 ccaccgcatc tggagaacca gcggttacca tggaggggat cagtatatac acttcagata
      121 actacaccga ggaaatgggc tcaggggact atgactccat gaaggaaccc tgtttccgtg
      181 aagaaaatgc taatttcaat aaaatcttcc tgcccaccat ctactccatc atcttcttaa
      241 ctggcattgt gggcaatgga ttggtcatcc tggtcatggg ttaccagaag aaactgagaa
      301 gcatgacgga caagtacagg ctgcacctgt cagtggccga cctcctcttt gtcatcacgc
      361 ttcccttctg ggcagttgat gccgtggcaa actggtactt tgggaacttc ctatgcaagg
      421 cagtccatgt catctacaca gtcaacctct acagcagtgt cctcatcctg gccttcatca
      481 gtctggaccg ctacctggcc atcgtccacg ccaccaacag tcagaggcca aggaagctgt
      541 tggctgaaaa ggtggtctat gttggcgtct ggatccctgc cctcctgctg actattcccg
      601 acttcatctt tgccaacgtc agtgaggcag atgacagata tatctgtgac cgcttctacc
      661 ccaatgactt gtgggtggtt gtgttccagt ttcagcacat catggttggc cttatcctgc
      721 ctggtattgt catcctgtcc tgctattgca ttatcatctc caagctgtca cactccaagg
      781 gccaccagaa gcgcaaggcc ctcaagacca cagtcatcct catcctggct ttcttcgcct
      841 gttggctgcc ttactacatt gggatcagca tcgactcctt catcctcctg gaaatcatca
      901 agcaagggtg tgagtttgag aacactgtgc acaagtggat ttccatcacc gaggccctag
      961 ctttcttcca ctgttgtctg aaccccatcc tctatgcttt ccttggagcc aaatttaaaa
     1021 cctctgccca gcacgcactc acctctgtga gcagagggtc cagcctcaag atcctctcca
     1081 aaggaaagcg aggtggacat tcatctgttt ccactgagtc tgagtcttca agttttcact
     1141 ccagctaaca cagatgtaaa agactttttt ttatacgata aataactttt ttttaagtta
     1201 cacatttttc agatataaaa gactgaccaa tattgtacag tttttattgc ttgttggatt
     1261 tttgtcttgt gtttctttag tttttgtgaa gtttaattga cttatttata taaatttttt
     1321 ttgtttcata ttgatgtgtg tctaggcagg acctgtggcc aagttcttag ttgctgtatg
     1381 tctcgtggta ggactgtaga aaagggaact gaacattcca gagcgtgtag tgaatcacgt
     1441 aaagctagaa atgatcccca gctgtttatg catagataat ctctccattc ccgtggaacg
     1501 tttttcctgt tcttaagacg tgattttgct gtagaagatg gcacttataa ccaaagccca
     1561 aagtggtata gaaatgctgg tttttcagtt ttcaggagtg ggttgatttc agcacctaca
     1621 gtgtacagtc ttgtattaag ttgttaataa aagtacatgt taaactta
//
