LOCUS       NM_001504               1615 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 3 (CXCR3), transcript
            variant 1, mRNA.
ACCESSION   NM_001504
VERSION     NM_001504.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Wang,F., Guo,B., Jia,Z., Jing,Z., Wang,Q., Li,M., Lu,B., Liang,W.,
            Hu,W. and Fu,X.
  TITLE     The Role of CXCR3 in Nervous System-Related Diseases
  JOURNAL   Mediators Inflamm 2024, 8347647 (2024)
   PUBMED   39429695
  REMARK    GeneRIF: The Role of CXCR3 in Nervous System-Related Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Wang,K., Wu,J., Yang,Z., Zheng,B., Shen,S., Wang,R.R., Zhang,Y.,
            Wang,H.Y., Chen,L. and Qiu,X.
  TITLE     Hyperactivation of beta-catenin signal in hepatocellular carcinoma
            recruits myeloid-derived suppressor cells through PF4-CXCR3 axis
  JOURNAL   Cancer Lett 586, 216690 (2024)
   PUBMED   38307410
  REMARK    GeneRIF: Hyperactivation of beta-catenin signal in hepatocellular
            carcinoma recruits myeloid-derived suppressor cells through
            PF4-CXCR3 axis.
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Liu,H., Wang,Y., Le,Q., Tong,J. and Wang,H.
  TITLE     The IFN-gamma-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological
            mechanism and treatment
  JOURNAL   Eur J Immunol 54 (4), e2250281 (2024)
   PUBMED   37937817
  REMARK    GeneRIF: The IFN-gamma-CXCL9/CXCL10-CXCR3 axis in vitiligo:
            Pathological mechanism and treatment.
            Review article
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Hosaka,S., Imagawa,K., Yano,Y., Lin,L., Shiono,J.,
            Takahashi-Igari,M., Hara,H., Hayashi,D., Imai,H., Morita,A.,
            Fukushima,H. and Takada,H.
  TITLE     The CXCL10-CXCR3 axis plays an important role in Kawasaki disease
  JOURNAL   Clin Exp Immunol 216 (1), 104-111 (2024)
   PUBMED   37952216
  REMARK    GeneRIF: The CXCL10-CXCR3 axis plays an important role in Kawasaki
            disease.
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Shamsi,A., Roghani,S.A., Abdan,Z., Soufivand,P., Pournazari,M.,
            Bahrehmand,F., Vafaei,A., Salari,N., Soroush,M.G. and Taghadosi,M.
  TITLE     CXCL9 and its Receptor CXCR3, an Important Link Between
            Inflammation and Cardiovascular Risks in RA Patients
  JOURNAL   Inflammation 46 (6), 2374-2385 (2023)
   PUBMED   37542661
  REMARK    GeneRIF: CXCL9 and its Receptor CXCR3, an Important Link Between
            Inflammation and Cardiovascular Risks in RA Patients.
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Qin,S., Rottman,J.B., Myers,P., Kassam,N., Weinblatt,M.,
            Loetscher,M., Koch,A.E., Moser,B. and Mackay,C.R.
  TITLE     The chemokine receptors CXCR3 and CCR5 mark subsets of T cells
            associated with certain inflammatory reactions
  JOURNAL   J Clin Invest 101 (4), 746-754 (1998)
   PUBMED   9466968
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Bonecchi,R., Bianchi,G., Bordignon,P.P., D'Ambrosio,D., Lang,R.,
            Borsatti,A., Sozzani,S., Allavena,P., Gray,P.A., Mantovani,A. and
            Sinigaglia,F.
  TITLE     Differential expression of chemokine receptors and chemotactic
            responsiveness of type 1 T helper cells (Th1s) and Th2s
  JOURNAL   J Exp Med 187 (1), 129-134 (1998)
   PUBMED   9419219
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Loetscher,M., Gerber,B., Loetscher,P., Jones,S.A., Piali,L.,
            Clark-Lewis,I., Baggiolini,M. and Moser,B.
  TITLE     Chemokine receptor specific for IP10 and mig: structure, function,
            and expression in activated T-lymphocytes
  JOURNAL   J Exp Med 184 (3), 963-969 (1996)
   PUBMED   9064356
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Marchese,A., Heiber,M., Nguyen,T., Heng,H.H., Saldivia,V.R.,
            Cheng,R., Murphy,P.M., Tsui,L.C., Shi,X., Gregor,P. et al.
  TITLE     Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
            and GPR14, encoding receptors related to interleukin 8,
            neuropeptide Y, and somatostatin receptors
  JOURNAL   Genomics 29 (2), 335-344 (1995)
   PUBMED   8666380
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X95876.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001504.1.
            
            Summary: This gene encodes a G protein-coupled receptor with
            selectivity for three chemokines, termed CXCL9/Mig (monokine
            induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10
            kDa protein) and CXCL11/I-TAC (interferon-inducible T cell
            a-chemoattractant). Binding of chemokines to this protein induces
            cellular responses that are involved in leukocyte traffic, most
            notably integrin activation, cytoskeletal changes and chemotactic
            migration. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. One of the
            isoforms (CXCR3-B) shows high affinity binding to chemokine,
            CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1 (also known as CXCR3-A). This
            isoform functions as a receptor for chemokines CXCL9/Mig,
            CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.105067.1, X95876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373693.4/ ENSP00000362797.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1615              X95876.1           7-1621
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1615
                     /gene="CXCR3"
                     /gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
                     Mig-R; MigR"
                     /note="C-X-C motif chemokine receptor 3"
                     /db_xref="GeneID:2833"
                     /db_xref="HGNC:HGNC:4540"
                     /db_xref="MIM:300574"
     exon            1..74
                     /gene="CXCR3"
                     /gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
                     Mig-R; MigR"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1169
                     /gene="CXCR3"
                     /gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
                     Mig-R; MigR"
                     /note="isoform 1 is encoded by transcript variant 1; Mig
                     receptor; G protein-coupled receptor 9; C-X-C chemokine
                     receptor type 3; IP-10 receptor; chemokine (C-X-C motif)
                     receptor 3; interferon-inducible protein 10 receptor;
                     chemokine receptor 3"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 3 isoform 1"
                     /protein_id="NP_001495.1"
                     /db_xref="CCDS:CCDS14416.1"
                     /db_xref="GeneID:2833"
                     /db_xref="HGNC:HGNC:4540"
                     /db_xref="MIM:300574"
                     /translation="MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCP
                     QDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLL
                     VLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLY
                     RRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVL
                     QLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVL
                     VDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLL
                     RLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL"
     exon            75..1615
                     /gene="CXCR3"
                     /gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
                     Mig-R; MigR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR3"
                     /gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
                     Mig-R; MigR"
                     /note="hexamer: AATAAA"
     polyA_site      1615
                     /gene="CXCR3"
                     /gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
                     Mig-R; MigR"
                     /note="major polyA site"
ORIGIN      
        1 acaagcacca aagcagaggg gcaggcagca caccacccag cagccagagc accagcccag
       61 ccatggtcct tgaggtgagt gaccaccaag tgctaaatga cgccgaggtt gccgccctcc
      121 tggagaactt cagctcttcc tatgactatg gagaaaacga gagtgactcg tgctgtacct
      181 ccccgccctg cccacaggac ttcagcctga acttcgaccg ggccttcctg ccagccctct
      241 acagcctcct ctttctgctg gggctgctgg gcaacggcgc ggtggcagcc gtgctgctga
      301 gccggcggac agccctgagc agcaccgaca ccttcctgct ccacctagct gtagcagaca
      361 cgctgctggt gctgacactg ccgctctggg cagtggacgc tgccgtccag tgggtctttg
      421 gctctggcct ctgcaaagtg gcaggtgccc tcttcaacat caacttctac gcaggagccc
      481 tcctgctggc ctgcatcagc tttgaccgct acctgaacat agttcatgcc acccagctct
      541 accgccgggg gcccccggcc cgcgtgaccc tcacctgcct ggctgtctgg gggctctgcc
      601 tgcttttcgc cctcccagac ttcatcttcc tgtcggccca ccacgacgag cgcctcaacg
      661 ccacccactg ccaatacaac ttcccacagg tgggccgcac ggctctgcgg gtgctgcagc
      721 tggtggctgg ctttctgctg cccctgctgg tcatggccta ctgctatgcc cacatcctgg
      781 ccgtgctgct ggtttccagg ggccagcggc gcctgcgggc catgcggctg gtggtggtgg
      841 tcgtggtggc ctttgccctc tgctggaccc cctatcacct ggtggtgctg gtggacatcc
      901 tcatggacct gggcgctttg gcccgcaact gtggccgaga aagcagggta gacgtggcca
      961 agtcggtcac ctcaggcctg ggctacatgc actgctgcct caacccgctg ctctatgcct
     1021 ttgtaggggt caagttccgg gagcggatgt ggatgctgct cttgcgcctg ggctgcccca
     1081 accagagagg gctccagagg cagccatcgt cttcccgccg ggattcatcc tggtctgaga
     1141 cctcagaggc ctcctactcg ggcttgtgag gccggaatcc gggctcccct ttcgcccaca
     1201 gtctgacttc cccgcattcc aggctcctcc ctccctctgc cggctctggc tctccccaat
     1261 atcctcgctc ccgggactca ctggcagccc cagcaccacc aggtctcccg ggaagccacc
     1321 ctcccagctc tgaggactgc accattgctg ctccttagct gccaagcccc atcctgccgc
     1381 ccgaggtggc tgcctggagc cccactgccc ttctcatttg gaaactaaaa cttcatcttc
     1441 cccaagtgcg gggagtacaa ggcatggcgt agagggtgct gccccatgaa gccacagccc
     1501 aggcctccag ctcagcagtg actgtggcca tggtccccaa gacctctata tttgctcttt
     1561 tatttttatg tctaaaatcc tgcttaaaac ttttcaataa acaagatcgt cagga
//
