LOCUS       NM_001557               2853 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 2 (CXCR2), transcript
            variant 1, mRNA.
ACCESSION   NM_001557
VERSION     NM_001557.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Si,W., Liu,J., Wang,Y., Mao,Y., Zhang,Y., Xu,S., Guo,K., Zhang,Y.,
            Hu,Y. and Zhang,F.
  TITLE     IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113074 (2024)
   PUBMED   39244903
  REMARK    GeneRIF: IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway.
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Xiong,G., Chen,Z., Liu,Q., Peng,F., Zhang,C., Cheng,M., Ling,R.,
            Chen,S., Liang,Y., Chen,D. and Zhou,Q.
  TITLE     CD276 regulates the immune escape of esophageal squamous cell
            carcinoma through CXCL1-CXCR2 induced NETs
  JOURNAL   J Immunother Cancer 12 (5), e008662 (2024)
   PUBMED   38724465
  REMARK    GeneRIF: CD276 regulates the immune escape of esophageal squamous
            cell carcinoma through CXCL1-CXCR2 induced NETs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Yin,C., Liu,B., Dong,Z., Shi,S., Peng,C., Pan,Y., Bi,X., Nie,H.,
            Zhang,Y., Tai,Y., Hu,Q., Wang,X., Shao,X., An,H., Fang,J., Wang,C.
            and Liu,B.
  TITLE     CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint
            pain and inflammation in experimental gouty arthritis
  JOURNAL   Nat Commun 15 (1), 3263 (2024)
   PUBMED   38627393
  REMARK    GeneRIF: CXCL5 activates CXCR2 in nociceptive sensory neurons to
            drive joint pain and inflammation in experimental gouty arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Wang,L., Gao,J., Zheng,S., Luo,Z., Xu,Z., Che,H. and Wang,Z.
  TITLE     CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the
            Formation and Progression of RCC with Inferior Vena Cava Tumour
            Thrombus
  JOURNAL   Arch Esp Urol 77 (3), 292-302 (2024)
   PUBMED   38715171
  REMARK    GeneRIF: CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in
            the Formation and Progression of RCC with Inferior Vena Cava Tumour
            Thrombus.
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Cui,S., Chen,X., Li,J., Wang,W., Meng,D., Zhu,S. and Shen,S.
  TITLE     Endothelial CXCR2 deficiency attenuates renal inflammation and
            glycocalyx shedding through NF-kappaB signaling in diabetic kidney
            disease
  JOURNAL   Cell Commun Signal 22 (1), 191 (2024)
   PUBMED   38528533
  REMARK    GeneRIF: Endothelial CXCR2 deficiency attenuates renal inflammation
            and glycocalyx shedding through NF-kappaB signaling in diabetic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2853)
  AUTHORS   Morris,S.W., Nelson,N., Valentine,M.B., Shapiro,D.N., Look,A.T.,
            Kozlosky,C.J., Beckmann,M.P. and Cerretti,D.P.
  TITLE     Assignment of the genes encoding human interleukin-8 receptor types
            1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35
  JOURNAL   Genomics 14 (3), 685-691 (1992)
   PUBMED   1427896
REFERENCE   7  (bases 1 to 2853)
  AUTHORS   Lee,J., Horuk,R., Rice,G.C., Bennett,G.L., Camerato,T. and
            Wood,W.I.
  TITLE     Characterization of two high affinity human interleukin-8 receptors
  JOURNAL   J Biol Chem 267 (23), 16283-16287 (1992)
   PUBMED   1379593
REFERENCE   8  (bases 1 to 2853)
  AUTHORS   Murphy,P.M. and Tiffany,H.L.
  TITLE     Cloning of complementary DNA encoding a functional human
            interleukin-8 receptor
  JOURNAL   Science 253 (5025), 1280-1283 (1991)
   PUBMED   1891716
REFERENCE   9  (bases 1 to 2853)
  AUTHORS   Holmes,W.E., Lee,J., Kuang,W.J., Rice,G.C. and Wood,W.I.
  TITLE     Structure and functional expression of a human interleukin-8
            receptor
  JOURNAL   Science 253 (5025), 1278-1280 (1991)
   PUBMED   1840701
REFERENCE   10 (bases 1 to 2853)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L19593.1 and AC124768.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001557.3.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein-coupled receptor family. This protein is a receptor for
            interleukin 8 (IL8). It binds to IL8 with high affinity, and
            transduces the signal through a G-protein activated second
            messenger system. This receptor also binds to chemokine (C-X-C
            motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth
            stimulating activity, and has been shown to be a major component
            required for serum-dependent melanoma cell growth. This receptor
            mediates neutrophil migration to sites of inflammation. The
            angiogenic effects of IL8 in intestinal microvascular endothelial
            cells are found to be mediated by this receptor. Knockout studies
            in mice suggested that this receptor controls the positioning of
            oligodendrocyte precursors in developing spinal cord by arresting
            their migration. This gene, IL8RA, a gene encoding another high
            affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB,
            form a gene cluster in a region mapped to chromosome 2q33-q36.
            Alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037961.1, L19593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318507.7/ ENSP00000319635.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1509              L19593.1           6-1514
            1510-2853           AC124768.4         71508-72851
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2853
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="C-X-C motif chemokine receptor 2"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:HGNC:6027"
                     /db_xref="MIM:146928"
     exon            1..326
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..378
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..2853
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1486
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="interleukin 8 receptor, beta; CXCR2 gene for IL8
                     receptor type B; interleukin 8 receptor type 2; chemokine
                     (CXC) receptor 2; high affinity interleukin-8 receptor B;
                     GRO/MGSA receptor; interleukin-8 receptor type B; CXC-R2;
                     CXCR-2; IL-8R B; IL-8 receptor type 2"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 2"
                     /protein_id="NP_001548.1"
                     /db_xref="CCDS:CCDS2408.1"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:HGNC:6027"
                     /db_xref="MIM:146928"
                     /translation="MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESL
                     EINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP
                     IWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRY
                     LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSF
                     GFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL
                     MRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGL
                     ISKDSLPKDSRPSFVGSSSGHTSTTL"
     regulatory      2827..2832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="hexamer: AATAAA"
     polyA_site      2853
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="major polyA site"
ORIGIN      
        1 agagacagaa ggtggataga caaatctcca ccttcagact ggtaggctcc tccagaagcc
       61 atcagacagg aagatgtgaa aatccccagc actcatccca gaatcactaa gtggcacctg
      121 tcctgggcca aagtcccagg acagacctca ttgttcctct gtgggaatac ctccccagga
      181 gggcatcctg gatttccccc ttgcaaccca ggtcagaagt ttcatcgtca aggttgtttc
      241 atcttttttt tcctgtctaa cagctctgac taccacccaa ccttgaggca cagtgaagac
      301 atcggtggcc actccaataa cagcaggtca cagctgctct tctggaggtg tcctacaggt
      361 gaaaagccca gcgacccagt caggatttaa gtttacctca aaaatggaag attttaacat
      421 ggagagtgac agctttgaag atttctggaa aggtgaagat cttagtaatt acagttacag
      481 ctctaccctg cccccttttc tactagatgc cgccccatgt gaaccagaat ccctggaaat
      541 caacaagtat tttgtggtca ttatctatgc cctggtattc ctgctgagcc tgctgggaaa
      601 ctccctcgtg atgctggtca tcttatacag cagggtcggc cgctccgtca ctgatgtcta
      661 cctgctgaac ctagccttgg ccgacctact ctttgccctg accttgccca tctgggccgc
      721 ctccaaggtg aatggctgga tttttggcac attcctgtgc aaggtggtct cactcctgaa
      781 ggaagtcaac ttctatagtg gcatcctgct actggcctgc atcagtgtgg accgttacct
      841 ggccattgtc catgccacac gcacactgac ccagaagcgc tacttggtca aattcatatg
      901 tctcagcatc tggggtctgt ccttgctcct ggccctgcct gtcttacttt tccgaaggac
      961 cgtctactca tccaatgtta gcccagcctg ctatgaggac atgggcaaca atacagcaaa
     1021 ctggcggatg ctgttacgga tcctgcccca gtcctttggc ttcatcgtgc cactgctgat
     1081 catgctgttc tgctacggat tcaccctgcg tacgctgttt aaggcccaca tggggcagaa
     1141 gcaccgggcc atgcgggtca tctttgctgt cgtcctcatc ttcctgctct gctggctgcc
     1201 ctacaacctg gtcctgctgg cagacaccct catgaggacc caggtgatcc aggagacctg
     1261 tgagcgccgc aatcacatcg accgggctct ggatgccacc gagattctgg gcatccttca
     1321 cagctgcctc aaccccctca tctacgcctt cattggccag aagtttcgcc atggactcct
     1381 caagattcta gctatacatg gcttgatcag caaggactcc ctgcccaaag acagcaggcc
     1441 ttcctttgtt ggctcttctt cagggcacac ttccactact ctctaagacc tcctgcctaa
     1501 gtgcagcccc gtggggttcc tcccttctct tcacagtcac attccaagcc tcatgtccac
     1561 tggttcttct tggtctcagt gtcaatgcag cccccattgt ggtcacagga agtagaggag
     1621 gccacgttct tactagtttc ccttgcatgg tttagaaagc ttgccctggt gcctcacccc
     1681 ttgccataat tactatgtca tttgctggag ctctgcccat cctgcccctg agcccatggc
     1741 actctatgtt ctaagaagtg aaaatctaca ctccagtgag acagctctgc atactcatta
     1801 ggatggctag tatcaaaaga aagaaaatca ggctggccaa cggggtgaaa ccctgtctct
     1861 actaaaaata caaaaaaaaa aaaaaattag ccgggcgtgg tggtgagtgc ctgtaatcac
     1921 agctacttgg gaggctgaga tgggagaatc acttgaaccc gggaggcaga ggttgcagtg
     1981 agccgagatt gtgcccctgc actccagcct gagcgacagt gagactctgt ctcagtccat
     2041 gaagatgtag aggagaaact ggaactctcg agcgttgctg ggggggattg taaaatggtg
     2101 tgaccactgc agaagacagt atggcagctt tcctcaaaac ttcagacata gaattaacac
     2161 atgatcctgc aattccactt ataggaattg acccacaaga aatgaaagca gggacttgaa
     2221 cccatatttg tacaccaata ttcatagcag cttattcaca agacccaaaa ggcagaagca
     2281 acccaaatgt tcatcaatga atgaatgaat ggctaagcaa aatgtgatat gtacctaacg
     2341 aagtatcctt cagcctgaaa gaggaatgaa gtactcatac atgttacaac acggacgaac
     2401 cttgaaaact ttatgctaag tgaaataagc cagacatcaa cagataaata gtttatgatt
     2461 ccacctacat gaggtactga gagtgaacaa atttacagag acagaaagca gaacagtgat
     2521 taccagggac tgaggggagg ggagcatggg aagtgacggt ttaatgggca cagggtttat
     2581 gtttaggatg ttgaaaaagt tctgcagata aacagtagtg atagttgtac cgcaatgtga
     2641 cttaatgcca ctaaattgac acttaaaaat ggtttaaatg gtcaattttg ttatgtatat
     2701 tttatatcaa tttaaaaaaa aacctgagcc ccaaaaggta ttttaatcac caaggctgat
     2761 taaaccaagg ctagaaccac ctgcctatat tttttgttaa atgatttcat tcaatatctt
     2821 ttttttaata aaccattttt acttgggtgt tta
//
