LOCUS       NM_001168298            2656 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 2 (CXCR2), transcript
            variant 2, mRNA.
ACCESSION   NM_001168298
VERSION     NM_001168298.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Si,W., Liu,J., Wang,Y., Mao,Y., Zhang,Y., Xu,S., Guo,K., Zhang,Y.,
            Hu,Y. and Zhang,F.
  TITLE     IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113074 (2024)
   PUBMED   39244903
  REMARK    GeneRIF: IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway.
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   Xiong,G., Chen,Z., Liu,Q., Peng,F., Zhang,C., Cheng,M., Ling,R.,
            Chen,S., Liang,Y., Chen,D. and Zhou,Q.
  TITLE     CD276 regulates the immune escape of esophageal squamous cell
            carcinoma through CXCL1-CXCR2 induced NETs
  JOURNAL   J Immunother Cancer 12 (5), e008662 (2024)
   PUBMED   38724465
  REMARK    GeneRIF: CD276 regulates the immune escape of esophageal squamous
            cell carcinoma through CXCL1-CXCR2 induced NETs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2656)
  AUTHORS   Yin,C., Liu,B., Dong,Z., Shi,S., Peng,C., Pan,Y., Bi,X., Nie,H.,
            Zhang,Y., Tai,Y., Hu,Q., Wang,X., Shao,X., An,H., Fang,J., Wang,C.
            and Liu,B.
  TITLE     CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint
            pain and inflammation in experimental gouty arthritis
  JOURNAL   Nat Commun 15 (1), 3263 (2024)
   PUBMED   38627393
  REMARK    GeneRIF: CXCL5 activates CXCR2 in nociceptive sensory neurons to
            drive joint pain and inflammation in experimental gouty arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2656)
  AUTHORS   Wang,L., Gao,J., Zheng,S., Luo,Z., Xu,Z., Che,H. and Wang,Z.
  TITLE     CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the
            Formation and Progression of RCC with Inferior Vena Cava Tumour
            Thrombus
  JOURNAL   Arch Esp Urol 77 (3), 292-302 (2024)
   PUBMED   38715171
  REMARK    GeneRIF: CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in
            the Formation and Progression of RCC with Inferior Vena Cava Tumour
            Thrombus.
REFERENCE   5  (bases 1 to 2656)
  AUTHORS   Cui,S., Chen,X., Li,J., Wang,W., Meng,D., Zhu,S. and Shen,S.
  TITLE     Endothelial CXCR2 deficiency attenuates renal inflammation and
            glycocalyx shedding through NF-kappaB signaling in diabetic kidney
            disease
  JOURNAL   Cell Commun Signal 22 (1), 191 (2024)
   PUBMED   38528533
  REMARK    GeneRIF: Endothelial CXCR2 deficiency attenuates renal inflammation
            and glycocalyx shedding through NF-kappaB signaling in diabetic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2656)
  AUTHORS   Morris,S.W., Nelson,N., Valentine,M.B., Shapiro,D.N., Look,A.T.,
            Kozlosky,C.J., Beckmann,M.P. and Cerretti,D.P.
  TITLE     Assignment of the genes encoding human interleukin-8 receptor types
            1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35
  JOURNAL   Genomics 14 (3), 685-691 (1992)
   PUBMED   1427896
REFERENCE   7  (bases 1 to 2656)
  AUTHORS   Lee,J., Horuk,R., Rice,G.C., Bennett,G.L., Camerato,T. and
            Wood,W.I.
  TITLE     Characterization of two high affinity human interleukin-8 receptors
  JOURNAL   J Biol Chem 267 (23), 16283-16287 (1992)
   PUBMED   1379593
REFERENCE   8  (bases 1 to 2656)
  AUTHORS   Murphy,P.M. and Tiffany,H.L.
  TITLE     Cloning of complementary DNA encoding a functional human
            interleukin-8 receptor
  JOURNAL   Science 253 (5025), 1280-1283 (1991)
   PUBMED   1891716
REFERENCE   9  (bases 1 to 2656)
  AUTHORS   Holmes,W.E., Lee,J., Kuang,W.J., Rice,G.C. and Wood,W.I.
  TITLE     Structure and functional expression of a human interleukin-8
            receptor
  JOURNAL   Science 253 (5025), 1278-1280 (1991)
   PUBMED   1840701
REFERENCE   10 (bases 1 to 2656)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA674925.1, AC124768.4 and
            AJ710879.1.
            
            On May 31, 2019 this sequence version replaced NM_001168298.1.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein-coupled receptor family. This protein is a receptor for
            interleukin 8 (IL8). It binds to IL8 with high affinity, and
            transduces the signal through a G-protein activated second
            messenger system. This receptor also binds to chemokine (C-X-C
            motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth
            stimulating activity, and has been shown to be a major component
            required for serum-dependent melanoma cell growth. This receptor
            mediates neutrophil migration to sites of inflammation. The
            angiogenic effects of IL8 in intestinal microvascular endothelial
            cells are found to be mediated by this receptor. Knockout studies
            in mice suggested that this receptor controls the positioning of
            oligodendrocyte precursors in developing spinal cord by arresting
            their migration. This gene, IL8RA, a gene encoding another high
            affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB,
            form a gene cluster in a region mapped to chromosome 2q33-q36.
            Alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.345773.1, DA674925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               DA674925.1         5-580
            577-2522            AC124768.4         70772-72717
            2523-2656           AJ710879.1         1-134
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2656
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="C-X-C motif chemokine receptor 2"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:HGNC:6027"
                     /db_xref="MIM:146928"
     exon            1..66
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..129
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..181
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..2656
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1289
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="interleukin 8 receptor, beta; CXCR2 gene for IL8
                     receptor type B; interleukin 8 receptor type 2; chemokine
                     (CXC) receptor 2; high affinity interleukin-8 receptor B;
                     GRO/MGSA receptor; interleukin-8 receptor type B; CXC-R2;
                     CXCR-2; IL-8R B; IL-8 receptor type 2"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 2"
                     /protein_id="NP_001161770.1"
                     /db_xref="CCDS:CCDS2408.1"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:HGNC:6027"
                     /db_xref="MIM:146928"
                     /translation="MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESL
                     EINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP
                     IWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRY
                     LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSF
                     GFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL
                     MRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGL
                     ISKDSLPKDSRPSFVGSSSGHTSTTL"
     regulatory      2630..2635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="hexamer: AATAAA"
     polyA_site      2656
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB; WHIMS2"
                     /note="major polyA site"
ORIGIN      
        1 agtggtgata gctgagaata tgcagccgtt ttctccttcc tgggtacagt gctattctgc
       61 ctagagctct gactaccacc caaccttgag gcacagtgaa gacatcggtg gccactccaa
      121 taacagcagg tcacagctgc tcttctggag gtgtcctaca ggtgaaaagc ccagcgaccc
      181 agtcaggatt taagtttacc tcaaaaatgg aagattttaa catggagagt gacagctttg
      241 aagatttctg gaaaggtgaa gatcttagta attacagtta cagctctacc ctgccccctt
      301 ttctactaga tgccgcccca tgtgaaccag aatccctgga aatcaacaag tattttgtgg
      361 tcattatcta tgccctggta ttcctgctga gcctgctggg aaactccctc gtgatgctgg
      421 tcatcttata cagcagggtc ggccgctccg tcactgatgt ctacctgctg aacctagcct
      481 tggccgacct actctttgcc ctgaccttgc ccatctgggc cgcctccaag gtgaatggct
      541 ggatttttgg cacattcctg tgcaaggtgg tctcactcct gaaggaagtc aacttctata
      601 gtggcatcct gctactggcc tgcatcagtg tggaccgtta cctggccatt gtccatgcca
      661 cacgcacact gacccagaag cgctacttgg tcaaattcat atgtctcagc atctggggtc
      721 tgtccttgct cctggccctg cctgtcttac ttttccgaag gaccgtctac tcatccaatg
      781 ttagcccagc ctgctatgag gacatgggca acaatacagc aaactggcgg atgctgttac
      841 ggatcctgcc ccagtccttt ggcttcatcg tgccactgct gatcatgctg ttctgctacg
      901 gattcaccct gcgtacgctg tttaaggccc acatggggca gaagcaccgg gccatgcggg
      961 tcatctttgc tgtcgtcctc atcttcctgc tctgctggct gccctacaac ctggtcctgc
     1021 tggcagacac cctcatgagg acccaggtga tccaggagac ctgtgagcgc cgcaatcaca
     1081 tcgaccgggc tctggatgcc accgagattc tgggcatcct tcacagctgc ctcaaccccc
     1141 tcatctacgc cttcattggc cagaagtttc gccatggact cctcaagatt ctagctatac
     1201 atggcttgat cagcaaggac tccctgccca aagacagcag gccttccttt gttggctctt
     1261 cttcagggca cacttccact actctctaag acctcctgcc taagtgcagc cccgtggggt
     1321 tcctcccttc tcttcacagt cacattccaa gcctcatgtc cactggttct tcttggtctc
     1381 agtgtcaatg cagcccccat tgtggtcaca ggaagtagag gaggccacgt tcttactagt
     1441 ttcccttgca tggtttagaa agcttgccct ggtgcctcac cccttgccat aattactatg
     1501 tcatttgctg gagctctgcc catcctgccc ctgagcccat ggcactctat gttctaagaa
     1561 gtgaaaatct acactccagt gagacagctc tgcatactca ttaggatggc tagtatcaaa
     1621 agaaagaaaa tcaggctggc caacggggtg aaaccctgtc tctactaaaa atacaaaaaa
     1681 aaaaaaaaat tagccgggcg tggtggtgag tgcctgtaat cacagctact tgggaggctg
     1741 agatgggaga atcacttgaa cccgggaggc agaggttgca gtgagccgag attgtgcccc
     1801 tgcactccag cctgagcgac agtgagactc tgtctcagtc catgaagatg tagaggagaa
     1861 actggaactc tcgagcgttg ctggggggga ttgtaaaatg gtgtgaccac tgcagaagac
     1921 agtatggcag ctttcctcaa aacttcagac atagaattaa cacatgatcc tgcaattcca
     1981 cttataggaa ttgacccaca agaaatgaaa gcagggactt gaacccatat ttgtacacca
     2041 atattcatag cagcttattc acaagaccca aaaggcagaa gcaacccaaa tgttcatcaa
     2101 tgaatgaatg aatggctaag caaaatgtga tatgtaccta acgaagtatc cttcagcctg
     2161 aaagaggaat gaagtactca tacatgttac aacacggacg aaccttgaaa actttatgct
     2221 aagtgaaata agccagacat caacagataa atagtttatg attccaccta catgaggtac
     2281 tgagagtgaa caaatttaca gagacagaaa gcagaacagt gattaccagg gactgagggg
     2341 aggggagcat gggaagtgac ggtttaatgg gcacagggtt tatgtttagg atgttgaaaa
     2401 agttctgcag ataaacagta gtgatagttg taccgcaatg tgacttaatg ccactaaatt
     2461 gacacttaaa aatggtttaa atggtcaatt ttgttatgta tattttatat caatttaaaa
     2521 aaaaacctga gccccaaaag gtattttaat caccaaggct gattaaacca aggctagaac
     2581 cacctgccta tattttttgt taaatgattt cattcaatat ctttttttta ataaaccatt
     2641 tttacttggg tgttta
//
