LOCUS       NM_000634               2459 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens C-X-C motif chemokine receptor 1 (CXCR1), mRNA.
ACCESSION   NM_000634
VERSION     NM_000634.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Si,W., Liu,J., Wang,Y., Mao,Y., Zhang,Y., Xu,S., Guo,K., Zhang,Y.,
            Hu,Y. and Zhang,F.
  TITLE     IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113074 (2024)
   PUBMED   39244903
  REMARK    GeneRIF: IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway.
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Vermeersch,G., Proost,P., Struyf,S., Gouwy,M. and Devos,T.
  TITLE     CXCL8 and its cognate receptors CXCR1/CXCR2 in primary
            myelofibrosis
  JOURNAL   Haematologica 109 (7), 2060-2072 (2024)
   PUBMED   38426279
  REMARK    GeneRIF: CXCL8 and its cognate receptors CXCR1/CXCR2 in primary
            myelofibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2459)
  AUTHORS   Chang,Y.M., Huang,W.Y., Yang,S.H., Jan,C.I., Nieh,S., Lin,Y.S.,
            Chen,S.F. and Lin,Y.C.
  TITLE     Interleukin-8/CXCR1 Signaling Contributes to the Progression of
            Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion
  JOURNAL   Cells 13 (11), 968 (2024)
   PUBMED   38891100
  REMARK    GeneRIF: Interleukin-8/CXCR1 Signaling Contributes to the
            Progression of Pulmonary Adenocarcinoma Resulting in Malignant
            Pleural Effusion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2459)
  AUTHORS   Sarker,P., Pereira,G.M.V., Khullar,V., Yu,J. and Cartwright,R.
  TITLE     VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract
            Infections in Women: Genetic Association Study
  JOURNAL   Int Urogynecol J 35 (3), 695-701 (2024)
   PUBMED   38407596
  REMARK    GeneRIF: VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent
            Urinary Tract Infections in Women: Genetic Association Study.
REFERENCE   5  (bases 1 to 2459)
  AUTHORS   Naser,H.H., Kadhim,M.J. and Almhanna,H.
  TITLE     Investigating the impact of the genetic variant CXCR1 (rs2234671)
            in individuals with urinary tract infections
  JOURNAL   Hum Antibodies 32 (1), 9-18 (2024)
   PUBMED   38339925
  REMARK    GeneRIF: Investigating the impact of the genetic variant CXCR1
            (rs2234671) in individuals with urinary tract infections.
REFERENCE   6  (bases 1 to 2459)
  AUTHORS   Morris,S.W., Nelson,N., Valentine,M.B., Shapiro,D.N., Look,A.T.,
            Kozlosky,C.J., Beckmann,M.P. and Cerretti,D.P.
  TITLE     Assignment of the genes encoding human interleukin-8 receptor types
            1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35
  JOURNAL   Genomics 14 (3), 685-691 (1992)
   PUBMED   1427896
REFERENCE   7  (bases 1 to 2459)
  AUTHORS   Ahuja,S.K., Ozcelik,T., Milatovitch,A., Francke,U. and Murphy,P.M.
  TITLE     Molecular evolution of the human interleukin-8 receptor gene
            cluster
  JOURNAL   Nat Genet 2 (1), 31-36 (1992)
   PUBMED   1303245
REFERENCE   8  (bases 1 to 2459)
  AUTHORS   Lee,J., Horuk,R., Rice,G.C., Bennett,G.L., Camerato,T. and
            Wood,W.I.
  TITLE     Characterization of two high affinity human interleukin-8 receptors
  JOURNAL   J Biol Chem 267 (23), 16283-16287 (1992)
   PUBMED   1379593
REFERENCE   9  (bases 1 to 2459)
  AUTHORS   Holmes,W.E., Lee,J., Kuang,W.J., Rice,G.C. and Wood,W.I.
  TITLE     Structure and functional expression of a human interleukin-8
            receptor
  JOURNAL   Science 253 (5025), 1278-1280 (1991)
   PUBMED   1840701
REFERENCE   10 (bases 1 to 2459)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097483.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000634.2.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein-coupled receptor family. This protein is a receptor for
            interleukin 8 (IL8). It binds to IL8 with high affinity, and
            transduces the signal through a G-protein activated second
            messenger system. Knockout studies in mice suggested that this
            protein inhibits embryonic oligodendrocyte precursor migration in
            developing spinal cord. This gene, IL8RB, a gene encoding another
            high affinity IL8 receptor, as well as IL8RBP, a pseudogene of
            IL8RB, form a gene cluster in a region mapped to chromosome
            2q33-q36. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.224472.1,
                                           DRR138517.833245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295683.3/ ENSP00000295683.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC097483.3         9217-9271           c
            56-2459             AC097483.3         5150-7553           c
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2459
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /note="C-X-C motif chemokine receptor 1"
                     /db_xref="GeneID:3577"
                     /db_xref="HGNC:HGNC:6026"
                     /db_xref="MIM:146929"
     exon            1..55
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /inference="alignment:Splign:2.1.0"
     exon            56..2459
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1141
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /note="interleukin 8 receptor, alpha; high affinity
                     interleukin-8 receptor A; IL-8 receptor type 1; chemokine
                     (C-X-C motif) receptor 1; interleukin-8 receptor type 1;
                     interleukin-8 receptor type A; CXC-R1; CXCR-1; IL-8R A"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 1"
                     /protein_id="NP_000625.1"
                     /db_xref="CCDS:CCDS2409.1"
                     /db_xref="GeneID:3577"
                     /db_xref="HGNC:HGNC:6026"
                     /db_xref="MIM:146929"
                     /translation="MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVII
                     AYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG
                     WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGC
                     WGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVM
                     LFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQES
                     CERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARH
                     RVTSYTSSSVNVSSNL"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /note="hexamer: AATAAA"
     polyA_site      1974
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /note="major polyA site"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /note="hexamer: AATAAT"
     polyA_site      2459
                     /gene="CXCR1"
                     /gene_synonym="C-C; C-C-CKR-1; CD128; CD181; CDw128a;
                     CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA"
                     /note="major polyA site"
ORIGIN      
        1 actctgatct ctgactgcag ctcctactgt tggacacacc tggccggtgc ttcagttaga
       61 tcaaaccatt gctgaaactg aagaggacat gtcaaatatt acagatccac agatgtggga
      121 ttttgatgat ctaaatttca ctggcatgcc acctgcagat gaagattaca gcccctgtat
      181 gctagaaact gagacactca acaagtatgt tgtgatcatc gcctatgccc tagtgttcct
      241 gctgagcctg ctgggaaact ccctggtgat gctggtcatc ttatacagca gggtcggccg
      301 ctccgtcact gatgtctacc tgctgaacct ggccttggcc gacctactct ttgccctgac
      361 cttgcccatc tgggccgcct ccaaggtgaa tggctggatt tttggcacat tcctgtgcaa
      421 ggtggtctca ctcctgaagg aagtcaactt ctacagtggc atcctgctgt tggcctgcat
      481 cagtgtggac cgttacctgg ccattgtcca tgccacacgc acactgaccc agaagcgtca
      541 cttggtcaag tttgtttgtc ttggctgctg gggactgtct atgaatctgt ccctgccctt
      601 cttccttttc cgccaggctt accatccaaa caattccagt ccagtttgct atgaggtcct
      661 gggaaatgac acagcaaaat ggcggatggt gttgcggatc ctgcctcaca cctttggctt
      721 catcgtgccg ctgtttgtca tgctgttctg ctatggattc accctgcgta cactgtttaa
      781 ggcccacatg gggcagaagc accgagccat gagggtcatc tttgctgtcg tcctcatctt
      841 cctgctttgc tggctgccct acaacctggt cctgctggca gacaccctca tgaggaccca
      901 ggtgatccag gagagctgtg agcgccgcaa caacatcggc cgggccctgg atgccactga
      961 gattctggga tttctccata gctgcctcaa ccccatcatc tacgccttca tcggccaaaa
     1021 ttttcgccat ggattcctca agatcctggc tatgcatggc ctggtcagca aggagttctt
     1081 ggcacgtcat cgtgttacct cctacacttc ttcgtctgtc aatgtctctt ccaacctctg
     1141 aaaaccatcg atgaaggaat atctcttctc agaaggaaag aataaccaac accctgaggt
     1201 tgtgtgtgga aggtgatctg gctctggaca ggcactatct gggttttggg gggacgctat
     1261 aggatgtggg gaagttagga actggtgtct tcaggggcca caccaacctt ctgaggagct
     1321 gttgaggtac ctccaaggac cggcctttgc acctccatgg aaacgaagca ccatcattcc
     1381 cgttgaacgt cacatcttta acccactaac tggctaatta gcatggccac atctgagccc
     1441 cgaatctgac attagatgag agaacagggc tgaagctgtg tcctcatgag ggctggatgc
     1501 tctcgttgac cctcacagga gcatctcctc aactctgagt gttaagcgtt gagccaccaa
     1561 gctggtggct ctgtgtgctc tgatccgagc tcaggggggt ggttttccca tctcaggtgt
     1621 gttgcagtgt ctgctggaga cattgaggca ggcactgcca aaacatcaac ctgccagctg
     1681 gccttgtgag gagctggaaa cacatgttcc ccttgggggt ggtggatgaa caaagagaaa
     1741 gagggtttgg aagccagatc tatgccacaa gaaccccctt tacccccatg accaacatcg
     1801 cagacacatg tgctggccac ctgctgagcc ccaagtggaa cgagacaagc agcccttagc
     1861 ccttcccctc tgcagcttcc aggctggcgt gcagcatcag catccctaga aagccatgtg
     1921 cagccaccag tccattgggc aggcagatgt tcctaataaa gcttctgttc cgtgcttgtc
     1981 cctgtggaag tatcttggtt gtgacagagt caagggtgtg tgcagcattg ttggctgttc
     2041 ctgcagtaga atgggggcag cacctcctaa gaaggcacct ctctgggttg aagggcagtg
     2101 ttccctgggg ctttaactcc tgctagaaca gtctcttgag gcacagaaac tcctgttcat
     2161 gcccataccc ctggccaagg aagatccctt tgtccacaag taaaaggaaa tgctcctcca
     2221 gggagtctca gcttcaccct gaggtgagca tcatcttctg ggttaggcct tgcctaggca
     2281 tagccctgcc tcaagctatg tgagctcacc agtccctccc caaatgcttt ccatgagttg
     2341 cagttttttc ctagtctgtt ttccctcctt ggagacaggg ccctgtcggt ttattcactg
     2401 tatgtccttg gtgcctggag cctactaaat gctcaataaa taatgatcac aggaatgaa
//
