LOCUS       NM_002416               2761 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 9 (CXCL9), mRNA.
ACCESSION   NM_002416
VERSION     NM_002416.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Liao,W., Liu,T., Li,Y., Liang,H., Deng,J. and Shen,F.
  TITLE     The bioinfomatics analysis of the M1 macrophage-related gene CXCL9
            signature in cervical cancer
  JOURNAL   J Obstet Gynaecol 44 (1), 2373951 (2024)
   PUBMED   38963237
  REMARK    GeneRIF: The bioinfomatics analysis of the M1 macrophage-related
            gene CXCL9 signature in cervical cancer.
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Kersh,A.E., Sati,S., Huang,J., Murphy,C., Ahart,O. and Leung,T.H.
  TITLE     CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to
            skin in lichen planus
  JOURNAL   JCI Insight 9 (20), e179899 (2024)
   PUBMED   39190494
  REMARK    GeneRIF: CXCL9, CXCL10, and CCL19 synergistically recruit T
            lymphocytes to skin in lichen planus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Larkin,R.M., Lopez,D.C., Robbins,Y.L., Lassoued,W., Canubas,K.,
            Warner,A., Karim,B., Vulikh,K., Hodge,J.W., Floudas,C.S.,
            Gulley,J.L., Gallia,G.L., Allen,C.T. and London,N.R. Jr.
  TITLE     Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may
            improve olfactory neuroblastoma immunotherapeutic responses
  JOURNAL   J Transl Med 22 (1), 524 (2024)
   PUBMED   38822345
  REMARK    GeneRIF: Augmentation of tumor expression of HLA-DR, CXCL9, and
            CXCL10 may improve olfactory neuroblastoma immunotherapeutic
            responses.
            Erratum:[J Transl Med. 2024 Sep 11;22(1):836. doi:
            10.1186/s12967-024-05514-y. PMID: 39261932]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Hong,J., Cheng,H., Wang,P., Wu,Y., Lu,S., Zhou,Y., Wang,X.B. and
            Zhu,X.
  TITLE     CXCL9 may serve as a potential biomarker for primary Sjogren's
            syndrome with extra-glandular manifestations
  JOURNAL   Arthritis Res Ther 26 (1), 26 (2024)
   PUBMED   38229121
  REMARK    GeneRIF: CXCL9 may serve as a potential biomarker for primary
            Sjogren's syndrome with extra-glandular manifestations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Lieberman,N.A.P., Peddu,V., Xie,H., Shrestha,L., Huang,M.L.,
            Mears,M.C., Cajimat,M.N., Bente,D.A., Shi,P.Y., Bovier,F.,
            Roychoudhury,P., Jerome,K.R., Moscona,A., Porotto,M. and
            Greninger,A.L.
  TITLE     In vivo antiviral host response to SARS-CoV-2 by viral load, sex,
            and age
  JOURNAL   bioRxiv (2020)
   PUBMED   32607510
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
REFERENCE   7  (bases 1 to 2761)
  AUTHORS   Liao,F., Rabin,R.L., Yannelli,J.R., Koniaris,L.G., Vanguri,P. and
            Farber,J.M.
  TITLE     Human Mig chemokine: biochemical and functional characterization
  JOURNAL   J Exp Med 182 (5), 1301-1314 (1995)
   PUBMED   7595201
REFERENCE   8  (bases 1 to 2761)
  AUTHORS   Farber,J.M.
  TITLE     HuMig: a new human member of the chemokine family of cytokines
  JOURNAL   Biochem Biophys Res Commun 192 (1), 223-230 (1993)
   PUBMED   8476424
REFERENCE   9  (bases 1 to 2761)
  AUTHORS   Farber,J.M.
  TITLE     A macrophage mRNA selectively induced by gamma-interferon encodes a
            member of the platelet factor 4 family of cytokines
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5238-5242 (1990)
   PUBMED   2115167
REFERENCE   10 (bases 1 to 2761)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB141449.1, X72755.1,
            BC042178.1 and AC112719.4.
            
            On May 17, 2019 this sequence version replaced NM_002416.2.
            
            Summary: This antimicrobial gene is part of a chemokine superfamily
            that encodes secreted proteins involved in immunoregulatory and
            inflammatory processes. The protein encoded is thought to be
            involved in T cell trafficking. The encoded protein binds to C-X-C
            motif chemokine 3 and is a chemoattractant for lymphocytes but not
            for neutrophils. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095396.1, X72755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in immune response
                                                  or antiviral activity
            MANE Ensembl match                 :: ENST00000264888.6/
                                                  ENSP00000354901.4
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB141449.1         16-36
            22-2566             X72755.1           1-2545
            2567-2694           BC042178.1         2529-2656
            2695-2761           AC112719.4         27035-27101         c
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..2761
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /note="C-X-C motif chemokine ligand 9"
                     /db_xref="GeneID:4283"
                     /db_xref="HGNC:HGNC:7098"
                     /db_xref="MIM:601704"
     exon            1..124
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..438
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /note="monokine induced by gamma interferon; C-X-C motif
                     chemokine 9; monokine induced by interferon-gamma;
                     small-inducible cytokine B9; gamma-interferon-induced
                     monokine; chemokine (C-X-C motif) ligand 9"
                     /codon_start=1
                     /product="C-X-C motif chemokine 9 precursor"
                     /protein_id="NP_002407.1"
                     /db_xref="CCDS:CCDS34014.1"
                     /db_xref="GeneID:4283"
                     /db_xref="HGNC:HGNC:7098"
                     /db_xref="MIM:601704"
                     /translation="MKKSGVLFLLGIILLVLIGVQGTPVVRKGRCSCISTNQGTIHLQ
                     SLKDLKQFAPSPSCEKIEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNG
                     KKHQKKKVLKVRKSQRSRQKKTT"
     exon            125..251
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /inference="alignment:Splign:2.1.0"
     exon            252..336
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /inference="alignment:Splign:2.1.0"
     exon            337..2761
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /note="hexamer: AATAGA"
     polyA_site      2570
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /note="major polyA site"
     regulatory      2668..2673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
                     /note="hexamer: AATAAA"
     polyA_site      2694
                     /gene="CXCL9"
                     /gene_synonym="CMK; crg-10; Humig; MIG; SCYB9"
ORIGIN      
        1 aaagaatttc tcaggctcaa aatccaatac aggagtgact tggaactcca ttctatcact
       61 atgaagaaaa gtggtgttct tttcctcttg ggcatcatct tgctggttct gattggagtg
      121 caaggaaccc cagtagtgag aaagggtcgc tgttcctgca tcagcaccaa ccaagggact
      181 atccacctac aatccttgaa agaccttaaa caatttgccc caagcccttc ctgcgagaaa
      241 attgaaatca ttgctacact gaagaatgga gttcaaacat gtctaaaccc agattcagca
      301 gatgtgaagg aactgattaa aaagtgggag aaacaggtca gccaaaagaa aaagcaaaag
      361 aatgggaaaa aacatcaaaa aaagaaagtt ctgaaagttc gaaaatctca acgttctcgt
      421 caaaagaaga ctacataaga gaccacttca ccaataagta ttctgtgtta aaaatgttct
      481 attttaatta taccgctatc attccaaagg aggatggcat ataatacaaa ggcttattaa
      541 tttgactaga aaatttaaaa cattactctg aaattgtaac taaagttaga aagttgattt
      601 taagaatcca aacgttaaga attgttaaag gctatgattg tctttgttct tctaccaccc
      661 accagttgaa tttcatcatg cttaaggcca tgattttagc aatacccatg tctacacaga
      721 tgttcaccca accacatccc actcacaaca gctgcctgga agagcagccc taggcttcca
      781 cgtactgcag cctccagaga gtatctgagg cacatgtcag caagtcctaa gcctgttagc
      841 atgctggtga gccaagcagt ttgaaattga gctggacctc accaagctgc tgtggccatc
      901 aacctctgta tttgaatcag cctacaggcc tcacacacaa tgtgtctgag agattcatgc
      961 tgattgttat tgggtatcac cactggagat caccagtgtg tggctttcag agcctccttt
     1021 ctggctttgg aagccatgtg attccatctt gcccgctcag gctgaccact ttatttcttt
     1081 ttgttcccct ttgcttcatt caagtcagct cttctccatc ctaccacaat gcagtgcctt
     1141 tcttctctcc agtgcacctg tcatatgctc tgatttatct gagtcaactc ctttctcatc
     1201 ttgtccccaa caccccacag aagtgctttc ttctcccaat tcatcctcac tcagtccagc
     1261 ttagttcaag tcctgcctct taaataaacc tttttggaca cacaaattat cttaaaactc
     1321 ctgtttcact tggttcagta ccacatgggt gaacactcaa tggttaacta attcttgggt
     1381 gtttatccta tctctccaac cagattgtca gctccttgag ggcaagagcc acagtatatt
     1441 tccctgtttc ttccacagtg cctaataata ctgtggaact aggttttaat aattttttaa
     1501 ttgatgttgt tatgggcagg atggcaacca gaccattgtc tcagagcagg tgctggctct
     1561 ttcctggcta ctccatgttg gctagcctct ggtaacctct tacttattat cttcaggaca
     1621 ctcactacag ggaccaggga tgatgcaaca tccttgtctt tttatgacag gatgtttgct
     1681 cagcttctcc aacaataaga agcacgtggt aaaacacttg cggatattct ggactgtttt
     1741 taaaaaatat acagtttacc gaaaatcata taatcttaca atgaaaagga ctttatagat
     1801 cagccagtga ccaacctttt cccaaccata caaaaattcc ttttcccgaa ggaaaagggc
     1861 tttctcaata agcctcagct ttctaagatc taacaagata gccaccgaga tccttatcga
     1921 aactcatttt aggcaaatat gagttttatt gtccgtttac ttgtttcaga gtttgtattg
     1981 tgattatcaa ttaccacacc atctcccatg aagaaaggga acggtgaagt actaagcgct
     2041 agaggaagca gccaagtcgg ttagtggaag catgattggt gcccagttag cctctgcagg
     2101 atgtggaaac ctccttccag gggaggttca gtgaattgtg taggagaggt tgtctgtggc
     2161 cagaatttaa acctatactc actttcccaa attgaatcac tgctcacact gctgatgatt
     2221 tagagtgctg tccggtggag atcccacccg aacgtcttat ctaatcatga aactccctag
     2281 ttccttcatg taacttccct gaaaaatcta agtgtttcat aaatttgaga gtctgtgacc
     2341 cacttacctt gcatctcaca ggtagacagt atataactaa caaccaaaga ctacatattg
     2401 tcactgacac acacgttata atcatttatc atatatatac atacatgcat acactctcaa
     2461 agcaaataat ttttcacttc aaaacagtat tgacttgtat accttgtaat ttgaaatatt
     2521 ttctttgtta aaatagaatg gtatcaataa atagaccatt aatcagaaaa cagatcttga
     2581 ttttttttct cttgaatgta cccttcaact gttgaatgtt taatagtaaa tcttatatgt
     2641 ccttatttac tttttagctt tctctcaaat aaagtgtaac actagttgag ataacacatg
     2701 aaagctcttt aaagggtcga tcgggaacag gaaaaaaaac ctatggaaaa tatgacaaca
     2761 c
//
