LOCUS       NM_002993               1537 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.
ACCESSION   NM_002993
VERSION     NM_002993.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Dai,C.L., Yang,H.X., Liu,Q.P., Rahman,K. and Zhang,H.
  TITLE     CXCL6: A potential therapeutic target for inflammation and cancer
  JOURNAL   Clin Exp Med 23 (8), 4413-4427 (2023)
   PUBMED   37612429
  REMARK    GeneRIF: CXCL6: A potential therapeutic target for inflammation and
            cancer.
            Review article
            Erratum:[Clin Exp Med. 2023 Dec;23(8):4429. doi:
            10.1007/s10238-023-01209-8.. PMID: 37882888]
REFERENCE   2  (bases 1 to 1537)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   3  (bases 1 to 1537)
  AUTHORS   Guo,Q., Ding,X., Lv,F., Wang,A. and Wang,J.
  TITLE     circ_0006089 Facilitates Gastric Cancer Progression via Decoying
            miR- 515-5p and Up-regulating CXCL6
  JOURNAL   Protein Pept Lett 30 (4), 314-324 (2023)
   PUBMED   36892025
  REMARK    GeneRIF: circ_0006089 Facilitates Gastric Cancer Progression via
            Decoying miR- 515-5p and Up-regulating CXCL6.
REFERENCE   4  (bases 1 to 1537)
  AUTHORS   Zheng,S., Shen,T., Liu,Q., Liu,T., Tuerxun,A., Zhang,Q., Yang,L.,
            Han,X. and Lu,X.
  TITLE     CXCL6 fuels the growth and metastases of esophageal squamous cell
            carcinoma cells both in vitro and in vivo through upregulation of
            PD-L1 via activation of STAT3 pathway
  JOURNAL   J Cell Physiol 236 (7), 5373-5386 (2021)
   PUBMED   33368292
  REMARK    GeneRIF: CXCL6 fuels the growth and metastases of esophageal
            squamous cell carcinoma cells both in vitro and in vivo through
            upregulation of PD-L1 via activation of STAT3 pathway.
REFERENCE   5  (bases 1 to 1537)
  AUTHORS   Wang,X., Dai,Y., Zhang,X., Pan,K., Deng,Y., Wang,J. and Xu,T.
  TITLE     CXCL6 regulates cell permeability, proliferation, and apoptosis
            after ischemia-reperfusion injury by modulating Sirt3 expression
            via AKT/FOXO3a activation
  JOURNAL   Cancer Biol Ther 22 (1), 30-39 (2021)
   PUBMED   33241954
  REMARK    GeneRIF: CXCL6 regulates cell permeability, proliferation, and
            apoptosis after ischemia-reperfusion injury by modulating Sirt3
            expression via AKT/FOXO3a activation.
REFERENCE   6  (bases 1 to 1537)
  AUTHORS   Jang,Y. and Seo,S.H.
  TITLE     Gene expression pattern differences in primary human pulmonary
            epithelial cells infected with MERS-CoV or SARS-CoV-2
  JOURNAL   Arch Virol 165 (10), 2205-2211 (2020)
   PUBMED   32651741
REFERENCE   7  (bases 1 to 1537)
  AUTHORS   Rovai,L.E., Herschman,H.R. and Smith,J.B.
  TITLE     Cloning and characterization of the human granulocyte chemotactic
            protein-2 gene
  JOURNAL   J Immunol 158 (11), 5257-5266 (1997)
   PUBMED   9164944
REFERENCE   8  (bases 1 to 1537)
  AUTHORS   Froyen,G., Proost,P., Ronsse,I., Mitera,T., Haelens,A., Wuyts,A.,
            Opdenakker,G., Van Damme,J. and Billiau,A.
  TITLE     Cloning, bacterial expression and biological characterization of
            recombinant human granulocyte chemotactic protein-2 and
            differential expression of granulocyte chemotactic protein-2 and
            epithelial cell-derived neutrophil activating peptide-78 mRNAs
  JOURNAL   Eur J Biochem 243 (3), 762-769 (1997)
   PUBMED   9057843
REFERENCE   9  (bases 1 to 1537)
  AUTHORS   Proost,P., Wuyts,A., Conings,R., Lenaerts,J.P., Billiau,A.,
            Opdenakker,G. and Van Damme,J.
  TITLE     Human and bovine granulocyte chemotactic protein-2: complete amino
            acid sequence and functional characterization as chemokines
  JOURNAL   Biochemistry 32 (38), 10170-10177 (1993)
   PUBMED   8399143
REFERENCE   10 (bases 1 to 1537)
  AUTHORS   Proost,P., De Wolf-Peeters,C., Conings,R., Opdenakker,G.,
            Billiau,A. and Van Damme,J.
  TITLE     Identification of a novel granulocyte chemotactic protein (GCP-2)
            from human tumor cells. In vitro and in vivo comparison with
            natural forms of GRO, IP-10, and IL-8
  JOURNAL   J Immunol 150 (3), 1000-1010 (1993)
   PUBMED   8423327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP204144.1, AC108029.3 and
            U81234.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002993.3.
            
            Summary: The protein encoded by this gene is a member CXC chemokine
            family. The encoded protein is a chemotactic for neutrophil
            granulocytes and has antibacterial action against gram-negative and
            gram-positive bacteria. This gene and other members of the CXC
            chemokine gene family form a gene cluster in a region of chromosome
            4q. [provided by RefSeq, Jun 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U81234.1, ERR279869.1807.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000226317.10/ ENSP00000226317.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BP204144.1         123-139
            18-182              AC108029.3         56459-56623
            183-315             AC108029.3         56728-56860
            316-399             AC108029.3         56967-57050
            400-1509            AC108029.3         57387-58496
            1510-1537           U81234.1           1502-1529
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1537
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /note="C-X-C motif chemokine ligand 6"
                     /db_xref="GeneID:6372"
                     /db_xref="HGNC:HGNC:10643"
                     /db_xref="MIM:138965"
     exon            1..182
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..418
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /note="small inducible cytokine subfamily B (Cys-X-Cys),
                     member b; chemokine (C-X-C motif) ligand 6 (granulocyte
                     chemotactic protein 2); small inducible cytokine subfamily
                     B (Cys-X-Cys), member 6 (granulocyte chemotactic protein
                     2); C-X-C motif chemokine 6; chemokine alpha 3;
                     small-inducible cytokine B6"
                     /codon_start=1
                     /product="C-X-C motif chemokine 6 precursor"
                     /protein_id="NP_002984.1"
                     /db_xref="CCDS:CCDS3560.1"
                     /db_xref="GeneID:6372"
                     /db_xref="HGNC:HGNC:10643"
                     /db_xref="MIM:138965"
                     /translation="MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVL
                     TELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKV
                     IQKILDSGNKKN"
     exon            183..315
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /inference="alignment:Splign:2.1.0"
     exon            316..399
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1537
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /note="hexamer: AATAAA"
     polyA_site      1537
                     /gene="CXCL6"
                     /gene_synonym="CKA-3; GCP-2; GCP2; SCYB6"
                     /note="major polyA site"
ORIGIN      
        1 caaagtgctc tgtatcctcc agtctccgcg cctccaccca gctcaggaac ccgcgaaccc
       61 tctcttgacc actatgagcc tcccgtccag ccgcgcggcc cgtgtcccgg gtccttcggg
      121 ctccttgtgc gcgctgctcg cgctgctgct cctgctgacg ccgccggggc ccctcgccag
      181 cgctggtcct gtctctgctg tgctgacaga gctgcgttgc acttgtttac gcgttacgct
      241 gagagtaaac cccaaaacga ttggtaaact gcaggtgttc cccgcaggcc cgcagtgctc
      301 caaggtggaa gtggtagcct ccctgaagaa cgggaagcaa gtttgtctgg acccggaagc
      361 cccttttcta aagaaagtca tccagaaaat tttggacagt ggaaacaaga aaaactgagt
      421 aacaaaaaag accatgcatc ataaaattgc ccagtcttca gcggagcagt tttctggaga
      481 tccctggacc cagtaagaat aagaaggaag ggttggtttt tttccatttt ctacatggat
      541 tccctacttt gaagagtgtg ggggaaagcc tacgcttctc cctgaagttt acagctcagc
      601 taatgaagta ctaatatagt atttccacta tttactgtta ttttacctga taagttattg
      661 aaccctttgg caattgacca tattgtgagc aaagaatcac tggttattag tctttcaatg
      721 aatattgaat tgaagataac tattgtattt ctatcataca ttccttaaag tcttaccgaa
      781 aaggctgtgg atttcgtatg gaaataatgt tttattagtg tgctgttgag ggaggtatcc
      841 tgttgttctt actcactctt ctcataaaat aggaaatatt ttagttctgt ttcttgggga
      901 atatgttact ctttacccta ggatgctatt taagttgtac tgtattagaa cactgggtgt
      961 gtcataccgt tatctgtgca gaatatattt ccttattcag aatttctaaa aatttaagtt
     1021 ctgtaagggc taatatattc tcttcctatg gttttagacg tttgatgtct tcttagtatg
     1081 gcataatgtc atgatttact cattaaactt tgattttgta tgctattttt tcactatagg
     1141 atgactataa ttctggtcac taaatataca ctttagatag atgaagaagc ccaaaaacag
     1201 ataaattcct gattgctaat ttacatagaa atgtattctc ttggtttttt aaataaaagc
     1261 aaaattaaca atgatctgtg ctctgaaagt tttgaaaata tatttgaaca atttgaatat
     1321 aaattcatca tttagtcctc aaaatatata tagcattgct aagattttca gatatctatt
     1381 gtggatcttt taaaggtttt gaccattttg ttatgaggaa ttatacatgt atcacattca
     1441 ctatattaaa attgcacttt tattttttcc tgtgtgtcat gttggttttt ggtacttgta
     1501 ttgtcatttg gagaaacaat aaaagatttc taaacca
//
