LOCUS       NM_002994               2436 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.
ACCESSION   NM_002994
VERSION     NM_002994.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Sun,D., Tan,L., Chen,Y., Yuan,Q., Jiang,K., Liu,Y., Xue,Y.,
            Zhang,J., Cao,X., Xu,M., Luo,Y., Xu,Z., Xu,Z., Xu,W. and Shen,M.
  TITLE     CXCL5 impedes CD8+ T cell immunity by upregulating PD-L1 expression
            in lung cancer via PXN/AKT signaling phosphorylation and neutrophil
            chemotaxis
  JOURNAL   J Exp Clin Cancer Res 43 (1), 202 (2024)
   PUBMED   39034411
  REMARK    GeneRIF: CXCL5 impedes CD8[+] T cell immunity by upregulating PD-L1
            expression in lung cancer via PXN/AKT signaling phosphorylation and
            neutrophil chemotaxis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Lei,Q., Zhen,S., Zhang,L., Zhao,Q., Yang,L. and Zhang,Y.
  TITLE     A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC
            progression via NETosis
  JOURNAL   Cancer Immunol Immunother 73 (6), 108 (2024)
   PUBMED   38642131
  REMARK    GeneRIF: A2AR-mediated CXCL5 upregulation on macrophages promotes
            NSCLC progression via NETosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Jang,Y. and Seo,S.H.
  TITLE     Gene expression pattern differences in primary human pulmonary
            epithelial cells infected with MERS-CoV or SARS-CoV-2
  JOURNAL   Arch Virol 165 (10), 2205-2211 (2020)
   PUBMED   32651741
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Miyazaki,H., Patel,V., Wang,H., Edmunds,R.K., Gutkind,J.S. and
            Yeudall,W.A.
  TITLE     Down-regulation of CXCL5 inhibits squamous carcinogenesis
  JOURNAL   Cancer Res 66 (8), 4279-4284 (2006)
   PUBMED   16618752
REFERENCE   5  (bases 1 to 2436)
  AUTHORS   Wuyts,A., Govaerts,C., Struyf,S., Lenaerts,J.P., Put,W.,
            Conings,R., Proost,P. and Van Damme,J.
  TITLE     Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma
            from tumor cells and leukocytes reveals NH2-terminal heterogeneity.
            Functional comparison of different natural isoforms
  JOURNAL   Eur J Biochem 260 (2), 421-429 (1999)
   PUBMED   10095777
REFERENCE   6  (bases 1 to 2436)
  AUTHORS   O'Donovan,N., Galvin,M. and Morgan,J.G.
  TITLE     Physical mapping of the CXC chemokine locus on human chromosome 4
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 39-42 (1999)
   PUBMED   10343098
REFERENCE   7  (bases 1 to 2436)
  AUTHORS   Power,C.A., Furness,R.B., Brawand,C. and Wells,T.N.
  TITLE     Cloning of a full-length cDNA encoding the neutrophil-activating
            peptide ENA-78 from human platelets
  JOURNAL   Gene 151 (1-2), 333-334 (1994)
   PUBMED   7828901
REFERENCE   8  (bases 1 to 2436)
  AUTHORS   Corbett,M.S., Schmitt,I., Riess,O. and Walz,A.
  TITLE     Characterization of the gene for human neutrophil-activating
            peptide 78 (ENA-78)
  JOURNAL   Biochem Biophys Res Commun 205 (1), 612-617 (1994)
   PUBMED   7999089
REFERENCE   9  (bases 1 to 2436)
  AUTHORS   Chang,M.S., McNinch,J., Basu,R. and Simonet,S.
  TITLE     Cloning and characterization of the human neutrophil-activating
            peptide (ENA-78) gene
  JOURNAL   J Biol Chem 269 (41), 25277-25282 (1994)
   PUBMED   7929219
REFERENCE   10 (bases 1 to 2436)
  AUTHORS   Walz,A., Burgener,R., Car,B., Baggiolini,M., Kunkel,S.L. and
            Strieter,R.M.
  TITLE     Structure and neutrophil-activating properties of a novel
            inflammatory peptide (ENA-78) with homology to interleukin 8
  JOURNAL   J Exp Med 174 (6), 1355-1362 (1991)
   PUBMED   1744577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097709.3.
            
            On Nov 23, 2018 this sequence version replaced NM_002994.4.
            
            Summary: This gene encodes a protein that is a member of the CXC
            subfamily of chemokines. Chemokines, which recruit and activate
            leukocytes, are classified by function (inflammatory or
            homeostatic) or by structure. This protein is proposed to bind the
            G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to
            recruit neutrophils, to promote angiogenesis and to remodel
            connective tissues. This protein is thought to play a role in
            cancer cell proliferation, migration, and invasion. [provided by
            RefSeq, May 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.147496.1,
                                           SRR1660809.183638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000296027.5/ ENSP00000296027.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC097709.3         84422-84626         c
            206-338             AC097709.3         84155-84287         c
            339-422             AC097709.3         83961-84044         c
            423-2436            AC097709.3         81591-83604         c
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..2436
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /note="C-X-C motif chemokine ligand 5"
                     /db_xref="GeneID:6374"
                     /db_xref="HGNC:HGNC:10642"
                     /db_xref="MIM:600324"
     exon            1..205
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..441
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /note="small inducible cytokine subfamily B (Cys-X-Cys),
                     member 5 (epithelial-derived neutrophil-activating peptide
                     78); neutrophil-activating peptide ENA-78;
                     neutrophil-activating protein 78; C-X-C motif chemokine 5;
                     epithelial-derived neutrophil-activating protein 78;
                     chemokine (C-X-C motif) ligand 5"
                     /codon_start=1
                     /product="C-X-C motif chemokine 5 precursor"
                     /protein_id="NP_002985.1"
                     /db_xref="CCDS:CCDS34006.1"
                     /db_xref="GeneID:6374"
                     /db_xref="HGNC:HGNC:10642"
                     /db_xref="MIM:600324"
                     /translation="MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIASAGPAAAVL
                     RELRCVCLQTTQGVHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKV
                     IQKILDGGNKEN"
     exon            206..338
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /inference="alignment:Splign:2.1.0"
     exon            339..422
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /inference="alignment:Splign:2.1.0"
     exon            423..2436
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2415..2420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /note="hexamer: ATTAAA"
     polyA_site      2436
                     /gene="CXCL5"
                     /gene_synonym="ENA-78; SCYB5"
                     /note="major polyA site"
ORIGIN      
        1 acagtgctcc ggatcctcca atcttcgctc ctccaatctc cgctcctcca cccagttcag
       61 gaacccgcga ccgctcgcag cgctctcttg accactatga gcctcctgtc cagccgcgcg
      121 gcccgtgtcc ccggtccttc gagctccttg tgcgcgctgt tggtgctgct gctgctgctg
      181 acgcagccag ggcccatcgc cagcgctggt cctgccgctg ctgtgttgag agagctgcgt
      241 tgcgtttgtt tacagaccac gcaaggagtt catcccaaaa tgatcagtaa tctgcaagtg
      301 ttcgccatag gcccacagtg ctccaaggtg gaagtggtag cctccctgaa gaacgggaag
      361 gaaatttgtc ttgatccaga agcccctttt ctaaagaaag tcatccagaa aattttggac
      421 ggtggaaaca aggaaaactg attaagagaa atgagcacgc atggaaaagt ttcccagtct
      481 tcagcagaga agttttctgg aggtctctga acccagggaa gacaagaagg aaagattttg
      541 ttgttgtttg tttatttgtt tttccagtag ttagctttct tcctggattc ctcactttga
      601 agagtgtgag gaaaacctat gtttgccgct taagctttca gctcagctaa tgaagtgttt
      661 agcatagtac ctctgctatt tgctgttatt ttatctgcta tgctattgaa gttttggcaa
      721 ttgactatag tgtgagccag gaatcactgg ctgttaatct ttcaaagtgt cttgaattgt
      781 aggtgactat tatatttcca agaaatattc cttaagatat taactgagaa ggctgtggat
      841 ttaatgtgga aatgatgttt cataagaatt ctgttgatgg aaatacactg ttatcttcac
      901 ttttataaga aataggaaat attttaatgt ttcttgggga atatgttaga gaatttcctt
      961 actcttgatt gtgggatact atttaattat ttcactttag aaagctgagt gtttcacacc
     1021 ttatctatgt agaatatatt tccttattca gaatttctaa aagtttaagt tctatgaggg
     1081 ctaatatctt atcttcctat aattttagac attctttatc tttttagtat ggcaaactgc
     1141 catcatttac ttttaaactt tgattttata tgctatttat taagtatttt attaggagta
     1201 ccataattct ggtagctaaa tatatatttt agatagatga agaagctaga aaacaggcaa
     1261 attcctgact gctagtttat atagaaatgt attcttttag tttttaaagt aaaggcaaac
     1321 ttaacaatga cttgtactct gaaagttttg gaaacgtatt caaacaattt gaatataaat
     1381 ttatcattta gttataaaaa tatatagcga catcctcgag gccctagcat ttctccttgg
     1441 ataggggacc agagagagct tggaatgtta aaaacaaaac aaaacaaaaa aaaacaagga
     1501 gaagttgtcc aagggatgtc aattttttat ccctctgtat gggttagatt ttccaaaatc
     1561 ataatttgaa gaaggccagc atttatggta gaatatataa ttatatataa ggtggccacg
     1621 ctggggcaag ttccctcccc actcacagct ttggcccctt tcacagagta gaacctgggt
     1681 tagaggattg cagaagacga gcgggagcgg ggagggcagg gaagatgcct gtcgggtttt
     1741 tagcacagtt catttcactg ggattttgaa gcatttctgt ctgaatgtaa agcctgttct
     1801 agtcctggtg ggacacactg gggttggggg tgggggaaga tgcggtaatg aaaccggtta
     1861 gtcagtgttg tcttaatatc cttgataatg ctgtaaagtt tatttttaca aatatttctg
     1921 tttaagctat ttcacctttg tttggaaatc cttccctttt aaagagaaaa tgtgacactt
     1981 gtgaaaaggc ttgtaggaaa gctcctccct ttttttcttt aaacctttaa atgacaaacc
     2041 taggtaatta atggttgtga atttctattt ttgctttgtt tttaatgaac atttgtcttt
     2101 cagaatagga ttctgtgata atatttaaat ggcaaaaaca aaacataatt ttgtgcaatt
     2161 aacaaagcta ctgcaagaaa aataaaacat ttcttggtaa aaacgtatgt atttatatat
     2221 tatatattta tatataatat atattatata tttagcattg ctgagctttt tagatgccta
     2281 ttgtgtatct tttaaaggtt ttgaccattt tgttatgagt aattacatat atattacatt
     2341 cactatatta aaattgtact tttttactat gtgtctcatt ggttcatagt ctttattttg
     2401 tcctttgaat aaacattaaa agatttctaa acttca
//
