LOCUS       NM_002090               1075 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.
ACCESSION   NM_002090
VERSION     NM_002090.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Ren,H., Yang,X., Hou,W., Meng,J., Luo,D. and Zhang,C.
  TITLE     Comprehensive analysis of the clinical and biological significances
            for chemokine CXCL3 in cholangiocarcinoma
  JOURNAL   Medicine (Baltimore) 103 (11), e37460 (2024)
   PUBMED   38489741
  REMARK    GeneRIF: Comprehensive analysis of the clinical and biological
            significances for chemokine CXCL3 in cholangiocarcinoma.
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Cheng,Y., Yang,X., Liang,L., Xin,H., Dong,X., Li,W., Li,J., Guo,X.,
            Li,Y., He,J., Zhang,C. and Wang,W.
  TITLE     Elevated expression of CXCL3 in colon cancer promotes malignant
            behaviors of tumor cells in an ERK-dependent manner
  JOURNAL   BMC Cancer 23 (1), 1162 (2023)
   PUBMED   38031087
  REMARK    GeneRIF: Elevated expression of CXCL3 in colon cancer promotes
            malignant behaviors of tumor cells in an ERK-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Lou,F., Long,H., Luo,S., Liu,Y., Pu,J., Wang,H., Ji,P. and Jin,X.
  TITLE     Chronic restraint stress promotes the tumorigenic potential of oral
            squamous cell carcinoma cells by reprogramming fatty acid
            metabolism via CXCL3 mediated Wnt/beta-catenin pathway
  JOURNAL   Exp Neurol 359, 114268 (2023)
   PUBMED   36343679
  REMARK    GeneRIF: Chronic restraint stress promotes the tumorigenic
            potential of oral squamous cell carcinoma cells by reprogramming
            fatty acid metabolism via CXCL3 mediated Wnt/beta-catenin pathway.
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Blanco-Melo,D., Nilsson-Payant,B.E., Liu,W.C., Uhl,S., Hoagland,D.,
            Moller,R., Jordan,T.X., Oishi,K., Panis,M., Sachs,D., Wang,T.T.,
            Schwartz,R.E., Lim,J.K., Albrecht,R.A. and tenOever,B.R.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   6  (bases 1 to 1075)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL3 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   7  (bases 1 to 1075)
  AUTHORS   Wuyts,A., Govaerts,C., Struyf,S., Lenaerts,J.P., Put,W.,
            Conings,R., Proost,P. and Van Damme,J.
  TITLE     Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma
            from tumor cells and leukocytes reveals NH2-terminal heterogeneity.
            Functional comparison of different natural isoforms
  JOURNAL   Eur J Biochem 260 (2), 421-429 (1999)
   PUBMED   10095777
REFERENCE   8  (bases 1 to 1075)
  AUTHORS   Anisowicz,A., Messineo,M., Lee,S.W. and Sager,R.
  TITLE     An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha
            induction of gro in human fibroblasts
  JOURNAL   J Immunol 147 (2), 520-527 (1991)
   PUBMED   1906501
REFERENCE   9  (bases 1 to 1075)
  AUTHORS   Baker,N.E., Kucera,G. and Richmond,A.
  TITLE     Nucleotide sequence of the human melanoma growth stimulatory
            activity (MGSA) gene
  JOURNAL   Nucleic Acids Res 18 (21), 6453 (1990)
   PUBMED   2129556
REFERENCE   10 (bases 1 to 1075)
  AUTHORS   Tekamp-Olson,P., Gallegos,C., Bauer,D., McClain,J., Sherry,B.,
            Fabre,M., van Deventer,S. and Cerami,A.
  TITLE     Cloning and characterization of cDNAs for murine macrophage
            inflammatory protein 2 and its human homologues
  JOURNAL   J Exp Med 172 (3), 911-919 (1990)
   PUBMED   2201751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065743.1 and AW079760.1.
            
            On May 17, 2019 this sequence version replaced NM_002090.2.
            
            Summary: This antimicrobial gene encodes a member of the CXC
            subfamily of chemokines. The encoded protein is a secreted growth
            factor that signals through the G-protein coupled receptor, CXC
            receptor 2. This protein plays a role in inflammation and as a
            chemoattractant for neutrophils. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.25158.1,
                                           SRR5189667.233906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02400288 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in immune response
                                                  or antiviral activity
            MANE Ensembl match                 :: ENST00000296026.4/
                                                  ENSP00000296026.4
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1059              BC065743.1         5-1063
            1060-1075           AW079760.1         8-23                c
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1075
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /note="C-X-C motif chemokine ligand 3"
                     /db_xref="GeneID:2921"
                     /db_xref="HGNC:HGNC:4604"
                     /db_xref="MIM:139111"
     exon            1..178
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..402
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /note="GRO3 oncogene; C-X-C motif chemokine 3; MGSA gamma;
                     melanoma growth stimulatory activity gamma; GRO-gamma;
                     MIP2-beta; GRO-gamma(1-73); growth-regulated protein
                     gamma; macrophage inflammatory protein 2-beta; chemokine
                     (C-X-C motif) ligand 3"
                     /codon_start=1
                     /product="C-X-C motif chemokine 3 precursor"
                     /protein_id="NP_002081.2"
                     /db_xref="CCDS:CCDS34007.1"
                     /db_xref="GeneID:2921"
                     /db_xref="HGNC:HGNC:4604"
                     /db_xref="MIM:139111"
                     /translation="MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQ
                     CLQTLQGIHLKNIQSVNVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILN
                     KGSTN"
     exon            179..302
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /inference="alignment:Splign:2.1.0"
     exon            303..386
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1075
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      694..699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /note="hexamer: ATTAAA"
     polyA_site      720
                     /gene="CXCL3"
                     /gene_synonym="CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3"
                     /note="major polyA site"
ORIGIN      
        1 acacagcccg ggtcgcaggc acctccccgc cagctctccc gcttctcgca cagcttcccg
       61 acgcgtctgc tgagccccat ggcccacgcc acgctctccg ccgcccccag caatccccgg
      121 ctcctgcggg tggcgctgct gctcctgctc ctggtggccg ccagccggcg cgcagcagga
      181 gcgtccgtgg tcactgaact gcgctgccag tgcttgcaga cactgcaggg aattcacctc
      241 aagaacatcc aaagtgtgaa tgtaaggtcc cccggacccc actgcgccca aaccgaagtc
      301 atagccacac tcaagaatgg gaagaaagct tgtctcaacc ccgcatcccc catggttcag
      361 aaaatcatcg aaaagatact gaacaagggg agcaccaact gacaggagag aagtaagaag
      421 cttatcagcg tatcattgac acttcctgca gggtggtccc tgcccttacc agagctgaaa
      481 atgaaaaaga gaacagcagc tttctaggga cagctggaaa ggacttaatg tgtttgacta
      541 tttcttacga gggttctact tatttatgta tttatttttg aaagcttgta ttttaatatt
      601 ttacatgctg ttatttaaag atgtgagtgt gtttcatcaa acatagctca gtcctgatta
      661 tttaattgga atatgatggg ttttaaatgt gtcattaaac taatatttag tgggagacca
      721 taatgtgtca gccaccttga taaatgacag ggtggggaac tggagggtgg ggggattgaa
      781 atgcaagcaa ttagtggatc actgttaggg taagggaatg tatgtacaca tctatttttt
      841 atactttttt tttaaaaaaa gaatgtcagt tgttatttat tcaaattatc tcacattatg
      901 tgttcaacat ttttatgctg aagtttccct tagacatttt atgtcttgct tgtagggcat
      961 aatgccttgt ttaatgtcca ttctgcagcg tttctctttc ccttggaaaa gagaatttat
     1021 cattactgtt acatttgtac aaatgacatg ataataaaag ttttatgaaa aaaaa
//
