LOCUS       NM_002089               1115 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.
ACCESSION   NM_002089
VERSION     NM_002089.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1115)
  AUTHORS   He,E., Chang,K., Dong,L., Jia,M., Sun,W. and Cui,H.
  TITLE     Identification and Validation of CXCL2 as a Key Gene for Childhood
            Obesity
  JOURNAL   Biochem Genet 62 (4), 2743-2765 (2024)
   PUBMED   38010448
  REMARK    GeneRIF: Identification and Validation of CXCL2 as a Key Gene for
            Childhood Obesity.
REFERENCE   2  (bases 1 to 1115)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   3  (bases 1 to 1115)
  AUTHORS   Cai,H., Chen,Y., Chen,X., Sun,W. and Li,Y.
  TITLE     Tumor-associated macrophages mediate gastrointestinal stromal tumor
            cell metastasis through CXCL2/CXCR2
  JOURNAL   Cell Immunol 384, 104642 (2023)
   PUBMED   36577281
  REMARK    GeneRIF: Tumor-associated macrophages mediate gastrointestinal
            stromal tumor cell metastasis through CXCL2/CXCR2.
REFERENCE   4  (bases 1 to 1115)
  AUTHORS   Zhang,J., Hou,W., Zuo,J., Huang,Z., Ding,X. and Bu,X.
  TITLE     CXCL2 acts as a prognostic biomarker and associated with immune
            infiltrates in stomach adenocarcinoma
  JOURNAL   Medicine (Baltimore) 101 (42), e31096 (2022)
   PUBMED   36281171
  REMARK    GeneRIF: CXCL2 acts as a prognostic biomarker and associated with
            immune infiltrates in stomach adenocarcinoma.
REFERENCE   5  (bases 1 to 1115)
  AUTHORS   Blanco-Melo,D., Nilsson-Payant,B.E., Liu,W.C., Uhl,S., Hoagland,D.,
            Moller,R., Jordan,T.X., Oishi,K., Panis,M., Sachs,D., Wang,T.T.,
            Schwartz,R.E., Lim,J.K., Albrecht,R.A. and tenOever,B.R.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   6  (bases 1 to 1115)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL2 has antimicrobial activity against E. coli and S.
            aureus.
REFERENCE   7  (bases 1 to 1115)
  AUTHORS   King,A.G., Johanson,K., Frey,C.L., DeMarsh,P.L., White,J.R.,
            McDevitt,P., McNulty,D., Balcarek,J., Jonak,Z.L., Bhatnagar,P.K.
            and Pelus,L.M.
  TITLE     Identification of unique truncated KC/GRO beta chemokines with
            potent hematopoietic and anti-infective activities
  JOURNAL   J Immunol 164 (7), 3774-3782 (2000)
   PUBMED   10725737
REFERENCE   8  (bases 1 to 1115)
  AUTHORS   Anisowicz,A., Messineo,M., Lee,S.W. and Sager,R.
  TITLE     An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha
            induction of gro in human fibroblasts
  JOURNAL   J Immunol 147 (2), 520-527 (1991)
   PUBMED   1906501
REFERENCE   9  (bases 1 to 1115)
  AUTHORS   Baker,N.E., Kucera,G. and Richmond,A.
  TITLE     Nucleotide sequence of the human melanoma growth stimulatory
            activity (MGSA) gene
  JOURNAL   Nucleic Acids Res 18 (21), 6453 (1990)
   PUBMED   2129556
REFERENCE   10 (bases 1 to 1115)
  AUTHORS   Iida,N. and Grotendorst,G.R.
  TITLE     Cloning and sequencing of a new gro transcript from activated human
            monocytes: expression in leukocytes and wound tissue
  JOURNAL   Mol Cell Biol 10 (10), 5596-5599 (1990)
   PUBMED   2078213
  REMARK    Erratum:[Mol Cell Biol 1990 Dec;10(12):6821]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX334969.2, X53799.1 and
            BC053653.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002089.3.
            
            Summary: This antimicrobial gene is part of a chemokine superfamily
            that encodes secreted proteins involved in immunoregulatory and
            inflammatory processes. The superfamily is divided into four
            subfamilies based on the arrangement of the N-terminal cysteine
            residues of the mature peptide. This chemokine, a member of the CXC
            subfamily, is expressed at sites of inflammation and may suppress
            hematopoietic progenitor cell proliferation. [provided by RefSeq,
            Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015753.1, SRR5189664.118449.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in immune response
                                                  or antiviral activity
            MANE Ensembl match                 :: ENST00000508487.3/
                                                  ENSP00000427279.1
            Protein has antimicrobial activity :: PMID: 10725737, 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BX334969.2         97-129
            34-1114             X53799.1           1-1081
            1115-1115           BC053653.1         2151-2151
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1115
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /note="C-X-C motif chemokine ligand 2"
                     /db_xref="GeneID:2920"
                     /db_xref="HGNC:HGNC:4603"
                     /db_xref="MIM:139110"
     exon            1..175
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..399
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /note="GRO2 oncogene; C-X-C motif chemokine 2; MGSA beta;
                     melanoma growth stimulatory activity beta; gro-beta;
                     MIP2-alpha; growth-regulated protein beta; macrophage
                     inflammatory protein 2-alpha; chemokine (C-X-C motif)
                     ligand 2"
                     /codon_start=1
                     /product="C-X-C motif chemokine 2 precursor"
                     /protein_id="NP_002080.1"
                     /db_xref="CCDS:CCDS34008.1"
                     /db_xref="GeneID:2920"
                     /db_xref="HGNC:HGNC:4603"
                     /db_xref="MIM:139110"
                     /translation="MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQ
                     CLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLK
                     NGKSN"
     exon            176..299
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..383
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..1115
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /note="hexamer: AATAAA"
     polyA_site      1115
                     /gene="CXCL2"
                     /gene_synonym="CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2;
                     MIP2A; SCYB2"
                     /note="major polyA site"
ORIGIN      
        1 acagagcccg ggccacaggc agctccttgc cagctctcct cctcgcacag ccgctcgaac
       61 cgcctgctga gccccatggc ccgcgccacg ctctccgccg cccccagcaa tccccggctc
      121 ctgcgggtgg cgctgctgct cctgctcctg gtggccgcca gccggcgcgc agcaggagcg
      181 cccctggcca ctgaactgcg ctgccagtgc ttgcagaccc tgcagggaat tcacctcaag
      241 aacatccaaa gtgtgaaggt gaagtccccc ggaccccact gcgcccaaac cgaagtcata
      301 gccacactca agaatgggca gaaagcttgt ctcaaccccg catcgcccat ggttaagaaa
      361 atcatcgaaa agatgctgaa aaatggcaaa tccaactgac cagaaggaag gaggaagctt
      421 attggtggct gttcctgaag gaggccctgc ccttacagga acagaagagg aaagagagac
      481 acagctgcag aggccacctg gattgcgcct aatgtgtttg agcatcactt aggagaagtc
      541 ttctatttat ttatttattt atttatttgt ttgttttaga agattctatg ttaatatttt
      601 atgtgtaaaa taaggttatg attgaatcta cttgcacact ctcccattat atttattgtt
      661 tattttaggt caaacccaag ttagttcaat cctgattcat atttaatttg aagatagaag
      721 gtttgcagat attctctagt catttgttaa tatttcttcg tgatgacata tcacatgtca
      781 gccactgtga tagaggctga ggaatccaag aaaatggcca gtgagatcaa tgtgacggca
      841 gggaaatgta tgtgtgtcta ttttgtaact gtaaagatga atgtcagttg ttatttattg
      901 aaatgatttc acagtgtgtg gtcaacattt ctcatgttga agctttaaga actaaaatgt
      961 tctaaatatc ccttggacat tttatgtctt tcttgtaagg catactgcct tgtttaatgt
     1021 taattatgca gtgtttccct ctgtgttaga gcagagaggt ttcgatattt attgatgttt
     1081 tcacaaagaa caggaaaata aaatatttaa aaata
//
