LOCUS       NM_198477               1080 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript
            variant 1, mRNA.
ACCESSION   NM_198477 XM_209141
VERSION     NM_198477.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Ding,J., Hillig,C., White,C.W., Fernandopulle,N.A., Anderton,H.,
            Kern,J.S., Menden,M.P. and Mackay,G.A.
  TITLE     CXCL17 induces activation of human mast cells via MRGPRX2
  JOURNAL   Allergy 79 (6), 1609-1612 (2024)
   PUBMED   38279626
  REMARK    GeneRIF: CXCL17 induces activation of human mast cells via MRGPRX2.
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Dominguez-Lopez,A., Blanco-Vazquez,M., Calderon-Garcia,A.A.,
            Garcia-Vazquez,C., Gonzalez-Garcia,M.J., Calonge,M. and
            Enriquez-de-Salamanca,A.
  TITLE     Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry
            eye disease: An in vitro and clinical investigation
  JOURNAL   Exp Eye Res 241, 109854 (2024)
   PUBMED   38453037
  REMARK    GeneRIF: Analysis of the mucosal chemokines CCL28, CXCL14, and
            CXCL17 in dry eye disease: An in vitro and clinical investigation.
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Li,Y., Liu,A., Liu,S., Yan,L., Yuan,Y. and Xu,Q.
  TITLE     Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and
            Progression
  JOURNAL   Int J Mol Sci 24 (1), 615 (2022)
   PUBMED   36614059
  REMARK    GeneRIF: Involvement of CXCL17 and GPR35 in Gastric Cancer
            Initiation and Progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Gowhari Shabgah,A., Jadidi-Niaragh,F., Ebrahimzadeh,F.,
            Mohammadi,H., Askari,E., Pahlavani,N., Malekahmadi,M., Ebrahimi
            Nik,M. and Gholizadeh Navashenaq,J.
  TITLE     A comprehensive review of chemokine CXC17 (VCC1) in cancer,
            infection, and inflammation
  JOURNAL   Cell Biol Int 46 (10), 1557-1570 (2022)
   PUBMED   35811438
  REMARK    GeneRIF: A comprehensive review of chemokine CXC17 (VCC1) in
            cancer, infection, and inflammation.
            Review article
REFERENCE   5  (bases 1 to 1080)
  AUTHORS   Tan,Y., Liu,L., Zhang,X., Xue,Y., Gao,J., Zhao,J., Chi,N. and
            Zhu,Y.
  TITLE     THUMPD3-AS1 Is Correlated with Gastric Cancer and Regulates Cell
            Function through miR-1252-3p and CXCL17
  JOURNAL   Crit Rev Eukaryot Gene Expr 32 (8), 69-80 (2022)
   PUBMED   36017917
  REMARK    GeneRIF: THUMPD3-AS1 Is Correlated with Gastric Cancer and
            Regulates Cell Function through miR-1252-3p and CXCL17.
REFERENCE   6  (bases 1 to 1080)
  AUTHORS   Burkhardt,A.M., Tai,K.P., Flores-Guiterrez,J.P.,
            Vilches-Cisneros,N., Kamdar,K., Barbosa-Quintana,O., Valle-Rios,R.,
            Hevezi,P.A., Zuniga,J., Selman,M., Ouellette,A.J. and Zlotnik,A.
  TITLE     CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary
            fibrosis that exhibits broad antimicrobial activity
  JOURNAL   J Immunol 188 (12), 6399-6406 (2012)
   PUBMED   22611239
  REMARK    GeneRIF: We conclude that CXCL17 is an antimicrobial mucosal
            chemokine that may play a role in the pathogenesis of interstitial
            lung diseases
REFERENCE   7  (bases 1 to 1080)
  AUTHORS   Weinstein,E.J., Head,R., Griggs,D.W., Sun,D., Evans,R.J.,
            Swearingen,M.L., Westlin,M.M. and Mazzarella,R.
  TITLE     VCC-1, a novel chemokine, promotes tumor growth
  JOURNAL   Biochem Biophys Res Commun 350 (1), 74-81 (2006)
   PUBMED   16989774
  REMARK    GeneRIF: VCC1 plays a role in angiogenesis and possibly in the
            development of tumors in some tissue types
REFERENCE   8  (bases 1 to 1080)
  AUTHORS   Pisabarro,M.T., Leung,B., Kwong,M., Corpuz,R., Frantz,G.D.,
            Chiang,N., Vandlen,R., Diehl,L.J., Skelton,N., Kim,H.S., Eaton,D.
            and Schmidt,K.N.
  TITLE     Cutting edge: novel human dendritic cell- and monocyte-attracting
            chemokine-like protein identified by fold recognition methods
  JOURNAL   J Immunol 176 (4), 2069-2073 (2006)
   PUBMED   16455961
  REMARK    GeneRIF: DMC induces migration of monocytes and immature dendritic
            cells. Expression studies show that DMC is constitutively expressed
            in lung, suggesting a potential role for DMC in recruiting
            monocytes and dendritic cells from blood into lung parenchyma
REFERENCE   9  (bases 1 to 1080)
  AUTHORS   Zlotnik,A., Yoshie,O. and Nomiyama,H.
  TITLE     The chemokine and chemokine receptor superfamilies and their
            molecular evolution
  JOURNAL   Genome Biol 7 (12), 243 (2006)
   PUBMED   17201934
  REMARK    Review article
REFERENCE   10 (bases 1 to 1080)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358433.1, BU684368.1 and
            AC011497.6.
            
            On May 17, 2019 this sequence version replaced NM_198477.2.
            
            Summary: The protein encoded by this gene is a mucosal chemokine
            that attracts immature dendritic cells and blood monocytes to the
            lungs. The encoded protein also promotes tumorigenesis through an
            angiogenic activity. Finally, this protein exhibits strong
            antimicrobial activity against E. coli, S. aureus, Salmonella, P.
            aeruginosa, and C. albicans. Two transcript variants, one
            protein-coding and the other non-protein coding, have been found
            for this gene. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292985.1, DB236758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000601181.6/
                                                  ENSP00000472467.1
            Protein has antimicrobial activity :: PMID: 22611239
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-815               AY358433.1         39-853
            816-820             BU684368.1         17-21               c
            821-1080            AC011497.6         70923-71182
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1080
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /note="C-X-C motif chemokine ligand 17"
                     /db_xref="GeneID:284340"
                     /db_xref="HGNC:HGNC:19232"
                     /db_xref="MIM:611387"
     exon            1..193
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..474
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /note="VEGF co-regulated chemokine 1; C-X-C motif
                     chemokine 17; dendritic cell and monocyte chemokine-like
                     protein; VEGF coregulated chemokine 1; chemokine (C-X-C
                     motif) ligand 17; 6-Cys CXCL17"
                     /codon_start=1
                     /product="C-X-C motif chemokine 17 precursor"
                     /protein_id="NP_940879.1"
                     /db_xref="CCDS:CCDS12608.1"
                     /db_xref="GeneID:284340"
                     /db_xref="HGNC:HGNC:19232"
                     /db_xref="MIM:611387"
                     /translation="MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQ
                     EGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRA
                     CQQFLKQCQLRSFALPL"
     exon            194..274
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..376
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..1080
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      627
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /note="major polyA site"
     regulatory      795..800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
                     /note="hexamer: AATAAA"
     polyA_site      817
                     /gene="CXCL17"
                     /gene_synonym="Dcip1; DMC; UNQ473; VCC-1; VCC1"
ORIGIN      
        1 atagaccacc aggctgagta tcctgacctg agtcatcccc agggatcagg agcctccagc
       61 agggaacctt ccattatatt cttcaagcaa cttacagctg caccgacagt tgcgatgaaa
      121 gttctaatct cttccctcct cctgttgctg ccactaatgc tgatgtccat ggtctctagc
      181 agcctgaatc caggggtcgc cagaggccac agggaccgag gccaggcttc taggagatgg
      241 ctccaggaag gcggccaaga atgtgagtgc aaagattggt tcctgagagc cccgagaaga
      301 aaattcatga cagtgtctgg gctgccaaag aagcagtgcc cctgtgatca tttcaagggc
      361 aatgtgaaga aaacaagaca ccaaaggcac cacagaaagc caaacaagca ttccagagcc
      421 tgccagcaat ttctcaaaca atgtcagcta agaagctttg ctctgccttt gtaggagctc
      481 tgagcgccca ctcttccaat taaacattct cagccaagaa gacagtgagc acacctacca
      541 gacactcttc ttctcccacc tcactctccc actgtaccca cccctaaatc attccagtgc
      601 tctcaaaaag catgtttttc aagatcattt tgtttgttgc tctctctagt gtcttcttct
      661 ctcgtcagtc ttagcctgtg ccctcccctt acccaggctt aggcttaatt acctgaaaga
      721 ttccaggaaa ctgtagcttc ctagctagtg tcatttaacc ttaaatgcaa tcaggaaagt
      781 agcaaacaga agtcaataaa tatttttaaa tgtcacagat caaaattgtt tccttcaaat
      841 ggggtctgcc aattcacaac cagatgaccc attttaccct attcactgca gactgaatcc
      901 agattctaca catacttatc cccaccaaga ccctcactct gtctccattg gcctacttgt
      961 tcatctttca ctcattcgac aaatctttct gaggtaagag cgaggtggga caaaaaaaaa
     1021 aaagcatacc aatgaaccag acacggtctt attaaagata atataggttt aaaaaaaaaa
//
