LOCUS       NM_001386809            2324 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 16 (CXCL16), transcript
            variant 1, mRNA.
ACCESSION   NM_001386809
VERSION     NM_001386809.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Huang,X., Fei,Y., Qiu,X., Qian,T., Shang,Q., Cui,J., Song,Y.,
            Sheng,S., Xiao,W., Yu,Q., Wang,T. and Wang,X.
  TITLE     MiR-625-5p is a potential therapeutic target in sepsis by
            regulating CXCL16/CXCR6 axis and endothelial barrier
  JOURNAL   Int Immunopharmacol 137, 112508 (2024)
   PUBMED   38889512
  REMARK    GeneRIF: MiR-625-5p is a potential therapeutic target in sepsis by
            regulating CXCL16/CXCR6 axis and endothelial barrier.
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Wan,Y., Mao,M., Li,M., Liu,J., Tong,X., Wang,J., Li,J., Yin,S. and
            Wu,C.
  TITLE     Serum CXCL16: A new predictor of liver inflammation in patients
            with chronic hepatitis B
  JOURNAL   J Viral Hepat 31 (2), 107-119 (2024)
   PUBMED   38146125
  REMARK    GeneRIF: Serum CXCL16: A new predictor of liver inflammation in
            patients with chronic hepatitis B.
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Liu,J., Zhang,J., Zhao,X., Pan,C., Liu,Y., Luo,S., Miao,X., Wu,T.
            and Cheng,X.
  TITLE     Identification of CXCL16 as a diagnostic biomarker for obesity and
            intervertebral disc degeneration based on machine learning
  JOURNAL   Sci Rep 13 (1), 21316 (2023)
   PUBMED   38044363
  REMARK    GeneRIF: Identification of CXCL16 as a diagnostic biomarker for
            obesity and intervertebral disc degeneration based on machine
            learning.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Zajkowska,M., Dulewicz,M., Kulczynska-Przybik,A., Safiejko,K.,
            Juchimiuk,M., Konopko,M., Kozlowski,L. and Mroczko,B.
  TITLE     CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of
            colorectal cancer
  JOURNAL   Sci Rep 13 (1), 17688 (2023)
   PUBMED   37848726
  REMARK    GeneRIF: CXCL5 and CXCL14, but not CXCL16 as potential biomarkers
            of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Santos,P.V.D., Toledo,D.N.M., Guimaraes,N.S., Perucci,L.O.,
            Andrade-Neto,V.F. and Talvani,A.
  TITLE     Upregulation of IL-33, CCL2, and CXCL16 levels in Brazilian
            pregnant women infected by Toxoplasma gondii
  JOURNAL   Acta Trop 243, 106931 (2023)
   PUBMED   37086937
  REMARK    GeneRIF: Upregulation of IL-33, CCL2, and CXCL16 levels in
            Brazilian pregnant women infected by Toxoplasma gondii.
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2324)
  AUTHORS   Shimaoka,T., Nakayama,T., Kume,N., Takahashi,S., Yamaguchi,J.,
            Minami,M., Hayashida,K., Kita,T., Ohsumi,J., Yoshie,O. and
            Yonehara,S.
  TITLE     Cutting edge: SR-PSOX/CXC chemokine ligand 16 mediates bacterial
            phagocytosis by APCs through its chemokine domain
  JOURNAL   J Immunol 171 (4), 1647-1651 (2003)
   PUBMED   12902461
  REMARK    GeneRIF: SR-PSOX/CXCL16 may play an important role in facilitating
            uptake of various pathogens and chemotaxis of T and NKT cells by
            antigen presenting cells through its chemokine domain.
REFERENCE   8  (bases 1 to 2324)
  AUTHORS   Wilbanks,A., Zondlo,S.C., Murphy,K., Mak,S., Soler,D., Langdon,P.,
            Andrew,D.P., Wu,L. and Briskin,M.
  TITLE     Expression cloning of the STRL33/BONZO/TYMSTRligand reveals
            elements of CC, CXC, and CX3C chemokines
  JOURNAL   J Immunol 166 (8), 5145-5154 (2001)
   PUBMED   11290797
REFERENCE   9  (bases 1 to 2324)
  AUTHORS   Shimaoka,T., Kume,N., Minami,M., Hayashida,K., Kataoka,H., Kita,T.
            and Yonehara,S.
  TITLE     Molecular cloning of a novel scavenger receptor for oxidized low
            density lipoprotein, SR-PSOX, on macrophages
  JOURNAL   J Biol Chem 275 (52), 40663-40666 (2000)
   PUBMED   11060282
REFERENCE   10 (bases 1 to 2324)
  AUTHORS   Matloubian,M., David,A., Engel,S., Ryan,J.E. and Cyster,J.G.
  TITLE     A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
  JOURNAL   Nat Immunol 1 (4), 298-304 (2000)
   PUBMED   11017100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091153.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027389.1, BC044930.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000293778.12/
                                                ENSP00000293778.7
            RefSeq Select criteria           :: based on manual assertion,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               AC091153.10        42106-42773
            669-807             AC091153.10        43114-43252
            808-890             AC091153.10        43544-43626
            891-1307            AC091153.10        46526-46942
            1308-1377           AC091153.10        47382-47451
            1378-2324           AC091153.10        47555-48501
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2324
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /note="C-X-C motif chemokine ligand 16"
                     /db_xref="GeneID:58191"
                     /db_xref="HGNC:HGNC:16642"
                     /db_xref="MIM:605398"
     exon            1..668
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..1354
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CXC chemokine ligand 16; C-X-C motif chemokine
                     16; small-inducible cytokine B16; transmembrane chemokine
                     CXCL16; scavenger receptor for phosphatidylserine and
                     oxidized low density lipoprotein; chemokine (C-X-C motif)
                     ligand 16"
                     /codon_start=1
                     /product="C-X-C motif chemokine 16 isoform 1 precursor"
                     /protein_id="NP_001373738.1"
                     /db_xref="CCDS:CCDS11052.2"
                     /db_xref="GeneID:58191"
                     /db_xref="HGNC:HGNC:16642"
                     /db_xref="MIM:605398"
                     /translation="MGRDLRPGSRVLLLLLLLLLVYLTQPGNGNEGSVTGSCYCGKRI
                     SSDSPPSVQFMNRLRKHLRAYHRCLYYTRFQLLSWSVCGGNKDPWVQELMSCLDLKEC
                     GHAYSGIVAHQKHLLPTSPPISQASEGASSDIHTPAQMLLSTLQSTQRPTLPVGSLSS
                     DKELTRPNETTIHTAGHSLAAGPEAGENQKQPEKNAGPTARTSATVPVLCLLAIIFIL
                     TAALSYVLCKRRRGQSPQSSPDLPVHYIPVAPDSNT"
     exon            669..807
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /inference="alignment:Splign:2.1.0"
     exon            808..890
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1307
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1377
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..2324
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /note="hexamer: ATTAAA"
     polyA_site      2324
                     /gene="CXCL16"
                     /gene_synonym="CXCLG16; SR-PSOX; SRPSOX"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcgtccg cgggtggctg ccccgcaggt gcgcgcggcc ggggctggcg gcgactctct
       61 ccaccgggcc gcccgggagg ctcatgcagc gcggctgggt cccgcggcgc ccggatcggg
      121 gaagtgaaag tgcctcggag gaggagggcc ggtccggcag tgcagccgcc tcacaggtcg
      181 gcggacgggc caggcgggcg gcctcctgaa ccgaaccgaa tcggctcctc gggccgtcgt
      241 cctcccgccc ctcctcgccc gccgccggag ttttctttcg gtttcttcca agattcctgg
      301 ccttccctcg acggagccgg gcccagtgcg ggggcgcagg gcgcgggagc tccacctcct
      361 cggctttccc tgcgtccaga ggctggcatg gcgcgggccg agtactgagc gcacggtcgg
      421 ggcacagcag ggccgggggg tgcagctggc tcgcgcctcc tctccggccg ccgtctcctc
      481 cggtccccgg cgaaagccat tgagacacca gctggacgtc acgcgccgga gcatgtctgg
      541 gagtcagagc gaggtggctc catccccgca gagtccgcgg agccccgaga tgggacggga
      601 cttgcggccc gggtcccgcg tgctcctgct cctgcttctg ctcctgctgg tgtacctgac
      661 tcagccaggc aatggcaacg agggcagcgt cactggaagt tgttattgtg gtaaaagaat
      721 ttcttccgac tccccgccat cggttcagtt catgaatcgt ctccggaaac acctgagagc
      781 ttaccatcgg tgtctatact acacgaggtt ccagctcctt tcctggagcg tgtgtggggg
      841 caacaaggac ccatgggttc aggaattgat gagctgtctt gatctcaaag aatgtggaca
      901 tgcttactcg gggattgtgg cccaccagaa gcatttactt cctaccagcc ccccaatttc
      961 tcaggcctca gagggggcat cttcagatat ccacacccct gcccagatgc tcctgtccac
     1021 cttgcagtcc actcagcgcc ccaccctccc agtaggatca ctgtcctcgg acaaagagct
     1081 cactcgtccc aatgaaacca ccattcacac tgcgggccac agtctggcag ctgggcctga
     1141 ggctggggag aaccagaagc agccggaaaa aaatgctggt cccacagcca ggacatcagc
     1201 cacagtgcca gtcctgtgcc tcctggccat catcttcatc ctcaccgcag ccctttccta
     1261 tgtgctgtgc aagaggagga gggggcagtc accgcagtcc tctccagatc tgccggttca
     1321 ttatatacct gtggcacctg actctaatac ctgagccaag aatggaagct tgtgaggaga
     1381 cggactctat gttgcccagg ctgttatgga actcctgagt caagtgatcc tcccaccttg
     1441 gcctctgaag gtgcgaggat tataggcgtc acctaccaca tccagcctac acgtatttgt
     1501 taatatctaa cataggacta accagccact gccctctctt aggcccctca tttaaaaacg
     1561 gttatactat aaaatctgct tttcacactg ggtgataata acttggacaa attctatgtg
     1621 tattttgttt tgttttgctt tgctttgttt tgagacggag tctcgctctg tcatccaggc
     1681 tggagtgcag tggcatgatc tcggctcact gcaaccccca tctcccaggt tcaagcgatt
     1741 ctcctgcctc ctcctgagta gctgggacta caggtgctca ccaccacacc cggctaattt
     1801 tttgtatttt tagtagagac ggggtttcac catgttgacc aggctggtct cgaactcctg
     1861 acctggtgat ctgcccaccc aggcctccca aagtgctggg attaaaggtg tgagccacca
     1921 tgcctggccc tatgtgtgtt ttttaactac taaaaattat ttttgtaatg attgagtctt
     1981 ctttatggaa acaactggcc tcagcccttg cgcccttact gtgattcctg gcttcatttt
     2041 ttgctgatgg ttccccctcg tcccaaatct ctctcccagt acaccagttg ttcctccccc
     2101 acctcagccc tctcctgcat cctcctgtac ccgcagcgaa ggcctgggct ttcccaccct
     2161 ccctccttag caggtgccgt gctgggacac catacgggtt ggtttcacct cctcagtccc
     2221 ttgcctaccc cagtgagagt ctgatcttgt ttttattgtt attgctttta ttattattgc
     2281 ttttattatc attaaaactc tagttcttgt tttgtctctc cgaa
//
