LOCUS       NM_004887               1687 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 14 (CXCL14), mRNA.
ACCESSION   NM_004887
VERSION     NM_004887.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Xu,Y., Deng,C., Chen,H., Song,Y., Xu,H., Song,G., Wang,X., Luo,T.,
            Chen,W., Ma,J., Zeng,A., Huang,S., Chen,Z., Fu,J., Gong,M., Tai,Y.,
            Huang,A., Feng,H., Hu,J., Zhu,X., Tang,Q., Lu,J. and Wang,J.
  TITLE     Osteosarcoma Cells Secrete CXCL14 That Activates Integrin
            alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche
  JOURNAL   Cancer Res 84 (7), 994-1012 (2024)
   PUBMED   38295227
  REMARK    GeneRIF: Osteosarcoma Cells Secrete CXCL14 That Activates Integrin
            alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Dominguez-Lopez,A., Blanco-Vazquez,M., Calderon-Garcia,A.A.,
            Garcia-Vazquez,C., Gonzalez-Garcia,M.J., Calonge,M. and
            Enriquez-de-Salamanca,A.
  TITLE     Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry
            eye disease: An in vitro and clinical investigation
  JOURNAL   Exp Eye Res 241, 109854 (2024)
   PUBMED   38453037
  REMARK    GeneRIF: Analysis of the mucosal chemokines CCL28, CXCL14, and
            CXCL17 in dry eye disease: An in vitro and clinical investigation.
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Giacobbi,N.S., Mullapudi,S., Nabors,H. and Pyeon,D.
  TITLE     The Chemokine CXCL14 as a Potential Immunotherapeutic Agent for
            Cancer Therapy
  JOURNAL   Viruses 16 (2), 302 (2024)
   PUBMED   38400076
  REMARK    GeneRIF: The Chemokine CXCL14 as a Potential Immunotherapeutic
            Agent for Cancer Therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Zhang,Y., Jin,Y., Li,J., Yan,Y., Wang,T., Wang,X., Li,Z. and Qin,X.
  TITLE     CXCL14 as a Key Regulator of Neuronal Development: Insights from
            Its Receptor and Multi-Omics Analysis
  JOURNAL   Int J Mol Sci 25 (3), 1651 (2024)
   PUBMED   38338930
  REMARK    GeneRIF: CXCL14 as a Key Regulator of Neuronal Development:
            Insights from Its Receptor and Multi-Omics Analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Al Hamwi,G., Namasivayam,V., Buschbell,B., Gedschold,R., Golz,S.
            and Muller,C.E.
  TITLE     Proinflammatory chemokine CXCL14 activates MAS-related G
            protein-coupled receptor MRGPRX2 and its putative mouse ortholog
            MRGPRB2
  JOURNAL   Commun Biol 7 (1), 52 (2024)
   PUBMED   38184723
  REMARK    GeneRIF: Proinflammatory chemokine CXCL14 activates MAS-related G
            protein-coupled receptor MRGPRX2 and its putative mouse ortholog
            MRGPRB2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL14 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Kurth,I., Willimann,K., Schaerli,P., Hunziker,T., Clark-Lewis,I.
            and Moser,B.
  TITLE     Monocyte selectivity and tissue localization suggests a role for
            breast and kidney-expressed chemokine (BRAK) in macrophage
            development
  JOURNAL   J Exp Med 194 (6), 855-861 (2001)
   PUBMED   11561000
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Cao,X., Zhang,W., Wan,T., He,L., Chen,T., Yuan,Z., Ma,S., Yu,Y. and
            Chen,G.
  TITLE     Molecular cloning and characterization of a novel CXC chemokine
            macrophage inflammatory protein-2 gamma chemoattractant for human
            neutrophils and dendritic cells
  JOURNAL   J Immunol 165 (5), 2588-2595 (2000)
   PUBMED   10946286
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   Frederick,M.J., Henderson,Y., Xu,X., Deavers,M.T., Sahin,A.A.,
            Wu,H., Lewis,D.E., El-Naggar,A.K. and Clayman,G.L.
  TITLE     In vivo expression of the novel CXC chemokine BRAK in normal and
            cancerous human tissue
  JOURNAL   Am J Pathol 156 (6), 1937-1950 (2000)
   PUBMED   10854217
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Hromas,R., Broxmeyer,H.E., Kim,C., Nakshatri,H., Christopherson,K.
            2nd, Azam,M. and Hou,Y.H.
  TITLE     Cloning of BRAK, a novel divergent CXC chemokine preferentially
            expressed in normal versus malignant cells
  JOURNAL   Biochem Biophys Res Commun 255 (3), 703-706 (1999)
   PUBMED   10049774
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034206.4.
            
            On Jul 19, 2019 this sequence version replaced NM_004887.4.
            
            Summary: This antimicrobial gene belongs to the cytokine gene
            family which encode secreted proteins involved in immunoregulatory
            and inflammatory processes. The protein encoded by this gene is
            structurally related to the CXC (Cys-X-Cys) subfamily of cytokines.
            Members of this subfamily are characterized by two cysteines
            separated by a single amino acid. This cytokine displays
            chemotactic activity for monocytes but not for lymphocytes,
            dendritic cells, neutrophils or macrophages. It has been implicated
            that this cytokine is involved in the homeostasis of
            monocyte-derived macrophages rather than in inflammation. [provided
            by RefSeq, Sep 2014].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358906.1, AK075514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            MANE Ensembl match                 :: ENST00000512158.6/
                                                  ENSP00000423783.1
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC034206.4         24421-24697         c
            278-383             AC034206.4         24140-24245         c
            384-497             AC034206.4         20278-20391         c
            498-1687            AC034206.4         16385-17574         c
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..1687
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /note="C-X-C motif chemokine ligand 14"
                     /db_xref="GeneID:9547"
                     /db_xref="HGNC:HGNC:10640"
                     /db_xref="MIM:604186"
     exon            1..277
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..513
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /note="CXC chemokine in breast and kidney; small inducible
                     cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); C-X-C
                     motif chemokine 14; MIP-2 gamma; small-inducible cytokine
                     B14; bolekine; chemokine BRAK; tumor-suppressing
                     chemokine; chemokine (C-X-C motif) ligand 14"
                     /codon_start=1
                     /product="C-X-C motif chemokine 14 precursor"
                     /protein_id="NP_004878.3"
                     /db_xref="CCDS:CCDS4188.2"
                     /db_xref="GeneID:9547"
                     /db_xref="HGNC:HGNC:10640"
                     /db_xref="MIM:604186"
                     /translation="MRLLAAALLLLLLALYTARVDGSKCKCSRKGPKIRYSDVKKLEM
                     KPKYPHCEEKMVIITTKSVSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE"
     exon            278..383
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /inference="alignment:Splign:2.1.0"
     exon            384..497
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1687
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /note="hexamer: AATAAA"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /note="hexamer: AATATA"
     polyA_site      1681
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /note="major polyA site"
     polyA_site      1687
                     /gene="CXCL14"
                     /gene_synonym="BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC;
                     SCYB14"
                     /note="major polyA site"
ORIGIN      
        1 gtggagagag cgcggagaca agcgcagagc gcagcgcacg gccacagaca gccctgggca
       61 tccaccgacg gcgcagccgg agccagcaga gccggaaggc gcgccccggg cagagaaagc
      121 cgagcagagc tgggtggcgt ctccgggccg ccgctccgac gggccagcgc cctccccatg
      181 tccctgctcc cacgccgcgc ccctccggtc agcatgaggc tcctggcggc cgcgctgctc
      241 ctgctgctgc tggcgctgta caccgcgcgt gtggacgggt ccaaatgcaa gtgctcccgg
      301 aagggaccca agatccgcta cagcgacgtg aagaagctgg aaatgaagcc aaagtacccg
      361 cactgcgagg agaagatggt tatcatcacc accaagagcg tgtccaggta ccgaggtcag
      421 gagcactgcc tgcaccccaa gctgcagagc accaagcgct tcatcaagtg gtacaacgcc
      481 tggaacgaga agcgcagggt ctacgaagaa tagggtgaaa aacctcagaa gggaaaactc
      541 caaaccagtt gggagacttg tgcaaaggac tttgcagatt aaaaaaaaaa aaaaaaaaaa
      601 aaaaaaaaaa aaaaaaaaaa aaagcctttc tttctcacag gcataagaca caaattatat
      661 attgttatga agcacttttt accaacggtc agtttttaca ttttatagct gcgtgcgaaa
      721 ggcttccaga tgggagaccc atctctcttg tgctccagac ttcatcacag gctgcttttt
      781 atcaaaaagg ggaaaactca tgcctttcct ttttaaaaaa tgcttttttg tatttgtcca
      841 tacgtcacta tacatctgag ctttataagc gcccgggagg aacaatgagc ttggtggaca
      901 catttcattg cagtgttgct ccattcctag cttgggaagc ttccgcttag aggtcctggc
      961 gcctcggcac agctgccacg ggctctcctg ggcttatggc cggtcacagc ctcagtgtga
     1021 ctccacagtg gcccctgtag ccgggcaagc aggagcaggt ctctctgcat ctgttctctg
     1081 aggaactcaa gtttggttgc cagaaaaatg tgcttcattc ccccctggtt aatttttaca
     1141 caccctagga aacatttcca agatcctgtg atggcgagac aaatgatcct taaagaaggt
     1201 gtggggtctt tcccaacctg aggatttctg aaaggttcac aggttcaata tttaatgctt
     1261 cagaagcatg tgaggttccc aacactgtca gcaaaaacct taggagaaaa cttaaaaata
     1321 tatgaataca tgcgcaatac acagctacag acacacattc tgttgacaag ggaaaacctt
     1381 caaagcatgt ttctttccct caccacaaca gaacatgcag tactaaagca atatatttgt
     1441 gattccccat gtaattcttc aatgttaaac agtgcagtcc tctttcgaaa gctaagatga
     1501 ccatgcgccc tttcctctgt acatataccc ttaagaacgc cccctccaca cactgccccc
     1561 cagtatatgc cgcattgtac tgctgtgtta tatgctatgt acatgtcaga aaccattagc
     1621 attgcatgca ggtttcatat tctttctaag atggaaagta ataaaatata tttgaaatgt
     1681 accaaaa
//
