LOCUS       NM_001371558            1171 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 13 (CXCL13), transcript
            variant 2, mRNA.
ACCESSION   NM_001371558 XM_006714063
VERSION     NM_001371558.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1171)
  AUTHORS   Law,C., Wacleche,V.S., Cao,Y., Pillai,A., Sowerby,J., Hancock,B.,
            Horisberger,A., Bracero,S., Skidanova,V., Li,Z., Adejoorin,I.,
            Dillon,E., Benque,I.J., Nunez,D.P., Simmons,D.P., Keegan,J.,
            Chen,L., Baker,T., Brohawn,P.Z., Al-Mossawi,H., Hao,L.Y., Jones,B.,
            Rao,N., Qu,Y., Alves,S.E., Jonsson,A.H., Shaw,K.S., Vleugels,R.A.,
            Massarotti,E., Costenbader,K.H., Brenner,M.B., Lederer,J.A.,
            Hultquist,J.F., Choi,J. and Rao,D.A.
  CONSRTM   Accelerating Medicines Partnership: RA/SLE Network
  TITLE     Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in
            lupus
  JOURNAL   Nature 631 (8022), 857-866 (2024)
   PUBMED   38987586
  REMARK    GeneRIF: Interferon subverts an AHR-JUN axis to promote CXCL13[+] T
            cells in lupus.
            Erratum:[Nature. 2024 Jul 26. doi: 10.1038/s41586-024-07845-8.
            PMID: 39060417]
REFERENCE   2  (bases 1 to 1171)
  AUTHORS   Ding,Y., Zhou,Q., Ding,B., Zhang,Y. and Shen,Y.
  TITLE     Transcriptome analysis reveals the clinical significance of CXCL13
            in Pan-Gyn tumors
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 116 (2024)
   PUBMED   38459390
  REMARK    GeneRIF: Transcriptome analysis reveals the clinical significance
            of CXCL13 in Pan-Gyn tumors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1171)
  AUTHORS   Zhao,Y.H., Zhu,W.X., Ye,Q.H., Zhang,P. and Wei,B.F.
  TITLE     Correlation of serum and local CXCL13 levels with disease severity
            in patients with non-traumatic osteonecrosis of femoral head
  JOURNAL   J Orthop Surg Res 19 (1), 162 (2024)
   PUBMED   38429811
  REMARK    GeneRIF: Correlation of serum and local CXCL13 levels with disease
            severity in patients with non-traumatic osteonecrosis of femoral
            head.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1171)
  AUTHORS   Achudhan,D., Lai,Y.L., Lin,Y.Y., Huang,Y.L., Tsai,C.H., Ho,T.L.,
            Ko,C.Y., Fong,Y.C., Huang,C.C. and Tang,C.H.
  TITLE     CXCL13 promotes TNF-alpha synthesis in rheumatoid arthritis through
            activating ERK/p38 pathway and inhibiting miR-330-3p generation
  JOURNAL   Biochem Pharmacol 221, 116037 (2024)
   PUBMED   38301965
  REMARK    GeneRIF: CXCL13 promotes TNF-alpha synthesis in rheumatoid
            arthritis through activating ERK/p38 pathway and inhibiting
            miR-330-3p generation.
REFERENCE   5  (bases 1 to 1171)
  AUTHORS   Erhart,D.K., Klose,V., Schaper,T., Tumani,H. and Senel,M.
  TITLE     CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large
            Cross-Sectional Study
  JOURNAL   Int J Mol Sci 25 (1), 425 (2023)
   PUBMED   38203597
  REMARK    GeneRIF: CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large
            Cross-Sectional Study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1171)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL13 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   7  (bases 1 to 1171)
  AUTHORS   Jenh,C.H., Cox,M.A., Hipkin,W., Lu,T., Pugliese-Sivo,C.,
            Gonsiorek,W., Chou,C.C., Narula,S.K. and Zavodny,P.J.
  TITLE     Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist
            for the human CXCR3 receptor
  JOURNAL   Cytokine 15 (3), 113-121 (2001)
   PUBMED   11554781
REFERENCE   8  (bases 1 to 1171)
  AUTHORS   Gosling,J., Dairaghi,D.J., Wang,Y., Hanley,M., Talbot,D., Miao,Z.
            and Schall,T.J.
  TITLE     Cutting edge: identification of a novel chemokine receptor that
            binds dendritic cell- and T cell-active chemokines including ELC,
            SLC, and TECK
  JOURNAL   J Immunol 164 (6), 2851-2856 (2000)
   PUBMED   10706668
REFERENCE   9  (bases 1 to 1171)
  AUTHORS   Gunn,M.D., Ngo,V.N., Ansel,K.M., Ekland,E.H., Cyster,J.G. and
            Williams,L.T.
  TITLE     A B-cell-homing chemokine made in lymphoid follicles activates
            Burkitt's lymphoma receptor-1
  JOURNAL   Nature 391 (6669), 799-803 (1998)
   PUBMED   9486651
REFERENCE   10 (bases 1 to 1171)
  AUTHORS   Legler,D.F., Loetscher,M., Roos,R.S., Clark-Lewis,I., Baggiolini,M.
            and Moser,B.
  TITLE     B cell-attracting chemokine 1, a human CXC chemokine expressed in
            lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
  JOURNAL   J Exp Med 187 (4), 655-660 (1998)
   PUBMED   9463416
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093758.3.
            
            On Jul 18, 2019 this sequence version replaced XM_006714063.4.
            
            Summary: B lymphocyte chemoattractant, independently cloned and
            named Angie, is an antimicrobial peptide and CXC chemokine strongly
            expressed in the follicles of the spleen, lymph nodes, and Peyer's
            patches. It preferentially promotes the migration of B lymphocytes
            (compared to T cells and macrophages), apparently by stimulating
            calcium influx into, and chemotaxis of, cells expressing Burkitt's
            lymphoma receptor 1 (BLR-1). It may therefore function in the
            homing of B lymphocytes to follicles. [provided by RefSeq, Oct
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.239533.1, BC012589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000682537.1/
                                                  ENSP00000507688.1
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on expression, longest
                                                  protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC093758.3         50645-50754
            111-243             AC093758.3         52528-52660
            244-324             AC093758.3         55439-55519
            325-1171            AC093758.3         55813-56659
FEATURES             Location/Qualifiers
     source          1..1171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1171
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /note="C-X-C motif chemokine ligand 13"
                     /db_xref="GeneID:10563"
                     /db_xref="HGNC:HGNC:10639"
                     /db_xref="MIM:605149"
     exon            1..110
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..376
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /note="B-cell chemoattractant; small inducible cytokine B
                     subfamily (Cys-X-Cys motif), member 13 (B-cell
                     chemoattractant); chemokine (C-X-C motif) ligand 13
                     (B-cell chemoattractant); B-cell-homing chemokine (ligand
                     for Burkitt's lymphoma receptor-1); C-X-C motif chemokine
                     13; B-cell-attracting chemokine 1; B-lymphocyte
                     chemoattractant; CXC chemokine BLC; b lymphocyte
                     chemoattractant; small-inducible cytokine B13; b
                     cell-attracting chemokine 1"
                     /codon_start=1
                     /product="C-X-C motif chemokine 13 precursor"
                     /protein_id="NP_001358487.1"
                     /db_xref="CCDS:CCDS3582.1"
                     /db_xref="GeneID:10563"
                     /db_xref="HGNC:HGNC:10639"
                     /db_xref="MIM:605149"
                     /translation="MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIP
                     RRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVP
                     VFKRKIP"
     exon            111..243
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /inference="alignment:Splign:2.1.0"
     exon            244..324
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /inference="alignment:Splign:2.1.0"
     exon            325..1171
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /note="hexamer: AATAAA"
     polyA_site      1171
                     /gene="CXCL13"
                     /gene_synonym="ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L;
                     SCYB13"
                     /note="major polyA site"
ORIGIN      
        1 acagcctgga ctcagagctc aagtctgaac tctacctcca gacagaatga agttcatctc
       61 gacatctctg cttctcatgc tgctggtcag cagcctctct ccagtccaag gtgttctgga
      121 ggtctattac acaagcttga ggtgtagatg tgtccaagag agctcagtct ttatccctag
      181 acgcttcatt gatcgaattc aaatcttgcc ccgtgggaat ggttgtccaa gaaaagaaat
      241 catagtctgg aagaagaaca agtcaattgt gtgtgtggac cctcaagctg aatggataca
      301 aagaatgatg gaagtattga gaaaaagaag ttcttcaact ctaccagttc cagtgtttaa
      361 gagaaagatt ccctgatgct gatatttcca ctaagaacac ctgcattctt cccttatccc
      421 tgctctggat tttagttttg tgcttagtta aatcttttcc aggaaaaaga acttccccat
      481 acaaataagc atgagactat gtaaaaataa ccttgcagaa gctgatgggg caaactcaag
      541 cttcttcact cacagcaccc tatatacact tggagtttgc attcttattc atcagggagg
      601 aaagtttctt tgaaaatagt tattcagtta taagtaatac aggattattt tgattatata
      661 cttgttgttt aatgtttaaa atttcttaga aaacaatgga atgagaattt aagcctcaaa
      721 tttgaacatg tggcttgaat taagaagaaa attatggcat atattaaaag caggcttcta
      781 tgaaagactc aaaaagctgc ctgggaggca gatggaactt gagcctgtca agaggcaaag
      841 gaatccatgt agtagatatc ctctgcttaa aaactcacta cggaggagaa ttaagtccta
      901 cttttaaaga atttctttat aaaatttact gtctaagatt aatagcattc gaagatcccc
      961 agacttcata gaatactcag ggaaagcatt taaagggtga tgtacacatg tatcctttca
     1021 cacatttgcc ttgacaaact tctttcactc acatcttttt cactgacttt ttttgtgggg
     1081 ggcggggccg gggggactct ggtatctaat tctttaatga ttcctataaa tctaatgaca
     1141 ttcaataaag ttgagcaaac attttactta a
//
