LOCUS       NM_199168               1928 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript
            variant 1, mRNA.
ACCESSION   NM_199168
VERSION     NM_199168.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1928)
  AUTHORS   Valiukevicius,P., Kaikaryte,K., Gedvilaite-Vaicechauskiene,G.,
            Balnyte,R. and Liutkeviciene,R.
  TITLE     CXCL12 Gene Polymorphisms and Serum Levels: Associations with
            Multiple Sclerosis Prevalence and Clinical Parameters in Lithuania
  JOURNAL   Int J Mol Sci 25 (17), 9554 (2024)
   PUBMED   39273501
  REMARK    GeneRIF: CXCL12 Gene Polymorphisms and Serum Levels: Associations
            with Multiple Sclerosis Prevalence and Clinical Parameters in
            Lithuania.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1928)
  AUTHORS   Park,A., Kim,S.E., Yu,J., Son,D., Kim,K.S., Koh,E. and Park,K.S.
  TITLE     Cadherin-6 is a novel mediator for the migration of mesenchymal
            stem cells to glioblastoma cells in response to stromal
            cell-derived factor-1
  JOURNAL   FEBS Open Bio 14 (7), 1192-1204 (2024)
   PUBMED   38719785
  REMARK    GeneRIF: Cadherin-6 is a novel mediator for the migration of
            mesenchymal stem cells to glioblastoma cells in response to stromal
            cell-derived factor-1.
REFERENCE   3  (bases 1 to 1928)
  AUTHORS   Ragkousis,A., Kazantzis,D., Georgalas,I., Theodossiadis,P.,
            Kroupis,C. and Chatziralli,I.
  TITLE     PON1, APOE and SDF-1 Gene Polymorphisms and Risk of Retinal Vein
            Occlusion: A Case-Control Study
  JOURNAL   Genes (Basel) 15 (6), 712 (2024)
   PUBMED   38927649
  REMARK    GeneRIF: PON1, APOE and SDF-1 Gene Polymorphisms and Risk of
            Retinal Vein Occlusion: A Case-Control Study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1928)
  AUTHORS   Ai,Y., Wan,C., Chen,Z., Wang,Y., Zhao,W. and Huang,W.
  TITLE     SDF-1 promotes metastasis of NSCLC by enhancing chemoattraction of
            megakaryocytes through the PI3K/Akt signaling pathway
  JOURNAL   J Biosci 49 (2024)
   PUBMED   38726826
  REMARK    GeneRIF: SDF-1 promotes metastasis of NSCLC by enhancing
            chemoattraction of megakaryocytes through the PI3K/Akt signaling
            pathway.
REFERENCE   5  (bases 1 to 1928)
  AUTHORS   Karin,N.
  TITLE     The multiple faces of CXCL12 (SDF-1alpha) in the regulation of
            immunity during health and disease
  JOURNAL   J Leukoc Biol 88 (3), 463-473 (2010)
   PUBMED   20501749
  REMARK    GeneRIF: The current review explores the different biological
            properties of CXCL12 and discusses the implications of CXCL12-based
            therapies for autoimmunity and cancer diseases.
            Review article
REFERENCE   6  (bases 1 to 1928)
  AUTHORS   Yu,L., Cecil,J., Peng,S.B., Schrementi,J., Kovacevic,S., Paul,D.,
            Su,E.W. and Wang,J.
  TITLE     Identification and expression of novel isoforms of human stromal
            cell-derived factor 1
  JOURNAL   Gene 374, 174-179 (2006)
   PUBMED   16626895
REFERENCE   7  (bases 1 to 1928)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL12 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   8  (bases 1 to 1928)
  AUTHORS   Oberlin,E., Amara,A., Bachelerie,F., Bessia,C., Virelizier,J.L.,
            Arenzana-Seisdedos,F., Schwartz,O., Heard,J.M., Clark-Lewis,I.,
            Legler,D.F., Loetscher,M., Baggiolini,M. and Moser,B.
  TITLE     The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents
            infection by T-cell-line-adapted HIV-1
  JOURNAL   Nature 382 (6594), 833-835 (1996)
   PUBMED   8752281
  REMARK    Erratum:[Nature 1996 Nov 21;384(6606):288]
REFERENCE   9  (bases 1 to 1928)
  AUTHORS   Bleul,C.C., Farzan,M., Choe,H., Parolin,C., Clark-Lewis,I.,
            Sodroski,J. and Springer,T.A.
  TITLE     The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin
            and blocks HIV-1 entry
  JOURNAL   Nature 382 (6594), 829-833 (1996)
   PUBMED   8752280
REFERENCE   10 (bases 1 to 1928)
  AUTHORS   Shirozu,M., Nakano,T., Inazawa,J., Tashiro,K., Tada,H.,
            Shinohara,T. and Honjo,T.
  TITLE     Structure and chromosomal localization of the human stromal
            cell-derived factor 1 (SDF1) gene
  JOURNAL   Genomics 28 (3), 495-500 (1995)
   PUBMED   7490086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137026.21, BC031072.1,
            BC039893.1 and AI092156.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2019 this sequence version replaced NM_199168.3.
            
            Summary: This antimicrobial gene encodes a stromal cell-derived
            alpha chemokine member of the intercrine family. The encoded
            protein functions as the ligand for the G-protein coupled receptor,
            chemokine (C-X-C motif) receptor 4, and plays a role in many
            diverse cellular functions, including embryogenesis, immune
            surveillance, inflammation response, tissue homeostasis, and tumor
            growth and metastasis. Mutations in this gene are associated with
            resistance to human immunodeficiency virus type 1 infections.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the shortest protein
            (isoform alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.867469.1,
                                           SRR3476690.602897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000343575.11/
                                                  ENSP00000339913.6
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL137026.21        176260-176262       c
            4-22                BC031072.1         4-22
            23-1861             BC039893.1         1-1839
            1862-1928           AI092156.1         13-79               c
FEATURES             Location/Qualifiers
     source          1..1928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..1928
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /note="C-X-C motif chemokine ligand 12"
                     /db_xref="GeneID:6387"
                     /db_xref="HGNC:HGNC:10672"
                     /db_xref="MIM:600835"
     exon            1..153
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..362
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /note="isoform alpha precursor is encoded by transcript
                     variant 1; intercrine reduced in hepatomas; pre-B cell
                     growth-stimulating factor; stromal cell-derived factor 1;
                     chemokine (C-X-C motif) ligand 12"
                     /codon_start=1
                     /product="stromal cell-derived factor 1 isoform alpha
                     precursor"
                     /protein_id="NP_954637.1"
                     /db_xref="CCDS:CCDS7207.1"
                     /db_xref="GeneID:6387"
                     /db_xref="HGNC:HGNC:10672"
                     /db_xref="MIM:600835"
                     /translation="MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANV
                     KHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK"
     exon            154..271
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..1928
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /note="hexamer: AATAAA"
     polyA_site      1862
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /note="major polyA site"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="CXCL12"
                     /gene_synonym="IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1"
ORIGIN      
        1 gccgcacttt cactctccgt cagccgcatt gcccgctcgg cgtccggccc ccgacccgcg
       61 ctcgtccgcc cgcccgcccg cccgcccgcg ccatgaacgc caaggtcgtg gtcgtgctgg
      121 tcctcgtgct gaccgcgctc tgcctcagcg acgggaagcc cgtcagcctg agctacagat
      181 gcccatgccg attcttcgaa agccatgttg ccagagccaa cgtcaagcat ctcaaaattc
      241 tcaacactcc aaactgtgcc cttcagattg tagcccggct gaagaacaac aacagacaag
      301 tgtgcattga cccgaagcta aagtggattc aggagtacct ggagaaagct ttaaacaagt
      361 aagcacaaca gccaaaaagg actttccgct agacccactc gaggaaaact aaaaccttgt
      421 gagagatgaa agggcaaaga cgtgggggag ggggccttaa ccatgaggac caggtgtgtg
      481 tgtggggtgg gcacattgat ctgggatcgg gcctgaggtt tgccagcatt tagaccctgc
      541 atttatagca tacggtatga tattgcagct tatattcatc catgccctgt acctgtgcac
      601 gttggaactt ttattactgg ggtttttcta agaaagaaat tgtattatca acagcatttt
      661 caagcagtta gttccttcat gatcatcaca atcatcatca ttctcattct cattttttaa
      721 atcaacgagt acttcaagat ctgaatttgg cttgtttgga gcatctcctc tgctcccctg
      781 gggagtctgg gcacagtcag gtggtggctt aacagggagc tggaaaaagt gtcctttctt
      841 cagacactga ggctcccgca gcagcgcccc tcccaagagg aaggcctctg tggcactcag
      901 ataccgactg gggctgggcg ccgccactgc cttcacctcc tctttcaacc tcagtgattg
      961 gctctgtggg ctccatgtag aagccactat tactgggact gtgctcagag acccctctcc
     1021 cagctattcc tactctctcc ccgactccga gagcatgctt aatcttgctt ctgcttctca
     1081 tttctgtagc ctgatcagcg ccgcaccagc cgggaagagg gtgattgctg gggctcgtgc
     1141 cctgcatccc tctcctccca gggcctgccc cacagctcgg gccctctgtg agatccgtct
     1201 ttggcctcct ccagaatgga gctggccctc tcctggggat gtgtaatggt ccccctgctt
     1261 acccgcaaaa gacaagtctt tacagaatca aatgcaattt taaatctgag agctcgcttt
     1321 gagtgactgg gttttgtgat tgcctctgaa gcctatgtat gccatggagg cactaacaaa
     1381 ctctgaggtt tccgaaatca gaagcgaaaa aatcagtgaa taaaccatca tcttgccact
     1441 accccctcct gaagccacag cagggtttca ggttccaatc agaactgttg gcaaggtgac
     1501 atttccatgc ataaatgcga tccacagaag gtcctggtgg tatttgtaac tttttgcaag
     1561 gcattttttt atatatattt ttgtgcacat ttttttttac gtttctttag aaaacaaatg
     1621 tatttcaaaa tatatttata gtcgaacaat tcatatattt gaagtggagc catatgaatg
     1681 tcagtagttt atacttctct attatctcaa actactggca atttgtaaag aaatatatat
     1741 gatatataaa tgtgattgca gcttttcaat gttagccaca gtgtattttt tcacttgtac
     1801 taaaattgta tcaaatgtga cattatatgc actagcaata aaatgctaat tgtttcatgg
     1861 tataaacgtc ctactgtatg tgggaattta tttacctgaa ataaaattca ttagttgtta
     1921 gtgatgga
//
