LOCUS       NM_005409               1479 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 11 (CXCL11), transcript
            variant 1, mRNA.
ACCESSION   NM_005409
VERSION     NM_005409.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Barbieri,F., Bajetto,A., Dellacasagrande,I., Solari,A., Wurth,R.,
            Fernandez,V., Rancati,S., Ceresa,D., Appolloni,I., De Luca,G.,
            Dono,M., Nozza,P., Schiapparelli,P., Gambaro,M., Fiaschi,P.,
            Gaggero,G., Costanzo,N., Thellung,S., Malatesta,P., Pagano,A.,
            Zona,G., De Pietri Tonelli,D. and Florio,T.
  TITLE     Stem-like signatures in human meningioma cells are under the
            control of CXCL11/CXCL12 chemokine activity
  JOURNAL   Neuro Oncol 25 (10), 1775-1787 (2023)
   PUBMED   37074930
  REMARK    GeneRIF: Stem-like signatures in human meningioma cells are under
            the control of CXCL11/CXCL12 chemokine activity.
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Kouroumalis,A., Nibbs,R.J., Aptel,H., Wright,K.L., Kolios,G. and
            Ward,S.G.
  TITLE     The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G
            alpha i-independent signaling and actin responses in human
            intestinal myofibroblasts
  JOURNAL   J Immunol 175 (8), 5403-5411 (2005)
   PUBMED   16210647
  REMARK    GeneRIF: This CSCR3 ligand has the ability to activate biochemical
            (e.g., PtdIns and MAP kinase activation) and functional events
            (actin reorganization) in intestinal myofibroblasts.
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Booth,V., Clark-Lewis,I. and Sykes,B.D.
  TITLE     NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)
  JOURNAL   Protein Sci 13 (8), 2022-2028 (2004)
   PUBMED   15273303
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Colvin,R.A., Campanella,G.S., Sun,J. and Luster,A.D.
  TITLE     Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and
            CXCL11 function
  JOURNAL   J Biol Chem 279 (29), 30219-30227 (2004)
   PUBMED   15150261
  REMARK    GeneRIF: CXCL9, CXCL10, and CXCL11 functions are mediated by
            intracellular domains of CXCR3
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL11 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Xanthou,G., Duchesnes,C.E., Williams,T.J. and Pease,J.E.
  TITLE     CCR3 functional responses are regulated by both CXCR3 and its
            ligands CXCL9, CXCL10 and CXCL11
  JOURNAL   Eur J Immunol 33 (8), 2241-2250 (2003)
   PUBMED   12884299
  REMARK    GeneRIF: CXCR3 ligands inhibit CCR3-mediated functional responses
            of both human eosinophils and CCR3 transfectants induced by all
            three eotaxins, with CXCL11 being the most efficacious antagonist.
REFERENCE   8  (bases 1 to 1479)
  AUTHORS   Basu,S., Schaefer,T.M., Ghosh,M., Fuller,C.L. and Reinhart,T.A.
  TITLE     Molecular cloning and sequencing of 25 different rhesus macaque
            chemokine cDNAs reveals evolutionary conservation among C, CC, CXC,
            AND CX3C families of chemokines
  JOURNAL   Cytokine 18 (3), 140-148 (2002)
   PUBMED   12126650
REFERENCE   9  (bases 1 to 1479)
  AUTHORS   Tensen,C.P., Flier,J., Rampersad,S.S., Sampat-Sardjoepersad,S.,
            Scheper,R.J., Boorsma,D.M. and Willemze,R.
  TITLE     Genomic organization, sequence and transcriptional regulation of
            the human CXCL 11(1) gene
  JOURNAL   Biochim Biophys Acta 1446 (1-2), 167-172 (1999)
   PUBMED   10395932
REFERENCE   10 (bases 1 to 1479)
  AUTHORS   Erdel,M., Laich,A., Utermann,G., Werner,E.R. and Werner-Felmayer,G.
  TITLE     The human gene encoding SCYB9B, a putative novel CXC chemokine,
            maps to human chromosome 4q21 like the closely related genes for
            MIG (SCYB9) and INP10 (SCYB10)
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 271-272 (1998)
   PUBMED   9730616
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP289021.1 and U66096.1.
            
            On May 17, 2019 this sequence version replaced NM_005409.4.
            
            Summary: Chemokines are a group of small (approximately 8 to 14
            kD), mostly basic, structurally related molecules that regulate
            cell trafficking of various types of leukocytes through
            interactions with a subset of 7-transmembrane, G protein-coupled
            receptors. Chemokines also play fundamental roles in the
            development, homeostasis, and function of the immune system, and
            they have effects on cells of the central nervous system as well as
            on endothelial cells involved in angiogenesis or angiostasis.
            Chemokines are divided into 2 major subfamilies, CXC and CC. This
            antimicrobial gene is a CXC member of the chemokine superfamily.
            Its encoded protein induces a chemotactic response in activated
            T-cells and is the dominant ligand for CXC receptor-3. The gene
            encoding this protein contains 4 exons and at least three
            polyadenylation signals which might reflect cell-specific
            regulation of expression. IFN-gamma is a potent inducer of
            transcription of this gene. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66096.1, BC110986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000306621.8/
                                                  ENSP00000306884.3
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BP289021.1         30-67
            39-1479             U66096.1           1-1441
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1479
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /note="C-X-C motif chemokine ligand 11"
                     /db_xref="GeneID:6373"
                     /db_xref="HGNC:HGNC:10638"
                     /db_xref="MIM:604852"
     exon            1..144
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..368
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; small inducible cytokine subfamily B
                     (Cys-X-Cys), member 11; chemokine (C-X-C motif) ligand 11;
                     small inducible cytokine subfamily B (Cys-X-Cys), member
                     9B; C-X-C motif chemokine 11; small inducible cytokine
                     B11; beta-R1; interferon gamma-inducible protein 9;
                     interferon-inducible T-cell alpha chemoattractant"
                     /codon_start=1
                     /product="C-X-C motif chemokine 11 isoform 1 precursor"
                     /protein_id="NP_005400.1"
                     /db_xref="CCDS:CCDS3574.1"
                     /db_xref="GeneID:6373"
                     /db_xref="HGNC:HGNC:10638"
                     /db_xref="MIM:604852"
                     /translation="MSVKGMAIALAVILCATVVQGFPMFKRGRCLCIGPGVKAVKVAD
                     IEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF"
     exon            145..271
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /inference="alignment:Splign:2.1.0"
     exon            272..344
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /inference="alignment:Splign:2.1.0"
     exon            345..1479
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /note="hexamer: AATACA"
     polyA_site      1365
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /note="major polyA site"
     regulatory      1446..1451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /note="hexamer: AATAAA"
     polyA_site      1479
                     /gene="CXCL11"
                     /gene_synonym="b-R1; H174; I-TAC; IP-9; IP9; SCYB11;
                     SCYB9B"
                     /note="major polyA site"
ORIGIN      
        1 gttcagcatt tctactcctt ccaagaagag cagcaaagct gaagtagcag cagcagcacc
       61 agcagcaaca gcaaaaaaca aacatgagtg tgaagggcat ggctatagcc ttggctgtga
      121 tattgtgtgc tacagttgtt caaggcttcc ccatgttcaa aagaggacgc tgtctttgca
      181 taggccctgg ggtaaaagca gtgaaagtgg cagatattga gaaagcctcc ataatgtacc
      241 caagtaacaa ctgtgacaaa atagaagtga ttattaccct gaaagaaaat aaaggacaac
      301 gatgcctaaa tcccaaatcg aagcaagcaa ggcttataat caaaaaagtt gaaagaaaga
      361 atttttaaaa atatcaaaac atatgaagtc ctggaaaaga gcatctgaaa aacctagaac
      421 aagtttaact gtgactactg aaatgacaag aattctacag taggaaactg agacttttct
      481 atggttttgt gactttcaac ttttgtacag ttatgtgaag gatgaaaggt gggtgaaagg
      541 accaaaaaca gaaatacagt cttcctgaat gaatgacaat cagaattcca ctgcccaaag
      601 gagtccaaca attaaatgga tttctaggaa aagctacctt aagaaaggct ggttaccatc
      661 ggagtttaca aagtgctttc acgttcttac ttgttgcatt atacattcat gcatttctag
      721 gctagagaac cttctagatt tgatgcttac aactattctg ttgtgactat gagaacattt
      781 ctgtctctag aagtcatctg tctgtattga tctttatgct atattactat ctgtggttac
      841 ggtggagaca ttgacattat tactggagtc aagcccttat aagtcaaaag catctatgtg
      901 tcgtaaaaca ttcctcaaac attttttcat gcaaatacac acttctttcc ccaaacatca
      961 tgtagcacat caatatgtag ggagacattc ttatgcatca tttggtttgt tttataacca
     1021 attcattaaa tgtaattcat aaaatgtact atgaaaaaaa ttatacgcta tgggatactg
     1081 gcaaaagtgc acatatttca taaccaaatt agtagcacca gtcttaattt gatgtttttc
     1141 aacttttatt cattgagatg ttttgaagca attaggatat gtgtgtttac tgtacttttt
     1201 gttttgatcc gtttgtataa atgatagcaa tatcttggac acatctgaaa tacaaaatgt
     1261 ttttgtctac caaagaaaaa tgttgaaaaa taagcaaatg tatacctagc aatcactttt
     1321 actttttgta attctgtctc ttagaaaaat acataatcta atcaatttct ttgttcatgc
     1381 ctatatactg taaaatttag gtatactcaa gactagttta aagaatcaaa gtcatttttt
     1441 tctctaataa actaccacaa cctttctttt ttaaaaaaa
//
