LOCUS       NM_001565               1175 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 10 (CXCL10), transcript
            variant 1, mRNA.
ACCESSION   NM_001565
VERSION     NM_001565.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Kersh,A.E., Sati,S., Huang,J., Murphy,C., Ahart,O. and Leung,T.H.
  TITLE     CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to
            skin in lichen planus
  JOURNAL   JCI Insight 9 (20), e179899 (2024)
   PUBMED   39190494
  REMARK    GeneRIF: CXCL9, CXCL10, and CCL19 synergistically recruit T
            lymphocytes to skin in lichen planus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Tanaka,Y., Imaizumi,T., Kobori,Y., Tachizaki,M., Shiratori,T.,
            Dobashi,M., Sato,M., Kawaguchi,S., Seya,K. and Tasaka,S.
  TITLE     Expression of ISG60 is induced by TLR3 signaling in BEAS-2B
            bronchial epithelial cells: Possible involvement in CXCL10
            expression
  JOURNAL   Mol Med Rep 30 (3) (2024)
   PUBMED   38963029
  REMARK    GeneRIF: Expression of ISG60 is induced by TLR3 signaling in
            BEAS-2B bronchial epithelial cells: Possible involvement in CXCL10
            expression.
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Xing,X., Zhao,C., Cai,S., Wang,J., Zhang,J., Sun,F., Huang,M. and
            Zhang,L.
  TITLE     Deciphering the mediating role of CXCL10 in hypothyroidism-induced
            idiopathic pulmonary fibrosis in European ancestry: a Mendelian
            randomization study
  JOURNAL   Front Immunol 15, 1379480 (2024)
   PUBMED   39185418
  REMARK    GeneRIF: Deciphering the mediating role of CXCL10 in
            hypothyroidism-induced idiopathic pulmonary fibrosis in European
            ancestry: a Mendelian randomization study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Chen,Z., Li,Y., Tan,X., Nie,S., Chen,B., Mei,X. and Wu,Z.
  TITLE     Dysregulated tryptophan metabolism and AhR pathway contributed to
            CXCL10 upregulation in stable non-segmental vitiligo
  JOURNAL   J Dermatol Sci 115 (1), 33-41 (2024)
   PUBMED   38955622
  REMARK    GeneRIF: Dysregulated tryptophan metabolism and AhR pathway
            contributed to CXCL10 upregulation in stable non-segmental
            vitiligo.
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Zhang,N., Zhao,Y.D. and Wang,X.M.
  TITLE     CXCL10 an important chemokine associated with cytokine storm in
            COVID-19 infected patients
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (13), 7497-7505 (2020)
   PUBMED   32706090
  REMARK    GeneRIF: CXCL10 an important chemokine associated with cytokine
            storm in COVID-19 infected patients.
            Review article
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Coperchini,F., Chiovato,L., Croce,L., Magri,F. and Rotondi,M.
  TITLE     The cytokine storm in COVID-19: An overview of the involvement of
            the chemokine/chemokine-receptor system
  JOURNAL   Cytokine Growth Factor Rev 53, 25-32 (2020)
   PUBMED   32446778
  REMARK    Review article
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CXCL10 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   Angiolillo,A.L., Sgadari,C., Taub,D.D., Liao,F., Farber,J.M.,
            Maheshwari,S., Kleinman,H.K., Reaman,G.H. and Tosato,G.
  TITLE     Human interferon-inducible protein 10 is a potent inhibitor of
            angiogenesis in vivo
  JOURNAL   J Exp Med 182 (1), 155-162 (1995)
   PUBMED   7540647
REFERENCE   9  (bases 1 to 1175)
  AUTHORS   Luster,A.D., Jhanwar,S.C., Chaganti,R.S., Kersey,J.H. and
            Ravetch,J.V.
  TITLE     Interferon-inducible gene maps to a chromosomal band associated
            with a (4;11) translocation in acute leukemia cells
  JOURNAL   Proc Natl Acad Sci U S A 84 (9), 2868-2871 (1987)
   PUBMED   2437586
REFERENCE   10 (bases 1 to 1175)
  AUTHORS   Luster,A.D., Unkeless,J.C. and Ravetch,J.V.
  TITLE     Gamma-interferon transcriptionally regulates an early-response gene
            containing homology to platelet proteins
  JOURNAL   Nature 315 (6021), 672-676 (1985)
   PUBMED   3925348
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010954.1 and AA505379.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001565.3.
            
            Summary: This antimicrobial gene encodes a chemokine of the CXC
            subfamily and ligand for the receptor CXCR3. Binding of this
            protein to CXCR3 results in pleiotropic effects, including
            stimulation of monocytes, natural killer and T-cell migration, and
            modulation of adhesion molecule expression. This gene may also be a
            key regulator of the 'cytokine storm' immune response to SARS-CoV-2
            infection. [provided by RefSeq, Sep 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.136912.1, BC010954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in cytokine storm
                                                  inflammatory response
            MANE Ensembl match                 :: ENST00000306602.3/
                                                  ENSP00000305651.1
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1172              BC010954.1         5-1176
            1173-1175           AA505379.1         14-16               c
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1175
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /note="C-X-C motif chemokine ligand 10"
                     /db_xref="GeneID:3627"
                     /db_xref="HGNC:HGNC:10637"
                     /db_xref="MIM:147310"
     exon            1..127
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..363
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /note="small inducible cytokine subfamily B (Cys-X-Cys),
                     member 10; protein 10 from interferon (gamma)-induced cell
                     line; gamma IP10; interferon-inducible cytokine IP-10;
                     C-X-C motif chemokine 10; small-inducible cytokine B10; 10
                     kDa interferon gamma-induced protein"
                     /codon_start=1
                     /product="C-X-C motif chemokine 10 precursor"
                     /protein_id="NP_001556.2"
                     /db_xref="CCDS:CCDS43240.1"
                     /db_xref="GeneID:3627"
                     /db_xref="HGNC:HGNC:10637"
                     /db_xref="MIM:147310"
                     /translation="MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRS
                     LEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP"
     exon            128..254
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /inference="alignment:Splign:2.1.0"
     exon            255..344
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /inference="alignment:Splign:2.1.0"
     exon            345..1175
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /note="hexamer: AATAAA"
     polyA_site      1175
                     /gene="CXCL10"
                     /gene_synonym="C7; crg-2; gIP-10; IFI10; INP10; IP-10;
                     mob-1; SCYB10"
                     /note="major polyA site"
ORIGIN      
        1 gagacattcc tcaattgctt agacatattc tgagcctaca gcagaggaac ctccagtctc
       61 agcaccatga atcaaactgc cattctgatt tgctgcctta tctttctgac tctaagtggc
      121 attcaaggag tacctctctc tagaactgta cgctgtacct gcatcagcat tagtaatcaa
      181 cctgttaatc caaggtcttt agaaaaactt gaaattattc ctgcaagcca attttgtcca
      241 cgtgttgaga tcattgctac aatgaaaaag aagggtgaga agagatgtct gaatccagaa
      301 tcgaaggcca tcaagaattt actgaaagca gttagcaagg aaaggtctaa aagatctcct
      361 taaaaccaga ggggagcaaa atcgatgcag tgcttccaag gatggaccac acagaggctg
      421 cctctcccat cacttcccta catggagtat atgtcaagcc ataattgttc ttagtttgca
      481 gttacactaa aaggtgacca atgatggtca ccaaatcagc tgctactact cctgtaggaa
      541 ggttaatgtt catcatccta agctattcag taataactct accctggcac tataatgtaa
      601 gctctactga ggtgctatgt tcttagtgga tgttctgacc ctgcttcaaa tatttccctc
      661 acctttccca tcttccaagg gtactaagga atctttctgc tttggggttt atcagaattc
      721 tcagaatctc aaataactaa aaggtatgca atcaaatctg ctttttaaag aatgctcttt
      781 acttcatgga cttccactgc catcctccca aggggcccaa attctttcag tggctaccta
      841 catacaattc caaacacata caggaaggta gaaatatctg aaaatgtatg tgtaagtatt
      901 cttatttaat gaaagactgt acaaagtaga agtcttagat gtatatattt cctatattgt
      961 tttcagtgta catggaataa catgtaatta agtactatgt atcaatgagt aacaggaaaa
     1021 ttttaaaaat acagatagat atatgctctg catgttacat aagataaatg tgctgaatgg
     1081 ttttcaaaat aaaaatgagg tactctcctg gaaatattaa gaaagactat ctaaatgttg
     1141 aaagatcaaa aggttaataa agtaattata actaa
//
