LOCUS       NM_001511               1174 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens C-X-C motif chemokine ligand 1 (CXCL1), transcript
            variant 1, mRNA.
ACCESSION   NM_001511
VERSION     NM_001511.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Pan,J.J., Xie,S.Z., Zheng,X., Xu,J.F., Xu,H., Yin,R.Q., Luo,Y.L.,
            Shen,L., Chen,Z.R., Chen,Y.R., Yu,S.Z., Lu,L., Zhu,W.W., Lu,M. and
            Qin,L.X.
  TITLE     Acetyl-CoA metabolic accumulation promotes hepatocellular carcinoma
            metastasis via enhancing CXCL1-dependent infiltration of
            tumor-associated neutrophils
  JOURNAL   Cancer Lett 592, 216903 (2024)
   PUBMED   38670307
  REMARK    GeneRIF: Acetyl-CoA metabolic accumulation promotes hepatocellular
            carcinoma metastasis via enhancing CXCL1-dependent infiltration of
            tumor-associated neutrophils.
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Xiong,G., Chen,Z., Liu,Q., Peng,F., Zhang,C., Cheng,M., Ling,R.,
            Chen,S., Liang,Y., Chen,D. and Zhou,Q.
  TITLE     CD276 regulates the immune escape of esophageal squamous cell
            carcinoma through CXCL1-CXCR2 induced NETs
  JOURNAL   J Immunother Cancer 12 (5), e008662 (2024)
   PUBMED   38724465
  REMARK    GeneRIF: CD276 regulates the immune escape of esophageal squamous
            cell carcinoma through CXCL1-CXCR2 induced NETs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Blanco-Melo,D., Nilsson-Payant,B.E., Liu,W.C., Uhl,S., Hoagland,D.,
            Moller,R., Jordan,T.X., Oishi,K., Panis,M., Sachs,D., Wang,T.T.,
            Schwartz,R.E., Lim,J.K., Albrecht,R.A. and tenOever,B.R.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: This protein displays antimicrobial activity against E.
            coli and S. aureus.
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   O'Donovan,N., Galvin,M. and Morgan,J.G.
  TITLE     Physical mapping of the CXC chemokine locus on human chromosome 4
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 39-42 (1999)
   PUBMED   10343098
REFERENCE   6  (bases 1 to 1174)
  AUTHORS   Horuk,R., Yansura,D.G., Reilly,D., Spencer,S., Bourell,J.,
            Henzel,W., Rice,G. and Unemori,E.
  TITLE     Purification, receptor binding analysis, and biological
            characterization of human melanoma growth stimulating activity
            (MGSA). Evidence for a novel MGSA receptor
  JOURNAL   J Biol Chem 268 (1), 541-546 (1993)
   PUBMED   8380167
REFERENCE   7  (bases 1 to 1174)
  AUTHORS   Lee,J., Horuk,R., Rice,G.C., Bennett,G.L., Camerato,T. and
            Wood,W.I.
  TITLE     Characterization of two high affinity human interleukin-8 receptors
  JOURNAL   J Biol Chem 267 (23), 16283-16287 (1992)
   PUBMED   1379593
REFERENCE   8  (bases 1 to 1174)
  AUTHORS   Anisowicz,A., Messineo,M., Lee,S.W. and Sager,R.
  TITLE     An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha
            induction of gro in human fibroblasts
  JOURNAL   J Immunol 147 (2), 520-527 (1991)
   PUBMED   1906501
REFERENCE   9  (bases 1 to 1174)
  AUTHORS   Baker,N.E., Kucera,G. and Richmond,A.
  TITLE     Nucleotide sequence of the human melanoma growth stimulatory
            activity (MGSA) gene
  JOURNAL   Nucleic Acids Res 18 (21), 6453 (1990)
   PUBMED   2129556
REFERENCE   10 (bases 1 to 1174)
  AUTHORS   Richmond,A., Balentien,E., Thomas,H.G., Flaggs,G., Barton,D.E.,
            Spiess,J., Bordoni,R., Francke,U. and Derynck,R.
  TITLE     Molecular characterization and chromosomal mapping of melanoma
            growth stimulatory activity, a growth factor structurally related
            to beta-thromboglobulin
  JOURNAL   EMBO J 7 (7), 2025-2033 (1988)
   PUBMED   2970963
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092438.5, BM554448.1 and
            BM996663.1.
            
            On May 17, 2019 this sequence version replaced NM_001511.3.
            
            Summary: This antimicrobial gene encodes a member of the CXC
            subfamily of chemokines. The encoded protein is a secreted growth
            factor that signals through the G-protein coupled receptor, CXC
            receptor 2. This protein plays a role in inflammation and as a
            chemoattractant for neutrophils. Aberrant expression of this
            protein is associated with the growth and progression of certain
            tumors. A naturally occurring processed form of this protein has
            increased chemotactic activity. Alternate splicing results in
            coding and non-coding variants of this gene. A pseudogene of this
            gene is found on chromosome 4. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.234646.1,
                                           DRR138517.117119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in immune response
                                                  or antiviral activity
            MANE Ensembl match                 :: ENST00000395761.4/
                                                  ENSP00000379110.3
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC092438.5         21025-21033
            10-766              BM554448.1         24-780
            767-1102            AC092438.5         22533-22868
            1103-1168           BM996663.1         16-81               c
            1169-1174           AC092438.5         22935-22940
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1174
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /note="C-X-C motif chemokine ligand 1"
                     /db_xref="GeneID:2919"
                     /db_xref="HGNC:HGNC:4602"
                     /db_xref="MIM:155730"
     exon            1..178
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..402
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /note="GRO1 oncogene (melanoma growth-stimulating
                     activity); fibroblast secretory protein; GRO1 oncogene
                     (melanoma growth stimulating activity, alpha); chemokine
                     (C-X-C motif) ligand 1 (melanoma growth stimulating
                     activity, alpha); growth-regulated alpha protein; MGSA
                     alpha; melanoma growth stimulatory activity alpha;
                     GRO-alpha(1-73); C-X-C motif chemokine 1;
                     neutrophil-activating protein 3"
                     /codon_start=1
                     /product="growth-regulated alpha protein precursor"
                     /protein_id="NP_001502.1"
                     /db_xref="CCDS:CCDS47074.1"
                     /db_xref="GeneID:2919"
                     /db_xref="HGNC:HGNC:4602"
                     /db_xref="MIM:155730"
                     /translation="MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAGASVATELRCQ
                     CLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLN
                     SDKSN"
     exon            179..302
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..386
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1174
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="CXCL1"
                     /gene_synonym="FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3;
                     SCYB1"
                     /note="major polyA site"
ORIGIN      
        1 acagagcccg ggccgcaggc acctcctcgc cagctcttcc gctcctctca cagccgccag
       61 acccgcctgc tgagccccat ggcccgcgct gctctctccg ccgcccccag caatccccgg
      121 ctcctgcgag tggcactgct gctcctgctc ctggtagccg ctggccggcg cgcagcagga
      181 gcgtccgtgg ccactgaact gcgctgccag tgcttgcaga ccctgcaggg aattcacccc
      241 aagaacatcc aaagtgtgaa cgtgaagtcc cccggacccc actgcgccca aaccgaagtc
      301 atagccacac tcaagaatgg gcggaaagct tgcctcaatc ctgcatcccc catagttaag
      361 aaaatcatcg aaaagatgct gaacagtgac aaatccaact gaccagaagg gaggaggaag
      421 ctcactggtg gctgttcctg aaggaggccc tgcccttata ggaacagaag aggaaagaga
      481 gacacagctg cagaggccac ctggattgtg cctaatgtgt ttgagcatcg cttaggagaa
      541 gtcttctatt tatttattta ttcattagtt ttgaagattc tatgttaata ttttaggtgt
      601 aaaataatta agggtatgat taactctacc tgcacactgt cctattatat tcattctttt
      661 tgaaatgtca accccaagtt agttcaatct ggattcatat ttaatttgaa ggtagaatgt
      721 tttcaaatgt tctccagtca ttatgttaat atttctgagg agcctgcaac atgccagcca
      781 ctgtgataga ggctggcgga tccaagcaaa tggccaatga gatcattgtg aaggcagggg
      841 aatgtatgtg cacatctgtt ttgtaactgt ttagatgaat gtcagttgtt atttattgaa
      901 atgatttcac agtgtgtggt caacatttct catgttgaaa ctttaagaac taaaatgttc
      961 taaatatccc ttggacattt tatgtctttc ttgtaaggca tactgccttg tttaatggta
     1021 gttttacagt gtttctggct tagaacaaag gggcttaatt attgatgttt tcatagagaa
     1081 tataaaaata aagcacttat agaaaaaact cgtttgattt ttggggggaa acaagggcta
     1141 cctttactgg aaaatctggt gatttatatc aata
//
