LOCUS       NM_001338               5593 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens CXADR Ig-like cell adhesion molecule (CXADR),
            transcript variant 1, mRNA.
ACCESSION   NM_001338
VERSION     NM_001338.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5593)
  AUTHORS   Tan,H.J., Deng,Z.H., Zhang,C., Deng,H.W. and Xiao,H.M.
  TITLE     CXADR promote epithelial-mesenchymal transition in endometriosis by
            modulating AKT/GSK-3beta signaling
  JOURNAL   Cell Cycle 22 (21-22), 2436-2448 (2023)
   PUBMED   38146657
  REMARK    GeneRIF: CXADR promote epithelial-mesenchymal transition in
            endometriosis by modulating AKT/GSK-3beta signaling.
REFERENCE   2  (bases 1 to 5593)
  AUTHORS   Oliviero,F., Klement,W., Mary,L., Dauwe,Y., Lippi,Y., Naylies,C.,
            Gayrard,V., Marchi,N. and Mselli-Lakhal,L.
  TITLE     CAR Protects Females from Diet-Induced Steatosis and Associated
            Metabolic Disorders
  JOURNAL   Cells 12 (18), 2218 (2023)
   PUBMED   37759441
  REMARK    GeneRIF: CAR Protects Females from Diet-Induced Steatosis and
            Associated Metabolic Disorders.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5593)
  AUTHORS   Nilchian,A., Plant,E., Parniewska,M.M., Santiago,A., Rossignoli,A.,
            Skogsberg,J., Hedin,U., Matic,L. and Fuxe,J.
  TITLE     Induction of the Coxsackievirus and Adenovirus Receptor in
            Macrophages During the Formation of Atherosclerotic Plaques
  JOURNAL   J Infect Dis 222 (12), 2041-2051 (2020)
   PUBMED   32852032
  REMARK    GeneRIF: Induction of the Coxsackievirus and Adenovirus Receptor in
            Macrophages During the Formation of Atherosclerotic Plaques.
REFERENCE   4  (bases 1 to 5593)
  AUTHORS   Herrmann,L., Filip,A., Lapuente,D., Tenbusch,M., Niehaus,K.,
            Rudolph,V. and Farr,M.
  TITLE     Naturally occurring variants in the transmembrane and cytoplasmic
            domains of the human Coxsackie- and adenovirus receptor have no
            impact on virus internalisation
  JOURNAL   Biochem Biophys Res Commun 527 (2), 401-405 (2020)
   PUBMED   32334832
  REMARK    GeneRIF: Naturally occurring variants in the transmembrane and
            cytoplasmic domains of the human Coxsackie- and adenovirus receptor
            have no impact on virus internalisation.
REFERENCE   5  (bases 1 to 5593)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5593)
  AUTHORS   Fechner,H., Haack,A., Wang,H., Wang,X., Eizema,K., Pauschinger,M.,
            Schoemaker,R., Veghel,R., Houtsmuller,A., Schultheiss,H.P.,
            Lamers,J. and Poller,W.
  TITLE     Expression of coxsackie adenovirus receptor and alphav-integrin
            does not correlate with adenovector targeting in vivo indicating
            anatomical vector barriers
  JOURNAL   Gene Ther 6 (9), 1520-1535 (1999)
   PUBMED   10490761
REFERENCE   7  (bases 1 to 5593)
  AUTHORS   Bergelson,J.M., Krithivas,A., Celi,L., Droguett,G., Horwitz,M.S.,
            Wickham,T., Crowell,R.L. and Finberg,R.W.
  TITLE     The murine CAR homolog is a receptor for coxsackie B viruses and
            adenoviruses
  JOURNAL   J Virol 72 (1), 415-419 (1998)
   PUBMED   9420240
REFERENCE   8  (bases 1 to 5593)
  AUTHORS   Carson,S.D., Chapman,N.N. and Tracy,S.M.
  TITLE     Purification of the putative coxsackievirus B receptor from HeLa
            cells
  JOURNAL   Biochem Biophys Res Commun 233 (2), 325-328 (1997)
   PUBMED   9144533
REFERENCE   9  (bases 1 to 5593)
  AUTHORS   Tomko,R.P., Xu,R. and Philipson,L.
  TITLE     HCAR and MCAR: the human and mouse cellular receptors for subgroup
            C adenoviruses and group B coxsackieviruses
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3352-3356 (1997)
   PUBMED   9096397
REFERENCE   10 (bases 1 to 5593)
  AUTHORS   Bergelson,J.M., Cunningham,J.A., Droguett,G., Kurt-Jones,E.A.,
            Krithivas,A., Hong,J.S., Horwitz,M.S., Crowell,R.L. and
            Finberg,R.W.
  TITLE     Isolation of a common receptor for Coxsackie B viruses and
            adenoviruses 2 and 5
  JOURNAL   Science 275 (5304), 1320-1323 (1997)
   PUBMED   9036860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313526.1 and AP000967.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001338.4.
            
            Summary: The protein encoded by this gene is a type I membrane
            receptor for group B coxsackieviruses and subgroup C adenoviruses.
            Several transcript variants encoding different isoforms have been
            found for this gene. Pseudogenes of this gene are found on
            chromosomes 15, 18, and 21. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1, alternatively referred to as
            alpha or CAREx7) represents the longest transcript and encodes the
            longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.145433.1,
                                           SRR1660805.32610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284878.12/ ENSP00000284878.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1185              AK313526.1         1-1185
            1186-5593           AP000967.2         43566-47973
FEATURES             Location/Qualifiers
     source          1..5593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     gene            1..5593
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /note="CXADR Ig-like cell adhesion molecule"
                     /db_xref="GeneID:1525"
                     /db_xref="HGNC:HGNC:2559"
                     /db_xref="MIM:602621"
     exon            1..130
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1185
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 46 kD coxsackievirus and adenovirus receptor
                     (CAR) protein; HCVADR; CVB3-binding protein;
                     coxsackievirus B-adenovirus receptor; coxsackie virus and
                     adenovirus receptor"
                     /codon_start=1
                     /product="coxsackievirus and adenovirus receptor isoform 1
                     precursor"
                     /protein_id="NP_001329.1"
                     /db_xref="CCDS:CCDS33519.1"
                     /db_xref="GeneID:1525"
                     /db_xref="HGNC:HGNC:2559"
                     /db_xref="MIM:602621"
                     /translation="MALLLCFVLLCGVVDFARSLSITTPEEMIEKAKGETAYLPCKFT
                     LSPEDQGPLDIEWLISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGD
                     ASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVVLVKPSGARCYVDGSEEIGSDFKI
                     KCEPKEGSLPLQYEWQKLSDSQKMPTSWLAEMTSSVISVKNASSEYSGTYSCTVRNRV
                     GSDQCLLRLNVVPPSNKAGLIAGAIIGTLLALALIGLIIFCCRKKRREEKYEKEVHHD
                     IREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERTPQSPT
                     LPPAKVAAPNLSRMGAIPVMIPAQSKDGSIV"
     exon            131..297
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     exon            298..502
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     exon            503..658
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     exon            659..781
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     exon            782..920
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     exon            921..5593
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /note="hexamer: AATAAA"
     polyA_site      3253
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /note="major polyA site"
     regulatory      5574..5579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /note="hexamer: AATAAA"
     polyA_site      5593
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggagc gcgcgaggcg cggggagcct gggaccagga gcgagagccg cctacctgca
       61 gccgccgccc acggcacggc agccaccatg gcgctcctgc tgtgcttcgt gctcctgtgc
      121 ggagtagtgg atttcgccag aagtttgagt atcactactc ctgaagagat gattgaaaaa
      181 gccaaagggg aaactgccta tctgccatgc aaatttacgc ttagtcccga agaccaggga
      241 ccgctggaca tcgagtggct gatatcacca gctgataatc agaaggtgga tcaagtgatt
      301 attttatatt ctggagacaa aatttatgat gactactatc cagatctgaa aggccgagta
      361 cattttacga gtaatgatct caaatctggt gatgcatcaa taaatgtaac gaatttacaa
      421 ctgtcagata ttggcacata tcagtgcaaa gtgaaaaaag ctcctggtgt tgcaaataag
      481 aagattcatc tggtagttct tgttaagcct tcaggtgcga gatgttacgt tgatggatct
      541 gaagaaattg gaagtgactt taagataaaa tgtgaaccaa aagaaggttc acttccatta
      601 cagtatgagt ggcaaaaatt gtctgactca cagaaaatgc ccacttcatg gttagcagaa
      661 atgacttcat ctgttatatc tgtaaaaaat gcctcttctg agtactctgg gacatacagc
      721 tgtacagtca gaaacagagt gggctctgat cagtgcctgt tgcgtctaaa cgttgtccct
      781 ccttcaaata aagctggact aattgcagga gccattatag gaactttgct tgctctagcg
      841 ctcattggtc ttatcatctt ttgctgtcgt aaaaagcgca gagaagaaaa atatgaaaag
      901 gaagttcatc acgatatcag ggaagatgtg ccacctccaa agagccgtac gtccactgcc
      961 agaagctaca tcggcagtaa tcattcatcc ctggggtcca tgtctccttc caacatggaa
     1021 ggatattcca agactcagta taaccaagta ccaagtgaag actttgaacg cactcctcag
     1081 agtccgactc tcccacctgc taaggtagct gcccctaatc taagtcgaat gggtgcgatt
     1141 cctgtgatga ttccagcaca gagcaaggat gggtctatag tatagagcct ccatatgtct
     1201 catctgtgct ctccgtgttc ctttcctttt tttgatatat gaaaacctat tctggtctaa
     1261 attgtgttac tagcctcaaa atacatcaaa aaataagtta atcaggaact gtacggaata
     1321 tatttttaaa aatttttgtt tggttatatc gaaatagtta caggcactaa agttagtaaa
     1381 gaaaagttta ccatctgaaa aagctggatt ttctttaaga ggttgattat aaagttttct
     1441 aaatttatca gtacctaagt aagatgtagc gctttgaata tgaaatcata ggtgaagaca
     1501 tgggtgaact tacttgcata ccaagttgat acttgaataa ccatctgaaa gtggtacttg
     1561 atcattttta ccattatttt taggatgtgt atttcattta tttatggccc accagtctcc
     1621 cccaaattag tacagaaata tccatgacaa aattacttac gtatgtttgt acttggtttt
     1681 acagctcctt tgaaaactct gtgtttggaa tatctctaaa aacatagaaa acactacagt
     1741 ggtttagaaa ttactaattt tacttctaag tcattcataa accttgtcta tgaaatgact
     1801 tcttaaatat ttagttgata gactgctaca ggtaataggg acttagcaag ctcttttata
     1861 tgctaaagga gcatctatca gattaagtta gaacatttgc tgtcagccac atattgagat
     1921 gacactaggt gcaatagcag ggatagattt tgttggtgag tagtctcatg ccttgagatc
     1981 tgtggtggtc ttcaaaatgg tggccagcca gatcaaggat gtagtatctc atagttccca
     2041 ggtgatattt ttcttattag aaaaatatta taactcattt gttgtttgac acttatagat
     2101 tgaaatttcc taatttattc taaattttaa gtggttcttt ggttccagtg ctttatgttg
     2161 ttgttgtttt tggatggtgt tacatattat atgttctaga aacatgtaat cctaaattta
     2221 ccctcttgaa tataatccct ggatgatatt ttttatcata aatgcagaat aatcaaatac
     2281 attttaagca agttaagtgt cctccatcaa ttctgtattc cagacttggg aggatgtaca
     2341 gttgctgttg tgtgatcaaa catgtctctg tgtagttcca gcaaatcaag ctgagctttg
     2401 aaaaagtttg tcttagtttt gtgaaggtga tttattctta aaaaaaaaaa agaaagaaaa
     2461 agaaaaaaag ataagaagga ggagtaaagg gactactcct ccttgccaaa tgtgctaaat
     2521 atcattttag gagaagaaag tgggtttatt gtatttccct taagattgtg agggagtgtg
     2581 gatacagtag aatgagccaa cagtttcttt ataataaata cggtctgcaa taaattattt
     2641 cactagctct aaaacctttc cctagatttt agtagggagt tggtttctgt taatatcttt
     2701 gggtgctgtg gtggtaaatg ctatattatg aacggtggca tgtatttaca gttagagtat
     2761 tgtgtgtaca ctttttaatg gtaaacttaa gctgaatgtg taatggattt gtgtatagtt
     2821 ttacatattt ggaagcattt taaaaacagg ttttaacctt atgtaaaatt acttttatac
     2881 tcgtgttaac attttcatct gtgccttttg gtaatttaat ttctattatg aatttctggt
     2941 gcctatgagc tagctatcac ctacctgaaa ggtgcttaga ggtgaaggta ctgtttctaa
     3001 aaacacatca ctgtgatacc tttctatcct cacattttca agcttgcctc ttttctgttc
     3061 tttgtggata taacttaagc aattgtgtta ttcataaagg tttagaaatt tcaatattcc
     3121 caacactcta tgtttctgat tttataacag tagccatttt tgaaagtcag atgtttggcc
     3181 tgttttatat gaataaagtt tatttataaa atattataaa aaataagtaa ataaacagaa
     3241 cattaataat aaagttttgg ttcttcctat tcctgacttt catataatga aaattatcct
     3301 attgatctaa gtagaagtta tcatagaaag tggacacgta taagactttc cttccttttt
     3361 ttttttaata acatatgagg aacaagactt ctcttcccat atacttcata ttttagagga
     3421 cattgtttta aaggcttatg tctcactgta aaattctgtc agccaaatag taccaatacg
     3481 ttttcaagta gttctcactg ataatttagt tgaaccagag atcaaatatt tgctcccgaa
     3541 ttactactgg taatcaagta gttgaacaaa aaattactaa agcatttccg ttagatcagt
     3601 caaggacagt actgcatctt tttttttttt ttttttttta agacggagtc tcggtctgtc
     3661 acccaggctg gagtgcagtg gcgggatctc ggctcactgc aagctccgcc tcccaggttc
     3721 acgccattct cctgcctcag cctcccgagc agctgggact acaggctccc atcaccacgc
     3781 tcggctaagt ttttgtaatt ttagtagaga cagggtttca ccgtgttagc caggatggtc
     3841 tcgatctcct gacctcgtga tctgcctgcc tcggcctccc aaagtgctgg gattacaggc
     3901 gtgaaccact gcacccggcc cagtactgca tcttaacagc aaagccattt tattctactt
     3961 tataactgag agacttgata ccatccatct ctttaggtta cagaggataa tttgaagaga
     4021 aatgttactg tagaatatat agttctgtac tttttttttt tttttttaag agatagggtt
     4081 tcactattgc tcaggctggt ctcaaactgc tgggctcagg agatcctcct gccttggcct
     4141 cccaaattgc tgggattaca ggtgtgagcc gcagcatcca gccagttctg tactttgaat
     4201 atggagtagt ttacagctat ttttttttct tactggtaat cttaactaat atgattccct
     4261 tgttagagag cctctcactc ccccaccccc aaaaatgtct actattcatg acagtaacca
     4321 attattctgg acaaattgct tctttttaat ttgagctatc tgccatggac tttctaaaat
     4381 ggaaacacag cctgagtgta tcttagggag agtttgattg aaaaaatcca aatcactatc
     4441 catatagatc atggatataa agagatacct gatttttatt aaaaagatac tttttcaaat
     4501 ttaagagtta atcttggaaa tttggaacaa gtaaaggggc aagtaaacct tttgatgaaa
     4561 tataaaagga actcattgca tgaagttgac tatcaaattc tgtgatgtgt ggcttcttaa
     4621 aaatattctc agtgtctttt gtgtgcgtgc agcatgtaca tttgatgtta tgtgaatgtt
     4681 gagttttttc ttctaatttt cacttcagca gtgtttaggg ctttcagatg ccttattcca
     4741 gtgtgaacag aaaaagttca tattttatgt ggttaatgct ttgatgtgtc acataaagag
     4801 tagtttgtag aaaatgttgg cacaatttta acttcttagt ggcttgtgac attatatatt
     4861 atatatatat atgtacatat atctttataa cattcctgtg tttagtagtg taaatgttct
     4921 gggcaagttt taatattttg aatgcctttg gatattccag caataaaggc atcatgttct
     4981 gcaataggat ttcttactca tttacctatt ttaacactaa aatagaccac aactgagcac
     5041 aaattccttt tataaatgtt atagaagcag ggaagaataa taaacacatt tgtgaattgt
     5101 ggttcagttt atttatcttt agggaaggct gatcatttat cttatagcag ataaccccag
     5161 cctcttattc attatggtta acttttataa tttatcttat tttataattt aagaatatag
     5221 tacatatcag ttgggtttgg ttttggtcat cgagactaaa agctccatca aaacagaact
     5281 ttgtgttttc tgctaactta tttaatgaca caagttttaa gagaaccaca attcattgat
     5341 tcacttattc ttttccctaa ttgtgaattt tagtgataaa tacacctgta ctactgagga
     5401 aaatattctg acacttcacg tgtgcaaagt atagaactga cagtgtcagt ttcagatttt
     5461 gtatgtacga tttctggctt atatatccaa tggtgcagat tttgaaattt gtaagaacaa
     5521 aatttgttaa gaaaaacaac ttgctctagt tttgtgacct tgtgtacttt tgaaataaaa
     5581 tcaagaaagc agt
//
