LOCUS       NP_001329                365 aa            linear   PRI 27-APR-2025
DEFINITION  coxsackievirus and adenovirus receptor isoform 1 precursor [Homo
            sapiens].
ACCESSION   NP_001329
VERSION     NP_001329.1
DBSOURCE    REFSEQ: accession NM_001338.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Tan,H.J., Deng,Z.H., Zhang,C., Deng,H.W. and Xiao,H.M.
  TITLE     CXADR promote epithelial-mesenchymal transition in endometriosis by
            modulating AKT/GSK-3beta signaling
  JOURNAL   Cell Cycle 22 (21-22), 2436-2448 (2023)
   PUBMED   38146657
  REMARK    GeneRIF: CXADR promote epithelial-mesenchymal transition in
            endometriosis by modulating AKT/GSK-3beta signaling.
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Oliviero,F., Klement,W., Mary,L., Dauwe,Y., Lippi,Y., Naylies,C.,
            Gayrard,V., Marchi,N. and Mselli-Lakhal,L.
  TITLE     CAR Protects Females from Diet-Induced Steatosis and Associated
            Metabolic Disorders
  JOURNAL   Cells 12 (18), 2218 (2023)
   PUBMED   37759441
  REMARK    GeneRIF: CAR Protects Females from Diet-Induced Steatosis and
            Associated Metabolic Disorders.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Nilchian,A., Plant,E., Parniewska,M.M., Santiago,A., Rossignoli,A.,
            Skogsberg,J., Hedin,U., Matic,L. and Fuxe,J.
  TITLE     Induction of the Coxsackievirus and Adenovirus Receptor in
            Macrophages During the Formation of Atherosclerotic Plaques
  JOURNAL   J Infect Dis 222 (12), 2041-2051 (2020)
   PUBMED   32852032
  REMARK    GeneRIF: Induction of the Coxsackievirus and Adenovirus Receptor in
            Macrophages During the Formation of Atherosclerotic Plaques.
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Herrmann,L., Filip,A., Lapuente,D., Tenbusch,M., Niehaus,K.,
            Rudolph,V. and Farr,M.
  TITLE     Naturally occurring variants in the transmembrane and cytoplasmic
            domains of the human Coxsackie- and adenovirus receptor have no
            impact on virus internalisation
  JOURNAL   Biochem Biophys Res Commun 527 (2), 401-405 (2020)
   PUBMED   32334832
  REMARK    GeneRIF: Naturally occurring variants in the transmembrane and
            cytoplasmic domains of the human Coxsackie- and adenovirus receptor
            have no impact on virus internalisation.
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 365)
  AUTHORS   Fechner,H., Haack,A., Wang,H., Wang,X., Eizema,K., Pauschinger,M.,
            Schoemaker,R., Veghel,R., Houtsmuller,A., Schultheiss,H.P.,
            Lamers,J. and Poller,W.
  TITLE     Expression of coxsackie adenovirus receptor and alphav-integrin
            does not correlate with adenovector targeting in vivo indicating
            anatomical vector barriers
  JOURNAL   Gene Ther 6 (9), 1520-1535 (1999)
   PUBMED   10490761
REFERENCE   7  (residues 1 to 365)
  AUTHORS   Bergelson,J.M., Krithivas,A., Celi,L., Droguett,G., Horwitz,M.S.,
            Wickham,T., Crowell,R.L. and Finberg,R.W.
  TITLE     The murine CAR homolog is a receptor for coxsackie B viruses and
            adenoviruses
  JOURNAL   J Virol 72 (1), 415-419 (1998)
   PUBMED   9420240
REFERENCE   8  (residues 1 to 365)
  AUTHORS   Carson,S.D., Chapman,N.N. and Tracy,S.M.
  TITLE     Purification of the putative coxsackievirus B receptor from HeLa
            cells
  JOURNAL   Biochem Biophys Res Commun 233 (2), 325-328 (1997)
   PUBMED   9144533
REFERENCE   9  (residues 1 to 365)
  AUTHORS   Tomko,R.P., Xu,R. and Philipson,L.
  TITLE     HCAR and MCAR: the human and mouse cellular receptors for subgroup
            C adenoviruses and group B coxsackieviruses
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3352-3356 (1997)
   PUBMED   9096397
REFERENCE   10 (residues 1 to 365)
  AUTHORS   Bergelson,J.M., Cunningham,J.A., Droguett,G., Kurt-Jones,E.A.,
            Krithivas,A., Hong,J.S., Horwitz,M.S., Crowell,R.L. and
            Finberg,R.W.
  TITLE     Isolation of a common receptor for Coxsackie B viruses and
            adenoviruses 2 and 5
  JOURNAL   Science 275 (5304), 1320-1323 (1997)
   PUBMED   9036860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313526.1 and AP000967.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a type I membrane
            receptor for group B coxsackieviruses and subgroup C adenoviruses.
            Several transcript variants encoding different isoforms have been
            found for this gene. Pseudogenes of this gene are found on
            chromosomes 15, 18, and 21. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1, alternatively referred to as
            alpha or CAREx7) represents the longest transcript and encodes the
            longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.145433.1,
                                           SRR1660805.32610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284878.12/ ENSP00000284878.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     Protein         1..365
                     /product="coxsackievirus and adenovirus receptor isoform 1
                     precursor"
                     /note="46 kD coxsackievirus and adenovirus receptor (CAR)
                     protein; HCVADR; CVB3-binding protein; coxsackievirus
                     B-adenovirus receptor; coxsackie virus and adenovirus
                     receptor; CXADR Ig-like cell adhesion molecule"
                     /calculated_mol_wt=37978
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2071
     mat_peptide     20..365
                     /product="Coxsackievirus and adenovirus receptor.
                     /id=PRO_0000014739"
                     /note="propagated from UniProtKB/Swiss-Prot (P78310.1)"
                     /calculated_mol_wt=37978
     Region          20..136
                     /region_name="IgV_CAR_like"
                     /note="Immunoglobulin Variable (V) domain of the
                     Coxsackievirus and Adenovirus Receptor (CAR), and similar
                     proteins; cd20960"
                     /db_xref="CDD:409552"
     Region          20..44
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409552"
     Region          20..22
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409552"
     Region          26..31
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409552"
     Region          35..45
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409552"
     Region          45..53
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409552"
     Region          53..59
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409552"
     Region          54..59
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409552"
     Region          60..88
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409552"
     Region          69..75
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409552"
     Region          78..81
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409552"
     Region          89..123
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409552"
     Region          90..93
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409552"
     Region          101..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409552"
     Site            106
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Region          116..124
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409552"
     Region          116..124
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409552"
     Region          124..127
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409552"
     Region          128..136
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409552"
     Region          128..136
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409552"
     Region          155..229
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          158..162
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          172..178
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          195..199
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            201
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Region          209..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..225
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            238..258
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P78310.1)"
     Region          269..343
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P78310.1)"
     Site            297
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P97792; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P97792; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Site            306
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Site            323
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     Region          360..365
                     /region_name="PDZ-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (P78310.1)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P97792; propagated from
                     UniProtKB/Swiss-Prot (P78310.1)"
     CDS             1..365
                     /gene="CXADR"
                     /gene_synonym="CAR; CAR4/6; HCAR"
                     /coded_by="NM_001338.5:88..1185"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS33519.1"
                     /db_xref="GeneID:1525"
                     /db_xref="HGNC:HGNC:2559"
                     /db_xref="MIM:602621"
ORIGIN      
        1 malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis
       61 padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc
      121 kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd
      181 sqkmptswla emtssvisvk nasseysgty sctvrnrvgs dqcllrlnvv ppsnkaglia
      241 gaiigtllal aligliifcc rkkrreekye kevhhdired vpppksrtst arsyigsnhs
      301 slgsmspsnm egysktqynq vpsedfertp qsptlppakv aapnlsrmga ipvmipaqsk
      361 dgsiv
//
