LOCUS       NM_001337               3106 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens C-X3-C motif chemokine receptor 1 (CX3CR1), transcript
            variant 4, mRNA.
ACCESSION   NM_001337
VERSION     NM_001337.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Martinez-Flores,R., Lozano-Burgos,C., Niklander,S.E.,
            Fernandez-Cuya,M., Lopes,M.A. and Gonzalez-Arriagada,W.A.
  TITLE     Relationship between aggressive features of oral squamous cell
            carcinoma and the immunoexpression of CX3CR1, CX3CL1 and ITGAV
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 138 (1), 79-87 (2024)
   PUBMED   38760287
  REMARK    GeneRIF: Relationship between aggressive features of oral squamous
            cell carcinoma and the immunoexpression of CX3CR1, CX3CL1 and
            ITGAV.
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Fritze,J., Muralidharan,C., Stamp,E. and Ahlenius,H.
  TITLE     Microglia undergo disease-associated transcriptional activation and
            CX3C motif chemokine receptor 1 expression regulates neurogenesis
            in the aged brain
  JOURNAL   Dev Neurobiol 84 (3), 128-141 (2024)
   PUBMED   38616340
  REMARK    GeneRIF: Microglia undergo disease-associated transcriptional
            activation and CX3C motif chemokine receptor 1 expression regulates
            neurogenesis in the aged brain.
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Frias-Anaya,E., Gallego-Gutierrez,H., Gongol,B., Weinsheimer,S.,
            Lai,C.C., Orecchioni,M., Sriram,A., Bui,C.M., Nelsen,B., Hale,P.,
            Pham,A., Shenkar,R., DeBiasse,D., Lightle,R., Girard,R., Li,Y.,
            Srinath,A., Daneman,R., Nudleman,E., Sun,H., Guma,M., Dubrac,A.,
            Mesarwi,O.A., Ley,K., Kim,H., Awad,I.A., Ginsberg,M.H. and
            Lopez-Ramirez,M.A.
  TITLE     Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease
            Through CX3CR1-CX3CL1 Signaling
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), 1246-1264 (2024)
   PUBMED   38660801
  REMARK    GeneRIF: Mild Hypoxia Accelerates Cerebral Cavernous Malformation
            Disease Through CX3CR1-CX3CL1 Signaling.
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Picavet,L.W., van Vroonhoven,E.C.N., Scholman,R.C., Smits,Y.T.H.,
            Banerjee,R., Besteman,S.B., Viveen,M.C., van der Vlist,M.M.,
            Tanenbaum,M.E., Lebbink,R.J., Vastert,S.J. and van Loosdregt,J.
  TITLE     m6A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by
            Downregulating Membrane CX3CR1 Expression
  JOURNAL   Viruses 16 (5), 778 (2024)
   PUBMED   38793659
  REMARK    GeneRIF: m[6]A Reader YTHDC1 Impairs Respiratory Syncytial Virus
            Infection by Downregulating Membrane CX3CR1 Expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Qian,X., Zheng,Y., Xu,L., Liu,Z., Chen,M., Tong,F., Fan,P.,
            Chen,Z., Dong,N., Zhang,C. and Liu,J.
  TITLE     Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm
            pathogenesis: insights from Mendelian randomization and
            transcriptomic analyses
  JOURNAL   Front Immunol 15, 1383607 (2024)
   PUBMED   38715600
  REMARK    GeneRIF: Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm
            pathogenesis: insights from Mendelian randomization and
            transcriptomic analyses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Fong,A.M., Robinson,L.A., Steeber,D.A., Tedder,T.F., Yoshie,O.,
            Imai,T. and Patel,D.D.
  TITLE     Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte
            capture, firm adhesion, and activation under physiologic flow
  JOURNAL   J Exp Med 188 (8), 1413-1419 (1998)
   PUBMED   9782118
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Combadiere,C., Salzwedel,K., Smith,E.D., Tiffany,H.L., Berger,E.A.
            and Murphy,P.M.
  TITLE     Identification of CX3CR1. A chemotactic receptor for the human CX3C
            chemokine fractalkine and a fusion coreceptor for HIV-1
  JOURNAL   J Biol Chem 273 (37), 23799-23804 (1998)
   PUBMED   9726990
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Imai,T., Hieshima,K., Haskell,C., Baba,M., Nagira,M., Nishimura,M.,
            Kakizaki,M., Takagi,S., Nomiyama,H., Schall,T.J. and Yoshie,O.
  TITLE     Identification and molecular characterization of fractalkine
            receptor CX3CR1, which mediates both leukocyte migration and
            adhesion
  JOURNAL   Cell 91 (4), 521-530 (1997)
   PUBMED   9390561
REFERENCE   9  (bases 1 to 3106)
  AUTHORS   Raport,C.J., Schweickart,V.L., Eddy,R.L. Jr., Shows,T.B. and
            Gray,P.W.
  TITLE     The orphan G-protein-coupled receptor-encoding gene V28 is closely
            related to genes for chemokine receptors and is expressed in
            lymphoid and neural tissues
  JOURNAL   Gene 163 (2), 295-299 (1995)
   PUBMED   7590284
REFERENCE   10 (bases 1 to 3106)
  AUTHORS   Combadiere,C., Ahuja,S.K. and Murphy,P.M.
  TITLE     Cloning, chromosomal localization, and RNA expression of a human
            beta chemokine receptor-like gene
  JOURNAL   DNA Cell Biol 14 (8), 673-680 (1995)
   PUBMED   7646814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG541473.1, U20350.1 and
            AC092053.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001337.3.
            
            Summary: Fractalkine is a transmembrane protein and chemokine
            involved in the adhesion and migration of leukocytes. The protein
            encoded by this gene is a receptor for fractalkine. The encoded
            protein also is a coreceptor for HIV-1, and some variations in this
            gene lead to increased susceptibility to HIV-1 infection and rapid
            progression to AIDS. Four transcript variants encoding two
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2010].
            
            Transcript Variant: This variant (4, also known as V28) differs in
            the 5' UTR and coding sequence compared to variant 1. The resulting
            isoform (b) is shorter at the N-terminus compared to isoform a.
            Variants 2, 3, and 4 all encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028078.1, AK225764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399220.3/ ENSP00000382166.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BG541473.1         2-6
            6-1651              U20350.1           1-1646
            1652-3106           AC092053.3         30212-31666
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..3106
                     /gene="CX3CR1"
                     /gene_synonym="CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28"
                     /note="C-X3-C motif chemokine receptor 1"
                     /db_xref="GeneID:1524"
                     /db_xref="HGNC:HGNC:2558"
                     /db_xref="MIM:601470"
     exon            1..83
                     /gene="CX3CR1"
                     /gene_synonym="CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28"
                     /inference="alignment:Splign:2.1.0"
     exon            84..3106
                     /gene="CX3CR1"
                     /gene_synonym="CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1160
                     /gene="CX3CR1"
                     /gene_synonym="CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28"
                     /note="isoform b is encoded by transcript variant 4;
                     chemokine (C-C) receptor-like 1; chemokine (C-X3-C)
                     receptor 1; CX3C chemokine receptor 1; beta chemokine
                     receptor-like 1; fractalkine receptor; CMK-BRL1;
                     CMK-BRL-1; C-X3-C CKR-1; G-protein coupled receptor 13;
                     chemokine (C-X3-C motif) receptor 1"
                     /codon_start=1
                     /product="CX3C chemokine receptor 1 isoform b"
                     /protein_id="NP_001328.1"
                     /db_xref="CCDS:CCDS43069.1"
                     /db_xref="GeneID:1524"
                     /db_xref="HGNC:HGNC:2558"
                     /db_xref="MIM:601470"
                     /translation="MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAI
                     GLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMC
                     KFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILV
                     AAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTL
                     FSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALS
                     VTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRH
                     GSVLSSNFTYHTSDGDALLLL"
     regulatory      3085..3090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CX3CR1"
                     /gene_synonym="CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28"
                     /note="hexamer: AATACA"
     polyA_site      3106
                     /gene="CX3CR1"
                     /gene_synonym="CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28"
                     /note="major polyA site"
ORIGIN      
        1 gaaatactcg tctctggtaa agtctgagca ggacagggtg gctgactggc agatccagag
       61 gttcccttgg cagtccacgc caggccttca ccatggatca gttccctgaa tcagtgacag
      121 aaaactttga gtacgatgat ttggctgagg cctgttatat tggggacatc gtggtctttg
      181 ggactgtgtt cctgtccata ttctactccg tcatctttgc cattggcctg gtgggaaatt
      241 tgttggtagt gtttgccctc accaacagca agaagcccaa gagtgtcacc gacatttacc
      301 tcctgaacct ggccttgtct gatctgctgt ttgtagccac tttgcccttc tggactcact
      361 atttgataaa tgaaaagggc ctccacaatg ccatgtgcaa attcactacc gccttcttct
      421 tcatcggctt ttttggaagc atattcttca tcaccgtcat cagcattgat aggtacctgg
      481 ccatcgtcct ggccgccaac tccatgaaca accggaccgt gcagcatggc gtcaccatca
      541 gcctaggcgt ctgggcagca gccattttgg tggcagcacc ccagttcatg ttcacaaagc
      601 agaaagaaaa tgaatgcctt ggtgactacc ccgaggtcct ccaggaaatc tggcccgtgc
      661 tccgcaatgt ggaaacaaat tttcttggct tcctactccc cctgctcatt atgagttatt
      721 gctacttcag aatcatccag acgctgtttt cctgcaagaa ccacaagaaa gccaaagcca
      781 ttaaactgat ccttctggtg gtcatcgtgt ttttcctctt ctggacaccc tacaacgtta
      841 tgattttcct ggagacgctt aagctctatg acttctttcc cagttgtgac atgaggaagg
      901 atctgaggct ggccctcagt gtgactgaga cggttgcatt tagccattgt tgcctgaatc
      961 ctctcatcta tgcatttgct ggggagaagt tcagaagata cctttaccac ctgtatggga
     1021 aatgcctggc tgtcctgtgt gggcgctcag tccacgttga tttctcctca tctgaatcac
     1081 aaaggagcag gcatggaagt gttctgagca gcaattttac ttaccacacg agtgatggag
     1141 atgcattgct ccttctctga agggaatccc aaagccttgt gtctacagag aacctggagt
     1201 tcctgaacct gatgctgact agtgaggaaa gatttttgtt gttatttctt acaggcacaa
     1261 aatgatggac ccaatgcaca caaaacaacc ctagagtgtt gttgagaatt gtgctcaaaa
     1321 tttgaagaat gaacaaattg aactctttga atgacaaaga gtagacattt ctcttactgc
     1381 aaatgtcatc agaacttttt ggtttgcaga tgacaaaaat tcaactcaga ctagtttagt
     1441 taaatgaggg tggtgaatat tgttcatatt gtggcacaag caaaagggtg tctgagccct
     1501 caaagtgagg ggaaaccagg gcctgagcca agctagaatt ccctctctct gactctcaaa
     1561 tcttttagtc attatagatc ccccagactt tacatgacac agctttatca ccagagaggg
     1621 actgacaccc atgtttctct ggccccaagg gcaaaattcc cagggaagtg ctctgatagg
     1681 ccaagtttgt atcaggtgcc catccctgga aggtgctgtt atccatgggg aagggatata
     1741 taagatggaa gcttccagtc caatctcatg gagaagcaga aatacatatt tccaagaagt
     1801 tggatgggtg ggtactattc tgattacaca aaacaaatgc cacacatcac ccttaccatg
     1861 tgcctgatcc agcctctccc ctgattacac cagcctcgtc ttcattaagc cctcttccat
     1921 catgtcccca aacctgcaag ggctccccac tgcctactgc atcgagtcaa aactcaaatg
     1981 cttggcttct catacgtcca ccatggggtc ctaccaatag attccccatt gcctcctcct
     2041 tcccaaagga ctccacccat cctatcagcc tgtctcttcc atatgacctc atgcatctcc
     2101 acctgctccc aggccagtaa gggaaataga aaaaccctgc ccccaaataa gaagggatgg
     2161 attccaaccc caactccagt agcttgggac aaatcaagct tcagtttcct ggtctgtaga
     2221 agagggataa ggtacctttc acatagagat catcctttcc agcatgagga actagccacc
     2281 aactcttgca ggtctcaacc cttttgtctg cctcttagac ttctgctttc cacacctggc
     2341 actgctgtgc tgtgcccaag ttgtggtgct gacaaagctt ggaagagcct gcaggtgctg
     2401 ctgcgtggca tagcccagac acagaagagg ctggttctta cgatggcacc cagtgagcac
     2461 tcccaagtct acagagtgat agccttccgt aacccaactc tcctggactg ccttgaatat
     2521 cccctcccag tcaccttgtg gcaagcccct gcccatctgg gaaaataccc catcattcat
     2581 gctactgcca acctggggag ccagggctat gggagcagct tttttttccc ccctagaaac
     2641 gtttggaaca atctaaaagt ttaaagctcg aaaacaattg taataatgct aaagaaaaag
     2701 tcatccaatc taaccacatc aatattgtca ttcctgtatt cacccgtcca gaccttgttc
     2761 acactctcac atgtttagag ttgcaatcgt aatgtacaga tggttttata atctgatttg
     2821 ttttcctctt aacgttagac cacaaatagt gctcgctttc tatgtagttt ggtaattatc
     2881 attttagaag actctaccag actgtgtatt cattgaagtc agatgtggta actgttaaat
     2941 tgctgtgtat ctgatagctc tttggcagtc tatatgtttg tataatgaat gagagaataa
     3001 gtcatgttcc ttcaagatca tgtaccccaa tttacttgcc attactcaat tgataaacat
     3061 ttaacttgtt tccaatgttt agcaaataca tattttatag aacttc
//
