LOCUS       NM_025087               2444 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cell wall biogenesis 43 C-terminal homolog (CWH43),
            transcript variant 1, mRNA.
ACCESSION   NM_025087
VERSION     NM_025087.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2444)
  AUTHORS   Lee,C.C., Tsai,K.Y., Lee,A.W., Wei,P.L., Huang,C.Y., Batzorig,U.
            and Chang,Y.J.
  TITLE     CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of
            TTK in Colorectal Cancer
  JOURNAL   Int J Mol Sci 24 (20), 15262 (2023)
   PUBMED   37894942
  REMARK    GeneRIF: CWH43 Is a Novel Tumor Suppressor Gene with Negative
            Regulation of TTK in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2444)
  AUTHORS   Yang,D., Yang,H., Luiselli,G., Ogagan,C., Dai,H., Chiu,L.,
            Carroll,R.S. and Johnson,M.D.
  TITLE     Increased plasmin-mediated proteolysis of L1CAM in a mouse model of
            idiopathic normal pressure hydrocephalus
  JOURNAL   Proc Natl Acad Sci U S A 118 (33) (2021)
   PUBMED   34380733
  REMARK    GeneRIF: Increased plasmin-mediated proteolysis of L1CAM in a mouse
            model of idiopathic normal pressure hydrocephalus.
REFERENCE   3  (bases 1 to 2444)
  AUTHORS   Lange,C.M., Kutalik,Z., Morikawa,K., Bibert,S., Cerny,A.,
            Dollenmaier,G., Dufour,J.F., Gerlach,T.J., Heim,M.H.,
            Malinverni,R., Mullhaupt,B., Negro,F., Moradpour,D. and Bochud,P.Y.
  CONSRTM   Swiss Hepatitis C Cohort Study Group
  TITLE     Serum ferritin levels are associated with a distinct phenotype of
            chronic hepatitis C poorly responding to pegylated interferon-alpha
            and ribavirin therapy
  JOURNAL   Hepatology 55 (4), 1038-1047 (2012)
   PUBMED   22095909
REFERENCE   4  (bases 1 to 2444)
  AUTHORS   Umemura,M., Fujita,M., Yoko-O,T., Fukamizu,A. and Jigami,Y.
  TITLE     Saccharomyces cerevisiae CWH43 is involved in the remodeling of the
            lipid moiety of GPI anchors to ceramides
  JOURNAL   Mol Biol Cell 18 (11), 4304-4316 (2007)
   PUBMED   17761529
REFERENCE   5  (bases 1 to 2444)
  AUTHORS   Ghugtyal,V., Vionnet,C., Roubaty,C. and Conzelmann,A.
  TITLE     CWH43 is required for the introduction of ceramides into GPI
            anchors in Saccharomyces cerevisiae
  JOURNAL   Mol Microbiol 65 (6), 1493-1502 (2007)
   PUBMED   17714445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA426878.1, AK025164.1, AC020593.6 and AI377551.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025087.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025164.1, BC137387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226432.9/ ENSP00000226432.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               DA426878.1         28-186
            160-1273            AK025164.1         187-1300
            1274-1274           AC020593.6         114744-114744
            1275-2219           AK025164.1         1302-2246
            2220-2443           AI377551.1         2-225               c
            2444-2444           AK025164.1         2471-2471
FEATURES             Location/Qualifiers
     source          1..2444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p11"
     gene            1..2444
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /note="cell wall biogenesis 43 C-terminal homolog"
                     /db_xref="GeneID:80157"
                     /db_xref="HGNC:HGNC:26133"
                     /db_xref="MIM:618561"
     exon            1..198
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2255
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PGAP2-interacting protein; cell wall biogenesis protein 43
                     C-terminal homolog"
                     /codon_start=1
                     /product="PGAP2-interacting protein isoform 1"
                     /protein_id="NP_079363.2"
                     /db_xref="CCDS:CCDS3486.1"
                     /db_xref="GeneID:80157"
                     /db_xref="HGNC:HGNC:26133"
                     /db_xref="MIM:618561"
                     /translation="MPSLWREILLESLLGCVSWSLYHDLGPMIYYFPLQTLELTGLEG
                     FSIAFLSPIFLTITPFWKLVNKKWMLTLLRIITIGSIASFQAPNAKLRLMVLALGVSS
                     SLIVQAVTWWSGSHLQRYLRIWGFILGQIVLVVLRIWYTSLNPIWSYQMSNKVILTLS
                     AIATLDRIGTDGDCSKPEEKKTGEVATGMASRPNWLLAGAAFGSLVFLTHWVFGEVSL
                     VSRWAVSGHPHPGPDPNPFGGAVLLCLASGLMLPSCLWFRGTGLIWWVTGTASAAGLL
                     YLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCT
                     AFKFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKY
                     MKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERS
                     AHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALS
                     RYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVS
                     KLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLG
                     YARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGH
                     NYENNHHFHMNTPKYFL"
     exon            199..390
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            391..511
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            512..666
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..868
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            869..957
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1215
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1341
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1421
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1527
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1663
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1813
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1958
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2020
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2176
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2444
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /note="hexamer: AATAAA"
     polyA_site      2444
                     /gene="CWH43"
                     /gene_synonym="CWH43-C; PGAP2IP"
                     /note="major polyA site"
ORIGIN      
        1 agttggctgg ggctcacttg gcaacgggac gcgggaacga ggggcgcgga cgcaggcccg
       61 ggaggacgcg gcggcgggaa cctgggggcg cagggctagg gcagcgggcc cgacccgcac
      121 ggctttcctg gaaagcgctg cccctcgccg cggcgatgcc ctcgctgtgg agagaaatcc
      181 tcttggagtc gctgctggga tgtgtttctt ggtctctcta ccatgacctg ggaccgatga
      241 tctattactt tcctttgcaa acactagaac tcactgggct tgaaggtttt agtatagcat
      301 ttctttctcc aatattccta acaattactc ctttctggaa attggttaac aagaagtgga
      361 tgctaaccct gctgaggata atcactattg gcagcatagc ctccttccag gctccaaatg
      421 ccaaacttcg actgatggtt cttgcgcttg gggtgtcttc ctcactgata gtgcaagctg
      481 tgacttggtg gtcaggaagt catttgcaaa ggtacctcag aatttgggga ttcattttag
      541 gacagattgt tcttgttgtt ctacgcatat ggtatacttc actaaaccca atctggagtt
      601 atcagatgtc caacaaagtg atactgacat taagtgccat agccacactt gatcgtattg
      661 gcacagatgg tgactgcagt aaacctgaag aaaagaagac tggtgaggta gccacgggga
      721 tggcctctag acccaactgg ctgctggcag gggctgcttt tggtagcctt gtgttcctca
      781 cccactgggt ttttggagaa gtctctcttg tttccagatg ggcagtgagt gggcatccac
      841 atccagggcc agatcctaac ccatttggag gtgcagtact gctgtgcttg gcaagtggat
      901 tgatgcttcc atcttgtttg tggtttcgtg gtactggttt gatctggtgg gttacaggaa
      961 cagcttcagc tgcggggctc ctttacctgc acacatgggc agctgctgtg tctggctgtg
     1021 tcttcgccat ctttactgca tccatgtggc cccaaacact tggacacctt attaactcag
     1081 ggacaaaccc tgggaaaacc atgaccattg ccatgatatt ttatcttcta gaaatatttt
     1141 tctgtgcctg gtgcacagct tttaagtttg tcccaggagg tgtctacgct agagaaagat
     1201 cagatgtgct tttggggaca atgatgttaa ttatcgggct gaatatgcta tttggtccta
     1261 agaaaaacct tgacttgctt cttcaaacaa aaaacagttc taaagtgctt ttcagaaaga
     1321 gtgaaaaata catgaaactt tttctgtggc tgcttgttgg tgtgggattg ttgggattag
     1381 gactacggca taaagcctat gagagaaaac tgggcaaagt ggcaccaacc aaagaggtct
     1441 ctgctgccat ctggcctttc aggtttggat atgacaatga agggtggtct agtctagaaa
     1501 gatcagctca cctgctcaat gaaacaggtg cagatttcat aacaattttg gagagtgatg
     1561 cttctaagcc ctatatgggg aacaatgact taaccatgtg gctaggggaa aagttgggtt
     1621 tctatacaga ctttggtcca agcacaaggt atcacacttg ggggattatg gctttgtcaa
     1681 gatacccaat tgtgaaatct gagcatcacc ttcttccgtc accagagggc gagatcgcac
     1741 cagccatcac attgaccgtt aacatttcgg gcaagctggt ggattttgtc gtgacacact
     1801 ttgggaacca cgaagatgac ctcgacagga aactgcaggc tattgctgtt tcaaaactac
     1861 tgaaaagtag ctctaatcaa gtgatatttc tgggatatat cacttcagca cctggctcca
     1921 gagattatct acagctcact gaacatggca atgtgaagga tatcgacagc actgatcatg
     1981 acagatggtg tgaatacatt atgtatcgag ggctgatcag gttgggttat gcaagaatct
     2041 cccatgctga actgagtgat tcagaaattc agatggcaaa atttaggatc cctgatgacc
     2101 ccactaatta tagagacaac cagaaagtgg tcatagacca cagagaagtt tctgagaaaa
     2161 ttcattttaa tcccagattt ggatcctaca aagaaggaca caattatgaa aacaaccatc
     2221 attttcatat gaatactccc aaatactttt tatgaaacat ttaaaacaag aagttattgg
     2281 ctgggaaaat ctaagaaaaa aagtatgtaa gataaaaaga agagattaat gaaagtggga
     2341 aaatacacat gaagaacctc aacttaaaaa acacatggta tctatgcagt gggaaattac
     2401 ctccatttgt aaactatgtt gcttaataaa aacatttctc taaa
//
