LOCUS       NM_152434               3244 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens CWF19 like cell cycle control factor 2 (CWF19L2),
            mRNA.
ACCESSION   NM_152434
VERSION     NM_152434.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Nordgard,S.H., Johansen,F.E., Alnaes,G.I., Bucher,E., Syvanen,A.C.,
            Naume,B., Borresen-Dale,A.L. and Kristensen,V.N.
  TITLE     Genome-wide analysis identifies 16q deletion associated with
            survival, molecular subtypes, mRNA expression, and germline
            haplotypes in breast cancer patients
  JOURNAL   Genes Chromosomes Cancer 47 (8), 680-696 (2008)
   PUBMED   18398821
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126881.1 and BX648704.1.
            
            On Mar 29, 2021 this sequence version replaced NM_152434.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648704.1, BX649022.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282251.10/ ENSP00000282251.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1322              AK126881.1         15-1336
            1323-2550           BX648704.1         1323-2550
            2551-3244           AK126881.1         2563-3256
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..3244
                     /gene="CWF19L2"
                     /note="CWF19 like cell cycle control factor 2"
                     /db_xref="GeneID:143884"
                     /db_xref="HGNC:HGNC:26508"
     exon            1..114
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2694
                     /gene="CWF19L2"
                     /note="CWF19 like 2, cell cycle control"
                     /codon_start=1
                     /product="CWF19-like protein 2"
                     /protein_id="NP_689647.2"
                     /db_xref="CCDS:CCDS8336.2"
                     /db_xref="GeneID:143884"
                     /db_xref="HGNC:HGNC:26508"
                     /translation="MATSMAAASGRFESAKSIEERKEQTRNARAEVLRQAKANFEKEE
                     RRKELKRLRGEDTWMLPDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKY
                     EKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFM
                     SVKTVSSSSLKAEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSS
                     ITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFEDIVAERYGSMEIFQSKLEDAEKAA
                     STKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIG
                     DEKDKRPGSLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSS
                     SALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPEDP
                     REKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGN
                     MELAEQLKVQLEKANKFKETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNTPGKS
                     LESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMASK
                     FMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSS
                     QFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSL
                     VKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSM
                     NKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHKFPHYFGKEIIGGMLDI
                     EPRLWRKGIRESFEDQRKKALQFAQWWKPYDFTKSKNY"
     exon            115..225
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..348
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..459
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..579
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..673
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..789
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1442
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1536
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1626
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1743
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1881
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2094
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2211
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2367
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2448
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2550
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..3244
                     /gene="CWF19L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CWF19L2"
                     /note="hexamer: ATTAAA"
     polyA_site      3244
                     /gene="CWF19L2"
                     /note="major polyA site"
ORIGIN      
        1 agctttacga tggcaacaag tatggcggct gctagtggta gatttgaaag tgcgaagagt
       61 atcgaagagc ggaaagaaca gacccggaat gccagggccg aggtgttgcg ccaggctaaa
      121 gccaattttg aaaaagaaga aaggcgtaaa gaacttaagc gacttcgggg tgaggataca
      181 tggatgctac ctgatgtgaa tgagagaatt gaacagttct cacaggaaca ctctgtgaag
      241 aaaaagaaga aaaaagacaa gcattcaaaa aaagcaaaga aagaaaagaa aaaaaagagc
      301 aagaaacaga aatatgaaaa aaacaatgag tcatctgata gctcatcaag ctctgaagat
      361 gagtgggttg aggctgttcc atcccagact cctgacaagg aaaaagcctg gaaagtgaaa
      421 gatgaaaagt caggaaaaga tgacacccaa attatcaaga gggatgagtg gatgactgtt
      481 gattttatgt ctgttaaaac tgtgtcatca tcatcactca aagctgaaaa ggaaactatg
      541 aggaaaatag agcaagagaa aaaccaagcg cttgaacagt ccaaactgat ggaaagagaa
      601 ttgaatccgt actggaagga tggtgggaca ggtcttccac ctgaagactg tagtgtgtca
      661 tcgattacta aagtttcagt ggtagaagat ggtggattaa gctggctaag gaaatcttat
      721 ctaagaatga aggaacaagc tgagaaacaa agtagaaact ttgaggacat tgtagccgaa
      781 agatatgggt caatggaaat atttcagtca aaattagaag atgctgaaaa agctgcatcc
      841 acgaaagaag attatagacg ggaacggtgg aggaaaccca catattcaga taaagcacaa
      901 aattgtcaag aaagtagaga atcagactta gtaaaatatg gtaacagttc aagggataga
      961 tatgctacaa cagatactgc aaaaaatagc aataatgaaa aatttattgg tgatgaaaaa
     1021 gataagagac ctgggtcttt agaaacgtgt agaagagaat ctaacccaag gcaaaatcaa
     1081 gagttttctt ttggcaattt gagagctaaa ttcttgagac cctctgatga tgaagaactg
     1141 tcatttcaca gcaagggcag aaaatttgaa ccacttagtt catcttcagc attggtagct
     1201 cagggctctt tgtgtagtgg ttttagaaaa cccaccaaga acagtgaaga aagattaaca
     1261 tcatggagtc gctctgatgg gagaggagac aagaaacatt caaatcaaaa gccatcggaa
     1321 accagtactg atgaacacca acatgttcca gaagacccaa gagaaaaatc acaagatgaa
     1381 gtcttgagag atgaccctcc aaaaaaagaa catctacggg atacaaagtc tacatttgct
     1441 ggcagtccag agcgtgagtc cattcacatc ctgagtgttg atgagaagaa caagttggga
     1501 gccaagatta tcaaagcaga gatgatgggg aatatggaat tagctgaaca acttaaagtt
     1561 caacttgaaa aggcaaataa attcaaagaa actataacac agataccaaa aaaatctggg
     1621 gtagagaatg aagaccagca agaagtaatc cttgtcagaa cagatcagtc tggaagagta
     1681 tggcctgtga acacacccgg aaaatctctg gaatcacaag gaggaagaag aaagagacag
     1741 atggtttcaa cccatgagga aagagaaagg gtcagatact ttcatgatga tgataatcta
     1801 agcctaaatg atttagtcaa aaatgaaaag atgggaacag cagaaaatca aaacaagctc
     1861 tttatgagaa tggcatctaa gtttatggga aaaacagatg gagactatta caccctggat
     1921 gacatgtttg tctccaaagc agctgagaga gaacgtcttg gtgaagagga agagaaccaa
     1981 aggaaaaaag ctattgctga gcatcggagt cttgctgcac aaatggaaaa atgtctgtat
     2041 tgttttgaca gctctcaatt tcccaagcat cttattgttg caataggtgt taaggtttat
     2101 ttatgtttac ccaacgtacg gtctcttact gaggggcact gcctgatagt ccctttgcag
     2161 caccatagag cagctacttt gttggatgaa gacatctggg aggagatcca gatgttcaga
     2221 aaatcattgg taaagatgtt tgaagataaa ggattagact gcattttttt ggaaactaat
     2281 atgagcatga agaaacagta tcacatggtt tatgaatgta ttcctcttcc caaggaagtg
     2341 ggtgacatgg ctcccatcta ttttaagaaa gccataatgg aatctgatga agagtggtcc
     2401 atgaacaaga agttgataga tctctcttca aaagatatca gaaagtctgt acccagaggg
     2461 ttaccttact tctctgtgga ttttggcctt cacggagggt ttgcccatgt cattgaagat
     2521 cagcacaaat tccctcatta ctttggaaag gaaatcatag gtgggatgct ggatatagaa
     2581 ccaagacttt ggaggaaagg catccgagaa agctttgagg atcagaggaa aaaagcactg
     2641 cagtttgctc agtggtggaa accatatgac ttcaccaaaa gtaaaaacta ttgaggtgta
     2701 ccttccattt taaaattttt cttcagatcc cgttcagttt tatttccatt gcatctaatg
     2761 aagcaactga ccctcaggtc acaggcagag agagtcacag cagcagactg ctctgggtca
     2821 gtgacaactg tacatcagga gattgtgttg ttttcttctt cacctgctcc tatctatgga
     2881 cttcatttta gtcaccatgg agtaaaaaca tatattcgat gatctgctca cattcctgct
     2941 ctctacctac ttcttggtat tccgaattgt tcagttaatt tagagaaggc cttttctgaa
     3001 gggatatcta aaaagcatag gaaatccttg gttcagaggg aagtgggtct gcttcatggt
     3061 tgttaagtct actgtctggc ttcttttgca tttttaaaaa taagacgatt taattttaat
     3121 ttcataggat tttatagaaa agctcttaat tttctactag cagtatatag tatcacttct
     3181 attctttttg ttaaaggaaa aggaaatgtc cccaaagtat taaagaatta aatgatactg
     3241 aaaa
//
