LOCUS       NM_022034               1958 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens CUB and zona pellucida like domains 1 (CUZD1),
            transcript variant 1, mRNA.
ACCESSION   NM_022034
VERSION     NM_022034.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Just,A., Thiel,F.G. and Weiss,F.U.
  TITLE     Association analysis of CUZD1 variants in European chronic
            pancreatitis patients
  JOURNAL   Pancreatology 23 (8), 1041-1042 (2023)
   PUBMED   37858432
  REMARK    GeneRIF: Association analysis of CUZD1 variants in European chronic
            pancreatitis patients.
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Rygiel,A.M., Unger,L.S., Sorgel,F.L., Masson,E., Matsumoto,R.,
            Ewers,M., Chen,J.M., Bugert,P., Buscail,L., Gambin,T., Oracz,G.,
            Winiewska-Szajewska,M., Mianowska,A., Poznanski,J., Kosinska,J.,
            Stawinski,P., Ploski,R., Koziel,D., Gluszek,S., Laumen,H.,
            Lindgren,F., Lohr,J.M., Orekhova,A., Rebours,V., Rosendahl,J.,
            Parniczky,A., Hegyi,P., Sasaki,A., Kataoka,F., Tanaka,Y.,
            Hamada,S., Sahin-Toth,M., Hegyi,E., Ferec,C., Masamune,A. and
            Witt,H.
  TITLE     Variants in the pancreatic CUB and zona pellucida-like domains 1
            (CUZD1) gene in early-onset chronic pancreatitis - A possible new
            susceptibility gene
  JOURNAL   Pancreatology 22 (5), 564-571 (2022)
   PUBMED   35589511
  REMARK    GeneRIF: Variants in the pancreatic CUB and zona pellucida-like
            domains 1 (CUZD1) gene in early-onset chronic pancreatitis - A
            possible new susceptibility gene.
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Mapes,J., Anandan,L., Li,Q., Neff,A., Clevenger,C.V., Bagchi,I.C.
            and Bagchi,M.K.
  TITLE     Aberrantly high expression of the CUB and zona pellucida-like
            domain-containing protein 1 (CUZD1) in mammary epithelium leads to
            breast tumorigenesis
  JOURNAL   J Biol Chem 293 (8), 2850-2864 (2018)
   PUBMED   29321207
  REMARK    GeneRIF: Data suggest that overexpression of CUZD1, regulator of
            growth factor signaling pathways controlled by PRLR and STAT5,
            promotes tumorigenesis in mammary epithelial cells. (CUZD1 = CUB
            and zona pellucida-like domain-containing protein-1; PRLR =
            prolactin receptor; STAT5 = signal transducer and activator of
            transcription-5)
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Farkona,S., Soosaipillai,A., Filippou,P., Korbakis,D., Serra,S.,
            Ruckert,F., Diamandis,E.P. and Blasutig,I.M.
  TITLE     Generation of monoclonal antibodies and development of an
            immunofluorometric assay for the detection of CUZD1 in tissues and
            biological fluids
  JOURNAL   Clin Biochem 50 (18), 1168-1174 (2017)
   PUBMED   28746862
  REMARK    GeneRIF: This study describes the development of tools targeting
            CUZD1 protein, its tissue expression pattern and levels in several
            biological fluids. These new tools will facilitate future
            investigations aiming to delineate the role of CUZD1 in physiology
            and pathobiology.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Papp,M., Sipeki,N., Tornai,T., Altorjay,I., Norman,G.L., Shums,Z.,
            Roggenbuck,D., Fechner,K., Stocker,W., Antal-Szalmas,P., Veres,G.
            and Lakatos,P.L.
  TITLE     Rediscovery of the Anti-Pancreatic Antibodies and Evaluation of
            their Prognostic Value in a Prospective Clinical Cohort of Crohn's
            Patients: The Importance of Specific Target Antigens [GP2 and
            CUZD1]
  JOURNAL   J Crohns Colitis 9 (8), 659-668 (2015)
   PUBMED   25968583
  REMARK    GeneRIF: Totals of 12.4% and 20.8% of Crohn's disease patients were
            positive for IgA/IgG type of anti-GP2 and anti-CUZD1, respectively.
            Positivity for anti-pancreatic autoantibodies predicted a faster
            progression towards complicated disease course.
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Blanchetot,C., Chagnon,M., Dube,N., Halle,M. and Tremblay,M.L.
  TITLE     Substrate-trapping techniques in the identification of cellular PTP
            targets
  JOURNAL   Methods 35 (1), 44-53 (2005)
   PUBMED   15588985
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Leong,C.T., Ng,C.Y., Ong,C.K., Ng,C.P., Ma,Z.S., Nguyen,T.H.,
            Tay,S.K. and Huynh,H.
  TITLE     Molecular cloning, characterization and isolation of novel spliced
            variants of the human ortholog of a rat estrogen-regulated
            membrane-associated protein, UO-44
  JOURNAL   Oncogene 23 (33), 5707-5718 (2004)
   PUBMED   15184879
  REMARK    Erratum:[Oncogene. 2004 Nov 18;23(54):8857]
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Cayabyab,F.S., Tsui,F.W. and Schlichter,L.C.
  TITLE     Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1
  JOURNAL   J Biol Chem 277 (50), 48130-48138 (2002)
   PUBMED   12361947
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Huynh,H., Ng,C.Y., Lim,K.B., Ong,C.K., Ong,C.S., Tran,E., Tuyen
            Nguyen,T.T. and Chan,T.W.
  TITLE     Induction of UO-44 gene expression by tamoxifen in the rat uterus
            and ovary
  JOURNAL   Endocrinology 142 (7), 2985-2995 (2001)
   PUBMED   11416020
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Chen,D., Xu,X., Zhu,L.J., Angervo,M., Li,Q., Bagchi,M.K. and
            Bagchi,I.C.
  TITLE     Cloning and uterus/oviduct-specific expression of a novel
            estrogen-regulated gene (ERG1)
  JOURNAL   J Biol Chem 274 (45), 32215-32224 (1999)
   PUBMED   10542259
  REMARK    Erratum:[J Biol Chem 2000 Feb 18;275(7):5248]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY260047.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022034.5.
            
            Transcript Variant: This variant (1), also known as UO-44D,
            represents the longer transcript and encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY260047.1, SRR1660809.253342.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392790.6/ ENSP00000376540.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1958              AY260047.1         319-2276
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..1958
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /note="CUB and zona pellucida like domains 1"
                     /db_xref="GeneID:50624"
                     /db_xref="HGNC:HGNC:17937"
                     /db_xref="MIM:616644"
     exon            1..96
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1838
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /note="estrogen regulated gene 1; CUB and zona
                     pellucida-like domain-containing protein 1; transmembrane
                     protein UO-44; CUB and ZP domain-containing protein 1"
                     /codon_start=1
                     /product="CUB and zona pellucida-like domain-containing
                     protein 1 precursor"
                     /protein_id="NP_071317.2"
                     /db_xref="CCDS:CCDS7631.1"
                     /db_xref="GeneID:50624"
                     /db_xref="HGNC:HGNC:17937"
                     /db_xref="MIM:616644"
                     /translation="MELVRRLMPLTLLILSCLAELTMAEAEGNASCTVSLGGANMAET
                     HKAMILQLNPSENCTWTIERPENKSIRIIFSYVQLDPDGSCESENIKVFDGTSSNGPL
                     LGQVCSKNDYVPVFESSSSTLTFQIVTDSARIQRTVFVFYYFFSPNISIPNCGGYLDT
                     LEGSFTSPNYPKPHPELAYCVWHIQVEKDYKIKLNFKEIFLEIDKQCKFDFLAIYDGP
                     STNSGLIGQVCGRVTPTFESSSNSLTVVLSTDYANSYRGFSASYTSIYAENINTTSLT
                     CSSDRMRVIISKSYLEAFNSNGNNLQLKDPTCRPKLSNVVEFSVPLNGCGTIRKVEDQ
                     SITYTNIITFSASSTSEVITRQKQLQIIVKCEMGHNSTVEIIYITEDDVIQSQNALGK
                     YNTSMALFESNSFEKTILESPYYVDLNQTLFVQVSLHTSDPNLVVFLDTCRASPTSDF
                     ASPTYDLIKSGCSRDETCKVYPLFGHYGRFQFNAFKFLRSMSSVYLQCKVLICDSSDH
                     QSRCNQGCVSRSKRDISSYKWKTDSIIGPIRLKRDRSASGNSGFQHETHAEETPNQPF
                     NSVHLFSFMVLALNVVTVATITVRHFVNQRADYKYQKLQNY"
     exon            97..247
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            248..462
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            463..613
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            614..831
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1004
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1396
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1665
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1958
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="CUZD1"
                     /gene_synonym="ERG-1; ERG1; ITMAP1; UO-44"
                     /note="major polyA site"
ORIGIN      
        1 agcgccttgc caaaatggag cttgtaagaa ggctcatgcc attgaccctc ttaattctct
       61 cctgtttggc ggagctgaca atggcggagg ctgaaggcaa tgcaagctgc acagtcagtc
      121 tagggggtgc caatatggca gagacccaca aagccatgat cctgcaactc aatcccagtg
      181 agaactgcac ctggacaata gaaagaccag aaaacaaaag catcagaatt atcttttcct
      241 atgtccagct tgatccagat ggaagctgtg aaagtgaaaa cattaaagtc tttgacggaa
      301 cctccagcaa tgggcctctg ctagggcaag tctgcagtaa aaacgactat gttcctgtat
      361 ttgaatcatc atccagtaca ttgacgtttc aaatagttac tgactcagca agaattcaaa
      421 gaactgtctt tgtcttctac tacttcttct ctcctaacat ctctattcca aactgtggcg
      481 gttacctgga taccttggaa ggatccttca ccagccccaa ttacccaaag ccgcatcctg
      541 agctggctta ttgtgtgtgg cacatacaag tggagaaaga ttacaagata aaactaaact
      601 tcaaagagat tttcctagaa atagacaaac agtgcaaatt tgattttctt gccatctatg
      661 atggcccctc caccaactct ggcctgattg gacaagtctg tggccgtgtg actcccacct
      721 tcgaatcgtc atcaaactct ctgactgtcg tgttgtctac agattatgcc aattcttacc
      781 ggggattttc tgcttcctac acctcaattt atgcagaaaa catcaacact acatctttaa
      841 cttgctcttc tgacaggatg agagttatta taagcaaatc ctacctagag gcttttaact
      901 ctaatgggaa taacttgcaa ctaaaagacc caacttgcag accaaaatta tcaaatgttg
      961 tggaattttc tgtccctctt aatggatgtg gtacaatcag aaaggtagaa gatcagtcaa
     1021 ttacttacac caatataatc accttttctg catcctcaac ttctgaagtg atcacccgtc
     1081 agaaacaact ccagattatt gtgaagtgtg aaatgggaca taattctaca gtggagataa
     1141 tatacataac agaagatgat gtaatacaaa gtcaaaatgc actgggcaaa tataacacca
     1201 gcatggctct ttttgaatcc aattcatttg aaaagactat acttgaatca ccatattatg
     1261 tggatttgaa ccaaactctt tttgttcaag ttagtctgca cacctcagat ccaaatttgg
     1321 tggtgtttct tgatacctgt agagcctctc ccacctctga ctttgcatct ccaacctacg
     1381 acctaatcaa gagtggatgt agtcgagatg aaacttgtaa ggtgtatccc ttatttggac
     1441 actatgggag attccagttt aatgccttta aattcttgag aagtatgagc tctgtgtatc
     1501 tgcagtgtaa agttttgata tgtgatagca gtgaccacca gtctcgctgc aatcaaggtt
     1561 gtgtctccag aagcaaacga gacatttctt catataaatg gaaaacagat tccatcatag
     1621 gacccattcg tctgaaaagg gatcgaagtg caagtggcaa ttcaggattt cagcatgaaa
     1681 cacatgcgga agaaactcca aaccagcctt tcaacagtgt gcatctgttt tccttcatgg
     1741 ttctagctct gaatgtggtg actgtagcga caatcacagt gaggcatttt gtaaatcaac
     1801 gggcagacta caaataccag aagctgcaga actattaact aacaggtcca accctaagtg
     1861 agacatgttt ctccaggatg ccaaaggaaa tgctacctcg tggctacaca tattatgaat
     1921 aaatgaggaa gggcctgaaa gtgacacaca ggcctgca
//
