LOCUS       NM_015267               6703 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens cut like homeobox 2 (CUX2), transcript variant 1,
            mRNA.
ACCESSION   NM_015267 XM_027045
VERSION     NM_015267.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6703)
  AUTHORS   Li,L., Zhu,G., Tan,K., Jiang,L., Li,Y., Zhu,X., Lin,Z., Zhang,X.,
            Chen,J. and Ma,C.
  TITLE     CUX2/KDM5B/SOX17 Axis Affects the Occurrence and Development of
            Breast Cancer
  JOURNAL   Endocrinology 163 (9) (2022)
   PUBMED   35881915
  REMARK    GeneRIF: CUX2/KDM5B/SOX17 Axis Affects the Occurrence and
            Development of Breast Cancer.
            Erratum:[Endocrinology. 2022 Nov 14;164(1):bqac199. doi:
            10.1210/endocr/bqac199.. PMID: 36527259]
REFERENCE   2  (bases 1 to 6703)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 6703)
  AUTHORS   Chen,I.C., Kuo,P.H., Yang,A.C., Tsai,S.J., Liu,T.H., Liu,H.J.,
            Lan,T.H., Chen,H.M., Huang,H.N., Chung,R.H. and Liu,Y.L.
  TITLE     CUX2, BRAP and ALDH2 are associated with metabolic traits in people
            with excessive alcohol consumption
  JOURNAL   Sci Rep 10 (1), 18118 (2020)
   PUBMED   33093602
  REMARK    GeneRIF: CUX2, BRAP and ALDH2 are associated with metabolic traits
            in people with excessive alcohol consumption.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6703)
  AUTHORS   Pan,H., Yang,M., Lu,L., Tao,B., He,X., Chen,H., Yi,H. and Tang,S.
  TITLE     Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with
            susceptibility to antituberculosis drug-induced hepatotoxicity:
            validation study in a Chinese Han population
  JOURNAL   Pharmacogenet Genomics 29 (4), 84-90 (2019)
   PUBMED   30720667
  REMARK    GeneRIF: this is the first study to explore and validate the
            relationships between seven SNPs in the FAM65B, AGBL4, and CUX2
            genes and ATDH in a Chinese population. On the basis of this
            case-control study, SNP rs10946737 in FAM65B may be associated with
            susceptibility to ATDH in Chinese Han anti-TB treatment patients.
REFERENCE   5  (bases 1 to 6703)
  AUTHORS   Barington,M., Risom,L., Ek,J., Uldall,P. and Ostergaard,E.
  TITLE     A recurrent de novo CUX2 missense variant associated with
            intellectual disability, seizures, and autism spectrum disorder
  JOURNAL   Eur J Hum Genet 26 (9), 1388-1391 (2018)
   PUBMED   29795476
  REMARK    GeneRIF: De novo variant c.1768G>A; p.(Glu590Lys) in CUX2 was
            identifies in a patient with intellectual disability, seizures, and
            autism spectrum disorder.
REFERENCE   6  (bases 1 to 6703)
  AUTHORS   Glaser,B., Kirov,G., Green,E., Craddock,N. and Owen,M.J.
  TITLE     Linkage disequilibrium mapping of bipolar affective disorder at
            12q23-q24 provides evidence for association at CUX2 and FLJ32356
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 132B (1), 38-45 (2005)
   PUBMED   15389760
REFERENCE   7  (bases 1 to 6703)
  AUTHORS   Jacobsen,N.J., Elvidge,G., Franks,E.K., O'Donovan,M.C., Craddock,N.
            and Owen,M.J.
  TITLE     CUX2, a potential regulator of NCAM expression: genomic
            characterization and analysis as a positional candidate
            susceptibility gene for bipolar disorder
  JOURNAL   Am J Med Genet 105 (3), 295-300 (2001)
   PUBMED   11353453
REFERENCE   8  (bases 1 to 6703)
  AUTHORS   Coqueret,O., Martin,N., Berube,G., Rabbat,M., Litchfield,D.W. and
            Nepveu,A.
  TITLE     DNA binding by cut homeodomain proteins is down-modulated by casein
            kinase II
  JOURNAL   J Biol Chem 273 (5), 2561-2566 (1998)
   PUBMED   9446557
REFERENCE   9  (bases 1 to 6703)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   10 (bases 1 to 6703)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC151245.1 and AC005805.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015267.3.
            
            Summary: This gene encodes a protein which contains three CUT
            domains and a homeodomain; both domains are DNA-binding motifs. A
            similar gene, whose gene product possesses different DNA-binding
            activities, is located on chromosome on chromosome 7. Two
            pseudogenes of this gene have been identified on chromosomes 10 and
            4. [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151245.1, AB006631.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261726.11/ ENSP00000261726.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4426              BC151245.1         152-4577
            4427-4427           AC005805.12        41462-41462
            4428-6703           BC151245.1         4579-6854
FEATURES             Location/Qualifiers
     source          1..6703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11-q24.12"
     gene            1..6703
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /note="cut like homeobox 2"
                     /db_xref="GeneID:23316"
                     /db_xref="HGNC:HGNC:19347"
                     /db_xref="MIM:610648"
     exon            1..76
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..4474
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein cut-like 2; homeobox protein cux-2"
                     /codon_start=1
                     /product="homeobox protein cut-like 2 isoform 1"
                     /protein_id="NP_056082.2"
                     /db_xref="CCDS:CCDS41837.1"
                     /db_xref="GeneID:23316"
                     /db_xref="HGNC:HGNC:19347"
                     /db_xref="MIM:610648"
                     /translation="MAANVGSMFQYWKRFDLRRLQKELNSVASELSARQEESEHSHKH
                     LIELRREFKKNVPEEIREMVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPDP
                     VPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPELLSPKEQREGTSPAGPTLTE
                     GSRLPGIPGKALLTETLLQRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHSALKATQ
                     AELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRL
                     ACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEASANQ
                     IADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSLPQGMAKPE
                     DSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPG
                     PEDPLSPSPGQPLLGPSLGPDGTRTFSLSPFPSLASGERLMMPPAAFKGEAGGLLVFP
                     PAFYGAKPPTAPATPAPGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQL
                     LKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLA
                     LRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANG
                     TTPASTSEDAIKSILEQARREMQAQQQALLEMEVAPRGRSVPPSPPERPSLATASQNG
                     APALVKQEEGSGGPAQAPLPVLSPAAFVQSIIRKVKSEIGDAGYFDHHWASDRGLLSR
                     PYASVSPSLSSSSSSGYSGQPNGRAWPRGDEAPVPPEDEAAAGAEDEPPRTGELKAEG
                     ATAEAGARLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGI
                     CQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQAVGQQPG
                     ASQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSGKMYSG
                     SQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSR
                     PKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSES
                     PATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQ
                     LNLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPD
                     SETEDQKPTVKELELQEGPEENSTPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGE
                     LDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPL
                     SFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSAS
                     PTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERAANREEALEWEF"
     exon            77..187
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            188..235
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            236..314
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            315..449
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            450..573
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            574..650
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            651..717
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            718..766
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            767..871
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1063
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1122
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1171
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1271
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1913
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2015
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2779
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2939
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3209
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3398
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3672
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..6703
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6684..6689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /note="hexamer: AATACA"
     polyA_site      6703
                     /gene="CUX2"
                     /gene_synonym="CDP2; CUTL2; DEE67; EIEE67"
                     /note="major polyA site"
ORIGIN      
        1 gatagccccc aagatggccg ccaatgtggg atcgatgttt caatattgga agcgatttga
       61 tctacggcga ctccagaagg agcttaattc cgtcgcttct gagctgtctg cacggcagga
      121 ggagagtgaa cattctcata aacatttaat tgaactccgc cgggaattta agaaaaatgt
      181 acctgaggaa atcagagaga tggtggctcc tgtattaaaa agcttccaag ccgaggtggt
      241 ggcccttagt aagagaagtc aggaggcgga ggctgctttt ctgagtgttt acaagcaatt
      301 aattgaagca ccagaccccg tgcctgtgtt tgaggcggca cgcagcctag acgacagact
      361 gcagcccccc agctttgacc ccagtgggca gccccggcga gacctccaca cttcgtggaa
      421 gaggaacccc gagctcctca gccccaaaga gcagagagag gggacgtcgc ctgccgggcc
      481 cacgctgacc gagggaagcc gcctcccagg cattcccggg aaagccctcc tgacagaaac
      541 cttgctgcag agaaatgagg cggaaaaaca aaagggcctt caagaagtac agatcacttt
      601 ggcggccaga ctgggggagg cagaggagaa aatcaaagtc ctacattcag cgctaaaggc
      661 tacgcaggca gagctgctag agctgcggcg gaagtacgac gaggaggcag catccaaggc
      721 agatgaagtc ggcctgatca tgaccaacct ggagaaagct aatcagcgag ctgaggctgc
      781 ccagcgggag gtggaaagtc tccgggaaca gctggcctct gtcaacagct ccatccgcct
      841 ggcttgctgc tctccccagg ggcccagtgg ggataaggtg aacttcactc tgtgctcggg
      901 ccctcggctg gaggccgcgc tggcctccaa ggacagggag atcctgcggc tgctgaagga
      961 cgtgcagcac ctccagagct cactgcagga gctggaggag gcatccgcca accagatcgc
     1021 cgacctggag cggcagctca cggccaagtc cgaggccata gaaaagctgg aagagaagct
     1081 ccaggcccag tctgactatg aggaaattaa aacggagctg agcatcctga aagccatgaa
     1141 gctggcctcc agcacctgca gcctccccca gggcatggcc aagcctgaag actcactgct
     1201 tattgcaaag gaggccttct tccccacgca gaaattcctt ctggagaagc ccagcctcct
     1261 ggccagccct gaggaagacc catcagagga cgattccatc aaggattcac tgggcacgga
     1321 gcagtcctac ccctcccctc agcagctccc acctccacca gggccagaag accccctgtc
     1381 tcccagcccc gggcagcccc tgctgggccc cagcttgggg cctgacggca ctcggacttt
     1441 ctcgctgtcc cccttcccca gcctggcatc aggggagaga ctgatgatgc ccccagccgc
     1501 cttcaaggga gaggcgggcg gcctgctggt gttcccccca gccttctatg gcgccaagcc
     1561 ccccacagcc cctgccaccc cggcccctgg ccctgagcca ctgggcggtc ctgagcccgc
     1621 ggatggtggt gggggcggag cggcggggcc cggggcagag gaggagcagc tggacacggc
     1681 agagatcgcc ttccaggtga aggagcagct gctgaaacac aacatcgggc agcgggtgtt
     1741 tgggcattac gtgctggggc tgtcgcaggg ctcggtcagc gagatcctag cccggcccaa
     1801 gccctggcgc aagctcacgg tgaagggcaa ggagcccttc atcaagatga agcagttcct
     1861 gtcggatgag cagaatgtac tggcgctcag gaccatccaa gtgcggcagc gaggcagcat
     1921 caccccgaga atccgcacgc ctgagacagg ctcagacgac gccatcaaga gcattctaga
     1981 gcaggccaag aaggagatcg agtcgcagaa gggcggcgag cccaagacct cggtggcccc
     2041 gctgagcatc gccaacggca cgacccccgc cagcacctcg gaggacgcca tcaagagcat
     2101 cctggagcag gcacgccgtg agatgcaggc gcaacagcag gcgctgctgg agatggaggt
     2161 ggcgcccagg ggccgctcgg tgcccccctc gcccccggag cggccatcac tggccaccgc
     2221 gagccagaac ggggccccgg ccttggtgaa gcaggaggag ggcagcgggg gccccgcgca
     2281 ggcgccgctc ccggtcctgt cccccgccgc cttcgtgcag agcatcatcc gcaaggtcaa
     2341 gtccgagatc ggcgacgccg gctacttcga ccaccactgg gcctccgacc gcggcctgct
     2401 cagccgcccc tacgcctccg tgtcgccctc gctgtcctcc tcctcctcct ctggctactc
     2461 tggccagccc aacggccgcg cctggccccg cggggacgag gcccctgtgc cccccgagga
     2521 cgaggcggcg gcaggggcgg aggacgaacc ccccaggacg ggcgagctca aggctgaggg
     2581 cgcgacggcc gaggcgggcg cgcggctgcc ctactacccg gcctacgtgc cgcgcaccct
     2641 gaagcccacc gtgccgccgc tgacccccga gcagtacgag ctgtacatgt accgtgaggt
     2701 agacacgctg gagctcaccc gccaggtcaa ggagaagctg gccaagaacg gcatctgcca
     2761 gaggatcttc ggggagaagg tgctgggcct gtcacagggc agcgtgagcg acatgctgtc
     2821 ccggccgaag ccatggagca agctgacgca gaaggggcgg gagcccttca tccgcatgca
     2881 gctgtggctc tctgaccagc tcggccaggc agtgggccag cagcctggtg cctcccaggc
     2941 cagtcccaca gaaccaaggt cctcaccatc cccacccccc agccccacag agcctgagaa
     3001 gagctcccag gagccgttga gcctgtccct ggagagcagc aaggagaacc agcagccaga
     3061 gggccgctcc agctcctcgt tgagcgggaa gatgtactca ggcagccagg ccccaggggg
     3121 catccaggag atcgtggcca tgtcccccga gctggacacg tactccatca ccaagagggt
     3181 gaaggaggtc ctcacagaca acaatctagg gcagcggctg tttggggaaa gcatcctggg
     3241 tctgacacag ggctccgtgt ctgacctgct gtcccggccc aaaccctggc acaagctgag
     3301 cctgaagggg cgggagcctt ttgtccgcat gcagctgtgg ctcaatgacc cccataacgt
     3361 ggagaagctg agggatatga agaagctgga gaagaaagcc tacctgaaac gtcgctatgg
     3421 cctcatcagc accggctcag acagtgagtc cccggccacc cgctcagagt gccccagccc
     3481 ctgcctgcag ccccaggacc tgagcctcct gcagatcaag aagccccggg tggtgctggc
     3541 acccgaggag aaggaggcac tgcggaaggc ctatcagctg gaaccctacc cctcgcagca
     3601 gaccatcgag ctcctctcct tccagctcaa cctcaagacc aacaccgtca tcaactggtt
     3661 ccacaactac aggtcccgga tgcgccggga gatgttggtg gaggggaccc aggatgagcc
     3721 agaccttgat ccaagcgggg gtcctggaat cctaccgcca ggccactccc acccagaccc
     3781 caccccgcag agccctgact ctgagactga ggaccagaag ccaaccgtga aggaactgga
     3841 gcttcaggag ggccctgagg agaacagcac acccctgacc acccaggaca aggcccaagt
     3901 gaggatcaag caggaacaga tggaggagga tgctgaggaa gaggcaggca gccagcccca
     3961 ggactcaggg gagctggaca aaggccaagg tccccccaaa gaggagcatc ccgaccctcc
     4021 gggtaatgat ggactcccaa aagtggctcc cgggcccctc cttccaggtg gatccacccc
     4081 agactgtccc tcacttcatc cccaacagga gagtgaggcc ggggagcgac ttcacccgga
     4141 ccctttaagt tttaagtcag cctcagagtc ctcacgctgc agcctggagg tgtcactgaa
     4201 ctcgccctcg gccgcctcct caccaggcct catgatgtct gtgtcacctg tcccctcctc
     4261 ctcagctccc atctccccat ccccacctgg cgccccccct gccaaagtgc cgagtgccag
     4321 ccccactgct gacatggctg gagccttgca ccccagtgcc aaggtgaacc ccaacttgca
     4381 gcggcggcat gagaagatgg ccaatctgaa caacatcatt taccgagtag agcgggctgc
     4441 caatcgggag gaggccctgg agtgggagtt ctgaaggcag ggtgaggggg caagggacat
     4501 accctggtaa ctaccttcct tctcgcactt actctcctca acaggatggg gtaagggagg
     4561 gaggaactca accatcaaaa tgtggacagc aatgttatgc cgtttacgtt ttttgttgta
     4621 atcctagttc tatgaagctg tgtgagcagg tgggtcaaat gccattgcct ccacttttct
     4681 gcacccccct gctcctcttc accctgaccc ctctgcagga ggcagaagca aaatggcacc
     4741 acatattcac ctgaaaactc caaactcttt tagaaaaata aataaatatt tatagacctc
     4801 ttttagatat tttaataaag gatcctttgg aatttatccc agctgatgct gttttgatat
     4861 tacagagagt tataaaatca ggatgctgtc acaactgttg cgaagtatac actgaagttg
     4921 tgtcgttttt gccactagat gagattaaaa gaagacaatt attcaaagcc atcacaaaac
     4981 actataagac tgaccaaaat ttagataacc tttgaaccac gatttttttc cacatctgtc
     5041 tgtgagacac agcgcaatgc tactgccctt ccagaaactg tgctaaaaag agaaagtcca
     5101 aaagactcta aacaaaaacc tcgacgccgt tgaggatgtg tttcattctg gtggtctgtt
     5161 ttgcaagctt gataacagaa tgtccgtgcc attgtaaatg ttgtagagat gtgggccgtg
     5221 gcccaaccgt cctatatgag atgtagcatg gtacagaaca aactgcttac acaggtctca
     5281 ctagttagaa acctgtgggc catggaggtc agacatccat cttgtccatc tataggcaag
     5341 aagtgtttcc agatcctttg gaaaggtggg catggggcag gtgcttggag agtggcgttt
     5401 gagccagagc gaccccattt cccgtgtgaa ccataggcac aacccaggaa gtttccccac
     5461 ttgtaggagt gtgggtattc cagagcaaga ctgtggccac catcttcccc tcttggtgtt
     5521 ttccgaaagt gacagtgttg gtcatcccat gaccactgaa gcttagtaac cagcgccaaa
     5581 aagtagattc atcaaactag agaccccagc tccccttctc gccatcttct ttctcaagtt
     5641 gaccgtggtg ctgtttctgg aaggcatctg caactccaag tccatgcaga actctggaag
     5701 gccaagttca tcgcagcatg ttcaccatat cccagcctcc aaatctatcc tcctaccttc
     5761 caacgcatga cctgttgggg agcagagact taacccccaa ctcagaggaa cccttcctcc
     5821 agcgtctttg gcatggtttc tagggtgaga gttcccaatt tggatagaac ggccaccata
     5881 ttggttactg aatctctctc ccttgttttt attacgtttc ctttttcaaa ctgtccatgg
     5941 gaaggctgaa ttgagtgact ccccagaatg aagatgagaa ggtgaatata atcaatgcca
     6001 atgtaatgcc agcgggtgag atggccgatg gaggtttcaa agatgtagct agcattttga
     6061 aaccatatgg gcaaaacccg gcaaccagaa ggggacagat aaggaccgtt ccagaaatcc
     6121 caactctcac acccagccca ggctgcagtc tccacaccaa acagtcaaca aaacacaaac
     6181 cctgaaggaa aaccttttcc atacacccag gctatgcatt gaagagtttt ccactgtata
     6241 catttttatc cagatgaagg tatttttata ttttgacaat aggaaacagt gaccattttc
     6301 agagtaatca aatctggaac aaatgaaaca tcttttagcc accaccaccc tgttgcaatt
     6361 aagacaaccg tgggggaaca caccactttt tactgttgaa accaacacaa cgttgaaatc
     6421 caggcttata cgcagactcc gattcctaga gaactaaatt tggctttagt gtgacgggat
     6481 ttgattaagc acttagtata gtcttttgaa cacggaaatc ctgttgtact taaagctagc
     6541 ggacccgtga acaactttgt caggttcacg tcctataacg gttaaaaaac acacacacac
     6601 atacacaaac cgtttctatg agagattgat gaactttgtt taaaatttta aaaaaaggaa
     6661 cacgttctgt aaacgagtcg ctaaatacag aattgtataa taa
//
