LOCUS       NM_181552              13723 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens cut like homeobox 1 (CUX1), transcript variant 1,
            mRNA.
ACCESSION   NM_181552
VERSION     NM_181552.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13723)
  AUTHORS   Zhang,H., Zhong,L., Wang,M., Wan,P., Chu,X., Chen,S., Zhou,Z.,
            Shao,X. and Liu,B.
  TITLE     p110CUX1 promotes acute myeloid leukemia progression via regulating
            pyridoxal phosphatase expression and activating PI3K/AKT/mTOR
            signaling pathway
  JOURNAL   Mol Carcinog 63 (11), 2063-2077 (2024)
   PUBMED   38994801
  REMARK    GeneRIF: p110CUX1 promotes acute myeloid leukemia progression via
            regulating pyridoxal phosphatase expression and activating
            PI3K/AKT/mTOR signaling pathway.
REFERENCE   2  (bases 1 to 13723)
  AUTHORS   Wu,Y., Jiang,D., Liu,Q., Yan,S., Liu,X., Wu,T., Sun,W. and Li,G.
  TITLE     Cathepsin L induces cellular senescence by upregulating CUX1 and
            p16INK4a
  JOURNAL   Aging (Albany NY) 16 (13), 10749-10764 (2024)
   PUBMED   38944813
  REMARK    GeneRIF: Cathepsin L induces cellular senescence by upregulating
            CUX1 and p16[INK4a].
REFERENCE   3  (bases 1 to 13723)
  AUTHORS   Yue,R.Z., Wang,J., Lin,F., Li,C.J., Su,B.H. and Zeng,R.
  TITLE     CUX1 attenuates the apoptosis of renal tubular epithelial cells
            induced by contrast media through activating the PI3K/AKT signaling
            pathway
  JOURNAL   BMC Nephrol 25 (1), 192 (2024)
   PUBMED   38849771
  REMARK    GeneRIF: CUX1 attenuates the apoptosis of renal tubular epithelial
            cells induced by contrast media through activating the PI3K/AKT
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13723)
  AUTHORS   Wang,M., Zhong,L., Zhang,H., Wan,P., Chu,X., Shao,X., Chen,S.,
            Zhou,Z., Yu,L. and Liu,B.
  TITLE     p200CUX1-regulated BMP8B inhibits the progression of acute myeloid
            leukemia via the MAPK signaling pathway
  JOURNAL   Med Oncol 41 (7), 166 (2024)
   PUBMED   38819709
  REMARK    GeneRIF: p200CUX1-regulated BMP8B inhibits the progression of acute
            myeloid leukemia via the MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13723)
  AUTHORS   Liu,W., Kurkewich,J.L., Stoddart,A., Khan,S., Anandan,D.,
            Gaubil,A.N., Wolfgeher,D.J., Jueng,L., Kron,S.J. and McNerney,M.E.
  TITLE     CUX1 regulates human hematopoietic stem cell chromatin
            accessibility via the BAF complex
  JOURNAL   Cell Rep 43 (5), 114227 (2024)
   PUBMED   38735044
  REMARK    GeneRIF: CUX1 regulates human hematopoietic stem cell chromatin
            accessibility via the BAF complex.
REFERENCE   6  (bases 1 to 13723)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
  REMARK    GeneRIF: Data report the characterization of a mammalian
            coiled-coil protein, CASP, a Golgi protein that shares with giantin
            a conserved histidine in its transmembrane domain.
REFERENCE   7  (bases 1 to 13723)
  AUTHORS   Chernousov,M.A., Stahl,R.C. and Carey,D.J.
  TITLE     Schwann cells secrete a novel collagen-like adhesive protein that
            binds N-syndecan
  JOURNAL   J Biol Chem 271 (23), 13844-13853 (1996)
   PUBMED   8662884
REFERENCE   8  (bases 1 to 13723)
  AUTHORS   Scherer,S.W., Neufeld,E.J., Lievens,P.M., Orkin,S.H., Kim,J. and
            Tsui,L.C.
  TITLE     Regional localization of the CCAAT displacement protein gene
            (CUTL1) to 7q22 by analysis of somatic cell hybrids
  JOURNAL   Genomics 15 (3), 695-696 (1993)
   PUBMED   8468066
REFERENCE   9  (bases 1 to 13723)
  AUTHORS   Neufeld,E.J., Skalnik,D.G., Lievens,P.M. and Orkin,S.H.
  TITLE     Human CCAAT displacement protein is homologous to the Drosophila
            homeoprotein, cut
  JOURNAL   Nat Genet 1 (1), 50-55 (1992)
   PUBMED   1301999
REFERENCE   10 (bases 1 to 13723)
  AUTHORS   Ottolenghi,S., Mantovani,R., Nicolis,S., Ronchi,A. and Giglioni,B.
  TITLE     DNA sequences regulating human globin gene transcription in
            nondeletional hereditary persistence of fetal hemoglobin
  JOURNAL   Hemoglobin 13 (6), 523-541 (1989)
   PUBMED   2481658
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005096.4, M74099.1,
            BC066592.1, AC005088.3 and BC040199.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_181552.3.
            
            Summary: The protein encoded by this gene is a member of the
            homeodomain family of DNA binding proteins. It may regulate gene
            expression, morphogenesis, and differentiation and it may also play
            a role in the cell cycle progession. Several alternatively spliced
            transcript variants encoding different isoforms have been
            identified.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) has an alternate 5' exon, as
            compared to variant 4. The resulting isoform (a) has a shorter and
            distinct N-terminus, as compared to isoform d.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M74099.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292535.12/ ENSP00000292535.7
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC005096.4         125081-125108
            29-1657             M74099.1           58-1686
            1658-4537           BC066592.1         1697-4576
            4538-12332          AC005088.3         43992-51786
            12333-13723         BC040199.1         1809-3199
FEATURES             Location/Qualifiers
     source          1..13723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..13723
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /note="cut like homeobox 1"
                     /db_xref="GeneID:1523"
                     /db_xref="HGNC:HGNC:2557"
                     /db_xref="MIM:116896"
     exon            1..44
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..4532
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /note="isoform a is encoded by transcript variant 1; golgi
                     integral membrane protein 6; protein CASP; cut homolog;
                     putative protein product of Nbla10317; homeobox protein
                     cux-1; CCAAT displacement protein; CUX1 gene Alternatively
                     Spliced Product; mutant CUX1; CDP/Cux p200"
                     /codon_start=1
                     /product="Homeobox protein cut-like 1 isoform a"
                     /protein_id="NP_853530.2"
                     /db_xref="CCDS:CCDS5721.1"
                     /db_xref="GeneID:1523"
                     /db_xref="HGNC:HGNC:2557"
                     /db_xref="MIM:116896"
                     /translation="MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKN
                     TPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQ
                     LKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETI
                     ALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY
                     DEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV
                     EQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAK
                     NSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSL
                     QSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQ
                     FSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFS
                     TGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIK
                     HNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALR
                     SIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKREL
                     QVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITI
                     LTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQG
                     AADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGG
                     SGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSS
                     PIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLG
                     LSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVT
                     SLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSK
                     PPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQ
                     RLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRM
                     EKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRA
                     YQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD
                     SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPS
                     GTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPS
                     SAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKA
                     ASREEPIEWEF"
     exon            45..155
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            156..203
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            204..282
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            283..420
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            421..544
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            545..621
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            622..688
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            689..737
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            738..842
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1031
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1090
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1139
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1236
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1908
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1974
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2076
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2921
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3087
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3144
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3447
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3636
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3901
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..13723
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13698..13703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /note="hexamer: AGTAAA"
     polyA_site      13723
                     /gene="CUX1"
                     /gene_synonym="CASP; CDP; CDP/Cut; CDP1; Clox; COY1;
                     CUTL1; CUX; Cux/CDP; GDDI; GOLIM6; Nbla10317; p100; p110;
                     p200; p75"
                     /note="major polyA site"
ORIGIN      
        1 actctgccag gtggatgttg tgcgtagccg gagccaggtt gaagagagaa ctcgatgcca
       61 ccgcaacggt attggcgaac cggcaggatg aaagtgagca gtccagaaag cggcttatcg
      121 aacagagccg ggagttcaag aagaacactc cagaggattt gcgcaagcag gtagcgccgc
      181 tgctgaagag tttccaagga gagattgatg cactgagtaa aagaagcaag gaagctgaag
      241 cagctttctt gaatgtctac aaaagattga ttgacgtccc agatcccgta ccagctttgg
      301 atctcggaca gcaactccag ctcaaagtgc agcgcctgca cgatattgaa acagagaacc
      361 agaaacttag ggaaactctg gaagaataca acaaggaatt tgctgaagtg aaaaatcaag
      421 aggttacgat aaaagcactt aaagagaaaa tccgagaata tgaacagaca ctgaagaacc
      481 aagccgaaac catagctctt gagaaggaac agaagttaca gaatgacttt gcagaaaagg
      541 agagaaagct gcaggagaca cagatgtcca ccacctcaaa gctggaggaa gctgagcata
      601 aggttcagag cctacaaaca gccctggaaa aaactcgaac agaattattt gacctgaaaa
      661 ccaaatacga tgaagaaact actgcaaagg ccgacgagat tgaaatgatc atgacggacc
      721 ttgaaagggc aaaccagagg gcagaggtgg ctcagagaga ggcggagacc ttaagggaac
      781 agctctcatc ggccaatcac tccctccagc tggcctcaca gatccagaag gcaccagacg
      841 tggagcaggc catagaggtg ctgacccgct ccagcctaga agttgagttg gccgccaagg
      901 agcgggagat cgcacagctg gtggaggacg tgcagagact ccaggccagc ctcaccaagc
      961 tgcgggagaa ttcggccagc cagatctcac agcttgagca gcagctgagc gccaaaaaca
     1021 gcacactcaa acaactggaa gaaaaactca aaggccaggc tgactatgaa gaggtgaaga
     1081 aagagctgaa cattctgaag tccatggagt ttgcaccgtc cgagggcgct gggacacagg
     1141 atgcggccaa gcccctggag gtgctgttgc tggagaagaa ccgctcgctg cagtccgaga
     1201 acgccgcgct gcgcatctcc aacagcgacc tgagcgggtc agccaggagg aaagggaaag
     1261 accagcctga aagtcggcgc ccgggatctt tgccggcccc ccctccttct cagttgcccc
     1321 gcaacccggg ggagcaggct tccaatacta atggtacaca ccagttctca ccagcggggt
     1381 taagtcaaga ctttttcagc tcatccctgg caagccccag cctacccctg gcttctacag
     1441 gaaaatttgc actaaactct cttctccagc ggcagctaat gcagtccttc tactccaagg
     1501 ctatgcagga agccggaagc acaagcatga ttttttcaac aggtccatac agcacaaact
     1561 ccatatcttc ccaaagtcca ttacaacaaa gcccagatgt caatggcatg gccccatccc
     1621 ccagccagtc agaaagtgct gggagcgtct ccgagggcga ggagatggac actgcagaaa
     1681 tcgcccggca ggtcaaagag cagctgatta agcacaatat cggacaacgt attttcggac
     1741 attatgtgtt gggactgtct caagggtccg tgagcgagat tctggcccgg cccaagccat
     1801 ggaataaact gactgttcgt ggcaaggagc catttcacaa gatgaaacag ttcctctccg
     1861 atgagcagaa catcctggcc ctccgtagca tccaaggcag acaaagagag aatccaggcc
     1921 agagcctgaa cagactattt caggaagtac cgaaacgaag aaatgggtct gaaggtaaca
     1981 tcaccacccg gatccgagcc tcggagactg gctctgatga agccatcaag tccatcctag
     2041 agcaagccaa gagggagctc caagtgcaga aaactgcaga gccggcccag ccttcctccg
     2101 catccggcag cgggaactct gatgacgcca tccgctccat cctgcagcaa gcccgccggg
     2161 agatggaggc ccagcaggct gccctcgacc ctgccttaaa gcaggcacca ctgtcccaga
     2221 gtgacatcac catcctcacc cccaagcttc tgtccacctc gcccatgccc accgtgtcca
     2281 gctacccacc tctcgccatc tccctgaaga agccctccgc agctcctgag gccggtgcct
     2341 ctgctctgcc gaaccccccg gccctcaaaa aggaggccca ggacgccccc gggctggacc
     2401 cccagggagc agccgattgt gcacaagggg tcctgagaca ggtgaaaaat gaggtgggcc
     2461 gcagcggtgc ctggaaggac cactggtgga gcgcggtgca gccggagaga agaaatgccg
     2521 cctcctccga ggaggccaag gccgaagaaa cgggcggcgg gaaagagaag ggcagcggtg
     2581 gcagcggagg tggcagccag cctcgggccg agcgcagtca gctccaggga ccctcgtcgt
     2641 cagagtactg gaaggagtgg cccagcgctg agtccccata ctcccagagc tcagagctga
     2701 gtctgaccgg ggccagccgc agcgagacac cacagaacag ccccctgcca tcctccccga
     2761 tcgtgcccat gtccaagccc accaagccct cggtcccccc gctgaccccc gagcagtacg
     2821 aggtctacat gtaccaggag gtggacacca tcgagctcac ccggcaggtt aaggaaaagc
     2881 tggccaagaa cggcatctgc cagagaatct tcggggagaa ggtgctgggc ctgtcccagg
     2941 gcagcgtcag cgacatgctg tcccgaccga agccatggag caagctgacg cagaaaggcc
     3001 gagaaccctt catccggatg cagctctggc tgaacggcga gctaggccag ggtgttctac
     3061 ccgtccaggg ccagcagcaa gggccagtcc tccactccgt gacatcgctc caggacccgc
     3121 tgcagcaggg ctgtgtgagc tcagaaagca ctccaaagac ctccgccagc tgcagccctg
     3181 cccctgagtc cccgatgagt tccagtgagt cggtgaagag cctgaccgag ctggtccagc
     3241 agccctgtcc ccccatcgag gcgagcaagg acagcaagcc accagagccc agtgacccgc
     3301 cagcatccga ctcccagccc acaaccccgc tgcctctctc cggacactcg gccctcagca
     3361 tccaagaatt agtagccatg tccccggagc tggacaccta cggcataacc aagcgggtga
     3421 aggaggtgct gacggacaac aacctcggcc agcgcttatt tggggagacc atcttagggc
     3481 tcacccaagg ctctgtctct gacctccttg cccgccccaa accctggcat aagctcagtc
     3541 tgaaaggacg agagcccttc gtccggatgc agctgtggct gaacgacccc aacaatgtgg
     3601 agaagctgat ggacatgaaa cggatggaga agaaagccta catgaagcgg cggcacagct
     3661 cagtcagtga cagccagccc tgcgaaccgc cctctgtcgg caccgagtac agccagggcg
     3721 ccagccccca gccccagcac cagctgaaga aaccccgggt ggtgctggct ccggaggaga
     3781 aggaggcgct gaaacgagcg tatcagcaaa agccataccc gtcaccaaaa accatcgaag
     3841 acctcgccac ccagctcaac ctgaaaacca gcaccgtcat caactggttc cacaactaca
     3901 ggtctcggat ccgcagagaa ctgttcattg aggaaattca ggccgggagt cagggccagg
     3961 cgggcgccag cgactcaccc tcggcccgca gcggccgggc ggcgcccagc tcggagggcg
     4021 acagctgcga cggcgtggag gccactgagg gcccaggcag cgccgacacc gaggagccca
     4081 agtctcaggg agaggccgag cgggaggagg tgccgcggcc ggcggagcag acggagccgc
     4141 cgccctcggg gaccccgggc ccggacgacg cccgcgacga cgaccacgag ggaggccccg
     4201 tggaaggccc ggggcccctg cccagccccg cctccgcgac cgccaccgcc gcgcccgcgg
     4261 cccccgagga cgccgctacc tcagccgccg ccgcgccggg ggagggcccc gcggccccga
     4321 gctccgcgcc gccgcccagc aacagcagca gcagcagcgc cccccgcagg cccagctcgc
     4381 tgcagagcct tttcggcctc cccgaggccg cgggcgcccg ggactcgcgc gacaaccccc
     4441 tgcgcaagaa gaaggccgcg aacttgaaca gcatcatcca ccgcctggag aaggccgcca
     4501 gccgggagga acctatcgaa tgggagttct gaggggccgc ggccctgggg cgggcagcca
     4561 ggctgggccg caagggcctg gacggggtcg gacggggcag gcgctgcgga caccgtggcc
     4621 tgggcttggc ccgcggcctg caccgacccc gggccggacc tgagcccgca gcccagaccc
     4681 cctccacggt ccgcggcctg caccgacccg aggcccagat ccaaggccgc ggcccagacc
     4741 cactctgcgg cccgggccga ccctgcggcc tccaccaacc ccgcggccca gacccagccc
     4801 gcggcctgga cccctggacc gctttgcgca cttaccgccc tgcgggccac agggcaaaat
     4861 cgccataggc caaggtgcat atagaaaaca aaggagcatt aagcccaatc tatgtcgtgt
     4921 tttcaaggaa gaaaacggaa atgtgtggtc gagctttttt gtaccctgaa gtgttttttt
     4981 tattgcccta agtgatttcc acaggttctg gaataactct tacagctttg ccttgtgtcc
     5041 tcctgttccg tgtgggcttt aaaagaaaaa aaatcaaacc cacatattaa aagggggctt
     5101 tttatctgcc atctaatggc ttcagagcga taatacacta ttatcttctt aaaccaggaa
     5161 aaaataaaag ggggggtggg atttttcaga aaaattaaaa aagaaagttt ttgtagctgt
     5221 tcagttgcca ctaagagatt gcacagtcaa aacgactcta aacacactag tttggattcc
     5281 taaatatttt caagaaaaga atcttctcgt ttgaaacttt gaattaaaat aaaacacatt
     5341 tactccacat attttttaac aaaaagaaaa cgtcacatca ggaaactctg attttgtggt
     5401 agctgacata gtgttttctt gtacgtgaat agaatcctga catgtagtgc acattgatgt
     5461 atagctttaa ctgaccctgg gttttgcaga ccagggtttg tttaatacac tccattctag
     5521 gccaaatcag gacaaaaaaa agaaaaaaaa agaaaaaaaa aaaagaaaag atccgaatct
     5581 aggtatttta taatctgctt tttaacctct aaccgcagag cacgctgatc agacctcata
     5641 tcttggaggt ttaggagaca agttagaact gtagcatgta cctgttaatt ttgtttaatt
     5701 tatggtgtct caatctgtct gtgcgtctgc acgtgtgcaa gcattgaaag aaaggagaga
     5761 gtagtccggg cgagcacagc aggcagttcc agggccagac gggcccatcc ccaagtagat
     5821 agcagtctac ggatctctct ctggcacaga aggcacctca cctcacacca ctctcctgga
     5881 tacctgatga actgagccct cccaggggaa gacactcccc aggcctgggc agggcttaca
     5941 cgcgcactct ctctcttctt tccctttttc ttcccaccgc aagcactgat gaccctgttg
     6001 aactcgtggg aaacttcctt tctctgcagg agagagaacg tggcattctg ggctccccac
     6061 tcccatccct gtagaaatgg cccaaactca caccaaaacg tggatgctct tcaacttcca
     6121 aacctaccat ttgcccttct ttcatttcgc ctcttagttc tttttatgca cagttttagg
     6181 gcagtctaag tacaaactga aagtctaact tgtctctgat tcctcccttg tctatgtgta
     6241 tatgcgtgag aatagaggcg ggtgagagtg tgcgtgcgtg tgcgtgtgtg caattttata
     6301 cgtctgtgta ttttcttaag tacctgtgca cacgtagagt gcattactgc cacctttttc
     6361 aataagctgt tttatcagtt acggcttcta caagtttgct aatttagact tctttattgc
     6421 catatcttta aactaacaat agatgatttc ggtatatata tatatttttt tttgcttatt
     6481 tataggtgct gtattttatt atctgattgt taggaaggga tgaaaggggc aaatattctt
     6541 tagagggata gactgccggc agtattgggt ataatttaca agatgtagtt gtcatactgt
     6601 atattactga ttgaaaactt tttgaccgta ttgtgtatca ttgaaacctt tgtcttaggt
     6661 caacatcttt ggatgacatt ttaatggtgc attcattatt tcttaagttt aattaatatt
     6721 actttttttt ttatttgggg ggtgggaggg agttataatt ttaaaggtat gctctggctg
     6781 ttccacctcc gtgtgcttgt taattaactt gtaggacttt gactgtaaga tgtgaaacca
     6841 cgtttcttgc atgatgtttt agagattatt tcatttacag tcttttaacc tgcagctgca
     6901 gcacttagtt cacgttttca caaatttcaa gagtcactac actaaagaca atgccttttc
     6961 atgaataaga agttttcaga aggctctagg gggctgggag gcaggctgtt cgtttgtctt
     7021 ttgttggggg tatcatttct gaacttgaaa tccagttcag ggagaagaga attcaaaatt
     7081 agaggagctt aaggggacac gggtcaacat ctagctcgat tcaggtgcat tgagaagagt
     7141 gagttcacat cggtgaccct taggacagtg agtggcagag ccctgacgac tgtggtgtcc
     7201 tctccacaaa accctcaagg gacttttgtc atcatgtgtg atgaatcttt aaatatcgtc
     7261 taattttcat aagaatgaaa agaagttaac aggaaatagt aggctagggt ttagttttaa
     7321 aggcatgact gttatttaca aaggtgttaa atctgaggaa attgacaaat acagatttgt
     7381 ccattctagt ggccaaacag taacagtcta aaatgcagtc attttgaccc tcccaagcaa
     7441 tttagtcata tgtgttgttt tctcttttct gtttttactt cttagatttt taactaggtt
     7501 actgttggtt cccattctgt cttttttgcc agacttacat ctggtgccag atacaatcag
     7561 ttggttaaat tttgcttgca gttctgtgta ttttttttcc tctattattt atttttttaa
     7621 aaaaaataga gatcctaacc ttagatcttt gatgtgaagc tagcactgtc tgtaatactt
     7681 ctaagagctg ccactaaaat aatacagcaa tccgtggcca ggggagcacc ccctcctggt
     7741 tgggcccctc agttggagtc taagggttaa tctctcatct tgctaagcag tattcaagtg
     7801 ccttgaacag tgtcccctcg gcatggctcc ccttcagcag gctggcattc caagcagtgg
     7861 cccccgcagg cagccgaccc ccttcctctt cacgctctat gagtttaaaa agctgatttg
     7921 tacctctccc ctgggggaaa cggttccata taaaacacta acacttaatt acaagctcca
     7981 ttatgccatt ttaaatggct tctttttgtt aattggaggc attgttcata acttaaggct
     8041 tttgccatta acttagctgg ctaagcagag gctcggggta aaatcagtgt ttgcatttag
     8101 cctcttgacc cggagttccg gcccaagctc ccttgtgata gccgagatgg caggtgtgtg
     8161 agttctgtcc tagacctgtg cccaactcac ttccacccca gaggagtctt ctgtcctcct
     8221 ccccaacccc cgagctccct ggtaacctcc tcttgaactt ctgtatcagt gaagacatct
     8281 gtggtttctg ctcaccagac ctctctttag aaagggttat cagagccatg gagcttagct
     8341 caattggatt cttctagacg atcttaggag gcatcttggc atgaggcagc ttctaagcgt
     8401 ctcctgggac aggattgggg tgacagccca gggatgcatg catgggagaa ctctctgaga
     8461 aatgccagga tcgtggctca cagggaccca ccatcaaaac ctgctacttt gtgcaagtaa
     8521 ttgaggcaaa agataccagt cgacagcctc cctggggtag atcccttgta cctccaaagt
     8581 acaaatacct ccctgctcag tttccttcct gtcgccatct ttgttttctt cccattgaaa
     8641 aaccatcctg tctgatgtgg acgttcaggt ctgctggttg gcggtccggg cccagagtgc
     8701 agcagagctc tgggttaaat attcctttct ggccaccgcc caagcccagg tggccagctc
     8761 tcatacccca tctccctcct tggccagggc cagcatcagg cgtgcagctc atgaccagtt
     8821 tacacaggct gcaaagagat cgctgtgggc ctcggctgac tactttaaga ttatgccaca
     8881 gccaggccct aaaaagagag gggaacagga gtccccaggt gagctctctg acgggcaggt
     8941 gccttcccga ctaaggttgg actggatgac tttgttcctc ctgcatgcat gtcctttgat
     9001 gcaagggtga tcaatgaact ctgttgacat tctatgcaat gtttttcatt cctctgattt
     9061 tagcaaagca aatcttactg aaaaatagca gagccagggg aacagacgca tgtccttctg
     9121 ggagtcacac aaaagcagag agattttgaa ctgaggggcg acagcctttg ccttaaatgc
     9181 agtatgacag gcgcttcttg gcagaccagt aaaaacaaaa gcccatagac cttactcatc
     9241 ccaaggccga caagccagct gtacagggcg agatgtagca acacggggca tgagcggtgg
     9301 gcgtgctggg ctatttgctg tggtacttta ggctggaggt ttggctcctg tgctgccggt
     9361 ggggggccct gtccctcccc agatgtcctc cctcttcttc acactcctca ttgtcccttc
     9421 tacctcacta acctgtcttc tccatctgat gtcacccaga accacacccc acagaactgt
     9481 gaggcacgtg ggctggagag agcagaaaag ctgccagcgc agcagacacg aacatccctc
     9541 tgcctggtgg gccggctttg tgtgtctctc cttttgtgag cgcaacacgg acaaacagct
     9601 gtgctctgca aggcacacgg atgtttccct tccacctgtt cccaaagctc cagcagctgt
     9661 ttcttttgca ggcagggcgt ggtctcgggg ctccgagggt cttgtctttg gtccgccttc
     9721 ctttctgtcc agtcctgctc agctgttaag atccatcatg gccattatcc ttgtcccgga
     9781 ctgccccaaa gttcccagct ggctttgggg aacactgtag ctcttgggtg tctcttgtct
     9841 ctggcatggt tttagcgtca ctgcgaacac tcctttgcaa acatcaaaca tctcaaagac
     9901 ggaaaaggat agatggcttc ctccagccta cacgccccgt ccacagtggc atcaccctct
     9961 tatcccaaaa gaatatgcca gttcccatcc agcaccgaag aaaatcagct cctggggctg
    10021 gtggttggag gtgggtctgt ccactgtggg ggccaaagtg ttcccctgct ggagacagtt
    10081 tgcaagtaag aacctaagga tggggacagc atcctgtgct tgggcattga ccagccaaag
    10141 ctcacattta gaaagccctc agtgcttctg tggtttcacc tgggcatcga cgacattagg
    10201 gaagcctttg tgaccacaag ggcagggctt gtgccctgag tggcgaggtg gtgacctgag
    10261 gccagtgtga tgtggttgga tctcagcgtg tactgaatgc cagtctggcc ggcacactcg
    10321 aacgctaaga gaatggtcca atttgatgat cttatttcta tttcgatcag gttttgactt
    10381 tttgtagatg aaaactacca gggaaaaggg gaagcaggta cccaataaag tttagaaaga
    10441 tccagtctgt gaaaccctta gagatgggct gaaagttaag tccaccaacc cttgggctta
    10501 atcaggacgg aagaggaggg ggtgtggggg gcagagcgta aaacaagccc cagccctact
    10561 cccggccccc cagcccagtc ttcccaatcc cagaggcccc ggcggcctgt gctcctcacc
    10621 accctggtca ggggaataga aggaaatgca atttccgcct gtctgcccga cttccaaaaa
    10681 ctgcctcctc ctgcccaggc ctctcccacc accaccttcc ctccaaagat aaccgtgtcc
    10741 atgccatccg tggcatcatc tcgagttttc atttttggat gaagtgacat ttagctttaa
    10801 caagacattt ccaaagcgcc tagtctcctc caaaatgcta actttaaaag ttgggcattg
    10861 taggcgaaaa atcccaaaaa aaaaaaaaga caaaaaaaaa aggctggcga gagaaagaca
    10921 tttggctatg cataaatgtg cacttccccc atgcccccgt tcttaaactc ttaagatgcc
    10981 tttgagttgc ttttcatgaa tccttttagt ttacccgata atgttaagaa agcattagtc
    11041 tacgttactg taatttctgt agtgtttacg ctttaatttc taccacaaaa tatgctatat
    11101 gctatgtatc aagctttctg taatcagaaa gaaaaggtgc cttatatccc aatgtcacgg
    11161 ctacatccct atggaaatta atcagaagca cagtgtgtac ggaagcattg ggacttctgc
    11221 tggtgaaaca agagaccatt cagcaagaca cattgaagtg gcacggagct gcttttgttt
    11281 tataattctt ttttcccccc ttttccttct tcttttttat tattttatta ttttttttgt
    11341 actttgcttt aaacggaaag cacttaaata gatgactatg tgtaaaagct ctgtgcaatt
    11401 gaaatcattt ttcttcattt taaaaaaata acgtattgca caccaaatga actcaaagta
    11461 agctttagac caggacgatt caggttatga atgagtttgt tcactgtagt tccgtttgtt
    11521 catgaaccga agggaaaaca ggcctccccg actccctcca gtctcccagc ctgcctcttg
    11581 gtgaccactg tgctgggcgt gcagggcccg cgggctctgg ccggagccgc tggcctgacg
    11641 aggcaggata gggagtatcc gtgattcaga agctgagacc cttccccagt gtctgaggcc
    11701 acagccatcc cttccagcac ttaatcttgt cttgttgaaa tggactgact gctactgacc
    11761 tgccggcgtg cgtgagggtg attataaaag gatgtttcct tgagaaaaaa aaaattattt
    11821 ctatcctctt ctatttatta ttaggttaat catttaagta cttatcagga gtgtattgtt
    11881 attttgtgtt ttgttgtcat aaatgctttt tgctgtcact ctagtggtta ctatcctctg
    11941 ccttcctctc ctcccctact cccccagaga accaaggcgt ctgggggatt gactgggggg
    12001 cagagggggt ttccccagca aaatcaaaca cctgtctcca gagtagccac tcaaaaactg
    12061 gtggtctcta tgtgtctaac tttttaaatg agagtgttta tgaacaaaaa aatttaccaa
    12121 cgtgtgaggg agttgctgag ttgaagaatg ctcgcttgag gagcttcaga ggaatcttag
    12181 caaagccaag ttcagttccc caaagcctcc tagagcctct ggtaagactt ctgggttcat
    12241 gaagtttcgg cgagccgtgg tcagagaggg cgcggtggcc tggccaagac tttacctcca
    12301 agcgagagag tgatttcttg caaggcccgc atgggttgat acgttttggt tggttttttg
    12361 ttgttgtttt tcttgcgtac aaagttggtc aaaaccatct ttcaaagcaa cagtgttttg
    12421 tagtaccagg ctgtggcttg agggctcacc taggagatca taggcagagg gcccctttcc
    12481 cctataggtg gttcaacgtg gaggaaggtt gggtgtggag attgcttgct gtggccccaa
    12541 gctcagccag caggacaccc agttgttgcc aatcaggtgt gaaggtgagg cgccctgcct
    12601 tgatcccatg ggcccagcag aaggaaactt accccaggcc aaggcaaggg ccctgctcac
    12661 cccaaggtag gctgggaaga gcatctcttt ccatatcatc acctcccctt ctccaagatt
    12721 gccgggggcc ctgattttgt tctctctttg aaagaaaccc tccaccgaaa caatggtccc
    12781 catctcccca gaagcctttt tttttttcat ttttctctaa ttagtctatg catttctctc
    12841 tctcaaacca tcttctgcct cttcccttga gaaaacgggc atctcacgta cccccatctg
    12901 agacctcttg gaaaaaaaaa atcccgtgta ttctggagat gtgagaattc acccaaaatt
    12961 cttaaaacat tggagaatag cttgttataa aataaaagtg ggggtaaaaa gaaggtggtt
    13021 ttccccacat ccctttgcat tgaataagag acctagttct ttgcgtttgt gcaataactc
    13081 tttgctgctt gccttgagag cgggtagcac cacgctcctg tccagactac taacagcaca
    13141 agacgcactc acagggtggc ggaatcttcc ggaaaactct ctataagctc agctcccccc
    13201 accccacccc cactctagcg ttttgtcacg tcttacattt tagcagtatt ttatattttc
    13261 tgtaacgcac caagtcttag atctttctag agcttgtttg ttcatcctca caatcacaga
    13321 tttttttctc caatcctcac agagacccaa ttgaccaaaa aagaaaaaag gaaaaaaaaa
    13381 aagtcgtctt tttttttttt ttttgtacaa atcgctttga gatgcctctg gtgtgttgct
    13441 gtgtgacatc tctctggtaa cattttattt cttgctattt gtttttctac attaagagtc
    13501 aaagttgacc tggctggcgt gggggtgggg gaggcacccg tcggcccctt ggtgttgtcc
    13561 ctctgtcttt ggttagccat acgatgtttg ttctcagcac tgtacaacgg tccctatata
    13621 atacggagaa gcaatatcac tgtatgagac tcacaccatg tattattatt cactagcacc
    13681 ctaggtgtga taattgaagt aaatatcttt tatacaaaca caa
//
