LOCUS       NM_015960               1332 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cutC copper transporter (CUTC), mRNA.
ACCESSION   NM_015960
VERSION     NM_015960.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Aksu,M., Pleiner,T., Karaca,S., Kappert,C., Dehne,H.J., Seibel,K.,
            Urlaub,H., Bohnsack,M.T. and Gorlich,D.
  TITLE     Xpo7 is a broad-spectrum exportin and a nuclear import receptor
  JOURNAL   J Cell Biol 217 (7), 2329-2340 (2018)
   PUBMED   29748336
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Li,Y., Du,J., Zhang,P. and Ding,J.
  TITLE     Crystal structure of human copper homeostasis protein CutC reveals
            a potential copper-binding site
  JOURNAL   J Struct Biol 169 (3), 399-405 (2010)
   PUBMED   19878721
  REMARK    GeneRIF: Results suggest that hCutC functions as an enzyme with
            Cu(I) as a cofactor rather than a copper transporter and the
            potential Cu(I)-binding site consists of the two Cys residues and
            other conserved residues in the vicinity.
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Li,J., Ji,C., Chen,J., Yang,Z., Wang,Y., Fei,X., Zheng,M., Gu,X.,
            Wen,G., Xie,Y. and Mao,Y.
  TITLE     Identification and characterization of a novel Cut family cDNA that
            encodes human copper transporter protein CutC
  JOURNAL   Biochem Biophys Res Commun 337 (1), 179-183 (2005)
   PUBMED   16182249
  REMARK    GeneRIF: Cloning, expression and subcellular localization of CutC.
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Gupta,S.D., Lee,B.T., Camakaris,J. and Wu,H.C.
  TITLE     Identification of cutC and cutF (nlpE) genes involved in copper
            tolerance in Escherichia coli
  JOURNAL   J Bacteriol 177 (15), 4207-4215 (1995)
   PUBMED   7635807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD107559.1, BC011016.1 and BM738181.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015960.2.
            
            Summary: Members of the CUT family of copper transporters are
            associated with copper homeostasis and are involved in the uptake,
            storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed
            7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.263541.1,
                                           SRR1803611.256703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370476.10/ ENSP00000359507.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               CD107559.1         60-577
            519-1331            BC011016.1         510-1322
            1332-1332           BM738181.1         193-193
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..1332
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /note="cutC copper transporter"
                     /db_xref="GeneID:51076"
                     /db_xref="HGNC:HGNC:24271"
                     /db_xref="MIM:610101"
     exon            1..176
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..937
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /note="cutC copper transporter homolog"
                     /codon_start=1
                     /product="copper homeostasis protein cutC homolog"
                     /protein_id="NP_057044.2"
                     /db_xref="CCDS:CCDS7483.1"
                     /db_xref="GeneID:51076"
                     /db_xref="HGNC:HGNC:24271"
                     /db_xref="MIM:610101"
                     /translation="MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERG
                     GADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKAD
                     IRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALET
                     LLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGA
                     TEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV"
     exon            177..248
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            249..308
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            309..518
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            519..554
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            555..688
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            689..716
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            717..822
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1332
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="CUTC"
                     /gene_synonym="CGI-32"
                     /note="major polyA site"
ORIGIN      
        1 gtcggggacg cgcgcacggg cgcgcgcagc tgttgacgcg cttcttagct ggtgcgcgcc
       61 ggagcccaaa ttccaagtgg aaactgcagg cgcacgaggg aggaacgcgt ggagcatgaa
      121 aaggcagggg gcctcctctg agcgaaaacg agcgcggata ccgtccggga aggccggagc
      181 agcaaatgga tttctcatgg aagtttgtgt tgattcagtg gaatcagctg tgaatgcaga
      241 aagaggaggt gctgatcgga ttgaattatg ttctggttta tcagaggggg gaactacacc
      301 cagcatgggt gtccttcaag tagtgaagca gagtgttcag atcccagttt ttgtgatgat
      361 tcggccacgg ggaggtgatt ttttgtattc agatcgtgaa attgaggtga tgaaggctga
      421 cattcgtctt gccaagcttt atggtgctga tggtttggtt tttggggcat tgactgaaga
      481 tggacacatt gacaaagagc tgtgtatgtc ccttatggct atttgccgcc ctctgccagt
      541 cactttccac cgagcctttg acatggttca tgatccaatg gcagctctgg agaccctctt
      601 aaccttggga tttgaacgcg tgttgaccag tggatgtgac agttcagcat tagaagggct
      661 acccctaata aagcgactca ttgagcaggc aaaaggcagg attgtggtaa tgccaggagg
      721 tggtataaca gacagaaatc tacaaaggat ccttgagggt tcaggtgcta cagaattcca
      781 ctgttctgct cggtctacta gagactcggg aatgaagttt cgaaattcat ctgttgccat
      841 gggagcctca ctttcttgct cagaatattc cctaaaggta acagatgtga ccaaagtaag
      901 gactttgaat gctatcgcaa agaacatcct ggtgtagcca gacctctctg agagacatgg
      961 atatcacagg atgaaggtag aactataatc tgcaattctc tatgacacag ctttaacctt
     1021 cttctctggc caggacagtc gcaatctttg ttttaagttt cacatggcca tggagaatgt
     1081 gcccaagaag aaaaagaatt tgaaacagag atacagtcac ttcctttgct tagtcttacc
     1141 agtgattgtc atcatggtta aagctggtct gtgcttcttc catagacaga agcttagtct
     1201 gttttcagtg gaattaattg atgaactggg aaaattttaa ctgcatggta tgaattcaga
     1261 gtgtgactta agggtcaatt caaagcagta ttttgacttt tcatttgtaa aataaaaatt
     1321 tccactatta ca
//
