LOCUS       NM_001014840             855 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cutA divalent cation tolerance homolog (CUTA),
            transcript variant 5, mRNA.
ACCESSION   NM_001014840
VERSION     NM_001014840.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 855)
  AUTHORS   Lafontaine,N., Shore,C.J., Campbell,P.J., Mullin,B.H., Brown,S.J.,
            Panicker,V., Dudbridge,F., Brix,T.H., Hegedus,L., Wilson,S.G.,
            Bell,J.T. and Walsh,J.P.
  TITLE     Epigenome-wide Association Study Shows Differential DNA Methylation
            of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease
  JOURNAL   J Clin Endocrinol Metab 109 (4), 992-999 (2024)
   PUBMED   37962983
  REMARK    GeneRIF: Epigenome-wide Association Study Shows Differential DNA
            Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
REFERENCE   2  (bases 1 to 855)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 855)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 855)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 855)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 855)
  AUTHORS   Yang,J., Yang,H., Yan,L., Yang,L. and Yu,L.
  TITLE     Characterization of the human CUTA isoform2 present in the stably
            transfected HeLa cells
  JOURNAL   Mol Biol Rep 36 (1), 63-69 (2009)
   PUBMED   17924204
  REMARK    GeneRIF: expression profile of CUTA gene in tissues was examined &
            revealed CUTA gene was constitutively expressed in the 18 tissues
            tested; CUTA isoform2 was mainly located in mitochondria as a new
            potential mitochondrial protein
REFERENCE   7  (bases 1 to 855)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 855)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 855)
  AUTHORS   Perrier,A.L., Cousin,X., Boschetti,N., Haas,R., Chatel,J.M.,
            Bon,S., Roberts,W.L., Pickett,S.R., Massoulie,J., Rosenberry,T.L.
            and Krejci,E.
  TITLE     Two distinct proteins are associated with tetrameric
            acetylcholinesterase on the cell surface
  JOURNAL   J Biol Chem 275 (44), 34260-34265 (2000)
   PUBMED   10954708
REFERENCE   10 (bases 1 to 855)
  AUTHORS   Navaratnam,D.S., Fernando,F.S., Priddle,J.D., Giles,K., Clegg,S.M.,
            Pappin,D.J., Craig,I. and Smith,A.D.
  TITLE     Hydrophobic protein that copurifies with human brain
            acetylcholinesterase: amino acid sequence, genomic organization,
            and chromosomal localization
  JOURNAL   J Neurochem 74 (5), 2146-2153 (2000)
   PUBMED   10800960
  REMARK    GeneRIF: Fluorescence in situ hybridization localizes the gene to
            chromosome 6p21.32-p21.2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN363642.1, CB106834.1, AF106943.1 and AL662799.16.
            
            On Jun 2, 2019 this sequence version replaced NM_001014840.1.
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 5' coding region, compared to variant 1, resulting in a
            shorter protein (isoform 3). Isoform 3 has also been called isoform
            b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.262394.1,
                                           SRR7410570.262432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000488034.6/ ENSP00000417544.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CN363642.1         212-232
            22-466              CB106834.1         29-473
            467-755             AF106943.1         548-836
            756-855             AL662799.16        68811-68910         c
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..855
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /note="cutA divalent cation tolerance homolog"
                     /db_xref="GeneID:51596"
                     /db_xref="HGNC:HGNC:21101"
                     /db_xref="MIM:616953"
     exon            1..149
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..647
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 5; divalent cation tolerant protein CUTA; protein
                     CutA; acetylcholinesterase-associated protein; brain
                     acetylcholinesterase putative membrane anchor"
                     /codon_start=1
                     /product="protein CutA isoform 3 precursor"
                     /protein_id="NP_001014840.1"
                     /db_xref="CCDS:CCDS34433.1"
                     /db_xref="GeneID:51596"
                     /db_xref="HGNC:HGNC:21101"
                     /db_xref="MIM:616953"
                     /translation="MSGGRAPAVLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTM
                     ASGSPPTQPSPASDSGSGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQ
                     ITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNFPY
                     LQWVRQVTESVSDSITVLP"
     exon            150..364
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /inference="alignment:Splign:2.1.0"
     exon            365..424
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /inference="alignment:Splign:2.1.0"
     exon            425..470
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /inference="alignment:Splign:2.1.0"
     exon            471..520
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /inference="alignment:Splign:2.1.0"
     exon            521..855
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /inference="alignment:Splign:2.1.0"
     regulatory      727..732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /note="hexamer: AATAAA"
     polyA_site      747
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /note="major polyA site"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
                     /note="hexamer: AATATA"
     polyA_site      820
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
     polyA_site      855
                     /gene="CUTA"
                     /gene_synonym="ACHAP; C6orf82"
ORIGIN      
        1 aatcacgtgg ctgccaccca ggtaagaaga ggccgctctt cctggggttg tttctccgtg
       61 tgacgtgtgg cctttgagat caactctcct gtaccagcgt aggccgcatg agtggggggc
      121 gggctcccgc ggtcctgctc ggcggagtgg cctctctgct cctgtctttt gtttggatgc
      181 cggcgctgct gcctgtggcc tcccgccttt tgttgctacc ccgagtcttg ctgaccatgg
      241 cctctggaag ccctccgacc cagccctcgc cggcctcgga ttccggctct ggctacgttc
      301 cgggctcggt ctctgcagcc tttgttactt gccccaacga gaaggtcgcc aaggagatcg
      361 ccagggccgt ggtggagaag cgcctagcag cctgcgtcaa cctcatccct cagattacat
      421 ccatctatga gtggaaaggg aagatcgagg aagacagtga ggtgctgatg atgattaaaa
      481 cccaaagttc cttggtccca gctttgacag attttgttcg ttctgtgcac ccttacgaag
      541 tggccgaggt aattgcattg cctgtggaac aggggaactt tccgtacctg cagtgggtgc
      601 gccaggtcac agagtcagtt tctgactcta tcacagtcct gccatgatga gccctgttcc
      661 tgctcatcat gaagatcccc gcgatacttc aacgccttct gacttccagg tgatgactgg
      721 gcccccaata aatcccgtct ttgggtctct ctgccttttg cctgtttttt gtcatgtatg
      781 caaatttgtt gggagaatat aagtgcttct agtccctgta ttctctacat ctttcagaat
      841 gactcagagc tgcta
//
