LOCUS       NM_015089               7759 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cullin 9 (CUL9), mRNA.
ACCESSION   NM_015089
VERSION     NM_015089.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7759)
  AUTHORS   Horn-Ghetko,D., Hopf,L.V.M., Tripathi-Giesgen,I., Du,J.,
            Kostrhon,S., Vu,D.T., Beier,V., Steigenberger,B., Prabu,J.R.,
            Stier,L., Bruss,E.M., Mann,M., Xiong,Y. and Schulman,B.A.
  TITLE     Noncanonical assembly, neddylation and chimeric cullin-RING/RBR
            ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
  JOURNAL   Nat Struct Mol Biol 31 (7), 1083-1094 (2024)
   PUBMED   38605244
  REMARK    GeneRIF: Noncanonical assembly, neddylation and chimeric
            cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase
            complex.
REFERENCE   2  (bases 1 to 7759)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7759)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   4  (bases 1 to 7759)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   5  (bases 1 to 7759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7759)
  AUTHORS   Ko,H.S., Kim,S.W., Sriram,S.R., Dawson,V.L. and Dawson,T.M.
  TITLE     Identification of far upstream element-binding protein-1 as an
            authentic Parkin substrate
  JOURNAL   J Biol Chem 281 (24), 16193-16196 (2006)
   PUBMED   16672220
  REMARK    GeneRIF: FUBP1 is an authentic substrate of Parkin that might play
            an important role in development of Parkinson disease pathology
            along with aminoacyl-tRNA synthetase interacting multifunctional
            protein type 2
REFERENCE   7  (bases 1 to 7759)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   8  (bases 1 to 7759)
  AUTHORS   Nikolaev,A.Y., Li,M., Puskas,N., Qin,J. and Gu,W.
  TITLE     Parc: a cytoplasmic anchor for p53
  JOURNAL   Cell 112 (1), 29-40 (2003)
   PUBMED   12526791
  REMARK    GeneRIF: Parc, a Parkin-like ubiquitin ligase,is a critical
            regulator in controlling p53 subcellular cytoplasmic localization
            and subsequent function.
REFERENCE   9  (bases 1 to 7759)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 7759)
  AUTHORS   Moynihan,T.P., Ardley,H.C., Nuber,U., Rose,S.A., Jones,P.F.,
            Markham,A.F., Scheffner,M. and Robinson,P.A.
  TITLE     The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with
            RING finger/IBR motif-containing domains of HHARI and H7-AP1
  JOURNAL   J Biol Chem 274 (43), 30963-30968 (1999)
   PUBMED   10521492
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133375.25, AJ318215.1, KF458162.1 and BC002879.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015089.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ318215.1, AY145132.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252050.9/ ENSP00000252050.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AL133375.25        4483-4536
            55-587              AL133375.25        6589-7121
            588-1211            AJ318215.1         525-1148
            1212-1212           KF458162.1         164-164             c
            1213-6695           AJ318215.1         1150-6632
            6696-7755           BC002879.2         1974-3033
            7756-7759           AL133375.25        46871-46874
FEATURES             Location/Qualifiers
     source          1..7759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..7759
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /note="cullin 9"
                     /db_xref="GeneID:23113"
                     /db_xref="HGNC:HGNC:15982"
                     /db_xref="MIM:607489"
     exon            1..54
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            55..658
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..7617
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /note="parkin-like cytoplasmic p53 binding protein;
                     p53-associated parkin-like cytoplasmic protein;
                     UbcH7-associated protein 1; CUL-9"
                     /codon_start=1
                     /product="cullin-9"
                     /protein_id="NP_055904.1"
                     /db_xref="CCDS:CCDS4890.1"
                     /db_xref="GeneID:23113"
                     /db_xref="HGNC:HGNC:15982"
                     /db_xref="MIM:607489"
                     /translation="MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSV
                     LKCGEVGKVGVEEGKAEHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPR
                     DPGGLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTG
                     VFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHM
                     DFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSS
                     PELGAGDQSSPCATREKSRGQRELEFSMAVGNLISELVRSMGWARNLSEQGMSPPRPT
                     RSIFQPYISGPSLLLPTIVTTPRRQGWVFRQRSEFSSRSGYGEYVQQTLQPGMRVRML
                     DDYEEISAGDEGEFRQSNNGIPPVQVFWQSTGRTYWVHWHMLEILGPEEATEDKASAA
                     VEKGAGATVLGTAFPSWDWNPMDGLYPLPYLQPEPQKNERVGYLTQAEWWELLFFIKK
                     LDLCEQQPIFQNLWKNLDETLGEKALGEISVSVEMAESLLQVLSSRFEGSTLNDLLNS
                     QIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKSEASFSEEETESLKAKAEAPKTEAE
                     PTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEAASEMARALRGPGPRSSLDQHVA
                     AVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLVRPDRSLREKLVKMLVELLTN
                     QVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVCMQEYKTSVLVQQAGLAAL
                     KMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATRPGSESLLLTVPAAVIL
                     MLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPRTEPMPTTR
                     TILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPSAELLLDLERVLC
                     REGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVITRLLDFPEAMV
                     LPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGAKEILSKVL
                     DKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINI
                     PFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHY
                     ITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASRVI
                     LLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTI
                     RAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSP
                     LVQNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPP
                     GPSPEPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRA
                     PDFVPRYCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARY
                     IDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGS
                     SWLEGAVLEQIGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEK
                     RLEEEEEEEEEEEAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCD
                     ALDRFSSFYSQSQNHPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQ
                     TEEVSVETLLKDSDLSPELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRS
                     GEALWLIPPQAYLNVEKDEGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEA
                     WQKGPNPPGTLGHTVAGGVACTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMG
                     PCRGQADVPFCGSQSETSKPSPEAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQET
                     LNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCV
                     SPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAI
                     VSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKCGWASCF
                     NCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEG
                     CLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCSAMVSKAARQEKRFQDYNERCTFHHQA
                     REFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLEQARKVLAYACVYSFYSQDAEYMDV
                     VEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAI
                     LQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDE
                     FDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD"
     exon            659..813
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1314
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1450
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1644
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2050
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2243
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2451
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2648
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2866
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3113
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3219
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3447
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3538
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3710
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3816
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3912
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4088
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4222
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            4223..4402
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4512
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4695
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            4696..4856
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..5085
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            5086..5275
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5421
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            5422..5551
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            5552..5751
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            5752..5999
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6345
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6346..6486
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6487..6651
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6652..6815
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6816..6909
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6910..6984
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            6985..7095
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            7096..7213
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            7214..7347
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            7348..7421
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     exon            7422..7759
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7735..7740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /note="hexamer: AATAAA"
     polyA_site      7759
                     /gene="CUL9"
                     /gene_synonym="H7AP1; PARC"
                     /note="major polyA site"
ORIGIN      
        1 ggacggcggg accggccgct gggtcccagc gagggctgag ccgggcggtg ggaggaggtc
       61 aggatggtgg gggaacggca tgctggggac ctcatggtgc ccttagggcc tcggctgcag
      121 gcatatcctg aagaactcat tcgacagagg cctgggcatg acgggcatcc tgaatacctg
      181 atccgatgga gtgtcctgaa gtgtggggaa gtgggcaaag tgggtgtgga agaaggcaaa
      241 gcagagcaca tcctcatgtg gctgtcggct cctgaggtct acgccaactg ccctgggctg
      301 ttaggtgagc gggcactatc taagggactt cagcacgaac cagctggggt ttcaggaagc
      361 tttcctcgag atccaggagg cctggatgaa gtggcaatgg gagagatgga ggctgatgtt
      421 caggcgctgg tacgcagggc ggccaggcag ctggcagaaa gtgggacccc aagcctcacg
      481 gccgctgtgc ttcacaccat ccacgtgctc agtgcctacg ccagcatcgg gcccctcact
      541 ggtgtcttca gggagacagg agccctggac ctgctcatgc acatgttatg caatcctgag
      601 cctcagatcc gccggagtgc aggcaaaatg ctgcaggctc tggcagccca cgatgctggg
      661 agtcgggctc acgtccttct atcactgagc cagcaagatg gcatcgagca gcacatggat
      721 tttgacagtc gctatacatt gctggagctg tttgcagaaa ccacatcctc tgaagaacac
      781 tgcatggcct ttgagggcat tcatctgcct cagatcccag gaaagctgct tttctccttg
      841 gtgaagcgct acctttgtgt cacgtccctc ctggatcagc tgaatagcag tccagagctg
      901 ggagctggag accaaagctc cccatgtgcc acaagagaga aaagccgggg acagcgggaa
      961 ctggagttca gcatggctgt gggcaacctc atctctgagc ttgtgcggag catgggctgg
     1021 gcccggaacc tcagcgaaca gggcatgtca cctccccggc caacccggtc catctttcag
     1081 ccctacattt caggccccag ccttttactc cccaccattg tcaccacccc cagaagacaa
     1141 gggtgggtct tccgccagcg ctctgaattc tccagccgta gtggctatgg agaatatgtg
     1201 cagcagacac tgcagccagg gatgcgagtg cggatgctgg atgattatga ggagatcagt
     1261 gctggggacg agggcgagtt ccggcagagc aacaacggca ttccccctgt gcaggttttc
     1321 tggcagtcga caggccgcac ttactgggtg cactggcaca tgctggagat cctgggccct
     1381 gaggaagcca ctgaggataa ggcttcagca gctgtggaga agggggcagg ggctactgtg
     1441 ttgggcacag catttccctc ctgggactgg aatcctatgg atgggctgta ccctttgccg
     1501 tacctccagc ccgaacctca gaagaatgag agagtgggat atctgaccca ggctgaatgg
     1561 tgggagctgc ttttctttat caaaaagttg gacttgtgtg agcagcagcc aattttccag
     1621 aatctttgga agaacctgga tgagaccctg ggtgaaaagg ccctaggtga gatctctgtg
     1681 tccgtggaaa tggccgagag tctgctgcag gttctcagta gtcgatttga gggcagcact
     1741 ctcaatgacc tgctcaactc ccagatctac accaagtatg ggctgctgtc taatgaacca
     1801 agcagctcgt ctacttcacg aaatcactcc tgtaccccag atccagaaga ggagtccaag
     1861 tcggaggcca gcttctcaga ggaagagact gagtccctca aagcaaaggc cgaggcccct
     1921 aagacagagg ccgagcccac caagacaagg accgagaccc ccatggcaca gagtgattct
     1981 cagctgttta accagcttct ggtgactgag gggatgaccc tgcccactga gatgaaggag
     2041 gcagccagtg aaatggccag agccttgcgg ggtcccggtc ctcgcagctc cctggatcag
     2101 catgtggcag cggtcgtggc cactgtgcag atatccagct tggacacaaa cctgcagctt
     2161 tcagggctct ctgccctctc tcaggctgtg gaggaggtca ctgagcggga ccaccctctg
     2221 gtccgtcctg acagatcgct gagagagaag ctagtgaaga tgctggtgga gctgctgacc
     2281 aaccaggtgg gagagaagat ggtggtcgtg caggccctgc gcctccttta cctgctcatg
     2341 accaagcacg agtggcggcc gctctttgcc agggagggtg gcatctatgc tgtgctggtc
     2401 tgcatgcaag aatataagac ttctgtcttg gtgcagcagg ctgggctggc ggcactgaag
     2461 atgctggccg tcgccagctc ctcggagatc cccacttttg ttactggccg agattctatc
     2521 cactctttgt ttgatgctca gatgaccaga gagatcttcg ccagcatcga ctcagccaca
     2581 cgcccgggct ctgagagcct gctcctcact gtccctgcag ccgtgatcct gatgctgaat
     2641 actgaggggt gctcttctgc agcgagaaat ggcttactcc tgctcaacct acttttgtgc
     2701 aaccaccaca ctctgggaga ccagattata acccaagagc tgagagacac gttgtttagg
     2761 cactcaggga tagcaccaag aacagaacct atgcctacca cacgcaccat cctcatgatg
     2821 cttctcaatc gctactcaga gccgccgggc agccctgagc gtgcagcact agagaccccc
     2881 atcatccagg gtcaggatgg gtcccctgag ctactgattc gatccctggt tgggggccca
     2941 tctgcagaac tactcctgga cttggagcgt gtgctgtgcc gtgagggcag ccccggaggt
     3001 gccgtgaggc ccctcctcaa gcgcctccag caggagaccc agcctttcct cctgttgctg
     3061 cggactctgg atgctccggg gcccaacaag actctgctgc tgtctgtgct gagggtcata
     3121 acccgactgc tggatttccc tgaggcaatg gtcctcccct ggcacgaggt cttggagccc
     3181 tgcctcaact gcctgagtgg ccctagcagt gactccgaga ttgttcagga gctgacctgc
     3241 ttcctacatc gcctggcctc gatgcataag gactatgctg tggtgctctg ctgcctggga
     3301 gcaaaagaga tcctctccaa agtcctggac aagcactcag ctcagctgct gctgggctgt
     3361 gagcttcggg acctggtgac agagtgtgag aagtacgcac agctctatag caacctcacc
     3421 tccagcatcc tggccggctg cattcagatg gtgctgggcc agatcgaaga ccacagacga
     3481 acccaccaac ccatcaatat ccccttcttt gatgtgttcc tcaggcatct ctgccagggc
     3541 tccagtgtgg aagtgaagga ggacaagtgc tgggagaagg tggaggtgtc ctccaacccg
     3601 caccgagcca gcaagctgac ggaccacaac cccaagacct actgggagtc caacggcagc
     3661 accggctccc actacatcac cctgcacatg caccgtggtg ttcttgttag gcagctcact
     3721 ttgctggtgg ccagtgagga ctcaagctac atgccagcca gggtggtggt gtttgggggt
     3781 gacagcacca gctgcatcgg cactgagctc aacacggtga atgtgatgcc ctctgccagc
     3841 cgggtgatcc tcttggagaa cctgaaccgc ttctggccca tcatccagat ccgcataaag
     3901 cgctgccagc agggcggcat tgacacccgg gttcggggtg tggaggtcct gggccctaag
     3961 cccacattct ggccactgtt ccgggagcag ctgtgtcgcc gaacatgtct cttctacaca
     4021 attcgggcac aagcctggag ccgggacata gcagaggacc accggcgcct cctccagctc
     4081 tgtcccagac tgaacagggt tttgcgccac gagcagaatt ttgctgaccg cttcctccct
     4141 gatgatgagg ccgcccaggc actgggcaag acctgctggg aggccctggt cagccccctg
     4201 gtgcagaaca tcacctctcc cgatgcggaa ggcgtgagtg ccctgggatg gctgctggat
     4261 cagtacttag aacagagaga gacctctcgg aaccccttga gtcgagcagc gtcctttgct
     4321 tctcgagttc gtcgcctttg ccacttgctg gtgcatgtgg aacctcctcc tgggccttct
     4381 cctgagccat ccactcggcc cttcagcaag aacagcaagg gtcgggaccg gagcccggcg
     4441 ccttcgccag tgcttccaag cagcagcctg aggaacataa cccagtgctg gctgagcgtg
     4501 gtgcaggagc aggtcagcag attcctggct gcagcttgga gggccccaga ctttgtgcct
     4561 cgttactgta aactctatga gcacttgcag agagcaggct ccgagctgtt tgggcctcgg
     4621 gcagccttca tgctggctct gcgcagtggc ttctctggcg ccttgctgca gcagtccttc
     4681 ctcactgctg ctcacatgag tgagcagttt gccaggtaca ttgaccaaca gatccagggt
     4741 ggcctgattg gtggagcccc tggagtggaa atgctggggc agcttcagcg gcacctggaa
     4801 cccattatgg tcctttctgg tctggaactg gccacaactt ttgagcactt ctatcagcat
     4861 tatatggcgg accgtctcct gagctttggt tcgagctggc tggagggggc tgtgctagag
     4921 cagattggcc tctgttttcc caaccgcctc ccacagctga tgctgcagag cctgagcacc
     4981 tctgaggagc tgcagcgcca gttccacctc ttccagctcc agcggctcga caagttgttc
     5041 ttggagcagg aagatgagga ggaaaagaga ctagaggaag aggaggagga agaggaggaa
     5101 gaggaagctg agaaagaatt atttatcgaa gatccaagtc cagccatttc tatactggtc
     5161 ctgtcaccac gctgctggcc cgtctcccca ctctgctacc tgtaccatcc cagaaagtgc
     5221 cttcccacag aattctgtga tgcccttgac cgtttctcca gtttctacag ccagagtcag
     5281 aaccatccag tcctggacat gggaccacat cggcgactgc agtggacgtg gctgggccgg
     5341 gctgagctgc agtttgggaa gcagatactg catgtgtcca ccgtgcagat gtggctgctg
     5401 ctgaaattca atcagacaga ggaggtgtca gtagagacct tgctgaagga ttctgacctc
     5461 tccccagagc tgctgctcca ggcactcgtg cccctcacct cagggaatgg ccctttgacc
     5521 ctgcatgagg gccaggactt tccacacggg ggtgtgctgc ggcttcatga gcctgggccc
     5581 cagcgcagtg gggaggccct gtggctgata cctccccagg catacctgaa cgtagagaag
     5641 gatgaaggcc gaaccctgga acagaagagg aatctcttga gctgtcttct tgttcgtatt
     5701 ctcaaagccc atggggaaaa gggcctccac attgatcagc tggtttgtct ggtgctggag
     5761 gcctggcaga agggtccaaa tcctcctgga accctgggcc acactgttgc tgggggtgtg
     5821 gcctgtacca gtacagatgt cctctcttgc atcctgcacc tcttaggcca gggctacgtg
     5881 aaacggcgtg atgaccggcc ccagatcctg atgtatgccg ctccagagcc catggggccc
     5941 tgccggggtc aggcagatgt ccctttctgt ggcagccaga gcgaaacctc caagcccagc
     6001 ccagaagctg tggctaccct ggcatctcta cagctgcctg caggccgcac catgagcccc
     6061 caggaagtag aagggttgat gaagcagacg gtgcgtcagg tgcaggagac gctgaactta
     6121 gagccagatg tcgctcagca ccttttggct cattcccact ggggcgctga acagctgctg
     6181 cagagctaca gtgaggaccc tgagccactg ctgctggcag ctgggctgtg cgtacaccag
     6241 gctcaggctg tacccgtacg gcctgaccac tgccccgtct gtgtgagccc cctggggtgt
     6301 gacgacgacc tgccctctct ctgctgcatg cactattgct gtaagtcttg ctggaatgag
     6361 tacctgacaa ctcggatcga gcagaacctt gttttgaatt gcacctgccc cattgccgac
     6421 tgccccgccc agcccaccgg agccttcatt cgtgccatcg tctcctcgcc agaggtcatc
     6481 tccaagtatg agaaggcgct cctgcgtggc tatgtggaga gctgctccaa cctgacctgg
     6541 tgcaccaacc cccagggctg cgaccgcatc ctgtgccgcc agggcctggg ctgtgggacc
     6601 acctgctcca agtgtggctg ggcctcttgc ttcaactgta gcttccctga ggcacactac
     6661 cctgctagct gtggccatat gtctcagtgg gtcgacgacg gtggctacta tgacggcatg
     6721 agcgtggagg cgcagagcaa gcacctggcc aagctcatct ccaagcgctg tcccagctgt
     6781 caggctccca tcgagaagaa cgaggggtgc ctgcacatga cctgtgccaa atgtaaccat
     6841 ggattctgct ggcgctgcct caagtcctgg aagccaaatc acaaagacta ttacaactgc
     6901 tctgccatgg taagcaaggc agctcgccag gagaagcggt ttcaggacta taatgagagg
     6961 tgcactttcc atcaccaggc gcgggagttt gctgtgaact tgcggaaccg ggtgtctgcc
     7021 atccatgaag tgcccccgcc cagatccttc accttcctca atgatgcctg ccagggactg
     7081 gagcaggctc ggaaggtgct ggcctacgcc tgcgtgtaca gcttctacag ccaggacgca
     7141 gagtacatgg atgtggtgga gcagcagaca gagaacctgg agctgcacac caatgccctg
     7201 cagatcctcc tggaggaaac cctgctgcgg tgcagagacc tggcctcctc cctgcgcctc
     7261 ctgcgggccg actgcctcag cacgggcatg gagctgctcc ggcggatcca ggagaggctg
     7321 cttgccatcc tgcagcattc tgcccaggat ttccgggttg gtcttcagag tccatcagta
     7381 gaggcctggg aggcaaaagg acccaacatg cctggcagtc agccccaggc ctcctcaggg
     7441 ccagaggcag aagaggagga ggaagacgat gaggatgatg tgcccgagtg gcagcaggat
     7501 gagtttgatg aggagctgga caatgacagc ttctcctacg atgagtctga gaacctggac
     7561 caagagactt tcttctttgg tgatgaggaa gaggatgaag atgaggccta tgactgaggg
     7621 ggcagatgca ggaaacacct agagcagccc cagagtcacg gggctgaggg ggcgggagct
     7681 gcccctgtca tagggagggg gattcccagc gtctgtagtg cttcctgttt gctgaataaa
     7741 ggtctctttc tcacacaca
//
