LOCUS       NM_014780               5406 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens cullin 7 (CUL7), transcript variant 2, mRNA.
ACCESSION   NM_014780
VERSION     NM_014780.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5406)
  AUTHORS   Wang,C., Zhao,Z., Zhang,Y., Liang,W., Zhou,C., Lin,W., He,Y.,
            Wu,M., Meng,Z., Liao,Y., Li,M., El Akkawi,M., Zhao,J. and He,Y.
  TITLE     Identification and verification of the prognostic value of CUL7 in
            colon adenocarcinoma
  JOURNAL   Front Immunol 13, 1043512 (2022)
   PUBMED   36304472
  REMARK    GeneRIF: Identification and verification of the prognostic value of
            CUL7 in colon adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5406)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5406)
  AUTHORS   Tuysuz,B., Alp Unkar,Z., Turan,H., Gezdirici,A., Uludag Alkaya,D.,
            Kasap,B., Yesil,G., Vural,M. and Ercan,O.
  TITLE     Natural history of facial and skeletal features from neonatal
            period to adulthood in a 3M syndrome cohort with biallelic CUL7 or
            OBSL1 variants
  JOURNAL   Eur J Med Genet 64 (12), 104346 (2021)
   PUBMED   34597859
  REMARK    GeneRIF: Natural history of facial and skeletal features from
            neonatal period to adulthood in a 3M syndrome cohort with biallelic
            CUL7 or OBSL1 variants.
REFERENCE   4  (bases 1 to 5406)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   5  (bases 1 to 5406)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   6  (bases 1 to 5406)
  AUTHORS   Arai,T., Kasper,J.S., Skaar,J.R., Ali,S.H., Takahashi,C. and
            DeCaprio,J.A.
  TITLE     Targeted disruption of p185/Cul7 gene results in abnormal vascular
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9855-9860 (2003)
   PUBMED   12904573
REFERENCE   7  (bases 1 to 5406)
  AUTHORS   Dias,D.C., Dolios,G., Wang,R. and Pan,Z.Q.
  TITLE     CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29
            to form an SCF-like complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16601-16606 (2002)
   PUBMED   12481031
REFERENCE   8  (bases 1 to 5406)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   9  (bases 1 to 5406)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 5406)
  AUTHORS   Irving,M. and Holder-Espinasse,M.
  TITLE     Three M Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355385.15 and AL136304.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 18, 2019 this sequence version replaced NM_014780.4.
            
            Summary: The protein encoded by this gene is a component of an E3
            ubiquitin-protein ligase complex. The encoded protein interacts
            with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a
            cause of 3M syndrome type 1 (3M1). Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033647.1, SRR11853561.24882.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265348.9/ ENSP00000265348.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AL355385.15        5693-5922           c
            231-818             AL355385.15        4280-4867           c
            819-970             AL355385.15        3683-3834           c
            971-1471            AL355385.15        3039-3539           c
            1472-1610           AL355385.15        2331-2469           c
            1611-1807           AL355385.15        2034-2230           c
            1808-2063           AL355385.15        1478-1733           c
            2064-2301           AL355385.15        403-640             c
            2302-2407           AL355385.15        219-324             c
            2408-2635           AL136304.10        64462-64689         c
            2636-2726           AL136304.10        64093-64183         c
            2727-2898           AL136304.10        63818-63989         c
            2899-3004           AL136304.10        63568-63673         c
            3005-3100           AL136304.10        63169-63264         c
            3101-3276           AL136304.10        62809-62984         c
            3277-3410           AL136304.10        62334-62467         c
            3411-3593           AL136304.10        61030-61212         c
            3594-3700           AL136304.10        60656-60762         c
            3701-3883           AL136304.10        60384-60566         c
            3884-4044           AL136304.10        58497-58657         c
            4045-4261           AL136304.10        58112-58328         c
            4262-4532           AL136304.10        57738-58008         c
            4533-4678           AL136304.10        56424-56569         c
            4679-4805           AL136304.10        56148-56274         c
            4806-5011           AL136304.10        55849-56054         c
            5012-5406           AL136304.10        55199-55593         c
FEATURES             Location/Qualifiers
     source          1..5406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..5406
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /note="cullin 7"
                     /db_xref="GeneID:9820"
                     /db_xref="HGNC:HGNC:21024"
                     /db_xref="MIM:609577"
     exon            1..230
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            231..818
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..5335
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="cullin-7 isoform 2"
                     /protein_id="NP_055595.2"
                     /db_xref="CCDS:CCDS4881.1"
                     /db_xref="GeneID:9820"
                     /db_xref="HGNC:HGNC:21024"
                     /db_xref="MIM:609577"
                     /translation="MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLI
                     LRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGAL
                     DKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDP
                     RVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSR
                     CALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGA
                     QNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPGSIFQPQ
                     LADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEI
                     SAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAV
                     ASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPD
                     HQEVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYK
                     KYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRL
                     VEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTL
                     HLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSR
                     DYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCI
                     QMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKL
                     TDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTS
                     SLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPT
                     FWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLP
                     DDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPA
                     FFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRC
                     WRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGA
                     LLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEIAT
                     TFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHV
                     YQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
                     DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHP
                     ALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLS
                     ADMLNQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQA
                     EGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSL
                     GKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPN
                     PPLTFHTLQIRSRGVPYASCTATQSFSTFR"
     exon            819..970
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1471
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1610
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1807
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2063
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2301
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2407
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2635
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2726
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2898
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3004
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3100
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3276
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3410
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3593
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3700
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..3883
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4044
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4261
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4532
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4678
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4805
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            4806..5011
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5406
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5382..5387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /note="hexamer: AATAAA"
     polyA_site      5406
                     /gene="CUL7"
                     /gene_synonym="3M1; CUL-7; dJ20C7.5; KIAA0076"
                     /note="major polyA site"
ORIGIN      
        1 gtggcttttg gctggcggag ccgctggcag ggaccgggcc ccaccctgcc ccagtggctg
       61 ccgactcacg cgggtgcagc tctgttccgc ggaggcacgc cccctcccgt ctctccgtct
      121 cgaccccctc gcggggccca ggtggggccc aagtcgccgc cagcgtctgt gccgcgtccc
      181 ttgctctgtg aaggacaggc ctcgcgccag gaccccggtg gacttctgag gtgccaggat
      241 ggtgggagaa ctccgctaca gggaattcag ggtgcccctg gggcccggct tacatgccta
      301 tcctgatgag ctgatccgcc agcgcgtggg ccatgatggg catcctgagt accagatccg
      361 ttggctcatc ctgcggcgtg gcgatgaggg ggacgggggc tctggccaag tggactgcaa
      421 ggctgagcac atcctgctgt ggatgtccaa ggatgagatc tatgccaact gccacaagat
      481 gctgggcgag gatggccagg tcatcgggcc ctcccaggag tctgcagggg aggttggggc
      541 cctggacaaa tctgtgctgg aggagatgga aaccgacgtg aagtccctca ttcagagagc
      601 ccttcggcag ctggaggagt gtgtgggcac tatccctcct gctcctctac ttcacactgt
      661 ccacgtgctc agcgcctatg ccagcattga gcccctcact ggagtattca aggacccaag
      721 ggtcctggac ttgctcatgc acatgttgag tagtcctgat tatcagattc gctggagtgc
      781 aggccggatg atacaagccc tgtcctccca tgacgctggg acccggactc agatccttct
      841 gtcactgagc caacaagaag ccattgagaa acacctggat tttgacagcc gctgtgctct
      901 gctagcactg tttgcacagg ccacgctctc tgaacacccc atgtctttcg agggcattca
      961 gctaccacag gtcccaggaa gggtgctctt ctccctggtg aagcggtatt tgcatgtcac
     1021 ctcgctcctg gatcagctga acgacagtgc tgcggagcca ggagcccaga acacctctgc
     1081 tcctgaggag ttgagtgggg agaggggtca actggagctg gagttcagta tggccatggg
     1141 caccctgatc tcggagctgg tgcaagccat gcgctgggac caggcctcag acagaccaag
     1201 gagctcagca cggtcccccg gttccatctt ccagcctcag ctggcagatg tgagcccagg
     1261 gctccccgct gcccaggctc agccctcctt caggaggtca agacgttttc gccctcgttc
     1321 tgagttcgca agtggcaata cctatgcttt gtatgtgcgg gacacactgc agccggggat
     1381 gcgagtgcgg atgctggatg attatgagga gatcagtgcc ggggatgagg gcgagtttcg
     1441 gcagagcaac aacggtgtgc ctcctgtgca ggtattttgg gagtcaacag gccgcaccta
     1501 ttgggtgcac tggcacatgc tggagatctt gggctttgag gaagacattg aggacatggt
     1561 tgaggctgat gagtaccaag gggcagtggc cagtagagtc ctgggtagag ccctgcctgc
     1621 ctggcgctgg aggcccatga cagaactcta tgctgtgcct tatgtgctgc ctgaggatga
     1681 ggacactgag gagtgtgaac acctgaccct ggctgagtgg tgggaactcc tcttcttcat
     1741 caagaagctg gatggacctg accatcagga ggttctccag atcctccagg agaacctaga
     1801 tggggagatt ctggatgatg agatcctagc tgaactggcc gtgcccatag aattggccca
     1861 ggacttgctg ctgactctgc cacagcgact caatgacagt gccctcaggg acctgatcaa
     1921 ctgccatgtc tacaagaagt atgggcctga agccctagca gggaaccaag cctacccatc
     1981 ccttctagaa gcccaagaag atgtcctcct gctagacgcg caggcccagg ctaaggactc
     2041 agaagatgca gccaaagtgg aagcaaaaga acccccatct cagagtccca acactcccct
     2101 gcagcgtctg gtggagggtt atggtccagc tgggaaaatc ctcctggatc tagagcaagc
     2161 cctcagctca gaggggaccc aggagaacaa ggtcaagcca ctcctgctgc agctgcagcg
     2221 gcagccgcag cccttcctgg cactgatgca gagcctggac actccggaga ctaacaggac
     2281 cctgcacctg actgtgctga gaatcctgaa gcagctggtg gacttccccg aggcactgct
     2341 gctcccctgg cacgaggccg tggatgcctg catggcctgc ctgcggtccc caaacactga
     2401 tcgagaggtg ctccaggaac tgattttctt cctgcaccgc ctgacctcag tgagcaggga
     2461 ctatgccgtg gtgctgaatc agctgggagc aagagacgct atctccaagg ccctggaaaa
     2521 gcacctggga aagctggagc tggctcagga gctgcgggac atggtgttca agtgtgagaa
     2581 gcatgcccac ctctaccgca aactcatcac caacatcctg ggaggctgca tccagatggt
     2641 gctgggccag atcgaagacc acagacgaac ccaccaaccc atcaacatcc ctttctttga
     2701 tgtgttcctc agatacctgt gccagggctc cagtgtggaa gtgaaggagg acaagtgctg
     2761 ggagaaggtg gaggtgtcct ccaacccgca ccgggccagc aagctgacgg accacaaccc
     2821 caagacctat tgggagtcca acggcagcgc cggctcccac tacatcaccc tgcacatgcg
     2881 ccggggcatc ctcatcaggc aactgactct gcttgtggct agtgaggact cgagttacat
     2941 gccggcccga gtggtggtgt gcgggggtga tagcactagc tctcttcaca cggaactcaa
     3001 ctcggtgaat gtgatgccct ctgccagccg ggtgatcctc ctggagaacc tgacccgctt
     3061 ctggcccatc atccagatcc gcataaagcg ctgccagcag ggtggcattg atacgcgcat
     3121 tcgggggtta gagatcctag gccccaagcc cacgttctgg ccagtgttcc gggagcagct
     3181 ctgtcgtcac acacgcctct tctacatggt tcgggcacag gcctggagcc aggacatggc
     3241 agaggaccgc aggagcctcc tgcacctgag ttctagactc aacggtgctc tgcgccagga
     3301 gcagaatttt gctgaccgct tcctccctga tgacgaggct gcccaagctc tgggcaagac
     3361 ctgctgggag gccctggtca gccccgtggt gcagaacatc acctcccctg atgaggatgg
     3421 cattagcccc ctgggttggc tgctggacca gtacctggag tgtcaggaag ctgtcttcaa
     3481 cccccagagc cgcggcccag ctttcttctc gcgggtgcgc cgtctcactc acctgctggt
     3541 gcatgtcgag ccctgtgagg caccccctcc tgtggtggcc actcctcggc ccaaaggcag
     3601 aaacagaagc cacgactgga gctccttggc tacccggggc cttccaagca gcatcatgag
     3661 aaacctgacg cgctgttggc gggccgtggt ggagaagcag gtgaacaatt ttctgacctc
     3721 atcctggcgg gatgatgact ttgtgccacg ctactgtgag cactttaata ttctgcagaa
     3781 ctcaagctct gaactgtttg ggcctcgggc agccttcttg ctggcgctgc aaaatggctg
     3841 tgcgggagcc ttgctgaagc tcccttttct caaagctgcc cacgtgagtg agcagttcgc
     3901 ccggcacatt gaccagcaga tccagggcag ccggatcggt ggagcccagg aaatggagag
     3961 gctggcacag ctgcagcaat gcctgcaagc tgtcctgatt ttctccggct tggagatagc
     4021 caccactttt gagcattatt accagcacta catggcggac cgtctcctgg gcgtggtctc
     4081 gagctggctg gagggggccg tgctggagca gatcggtccc tgcttcccca accgcctccc
     4141 ccagcagatg ttgcagagcc tgagcacctc taaggagctg cagcgccagt tccacgtcta
     4201 ccagctccag cagctggatc aggaactcct gaagctggag gatacagaga agaaaataca
     4261 ggtgggcctt ggggccagtg gcaaggagca caagagcgag aaggaagagg aagctggggc
     4321 agcagcagtg gtggatgtgg cggagggaga ggaggaagag gaggagaatg aggacctcta
     4381 ctatgaaggg gcaatgccag aagtgtctgt gcttgtcctg tcccgacact cctggcctgt
     4441 tgcctcaatc tgccacacac tgaaccccag aacctgcctg ccctcctacc tgaggggcac
     4501 tttgaacaga tactccaact tctacaacaa gagtcagagc caccctgccc ttgagcgagg
     4561 ctcacagagg cgactgcagt ggacgtggct gggctgggct gagctgcagt ttgggaacca
     4621 gaccctgcat gtgtccaccg tgcagatgtg gctactgctg tatctcaacg acctgaaggc
     4681 ggtctctgtg gagagtctgc tggcgttctc agggctctcc gcagacatgc tcaatcaggc
     4741 gattgggccc ctcacctctt caagaggccc cctggacctt cacgagcaaa aggatatacc
     4801 aggaggggtc ctcaagattc gagatggcag caaggaaccc aggtcgagat gggacattgt
     4861 gcggctcatc ccacctcaga cgtacctgca agctgagggt gaagacggcc agaacttgga
     4921 gaagagacgg aatcttctga actgcctcat cgtccgaatc ctcaaggccc atggagatga
     4981 ggggctgcac attgaccagc ttgtctgtct ggtgctggag gcttggcaga agggcccgtg
     5041 tcctcccagg ggtttggtca gcagccttgg taaggggtct gcatgcagca gcactgacgt
     5101 cctctcctgc atcctacacc tcctgggcaa gggcacgctg agacgccatg acgaccggcc
     5161 ccaggtgctg tcctatgcag tccctgtgac tgtcatggag cctcacactg agtccctgaa
     5221 cccaggctcc tcaggcccca acccacccct caccttccat accctacaga ttcgctcccg
     5281 gggtgtgccc tatgcctcct gcactgccac ccagagcttc tctaccttcc ggtagcccta
     5341 gacttggggt caggggaagg tagagctgga gcttttacag aaataaaacc caagagtttg
     5401 attata
//
