LOCUS       NM_003478               6171 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cullin 5 (CUL5), mRNA.
ACCESSION   NM_003478
VERSION     NM_003478.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6171)
  AUTHORS   Chang,Y., Chen,Q., Li,H., Xu,J., Tan,M., Xiong,X. and Sun,Y.
  TITLE     The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor
            cascade in pancreatic cancer cells
  JOURNAL   Dev Cell 59 (10), 1317-1332 (2024)
   PUBMED   38574733
REFERENCE   2  (bases 1 to 6171)
  AUTHORS   Xu,P., Liu,Y., Liu,C., Guey,B., Li,L., Melenec,P., Ricci,J. and
            Ablasser,A.
  TITLE     The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for
            degradation
  JOURNAL   Nature 627 (8005), 873-879 (2024)
   PUBMED   38418882
REFERENCE   3  (bases 1 to 6171)
  AUTHORS   Duncan,E.D., Han,K.J., Trout,M.A. and Prekeris,R.
  TITLE     Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and
            activity during cell migration
  JOURNAL   J Cell Biol 221 (4) (2022)
   PUBMED   35293963
  REMARK    GeneRIF: Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization
            and activity during cell migration.
REFERENCE   4  (bases 1 to 6171)
  AUTHORS   Li,Z., Hu,N., Dai,L., Hou,X., Hu,W., Liang,W. and Wang,X.
  TITLE     Cullin-5 (CUL5) as a potential prognostic marker in a pan-cancer
            analysis of human tumors
  JOURNAL   Bioengineered 12 (1), 5348-5360 (2021)
   PUBMED   34415831
  REMARK    GeneRIF: Cullin-5 (CUL5) as a potential prognostic marker in a
            pan-cancer analysis of human tumors.
REFERENCE   5  (bases 1 to 6171)
  AUTHORS   Kostrhon,S., Prabu,J.R., Baek,K., Horn-Ghetko,D., von Gronau,S.,
            Klugel,M., Basquin,J., Alpi,A.F. and Schulman,B.A.
  TITLE     CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific
            NEDD8 activation
  JOURNAL   Nat Chem Biol 17 (10), 1075-1083 (2021)
   PUBMED   34518685
REFERENCE   6  (bases 1 to 6171)
  AUTHORS   Burnatowska-Hledin,M., Lazdins,I.B., Listenberger,L., Zhao,P.,
            Sharangpani,A., Folta,V. and Card,B.
  TITLE     VACM-1 receptor is specifically expressed in rabbit vascular
            endothelium and renal collecting tubule
  JOURNAL   Am J Physiol 276 (2), F199-F209 (1999)
   PUBMED   9950950
REFERENCE   7  (bases 1 to 6171)
  AUTHORS   North,W.G., Fay,M.J., Longo,K.A. and Du,J.
  TITLE     Expression of all known vasopressin receptor subtypes by small cell
            tumors implies a multifaceted role for this neuropeptide
  JOURNAL   Cancer Res 58 (9), 1866-1871 (1998)
   PUBMED   9581826
REFERENCE   8  (bases 1 to 6171)
  AUTHORS   Stankovic,T., Byrd,P.J., Cooper,P.R., McConville,C.M., Munroe,D.J.,
            Riley,J.H., Watts,G.D., Ambrose,H., McGuire,G., Smith,A.D.,
            Sutcliffe,A., Mills,T. and Taylor,A.M.
  TITLE     Construction of a transcription map around the gene for ataxia
            telangiectasia: identification of at least four novel genes
  JOURNAL   Genomics 40 (2), 267-276 (1997)
   PUBMED   9119394
REFERENCE   9  (bases 1 to 6171)
  AUTHORS   Byrd,P.J., Stankovic,T., McConville,C.M., Smith,A.D., Cooper,P.R.
            and Taylor,A.M.
  TITLE     Identification and analysis of expression of human VACM-1, a cullin
            gene family member located on chromosome 11q22-23
  JOURNAL   Genome Res 7 (1), 71-75 (1997)
   PUBMED   9037604
REFERENCE   10 (bases 1 to 6171)
  AUTHORS   Kipreos,E.T., Lander,L.E., Wing,J.P., He,W.W. and Hedgecock,E.M.
  TITLE     cul-1 is required for cell cycle exit in C. elegans and identifies
            a novel gene family
  JOURNAL   Cell 85 (6), 829-839 (1996)
   PUBMED   8681378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003307.3 and AP002433.5.
            
            On Aug 31, 2019 this sequence version replaced NM_003478.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063306.1, SRR11853567.6119.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393094.7/ ENSP00000376808.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               AP003307.3         78686-79160
            476-585             AP003307.3         103590-103699
            586-685             AP003307.3         116059-116158
            686-862             AP003307.3         119679-119855
            863-1004            AP003307.3         122449-122590
            1005-1150           AP003307.3         124436-124581
            1151-1231           AP003307.3         124664-124744
            1232-1325           AP003307.3         139885-139978
            1326-1456           AP003307.3         142121-142251
            1457-1564           AP003307.3         143179-143286
            1565-1629           AP003307.3         147965-148029
            1630-1762           AP003307.3         158316-158448
            1763-1894           AP003307.3         159281-159412
            1895-2018           AP003307.3         164180-164303
            2019-2194           AP003307.3         164601-164776
            2195-2356           AP003307.3         165319-165480
            2357-2475           AP003307.3         167425-167543
            2476-2599           AP003307.3         168195-168318
            2600-6171           AP002433.5         88768-92339
FEATURES             Location/Qualifiers
     source          1..6171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..6171
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /note="cullin 5"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
     exon            1..475
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..2794
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /note="Cullin-5 (vasopressin-activated calcium-mobilizing
                     receptor-1); Vasopressin-activated calcium-mobilizing
                     receptor-1; vasopressin-activated calcium-mobilizing
                     receptor 1"
                     /codon_start=1
                     /product="cullin-5"
                     /protein_id="NP_003469.2"
                     /db_xref="CCDS:CCDS31668.1"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
                     /translation="MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLF
                     SDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFT
                     QCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAM
                     KLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQA
                     PSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKET
                     ILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETIT
                     TDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQK
                     GVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVF
                     MRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQ
                     AFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH
                     SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE
                     LPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQK
                     RGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVE
                     ILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA"
     exon            476..585
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..685
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..862
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1004
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1150
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1231
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1325
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1456
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1564
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1629
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1762
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1894
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2018
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2194
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2356
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2475
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2599
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..6171
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6152..6157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /note="hexamer: AATAAA"
     polyA_site      6171
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtcccc gccctcgcgt cacgtgacgt ggccgcggaa cctgagctgc ggggcctaag
       61 ccgagctaaa ttcgttgcag gtggccgcgg cgggtgcaac cacaaaggct aatccgaagg
      121 agtcggggag gctcgtggag tcgatgcttc ctcttccaag tcaggtcggc tcccgttacc
      181 ttctcagcat tcgccgttcc ggtcttcctg agcgcgtgca tgaggtcttt cgcgtgggga
      241 agctccggtg accatgtagg ggagaagagt gaggaagctc ctggtgcttg ggacgaggtc
      301 agcgctgtcg gcgcgctgct ccagcgccca ccacaccctg gtgcgggccg acgggccctg
      361 ggccctggtg ggagctccgg cctccggtca aggcctggcc gggagcgcca cgaattctcg
      421 cgtcgtctcg cgagagtcca agttaaagaa catggcgacg tctaatctgt taaagaataa
      481 aggttctctt cagtttgaag acaaatggga ttttatgcgc ccgattgttt tgaagctttt
      541 acgccaggaa tctgttacaa aacagcagtg gtttgatctg ttttcggatg tgcatgcagt
      601 ctgtctttgg gatgataaag gcccagcaaa aattcatcag gctttaaaag aagatattct
      661 tgagtttatt aagcaagcac aggcacgagt actgagccat caagatgata cggctttgct
      721 aaaagcatat attgttgaat ggcgaaagtt ctttacacaa tgtgatattt taccaaaacc
      781 tttttgtcaa ctagagatta ctttaatggg taaacagggc agcaataaaa aatcaaatgt
      841 ggaagacagt attgttcgaa agcttatgct tgatacatgg aatgagtcaa tcttttcaaa
      901 cataaaaaac agactccaag atagtgcaat gaagctggta catgctgaga gattgggaga
      961 agcttttgat tctcagctgg ttattggagt aagagaatcc tatgttaacc tttgttctaa
     1021 tcctgaggat aaacttcaaa tttataggga caattttgag aaggcatact tggattcaac
     1081 agagagattt tatagaacac aagcaccctc gtatttacaa caaaatggtg tacagaatta
     1141 tatgaaatat gcagatgcta aattaaaaga agaagaaaaa cgagcactac gttatttaga
     1201 aacaagacga gaatgtaact ccgttgaagc actcatggaa tgctgtgtaa atgccctggt
     1261 gacatcattt aaagagacta tcttagctga gtgccaaggc atgatcaaga gaaatgaaac
     1321 tgaaaaatta catttaatgt tttcattgat ggacaaagtt cctaatggta tagagccaat
     1381 gttgaaagac ttggaggaac atatcattag tgctggcctg gcagatatgg tagcagctgc
     1441 tgaaactatt actactgact ctgagaaata cgttgagcag ttacttacac tatttaatag
     1501 atttagtaaa ctcgtcaaag aagcttttca agatgatcca cgatttctta ctgcaagaga
     1561 taaggcgtat aaagcagttg ttaatgatgc taccatattt aaacttgaat tacctttgaa
     1621 gcagaagggg gtgggattaa aaactcagcc tgaatcaaaa tgccctgagc tgcttgccaa
     1681 ttactgtgac atgttgctaa gaaaaacacc attaagcaaa aaactaacct ctgaagagat
     1741 tgaagcaaag cttaaagaag tgctcttggt acttaagtat gtacagaaca aagatgtttt
     1801 tatgaggtat cataaagctc atttgacacg acgtcttata ttagacatct ctgccgatag
     1861 tgaaattgaa gaaaacatgg tagagtggct aagagaagtt ggtatgccag cggattatgt
     1921 aaacaagctt gctagaatgt ttcaggacat aaaagtatct gaagatttga accaagcttt
     1981 taaggaaatg cacaaaaata ataaattggc attaccagct gattcagtta atataaaaat
     2041 tctgaatgct ggcgcctggt caagaagttc tgagaaagtc tttgtctcac ttcctactga
     2101 actggaggac ttgataccgg aagtagaaga attctacaaa aaaaatcata gtggtagaaa
     2161 attacattgg catcatctca tgtcaaatgg aattataaca tttaagaatg aagttggtca
     2221 atatgatttg gaggtaacca cgtttcagct cgctgtattg tttgcatgga accaaagacc
     2281 cagagagaaa atcagctttg aaaatcttaa gcttgcaact gaactccctg atgctgaact
     2341 taggaggact ttatggtctt tagtagcttt cccaaaactc aaacggcaag ttttgttgta
     2401 tgaacctcaa gtcaactcac ccaaagactt tacagaaggt accctcttct cagtgaacca
     2461 ggagttcagt ttaataaaaa atgcaaaggt tcagaaaagg ggtaaaatca acttgattgg
     2521 acgtttgcag ctcactacag aaaggatgag agaagaagag aatgaaggaa tagttcaact
     2581 acgaatacta agaacccagg aagctatcat acaaataatg aaaatgagaa agaaaattag
     2641 taatgctcag ctgcagactg aattagtaga aattttgaaa aacatgttct tgccacaaaa
     2701 gaaaatgata aaagagcaaa tagagtggct aatagagcac aaatacatca gaagagatga
     2761 atctgatatc aacactttca tatatatggc ataattttga atatcatgga caatatttag
     2821 aacccaaatt ttggagtgct tgggcagaaa gttgtaaagt ttgtgctgga gaaaggttta
     2881 tttggacttt gattacataa atattaaaat ctctgcctta ccttacaaaa acaactatat
     2941 tttgccaatc acattagtta gcatgatggc attcccttca tgttgcacac tctttgacag
     3001 catgctgttt tgtggagaaa cttgcattca tgaagagccc attatcaact tttaaaagtg
     3061 aatttgattt gtacccacca ggagaaatac agttgggaag ggtgagggtg gggttcttgt
     3121 tgcttttttc tcttttttcc tctcttaaaa aatgtacttg cacaaggaag gatcttcaga
     3181 tattcatgca ctgaaaaatg ctgttatctt ttgtttttaa aaaatgcaat taaaactaga
     3241 aatagcactc ttggtttctt ttgatgaaaa gagtgagctg gtcaatgcaa cattgggaaa
     3301 cggcagatgt aggtgagaag ttaagtattt aatagtatca aattgttcaa acattgctca
     3361 gtataataac tggattttaa tggtgaccta aaaatggtat taaatatttt caactttcaa
     3421 atgttggttt tctttaagca ggagactgct attttagttg ttgttaaatg atgaggagtt
     3481 tttttttttt taaatatggc tggaaagctt gttttgaaaa atgaagctta tattaattgt
     3541 tgcttcaata gtttaaaaaa tttatggaga taggtaggtc attatgattg cagagccaaa
     3601 atagcaaaac aaacatatta agtgtgttta ctaaacatat tgtgtgttta ctaacacact
     3661 taatgtttat atacctaata tttattatgc catatctgaa tttattaaaa acaacacaga
     3721 aatctcctgc tctgatatag ttatgtaact gatctcttaa tctgtagcat agaagtattt
     3781 tggtatttta aggtctcatg attagggatt tgtagcctca ggtttgaatc agtcacctag
     3841 gggtaagaga aaaaccacaa cataagacct gaaaaacaga agcaaaattg ttgcactctt
     3901 aatacgagca gtaaacttgc caaatatatg tacatatata tttatatatt ttaaaaataa
     3961 acatttttta aatcgtcaga aggcaacatt taccatgttc ctttcagtct atccaaagta
     4021 gcaacttaac tagttgctgg caactgaata cccagagtag tggaaatttt aggacttgag
     4081 gacgtgaaca acttgaaaga gaaaattgat tccccttgag gaaagaatgg ctcaacgtgg
     4141 atttttattc attgtggtgc acgtttcaaa ttttcttgca aattatttta tatcttattt
     4201 gatgttaagt aatattttta aagtatggtt tttgaagata gtaggaaatg gagtacagaa
     4261 aggcatacag tattatgtta cagtggagtg ctttcaagag catttcgtag gatctgtccc
     4321 catccgaaga ggctttgtga actgcctgct gaatggaagg aaagcaactt taaaacattt
     4381 agagttttgc tgagtatagc caaatgcctg ttctgaaact tataggaaat tggaattttg
     4441 tttaaaattt tacactttaa ggtagcaaat gtcaattatt agaccgagca tattgtgaag
     4501 aattaaacta aaattaatac gtacagtttt ctctaattag gtgactgttc ataatgggta
     4561 tatttggaat ttagaagaaa taattttgta gtaattgtgg cccttatgtt taacagataa
     4621 ttcagcattg gcgtatttgc ttgtcccaat acaagaatgc caaaggagga aacaggaaaa
     4681 attgccgtcc attttaaaaa tttaggtttg ttgttttaaa ccataattgt tctcagaact
     4741 tttttggaac ttctaatttt gggtcattta atttaagaat gagagtcatg atgttttgat
     4801 ttatgaaggt gaatttaatg caaaagtggg taacactaca ttcatagcaa agttttttat
     4861 taaattttat aaatttttaa tagccaatta tgtcctaatt gtattttggg gaatgaacag
     4921 cagcaaatac tgtaaatgta cagttttctt tttttttttt ttttggttat gtatacaaaa
     4981 gttttaacta ctttttggtg tttatgaaaa tcatttagtt gacaaggtgc ctatgccatt
     5041 gttaaatttt ctttaagtaa tttaacaaca gatttgctaa tttaaaaaaa aatgaaaaaa
     5101 aaaatcttac cagcagtttg taaaggtctg gaatcacagt tggcatcctt tattcaggtc
     5161 tcttctctcc agcgtacact taaaattggt gccgagcagg gatataacct gcagttaagt
     5221 gaaaagaaaa tccagcctcc ccctccaaaa aaaaaaaaaa aatttaattt ttaaaaatta
     5281 gtggtatggc aataagacac ttcagaggct atcttaacct ctgaataccc atcttctagt
     5341 ttaaagacag agacatccca tctggaaaat gttaacttgt gttgccatct cgttgccgga
     5401 gtaagtagac ataagacaga gtttaagaag taaaaatata gaaaaatttt gatggtcaca
     5461 atgagataaa tattagaata ttactattcc aatgattaaa tgaggatctt gaaataaatt
     5521 ctgaagtctt ccaattttta catttattgg aggggtccct gagttctgtc aactttttta
     5581 tttaagtctc ttgctcttat tttgtgcata aatgttaaac cttccaaaaa tgaaatgtta
     5641 gctttctttc ttttactttt tattaaattt aatagaaaat atgacctgag tagttaaaaa
     5701 gtattttgca ttatttgcag taagatgtct ctagcactgc tcaaagggca aattttaaaa
     5761 cttcagtctg ggtgaaagat ttgctagttt tacagaaaga tttgctatct taaactcaag
     5821 ctggtttttc tgttctcatg taagtgactg ggatgctgtc ttatgaattc ttccaaggtc
     5881 atgtttgtga aataaacatt acatgagagc tttcctgtca tctacactat atgttgtctg
     5941 gagtgttgaa caaatttatt ttagtttcta agttgtaatc tatcctcata tggtctatac
     6001 gattttgaat gtgtgccact acatactgag atgataatgc tgtacaattt taagtggtag
     6061 cagtttctgt atgcagtagg ctgaaatatt ttgatgaact gcttaatttt tggattttat
     6121 tttttaagtt gtataattta ttttcttgca aaataaaaat gtaatataaa a
//
