LOCUS       NM_001079872            5915 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens cullin 4B (CUL4B), transcript variant 2, mRNA.
ACCESSION   NM_001079872
VERSION     NM_001079872.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5915)
  AUTHORS   Wang,X., Xue,Q., Duan,Q., Sun,Z., Wu,Y., Yang,S., Xu,P., Cao,H.,
            Liao,F., Wang,X. and Miao,C.
  TITLE     Circ_0011058 alleviates RA pathology through the
            circ_0011058/miR-335-5p/CUL4B signal axis
  JOURNAL   Autoimmunity 57 (1), 2299587 (2024)
   PUBMED   38254314
  REMARK    GeneRIF: Circ_0011058 alleviates RA pathology through the
            circ_0011058/miR-335-5p/CUL4B signal axis.
REFERENCE   2  (bases 1 to 5915)
  AUTHORS   Karaosmanoglu,C., Yildiz,S.H., Akdogan,M. and Erdogan,M.O.
  TITLE     Association of CUL4B with the pathogenesis of age-related cataract
  JOURNAL   Int Ophthalmol 44 (1), 288 (2024)
   PUBMED   38937308
  REMARK    GeneRIF: Association of CUL4B with the pathogenesis of age-related
            cataract.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5915)
  AUTHORS   Wu,R., Li,X., Meng,Z., Li,P., He,Z. and Liang,L.
  TITLE     Phenotypic and genetic analysis of children with unexplained
            neurodevelopmental delay and neurodevelopmental comorbidities in a
            Chinese cohort using trio-based whole-exome sequencing
  JOURNAL   Orphanet J Rare Dis 19 (1), 205 (2024)
   PUBMED   38764027
  REMARK    GeneRIF: Phenotypic and genetic analysis of children with
            unexplained neurodevelopmental delay and neurodevelopmental
            comorbidities in a Chinese cohort using trio-based whole-exome
            sequencing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5915)
  AUTHORS   Ma,Y., Liu,X., Zhou,M., Sun,W., Jiang,B., Liu,Q., Wang,M., Zou,Y.,
            Liu,Q., Gong,Y. and Sun,G.
  TITLE     CUL4B mutations impair human cortical neurogenesis through
            PP2A-dependent inhibition of AKT and ERK
  JOURNAL   Cell Death Dis 15 (2), 121 (2024)
   PUBMED   38331954
  REMARK    GeneRIF: CUL4B mutations impair human cortical neurogenesis through
            PP2A-dependent inhibition of AKT and ERK.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5915)
  AUTHORS   Kreienbuhl,J., Changkhong,S., Orlowski,V., Kirschner,M.B., Opitz,I.
            and Meerang,M.
  TITLE     Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and
            Regulates TGF-beta1 Expression in Pleural Mesothelioma
  JOURNAL   Int J Mol Sci 24 (17), 13410 (2023)
   PUBMED   37686215
  REMARK    GeneRIF: Cullin 4B Ubiquitin Ligase Is Important for Cell Survival
            and Regulates TGF-beta1 Expression in Pleural Mesothelioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5915)
  AUTHORS   Jones,E.A., Clement-Jones,M. and Wilson,D.I.
  TITLE     JAGGED1 expression in human embryos: correlation with the Alagille
            syndrome phenotype
  JOURNAL   J Med Genet 37 (9), 658-662 (2000)
   PUBMED   10978356
REFERENCE   7  (bases 1 to 5915)
  AUTHORS   Hori,T., Osaka,F., Chiba,T., Miyamoto,C., Okabayashi,K.,
            Shimbara,N., Kato,S. and Tanaka,K.
  TITLE     Covalent modification of all members of human cullin family
            proteins by NEDD8
  JOURNAL   Oncogene 18 (48), 6829-6834 (1999)
   PUBMED   10597293
REFERENCE   8  (bases 1 to 5915)
  AUTHORS   Wada,H., Yeh,E.T. and Kamitani,T.
  TITLE     Identification of NEDD8-conjugation site in human cullin-2
  JOURNAL   Biochem Biophys Res Commun 257 (1), 100-105 (1999)
   PUBMED   10092517
REFERENCE   9  (bases 1 to 5915)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   10 (bases 1 to 5915)
  AUTHORS   Kipreos,E.T., Lander,L.E., Wing,J.P., He,W.W. and Hedgecock,E.M.
  TITLE     cul-1 is required for cell cycle exit in C. elegans and identifies
            a novel gene family
  JOURNAL   Cell 85 (6), 829-839 (1996)
   PUBMED   8681378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647096.1, BX537787.1,
            AY365125.1, AC002476.1 and CV573599.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 10, 2019 this sequence version replaced NM_001079872.1.
            
            Summary: This gene is a member of the cullin family. The encoded
            protein forms a complex that functions as an E3 ubiquitin ligase
            and catalyzes the polyubiquitination of specific protein substrates
            in the cell. The protein interacts with a ring finger protein, and
            is required for the proteolysis of several regulators of DNA
            replication including chromatin licensing and DNA replication
            factor 1 and cyclin E. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting isoform (2) has a shorter and unique
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647096.1, CR936722.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371322.11/ ENSP00000360373.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               BX647096.1         1-246
            247-324             BX537787.1         238-315
            325-2448            AY365125.1         1-2124
            2449-3980           BX537787.1         2440-3971
            3981-4833           AC002476.1         98778-99630         c
            4834-5184           CV573599.1         1-351
            5185-5915           AC002476.1         97696-98426         c
FEATURES             Location/Qualifiers
     source          1..5915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..5915
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="cullin 4B"
                     /db_xref="GeneID:8450"
                     /db_xref="HGNC:HGNC:2555"
                     /db_xref="MIM:300304"
     exon            1..880
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..3012
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="cullin-4B isoform 2"
                     /protein_id="NP_001073341.1"
                     /db_xref="CCDS:CCDS43987.1"
                     /db_xref="GeneID:8450"
                     /db_xref="HGNC:HGNC:2555"
                     /db_xref="MIM:300304"
                     /translation="MFPTGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSS
                     SSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
                     FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAK
                     SSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYN
                     LEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQ
                     NHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILL
                     LIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREV
                     PEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDEN
                     RIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
                     DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELE
                     KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFT
                     SKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPE
                     MVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE
                     GEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKH
                     KLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVY
                     NQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA"
     exon            881..996
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1100
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1170
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1244
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1407
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1497
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1580
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1648
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1767
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1960
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2065
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2176
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2262
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2370
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2484
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2590
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2763
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2916
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..5915
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5139..5144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="hexamer: AATAAA"
     polyA_site      5161
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="major polyA site"
     regulatory      5410..5415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="hexamer: TATAAA"
     polyA_site      5431
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
     regulatory      5759..5764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="hexamer: CATAAA"
     polyA_site      5777
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
     regulatory      5885..5890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="hexamer: ATTAAA"
     regulatory      5891..5896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
                     /note="hexamer: AAGAAA"
     polyA_site      5909
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
     polyA_site      5915
                     /gene="CUL4B"
                     /gene_synonym="CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2"
ORIGIN      
        1 agactcgctg agtcgctcct gcagaaaggg ggggagagag atcgaaaagc aggggagggg
       61 gacggcacgg ccgtttacct gtctgcctcc tcattcgctc tcccccctcg ttctgctcac
      121 tcctggtgtc agcctatccg ccttcccaaa ccctcccatt cccccggtgt agcccccccc
      181 ttcactttcc ttctcgtcct ctgtgtttct cctctcttct ttcttccctt ccccctctag
      241 cattgctacc ttctctccta cacgcacgca ggcatataaa cgtaggtttt tgatgctcct
      301 ctgcctgttg accccgctat tttcatgttt ccaacaggtt tttcttcccc cagtccctca
      361 gctgctgctg ctgctcagga ggtcagatct gccactgatg gtaataccag caccactccg
      421 cccacctctg ccaagaagag aaagttaaac agcagcagca gtagcagcag taacagtagt
      481 aacgagagag aagactttga ttccacctct tcctcctctt ccactcctcc tttacaaccc
      541 agggattcgg catccccttc aacctcgtcc ttctgcctgg gggtttcagt ggctgcttcc
      601 agccacgtac cgatacagaa gaagctgcgt tttgaagaca ccctggagtt tgtagggttt
      661 gatgcgaaga tggctgagga atcctcctcc tcctcctcct catcttcacc aactgctgca
      721 acatctcagc agcagcaact taaaaataag agtatattaa tctcttctgt ggcttcggtg
      781 catcatgcaa acggcctagc caaatcttct accaccgtct ctagctttgc taacagcaaa
      841 cctggctctg ctaagaagtt agtgatcaag aactttaaag ataagcctaa attaccagaa
      901 aactacacag atgaaacctg gcaaaaactg aaagaagcag tggaagctat tcagaatagt
      961 acttcaatta agtacaattt agaagaactc taccaggctg tagaaaatct ctgttcttac
     1021 aagatttctg caaacttgta caaacagctg agacagatct gcgaagatca catcaaagca
     1081 cagattcatc aattcagaga ggattcattg gatagcgttc tttttttaaa gaagattgat
     1141 agatgctggc aaaaccattg cagacaaatg atcatgatca ggagcatttt tttgtttctg
     1201 gatagaactt acgttcttca gaattcaatg ctaccctcca tttgggacat gggactggag
     1261 ttatttaggg ctcatattat aagtgatcag aaagtgcaga ataagacaat tgatggcatt
     1321 cttctcttga ttgagaggga aaggaatggt gaagcaattg atagaagttt acttcgaagc
     1381 cttttaagca tgctgtctga tttgcaaatt tatcaagatt cttttgaaca acgatttttg
     1441 gaagaaacta accggctcta tgcagctgaa ggccaaaaat taatgcaaga aagagaggtt
     1501 cctgaatatc tacatcatgt taacaaacgt ctagaagaag aagcagacag acttattact
     1561 tacttagatc agaccaccca gaagtcatta attgctactg tagaaaaaca acttctaggt
     1621 gaacacttaa cagcaattct tcagaaaggt ttaaataacc tccttgatga aaaccgaatt
     1681 caagatttgt ctcttctgta tcagctcttc agtagagttc gaggtggagt tcaggttctt
     1741 ttgcagcagt ggatcgaata tatcaaggca tttggcagca ctattgtaat taatcctgaa
     1801 aaagataaaa ccatggttca agaattgctg gattttaaag ataaggttga ccatataatt
     1861 gatatctgct ttctgaagaa tgagaaattt atcaatgcca tgaaagaagc atttgaaacg
     1921 ttcattaaca aaagaccaaa taaaccagct gaacttatag ctaagtatgt agattcaaaa
     1981 cttcgtgcag gcaacaaaga agctacagat gaagaacttg agaaaatgtt ggataaaatt
     2041 atgatcatat ttagatttat ctatggcaag gatgtttttg aggccttcta taagaaagat
     2101 ttagccaagc gcctgttagt cggaaagagt gcatctgtag atgctgaaaa atcaatgctg
     2161 tccaaactta aacatgaatg cggagctgct ttcaccagca aacttgaagg aatgtttaaa
     2221 gacatggaac tttctaaaga catcatgatt cagttcaaac agtatatgca gaatcagaat
     2281 gttccgggaa atattgagtt aactgtgaat atcctgacaa tgggctattg gccgacatat
     2341 gtgcctatgg aagttcattt accaccagag atggtaaaac ttcaggagat tttcaagaca
     2401 ttttacctag gcaaacatag tggcaggaaa cttcagtggc agtcaaccct aggacactgt
     2461 gtgttaaaag cagaatttaa agagggtaaa aaggaactcc aggtctctct ttttcaaaca
     2521 ctggtgctgc taatgtttaa tgagggagag gagttcagtt tagaagagat caagcaggca
     2581 actggaatag aggatggaga gttaaggaga acactgcagt cattagcctg tggcaaagct
     2641 agagttctgg cgaaaaatcc aaagggcaaa gacattgaag atggtgacaa gttcatttgt
     2701 aatgatgatt tcaaacataa acttttcagg ataaagatca atcaaatcca gatgaaagaa
     2761 acggttgaag aacaagcaag cactacagaa agagtatttc aagacagaca gtatcaaatt
     2821 gatgctgcaa ttgttcgaat tatgaagatg agaaagacac ttagccacaa tctccttgtt
     2881 tcagaagtgt acaaccagtt gaaatttcca gtaaagcctg ctgatcttaa gaagagaata
     2941 gaatctttaa ttgaccggga ctacatggaa agagataaag aaaatccaaa ccagtacaac
     3001 tatattgcat agaatgttgg ccttgcagca tttggtgtca tatgcagtag ccagtggata
     3061 aactaacctg ttgattcaat attatttgac tcctttttta ctaccgatga ccaaatgaag
     3121 cagtgtaatt aatggaaata gttgagtgga ctttttctca gtggttaaca tgcccatttt
     3181 aaagagtaat acttaccttt aagaagaatg ttgttgaact ctttgcatgt tatttagtat
     3241 gatgtgcaga aaacacttaa gaacgtacct ggtcttcatg aattcctctt tggaactggg
     3301 aaagagatcc ctgtggctat taaaaagggg ggagggttct tacacaccat taattatgaa
     3361 gcaaaaggtt tatttgctta aaatgtcatt taaagatact taaactgcat gcaaacttta
     3421 tttactgtac agagttctgg atgtatttat caaatagaaa aaccaccctt gacttggttg
     3481 ttcacccgtt ttgtgatttc ccttgaaaag agaaatgaat tgtcatagct attgatattt
     3541 tactaggtga tgttctgtta cactgaaagg gatgtttttt aaaaaaaatt atttggaaac
     3601 aagttttcaa gtagggggac agttgcttac ataatatctt gtatattcac atcctaaaaa
     3661 ttttcattta tgagtatggg atgtgtgtat atggcttagc cccaagttaa ctgtgctgat
     3721 taacaagtac ttataaaaat agctaaagta gaaaattaat gatcagttgt actagaggaa
     3781 catcatagaa gagaaaaatc caactcttta tattaaaaat gaatacaata agaaaattgc
     3841 aaaagagacc aaaatgaacg tgttttgtaa attgttacag gagcaaaaac tttgcaacta
     3901 gttttcaaca tactttagac tttaaatgtt gtttggacag ttttgtcttc aacttggacc
     3961 aattgtagat tgttacaggc ttcctaggat ttagcattcc tattttctct accaaagttt
     4021 tttttagaag catcccaact cttctctttg ttgataaata agcctttcct gtcatcttca
     4081 ttttaacttg ctaaaaccct agatacaaag gtcctccctc atttttccca cagagcccct
     4141 gtttgggaat ttgagattct gtgtcatgct ggttttcctt tcagaattgc ttgaaatcga
     4201 gttctcttag ccactggaca cctagttttc aggagaatgt cccaagattg tttatatata
     4261 caaaatggca aaagtactgt ttttcgaatt gataattcaa gcaaaggctt ctctttactg
     4321 tcactgattt ttttttgttt ttattttgtt tccttgtttc tatttccttg aagctttgaa
     4381 gggaggagaa gcagaaaatt ttgtttatgt ttgttaaaaa tcagaactac ttaatgcttt
     4441 ttgccacagc atatttcctt gcctgttgga gccgttagga agattaccta tgtcctaatc
     4501 ttcaacctga gaagattttt gactcttgtg tctactgttg attgtttgct tgagttctca
     4561 aagacctgtg gccaggtatt ttaaaaagtc gtctatttct ttctagttgc atcaacttgc
     4621 acactggtgt ctaactatat gtggtattcg gaacttgtaa ttcttattga gcagccattg
     4681 cctatatttt ctcagctcct cactgatttc tttatatgag ctcagctgac aagcaaatgc
     4741 agctattttg tttaccctct cttcataccg gaccatcaac aacagtgttc taactcatcc
     4801 ctgatggtct gtgagatgta gactattaca caagattcaa gttactcgta agcaactttt
     4861 agatagagtt ggtcctgtta ggaggagact cttgatgtca ccttcagtat cttgaaagcg
     4921 ggtcccctcc ccgaggctct taattctttg aaaacttgat gctgtttcag ctgaaaaatt
     4981 agcaagactg ttaaaaaaaa aaagttgagg ggagctgttt aagaaactga aaagtaattg
     5041 caaactacat tggataattg tgactttcag ttgttgttct gtatcagttg aatttttgtg
     5101 ctcttttccc tgtgtacgtg gtggttctat ttttctccaa taaaactttt atttaaaaaa
     5161 agtttctaga gaagatcttt aaaattcaag tattgtaaga aagttataaa atcacaggac
     5221 ttaaaatctt cctaacaact tctaatgaac tcacatttgt tgattttgtt atttttaaac
     5281 tttttaaaaa ttttgtaatg gttttgtggt aatgctataa gagtatgggg gagggcatgg
     5341 ttaacagggt gaggaaaatt cccaggaatc ctcaaggtgg ataattattc ttaaacatgc
     5401 ggatacaagt ataaacattg cttcattcaa atcctcagtg tcaaattgtt tcataaagtc
     5461 aatatgaaat gagtctagat ttgagttcag gggagaagaa aagattactc ttagttatgg
     5521 catttgctct gccttttctg ttaatagttt tttgagttct gggccagata ctctcagagt
     5581 aagatgttcc tcaaagtttt tgaacccagt tcctgagtct gcttgaatgg tcttaatatg
     5641 atgtctagcc atactcttga aatttttgct gtgtatgtga gtgtacagtt cagaaaacca
     5701 gtttatctgg gcatctggat ctaaagattt gagaagtttg ttttttaatc tggatattca
     5761 taaatctttt aaaatgagct ggtctttgtt ttcatgacca ctctgtttaa tgctgtgaat
     5821 ggcaggagtg ttgtgagcgt gttctattct cttatttaca taaaattgcc aaaacaaatt
     5881 gttcattaaa aagaaaagag cagtactgat gaaaa
//
