LOCUS       NM_003590               6756 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cullin 3 (CUL3), transcript variant 1, mRNA.
ACCESSION   NM_003590 XM_376176
VERSION     NM_003590.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6756)
  AUTHORS   Pratummanee,K., Kerdkumthong,K., Roytrakul,S., Tantimetta,P.,
            Runsaeng,P., Saeheng,S. and Obchoei,S.
  TITLE     Knockdown of cullin 3 inhibits progressive phenotypes and increases
            chemosensitivity in cholangiocarcinoma cells
  JOURNAL   Mol Med Rep 30 (5) (2024)
   PUBMED   39239747
  REMARK    GeneRIF: Knockdown of cullin 3 inhibits progressive phenotypes and
            increases chemosensitivity in cholangiocarcinoma cells.
REFERENCE   2  (bases 1 to 6756)
  AUTHORS   Namani,A., Veeraiyan,D. and Patra,T.
  TITLE     A comparative analysis indicates SLC7A11 expression regulate the
            prognostic value of KEAP1-NFE2L2-CUL3 mutations in human uterine
            corpus endometrial carcinoma
  JOURNAL   Free Radic Biol Med 222, 223-228 (2024)
   PUBMED   38876457
  REMARK    GeneRIF: A comparative analysis indicates SLC7A11 expression
            regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in
            human uterine corpus endometrial carcinoma.
REFERENCE   3  (bases 1 to 6756)
  AUTHORS   Pantazi,V., Miklos,V., Smith,P., Olah-Nemeth,O., Pankotai-Bodo,G.,
            Teja Dondapati,D., Ayaydin,F., D'Angiolella,V. and Pankotai,T.
  TITLE     Prognostic potential of CUL3 ligase with differential roles in
            luminal A and basal type breast cancer tumors
  JOURNAL   Sci Rep 14 (1), 14912 (2024)
   PUBMED   38942922
  REMARK    GeneRIF: Prognostic potential of CUL3 ligase with differential
            roles in luminal A and basal type breast cancer tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6756)
  AUTHORS   He,Z.X., Li,J., Wang,Q.F., Cheng,Q. and Ni,S.J.
  TITLE     [The effect of ubiquitin ligase Cullin3 on the proliferation,
            migration and invasion of triple-negative breast cancer cells and
            exploration of its mechanism]
  JOURNAL   Zhonghua Yi Xue Za Zhi 104 (20), 1868-1878 (2024)
   PUBMED   38782756
  REMARK    GeneRIF: [The effect of ubiquitin ligase Cullin3 on the
            proliferation, migration and invasion of triple-negative breast
            cancer cells and exploration of its mechanism].
REFERENCE   5  (bases 1 to 6756)
  AUTHORS   Boyden,L.M., Choi,M., Choate,K.A., Nelson-Williams,C.J., Farhi,A.,
            Toka,H.R., Tikhonova,I.R., Bjornson,R., Mane,S.M., Colussi,G.,
            Lebel,M., Gordon,R.D., Semmekrot,B.A., Poujol,A., Valimaki,M.J., De
            Ferrari,M.E., Sanjad,S.A., Gutkin,M., Karet,F.E., Tucci,J.R.,
            Stockigt,J.R., Keppler-Noreuil,K.M., Porter,C.C., Anand,S.K.,
            Whiteford,M.L., Davis,I.D., Dewar,S.B., Bettinelli,A.,
            Fadrowski,J.J., Belsha,C.W., Hunley,T.E., Nelson,R.D.,
            Trachtman,H., Cole,T.R., Pinsk,M., Bockenhauer,D., Shenoy,M.,
            Vaidyanathan,P., Foreman,J.W., Rasoulpour,M., Thameem,F.,
            Al-Shahrouri,H.Z., Radhakrishnan,J., Gharavi,A.G., Goilav,B. and
            Lifton,R.P.
  TITLE     Mutations in kelch-like 3 and cullin 3 cause hypertension and
            electrolyte abnormalities
  JOURNAL   Nature 482 (7383), 98-102 (2012)
   PUBMED   22266938
  REMARK    GeneRIF: fundamental role for KLHL3 and CUL3 in blood pressure,
            K(+) and pH homeostasis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6756)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   7  (bases 1 to 6756)
  AUTHORS   Du,M., Sansores-Garcia,L., Zu,Z. and Wu,K.K.
  TITLE     Cloning and expression analysis of a novel salicylate suppressible
            gene, Hs-CUL-3, a member of cullin/Cdc53 family
  JOURNAL   J Biol Chem 273 (38), 24289-24292 (1998)
   PUBMED   9733711
REFERENCE   8  (bases 1 to 6756)
  AUTHORS   Michel,J.J. and Xiong,Y.
  TITLE     Human CUL-1, but not other cullin family members, selectively
            interacts with SKP1 to form a complex with SKP2 and cyclin A
  JOURNAL   Cell Growth Differ 9 (6), 435-449 (1998)
   PUBMED   9663463
REFERENCE   9  (bases 1 to 6756)
  AUTHORS   Kipreos,E.T., Lander,L.E., Wing,J.P., He,W.W. and Hedgecock,E.M.
  TITLE     cul-1 is required for cell cycle exit in C. elegans and identifies
            a novel gene family
  JOURNAL   Cell 85 (6), 829-839 (1996)
   PUBMED   8681378
REFERENCE   10 (bases 1 to 6756)
  AUTHORS   Ellison,D.H.
  TITLE     Pseudohypoaldosteronism Type II
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22073419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ688156.1, AB014517.2 and
            AC073052.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_003590.4.
            
            Summary: This gene encodes a member of the cullin protein family.
            The encoded protein plays a critical role in the polyubiquitination
            and subsequent degradation of specific protein substrates as the
            core component and scaffold protein of an E3 ubiquitin ligase
            complex. Complexes including the encoded protein may also play a
            role in late endosome maturation. Mutations in this gene are a
            cause of type 2E pseudohypoaldosteronism. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014517.2, BC039598.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264414.9/ ENSP00000264414.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BQ688156.1         35-72
            39-4484             AB014517.2         1-4446
            4485-6756           AC073052.5         22010-24281         c
FEATURES             Location/Qualifiers
     source          1..6756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.2"
     gene            1..6756
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /note="cullin 3"
                     /db_xref="GeneID:8452"
                     /db_xref="HGNC:HGNC:2553"
                     /db_xref="MIM:603136"
     exon            1..420
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..2661
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cullin-3 isoform 1"
                     /protein_id="NP_003581.1"
                     /db_xref="CCDS:CCDS2462.1"
                     /db_xref="GeneID:8452"
                     /db_xref="HGNC:HGNC:2553"
                     /db_xref="MIM:603136"
                     /translation="MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEI
                     QRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFL
                     QTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH
                     LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQ
                     MESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTI
                     VEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGE
                     GKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFI
                     DDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDS
                     EKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVL
                     TTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGP
                     VKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPE
                     RELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQG
                     ESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVV
                     IKKRIEGLIEREYLARTPEDRKVYTYVA"
     exon            421..618
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            619..732
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            733..893
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1008
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1237
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1383
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1560
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1731
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1839
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1964
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2061
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2196
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2383
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2529
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..6756
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2978..2983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /note="hexamer: AATAAA"
     polyA_site      3001
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /note="major polyA site"
     regulatory      4133..4138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /note="hexamer: ATTAAA"
     polyA_site      4153
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
     regulatory      6735..6740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
                     /note="hexamer: ATTAAA"
     polyA_site      6756
                     /gene="CUL3"
                     /gene_synonym="CUL-3; NEDAUS; PHA2E"
ORIGIN      
        1 gaggacgacg ttcggcctgc gcagtgagat gtttgtccgt cgccgccgcc gccgccatcg
       61 cggaggagcg cgataaaggg agccgagccg gacgtgaggg ggaccccgcg gagccgccgc
      121 gccagcgcag ccccccagcc gcatcggagt cgccagagtc cgagccgccg ccgccgccgc
      181 cgccgccccc gccgccgccg cggctgccca ggggccggcc agctccccag ccctgcccgg
      241 gggtcgcgcc gccgccgccc ccagcgtcgc ccctagcctg cctgcccgcc ttaaatgtga
      301 caccggcgtc gcggagcgcg acctgaagcc gccgccgggg aggggacgag caccatgtcg
      361 aatctgagca aaggcacggg cagccggaag gacaccaaga tgcggatccg ggcctttccg
      421 atgaccatgg atgaaaaata tgtaaacagc atttgggacc ttctgaaaaa tgcaattcaa
      481 gaaatccagc gtaagaataa cagtggtctt agttttgagg agctctatag aaatgcatat
      541 acaatggttt tgcataaaca tggagaaaag ctctacactg gactaagaga agttgttacc
      601 gaacatctca taaataaggt gcgagaagat gtactaaatt cattgaataa caactttctt
      661 caaacgctaa atcaagcttg gaatgatcat caaacagcta tggtgatgat tagagacata
      721 ctaatgtaca tggaccgtgt gtatgtacaa caaaataatg tggagaacgt ctacaatttg
      781 ggattaatta tttttcgaga tcaagttgta cgttatgggt gtattaggga tcatctacgg
      841 caaactctat tggatatgat tgcaagagag cggaaaggag aagtcgtaga cagaggcgca
      901 ataagaaatg cttgccagat gttaatgatt ttaggtctcg aaggaagatc agtctatgaa
      961 gaagattttg aggctccttt tttggaaatg tctgcagaat tttttcagat ggaaagccag
     1021 aaatttttag cagaaaatag tgcttcagta tatataaaga aagtagaagc tagaattaat
     1081 gaagaaatag aacgagtgat gcactgcctt gacaaatcaa cggaagaacc aattgtaaag
     1141 gtggttgaaa gggaactcat ttccaagcac atgaagacta tagtagaaat ggagaattct
     1201 gggctagtac atatgttgaa aaatggaaag acagaagacc ttggttgcat gtacaagtta
     1261 tttagtcgtg tgccaaatgg tttgaaaaca atgtgtgagt gtatgagttc ctatttgagg
     1321 gagcaaggta aagctcttgt ttctgaagaa ggagaaggaa agaatcctgt tgactatatc
     1381 cagggcttat tggatctgaa gagtaggttc gatcgcttcc tcctggaatc attcaacaat
     1441 gaccgtctct ttaaacaaac tattgcgggt gactttgagt attttctcaa cctcaactcc
     1501 aggtctcctg aatacctctc attatttatt gatgataagc tgaaaaaggg agtcaaaggg
     1561 ctaacagaac aagaagtaga aacaatattg gataaagcaa tggtcctttt taggtttatg
     1621 caagaaaaag atgtatttga acgttattat aaacaacact tggcaaggag acttctcaca
     1681 aataaaagtg tttctgatga ctctgaaaaa aacatgatat ctaagttaaa gactgaatgt
     1741 ggatgtcagt tcacgtcaaa actggaagga atgtttaggg atatgagcat ctcaaacaca
     1801 acgatggatg aattcaggca acatctacag gcaactggtg tatctttagg tggtgttgat
     1861 cttacagtcc gggtgctcac gacaggatat tggcccactc agtcagccac accaaagtgc
     1921 aacatcccac cagcaccaag acatgctttt gagatattca gaaggttcta cttagccaaa
     1981 cacagtggtc gacagctcac actccagcat catatgggtt ctgcagatct caatgccaca
     2041 ttttatggac cagttaaaaa ggaagatgga tctgaagttg gtgttggagg tgcacaagta
     2101 actggctcta atacacggaa gcacatattg caagtttcca ctttccagat gaccatatta
     2161 atgctcttta ataatagaga aaaatacaca tttgaggaaa ttcagcaaga gacagatatc
     2221 cctgaaagag agcttgttag agccctacag tccctcgcct gtggtaaacc aacacagcgg
     2281 gttcttacaa aagaacccaa atcaaaggaa atagaaaatg gtcatatatt tacagttaat
     2341 gatcaattca catccaaact acacagagtc aagattcaaa cagttgctgc caaacaaggt
     2401 gaatccgacc cagagaggaa agaaacaagg cagaaagtag acgacgacag aaaacatgag
     2461 atagaagctg ctatagtgcg gataatgaaa tctagaaaga agatgcagca caatgttcta
     2521 gtagcggagg taactcagca gttgaaggcg cgattcttac caagtccagt tgttattaag
     2581 aaacgtattg aaggacttat tgagagagaa tatttggcac gaacacctga ggatcgcaaa
     2641 gtatacacat atgtagcata aaatgcgttc agaaatttga tttattcttg gactgtactc
     2701 ttcgcatgga ctgggaagtt cttttaaatc attaaatatt aagacgacca tctcttctat
     2761 taaattacag tacatgttct agaccattga gatcaagcct ttactccctt tgagagtttc
     2821 caacatcagt tgattgagct tcaggcttta caacgtttat ccctgtagag atcatcttta
     2881 cagttcctcg ggaaaatgtg aatgtgctgc gttttgtttt ctttactgta tgaaaacagg
     2941 aaaataaaag agaaatttag aaaatacagc tcattacaat aaaattgttg gatttcattt
     3001 ccccaggtct tcagtgttga tgtaaatgtg ttttgtagtg ttgcttagca ctttgcgcat
     3061 tgtgtaagtt gggtaacaaa aatggcaaaa gaaatgcaga tttcccagtt atcttgctct
     3121 gaagacattt ctttagctag tcttatttaa ttttaaaggt ttgataaata tacaaagacc
     3181 caagcataca atttgagcat gctgtattct accacttgca cttactcatc ttctagcctt
     3241 atgaccagga acctttgttt tgggctcaag tacacatcct gatttggttt ctccctgttg
     3301 taatttgaga tttcccaaat taagtcttat aatgattagg ttttgttctg agttatttct
     3361 agagaaagaa agtattttag tatgtgtaaa ttgtacaata atttttttgc tgttgtactc
     3421 actgctaata gtggattgta tagggtggtg tttttatttc atttattgta gacaaaaata
     3481 atgaatttag tatacacata cccactaatt caagtatgtc agagcacaaa gttggcagct
     3541 ggttatattt aattcagccc ctctgaaaag cacatacagt ctatactttg tttataaata
     3601 ccctaggtcc tccctgcccc taaatatata ttttggtgaa gctgtggtgc actattaatt
     3661 ttctgtttca aaatgcaatc taaagatgca ataaatatga tgaccttgat agttttaatg
     3721 aaatcttcaa ttcttgcagc tgtgttttgg aaagtgatta agcaatattt ctcaaacctg
     3781 atgattcttg gatatttagc tattgtcctc caaagagtca tcgtttcacg ttttcaaaca
     3841 tgtgctttgt gctgaagatt cttgtcagat atcctgtgct tccagagtat ttttatcttc
     3901 aattttattt aattttgttt cattttgttt tcataagaca atgtttcaga tatgtaatgg
     3961 ggcaaaccac tatagatttc tgttggatag aaaaatgaaa tgttactaat aagtttaaat
     4021 tgacccttcg ttgactatca gtactgttga tacatttatt agaatgtatg tctcagaaga
     4081 tggtttctgt ttaaatttat ggtcaagtta caacaactga attctaatat ggattaaaaa
     4141 ctccacataa atatttttcc ccatgcgtct tgggttataa ttttcctttt agacttgcaa
     4201 atatgctttt attgcaattt tgtctccatc tgtactgtag aattacaagc cttgtgctct
     4261 ttatctctac attttccact tctacatgat gcaattaaga tgccaatgaa aagtattgtg
     4321 aacattattc tcaggacact tttaccatac ttgagtagta ctaagtcagg tgtaacatgg
     4381 aaagctaagg gtttcacctt ctgattttga cataattgga aattttctat aatggtaaga
     4441 tgtttatagg aaagtaatgg tagttcatgt ttgagaattt ttttattgct ttcatttccc
     4501 agttaaatga tatttaacac ctgggaaaac aggacagctc agattgtcga gttagtaaac
     4561 atgagcgatg taaaaacttt atttgaaatc tcctaagtga gacattaaac attttagtgc
     4621 tagtttaagc cattaaaagt aaagtttaag tttacgtcat tgtctcaagt gtggctgtaa
     4681 aaatcagatc tagagtttag agacatactt gttaactttg gagcacaggt ttgatattta
     4741 tgcttctaaa tacattaaaa catttctgaa ttgcagttga atggttggag attgctggcg
     4801 atgtgatgct gcactgaaaa aactggtcac acaaaatgtt tatatgtttg actgcataag
     4861 tattatttta ggtcataaag gttataacaa aatacattta acattgcttt ctttttagca
     4921 agaggtcaca gatgctattt tttctcagtt tttaatgctt taatttgaaa gaaaaatgca
     4981 tcctaaccat tccatcctgt tggtgcagag aaattttggt gatttattag aagactttta
     5041 aggagggtgg atacatagtt tttcaactgc aaaaatcatg tcatctcttc agtaactgtt
     5101 aaagtgtaat tctctgcctt cattatcaag tccaggacag tgtttatttt gaatcgttaa
     5161 cattatttaa agactgaaaa ttcattgcaa ttagggaacg cacagcctca caaaaagtgg
     5221 ttgtgattgc aaggattctt tatgtcagtg aacttaaaaa gggaatgggg gaagagatgc
     5281 atgcctttct aaaggtatgc tagagtcacc tgtgtagcat tgtaattatg tactatcaaa
     5341 cccccaagat gctgatgata ggccttctct gtaagaatcc ttctcatagt gaagcactgt
     5401 tgatgttttg ttcaccggat atgttgggta gcagaaaagg cctagaacca gttttaagat
     5461 tatgcctaca tctctagaag actagtacac tggcatcatc ttaggtttct aaatattatt
     5521 taattcctta atttggaaag cagttttaat gtttacagtt taagatactc attttcagta
     5581 actagtgtta aagattttta tctttgcctg tctactgtaa cttaagactt tcatagaata
     5641 attttttata gagtatatgg tatattgtgt caatcttgga aggaaagctg ttgcatatca
     5701 attgtaggtc atgtatttta ctatatgttg catagtattt tgcattctgt aaatacgaat
     5761 gttaaaacat ttcaggtcag caaaattaga agtcatttct agtcctcaaa gcagaaataa
     5821 ttagaaatgt taacatttaa gtgcttatca tatgccagat actattctga atattttatg
     5881 tatattcatt catttagttg tcatattggc tttatgtgac ataactgtca ttataccagt
     5941 gttgtccaag gttgctagca ggaaatggca gagccaggag ttggacctag gtttaatcct
     6001 atccatattc catgttacaa attgacatga ttttccatat taaaaaattt tcatttattt
     6061 tgtacctcat tcacatgaat agtaatgtga caaactaaag ttaatacatg aagcattgca
     6121 atatggaatt ttgcacattt ttgttagctt tacattattt gctgatacca acttttggta
     6181 ggaaggaaaa cagggaaggt gattgctgct attctggaat gtgtccattg aaaagaaaat
     6241 aggcgctttg tctcctacaa tcttagagaa agttttacat acttaagtgg gtaccacaga
     6301 taggcatgta ccttaaattc aaatctacag ttttacaaaa tgttttcctt tgtgtgcctt
     6361 tcctatgtca aattagccag aaggaagaag agacgttaag aatggcagat aaatttaaca
     6421 ggtaatgata cagagattgg ccattacgcc agctctcagg agaaaaacaa ctaggatgtc
     6481 ttgaaacccg tgcatttaat tttagaaatg gcaaatttgt aagcgtgtca tttaagtaat
     6541 ttgatgctca gttttagggt ctaagttgac ctcgagtgag ccatgcaaaa atagctttaa
     6601 aattatacat gagcagctca aagtaaacgt gtatttttta gtaacaatga aattgtcaaa
     6661 tttcaagatt ttaataacag gacagttcaa ctaataaact ttattgcata caagatttat
     6721 tgcaatgtgg gaaaattaaa attctcagtc tcagaa
//
