LOCUS       NM_003592               3147 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens cullin 1 (CUL1), transcript variant 1, mRNA.
ACCESSION   NM_003592
VERSION     NM_003592.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3147)
  AUTHORS   Yang,T., Hu,J., Zhang,L., Liu,L., Pan,X., Zhou,Y., Wu,Y., Shi,X.,
            Obiegbusi,C.N. and Dong,X.
  TITLE     CircCUL1 inhibits trophoblast cell migration and invasion and
            promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth
            restriction via the ANXA1/PI3K/AKT axis
  JOURNAL   J Biochem Mol Toxicol 38 (7), e23759 (2024)
   PUBMED   39003567
  REMARK    GeneRIF: CircCUL1 inhibits trophoblast cell migration and invasion
            and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal
            growth restriction via the ANXA1/PI3K/AKT axis.
REFERENCE   2  (bases 1 to 3147)
  AUTHORS   Ma,Y., Huang,X., Wang,Y., Lei,Y., Yu,J., Yu,S., Gao,Y., Yang,J.,
            Zhao,F., Yu,H., Zeng,J., Chu,Y., Yang,M., Li,G., Xie,X. and
            Zhang,J.
  TITLE     NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by
            Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins
  JOURNAL   Adv Sci (Weinh) 11 (9), e2305907 (2024)
   PUBMED   38126621
  REMARK    GeneRIF: NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer
            by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
REFERENCE   3  (bases 1 to 3147)
  AUTHORS   Khalil,M.I., Yang,C., Vu,L., Chadha,S., Nabors,H., James,C.D.,
            Morgan,I.M. and Pyeon,D.
  TITLE     The membrane-associated ubiquitin ligase MARCHF8 stabilizes the
            human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in
            head and neck cancer
  JOURNAL   J Virol 98 (2), e0172623 (2024)
   PUBMED   38226814
  REMARK    GeneRIF: The membrane-associated ubiquitin ligase MARCHF8
            stabilizes the human papillomavirus oncoprotein E7 by degrading
            CUL1 and UBE2L3 in head and neck cancer.
REFERENCE   4  (bases 1 to 3147)
  AUTHORS   Baek,K., Scott,D.C., Henneberg,L.T., King,M.T., Mann,M. and
            Schulman,B.A.
  TITLE     Systemwide disassembly and assembly of SCF ubiquitin ligase
            complexes
  JOURNAL   Cell 186 (9), 1895-1911 (2023)
   PUBMED   37028429
  REMARK    GeneRIF: Systemwide disassembly and assembly of SCF ubiquitin
            ligase complexes.
            Erratum:[Cell. 2023 May 25;186(11):2492. doi:
            10.1016/j.cell.2023.04.036.. PMID: 37236156]
REFERENCE   5  (bases 1 to 3147)
  AUTHORS   Nardone,C., Palanski,B.A., Scott,D.C., Timms,R.T., Barber,K.W.,
            Gu,X., Mao,A., Leng,Y., Watson,E.V., Schulman,B.A., Cole,P.A. and
            Elledge,S.J.
  TITLE     A central role for regulated protein stability in the control of
            TFE3 and MITF by nutrients
  JOURNAL   Mol Cell 83 (1), 57-73 (2023)
   PUBMED   36608670
REFERENCE   6  (bases 1 to 3147)
  AUTHORS   Winston,J.T., Strack,P., Beer-Romero,P., Chu,C.Y., Elledge,S.J. and
            Harper,J.W.
  TITLE     The SCFbeta-TRCP-ubiquitin ligase complex associates specifically
            with phosphorylated destruction motifs in IkappaBalpha and
            beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
  JOURNAL   Genes Dev 13 (3), 270-283 (1999)
   PUBMED   9990852
  REMARK    Erratum:[Genes Dev 1999 Apr 15;13(8):1050]
REFERENCE   7  (bases 1 to 3147)
  AUTHORS   Ng,R.W., Arooz,T., Yam,C.H., Chan,I.W., Lau,A.W. and Poon,R.Y.
  TITLE     Characterization of the cullin and F-box protein partner Skp1
  JOURNAL   FEBS Lett 438 (3), 183-189 (1998)
   PUBMED   9827542
REFERENCE   8  (bases 1 to 3147)
  AUTHORS   Michel,J.J. and Xiong,Y.
  TITLE     Human CUL-1, but not other cullin family members, selectively
            interacts with SKP1 to form a complex with SKP2 and cyclin A
  JOURNAL   Cell Growth Differ 9 (6), 435-449 (1998)
   PUBMED   9663463
REFERENCE   9  (bases 1 to 3147)
  AUTHORS   Lisztwan,J., Marti,A., Sutterluty,H., Gstaiger,M., Wirbelauer,C.
            and Krek,W.
  TITLE     Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34
            with the F-box protein p45(SKP2): evidence for evolutionary
            conservation in the subunit composition of the CDC34-SCF pathway
  JOURNAL   EMBO J 17 (2), 368-383 (1998)
   PUBMED   9430629
REFERENCE   10 (bases 1 to 3147)
  AUTHORS   Kipreos,E.T., Lander,L.E., Wing,J.P., He,W.W. and Hedgecock,E.M.
  TITLE     cul-1 is required for cell cycle exit in C. elegans and identifies
            a novel gene family
  JOURNAL   Cell 85 (6), 829-839 (1996)
   PUBMED   8681378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096163.1, AF062536.1 and
            CA945052.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003592.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.50405.1,
                                           SRR1660809.172430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325222.9/ ENSP00000326804.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AK096163.1         31-360
            331-2686            AF062536.1         167-2522
            2687-3063           AK096163.1         2554-2930
            3064-3147           CA945052.1         18-101              c
FEATURES             Location/Qualifiers
     source          1..3147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..3147
                     /gene="CUL1"
                     /note="cullin 1"
                     /db_xref="GeneID:8454"
                     /db_xref="HGNC:HGNC:2551"
                     /db_xref="MIM:603134"
     exon            1..127
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            128..428
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2619
                     /gene="CUL1"
                     /note="CUL-1"
                     /codon_start=1
                     /product="cullin-1"
                     /protein_id="NP_003583.2"
                     /db_xref="CCDS:CCDS34772.1"
                     /db_xref="GeneID:8454"
                     /db_xref="HGNC:HGNC:2551"
                     /db_xref="MIM:603134"
                     /translation="MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYME
                     LYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTN
                     LLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIY
                     SLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDA
                     FAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQ
                     VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLG
                     ELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFV
                     AALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVM
                     VVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMF
                     QDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRF
                     TAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQ
                     LTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRV
                     NINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSS
                     RFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA"
     exon            429..603
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..771
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..822
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..913
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1077
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1240
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1371
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1479
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1586
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1635
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1767
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1885
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1962
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2094
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2187
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2235
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2318
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2424
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2538
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..3147
                     /gene="CUL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL1"
                     /note="hexamer: AATAAA"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3070
                     /gene="CUL1"
                     /note="major polyA site"
     polyA_site      3073
                     /gene="CUL1"
                     /note="major polyA site"
     regulatory      3118..3123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUL1"
                     /note="hexamer: AATAAA"
     polyA_site      3147
                     /gene="CUL1"
                     /note="major polyA site"
ORIGIN      
        1 aggcggggca gccccggtag ctgagggacg cagctagacc ttggcgggac ggggctttcg
       61 ccggggccca ggcccaggga ccaggcggag gcgtcgcggg agcctttggg gcaccacaga
      121 gatgcgggtt tgcctgcaat gagatttcat tctctacatt taaaggacat cctttctgag
      181 ctgctgtgaa taaatttgga atggtactgt atattttcat ctaatggaga actagctgta
      241 ctttgaataa ggattgctgc actggacgac tttagaacat ccctcacaat gtcgtcaacc
      301 cggagccaga acccccacgg cctgaagcag attggcctgg accagatctg ggacgacctc
      361 agagccggca tccagcaggt gtacacacgg cagagcatgg ccaagtccag atatatggag
      421 ctctacactc atgtttataa ctactgtact agtgttcacc agtcaaacca agcacgagga
      481 gctggagttc ctccttctaa gtcgaaaaag gggcagacac ctggaggagc tcagtttgtt
      541 ggcctggaat tatataaacg acttaaggaa tttttgaaga attacttgac aaatcttctt
      601 aaggatggag aagatttgat ggatgagagt gtactgaaat tctacactca acaatgggaa
      661 gattatcgat tttcaagcaa agtgctgaat ggaatttgtg cctacctcaa tagacattgg
      721 gttcgccgtg aatgtgacga aggacgaaaa ggaatatatg aaatctattc gcttgcattg
      781 gtgacttgga gagactgtct gttcaggcca ctgaataaac aggtaacaaa tgctgtttta
      841 aagctgattg aaaaggaaag gaatggtgaa accatcaata caagattgat tagtggagtt
      901 gtacagtctt acgtggaatt ggggctgaat gaagatgatg catttgcaaa gggccctacg
      961 ttaacagtgt ataaagaatc ctttgaatct caatttttgg ctgacacaga gagattttat
     1021 accagagaga gtactgaatt cttgcagcag aacccagtta ctgaatatat gaaaaaggca
     1081 gaggctcgtc tgcttgagga acaacgaaga gttcaggttt accttcatga aagcacacaa
     1141 gatgaattag caaggaaatg tgaacaagtc ctcattgaaa aacacttgga aattttccac
     1201 acagaatttc agaatttatt ggatgctgac aaaaatgaag atttgggacg catgtataat
     1261 cttgtatcta gaatccagga tggcctagga gaattgaaaa aactgttgga gacacacatt
     1321 cataatcagg gtcttgcagc cattgaaaag tgtggagaag ctgctttaaa tgaccccaaa
     1381 atgtatgtac agacagtgct tgatgttcat aaaaaataca atgccctggt aatgtctgca
     1441 ttcaacaatg acgctggctt tgtggctgct cttgataagg cttgtggtcg cttcataaac
     1501 aacaacgcgg ttaccaagat ggcccaatca tccagtaaat cccctgagtt gctggctcga
     1561 tactgtgact ccttgttgaa gaaaagttcc aagaacccag aggaggcaga actagaagac
     1621 acactcaatc aagtgatggt tgtcttcaag tacatagaag acaaagacgt atttcagaag
     1681 ttctatgcga agatgctcgc caagaggctc gtccaccaga acagtgcaag tgacgatgcc
     1741 gaagccagca tgatctccaa gttaaagcaa gcttgcgggt tcgagtacac ctctaaactt
     1801 cagcgcatgt ttcaagacat tggcgtgagc aaagatctga acgagcaatt caaaaagcac
     1861 ttgacaaact cagaacccct agacttggat ttcagcattc aagtgctgag ctccgggtcc
     1921 tggcccttcc agcagtcttg tacatttgcc ttgccgtcag agttggaacg tagttatcag
     1981 cgattcacag ctttctacgc cagccgccac agtggccgaa aattgacgtg gttatatcag
     2041 ttgtctaaag gagaattggt aactaactgc ttcaaaaaca gatatacttt gcaggcgtcg
     2101 acattccaga tggctatcct gcttcagtac aacacggaag atgcctacac tgtgcagcag
     2161 ctgaccgaca gcactcaaat taaaatggac attttggcgc aagttttaca gattttatta
     2221 aagtcgaagc tattggtctt ggaagatgaa aatgcaaatg ttgatgaggt ggaattgaag
     2281 ccagatacct taataaaatt atatcttggt tataaaaata agaaattaag ggttaacatc
     2341 aatgtgccaa tgaaaaccga acagaagcag gaacaagaaa ccacacacaa aaacatcgag
     2401 gaagaccgca aactactgat tcaggcggcc atcgtgagaa tcatgaagat gaggaaggtt
     2461 ctgaaacacc agcagttact tggcgaggtc ctcactcagc tgtcctccag gttcaaacct
     2521 cgagtccctg tgatcaagaa atgcattgac attctaattg agaaagaata tttggagcga
     2581 gtggatggtg aaaaggacac ctacagttac ttggcttaac ccttctggaa gggtctgact
     2641 gtgtgacccg cagcaaatag ttcatgttgg aaagaatgaa aacaactcaa gttcatagca
     2701 gccagcctgc cgccattgga cctccctttt aaaaactgag accaagactc ccatcagctg
     2761 gtctcggatt tacatcggaa ctgctcagga ttgatacatt tcaagtctgt aaatacggac
     2821 accaacgcca tttaccctaa tttaagaaca gcggggactg accctccgtg ccgagggctg
     2881 catgctaccg cactaagtca atacatgggc tccccgattc gcagctgtcg tcttggcagc
     2941 acttgtcacg ttggcagcac tttgagagca agtctgagtg gacccacatg taacctgcta
     3001 tgaaaaccat ttgtatagtg tgtttcattt tttaatgtgt gaaaataaag aaaattaaag
     3061 gatttctgta caagtcgcat tgggttttgt tttaagtttt actaatttct atatgtaaat
     3121 aaaagatata atgattgtgc aaattta
//
