LOCUS       NM_024040               1100 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CUE domain containing 2 (CUEDC2), mRNA.
ACCESSION   NM_024040
VERSION     NM_024040.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Roy,S., Saha,S., Dhar,D., Chakraborty,P., Singha Roy,K.,
            Mukherjee,C., Gupta,A., Bhattacharyya,S., Roy,A., Sengupta,S.,
            Roychoudhury,S. and Nath,S.
  TITLE     Molecular crosstalk between CUEDC2 and ERalpha influences the
            clinical outcome by regulating mitosis in breast cancer
  JOURNAL   Cancer Gene Ther 29 (11), 1697-1706 (2022)
   PUBMED   35732909
  REMARK    GeneRIF: Molecular crosstalk between CUEDC2 and ERalpha influences
            the clinical outcome by regulating mitosis in breast cancer.
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Ghatak,D., Datta,A., Roychowdhury,T., Chattopadhyay,S. and
            Roychoudhury,S.
  TITLE     MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant
            p53-Driven Cancer Stemness
  JOURNAL   Mol Cancer Res 19 (10), 1635-1650 (2021)
   PUBMED   34257080
  REMARK    GeneRIF: MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function
            Mutant p53-Driven Cancer Stemness.
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Mu,M., Niu,W., Zhang,X., Hu,S. and Niu,C.
  TITLE     LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively
            binding with miR-619-5p to regulate CUEDC2 expression and the
            PTEN/AKT/p21 pathway
  JOURNAL   Oncogene 39 (45), 6879-6892 (2020)
   PUBMED   32978519
  REMARK    GeneRIF: LncRNA BCYRN1 inhibits glioma tumorigenesis by
            competitively binding with miR-619-5p to regulate CUEDC2 expression
            and the PTEN/AKT/p21 pathway.
            Erratum:[Oncogene. 2021 Oct;40(40):5972-5973. doi:
            10.1038/s41388-021-01990-4.. PMID: 34400767]
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Xu,S., Huang,S., Li,D., Zou,Q., Yuan,Y. and Yang,Z.
  TITLE     Comparison of ADAM19 and CUEDC2 expression in EHCC and their
            clinicopathological significance
  JOURNAL   Biomark Med 14 (16), 1573-1584 (2020)
   PUBMED   32960074
  REMARK    GeneRIF: Comparison of ADAM19 and CUEDC2 expression in EHCC and
            their clinicopathological significance.
REFERENCE   5  (bases 1 to 1100)
  AUTHORS   Lingyun,H., Ailing,L., Yali,L., Yanqin,Y. and Jing,N.
  TITLE     Expression of CUE domain containing 2 protein in serous ovarian
            cancer tissue: predicting disease-free and overall survival of
            patients
  JOURNAL   J Int Med Res 48 (9), 300060520954770 (2020)
   PUBMED   32967504
  REMARK    GeneRIF: Expression of CUE domain containing 2 protein in serous
            ovarian cancer tissue: predicting disease-free and overall survival
            of patients.
REFERENCE   6  (bases 1 to 1100)
  AUTHORS   Pan,X., Zhou,T., Tai,Y.H., Wang,C., Zhao,J., Cao,Y., Chen,Y.,
            Zhang,P.J., Yu,M., Zhen,C., Mu,R., Bai,Z.F., Li,H.Y., Li,A.L.,
            Liang,B., Jian,Z., Zhang,W.N., Man,J.H., Gao,Y.F., Gong,W.L.,
            Wei,L.X. and Zhang,X.M.
  TITLE     Elevated expression of CUEDC2 protein confers endocrine resistance
            in breast cancer
  JOURNAL   Nat Med 17 (6), 708-714 (2011)
   PUBMED   21572428
  REMARK    GeneRIF: key factor in endocrine resistance in breast cancer
REFERENCE   7  (bases 1 to 1100)
  AUTHORS   Zhang,P.J., Zhao,J., Li,H.Y., Man,J.H., He,K., Zhou,T., Pan,X.,
            Li,A.L., Gong,W.L., Jin,B.F., Xia,Q., Yu,M., Shen,B.F. and
            Zhang,X.M.
  TITLE     CUE domain containing 2 regulates degradation of progesterone
            receptor by ubiquitin-proteasome
  JOURNAL   EMBO J 26 (7), 1831-1842 (2007)
   PUBMED   17347654
  REMARK    GeneRIF: These results identify a key post-translational mechanism
            that controls progesterone receptor protein levels and for the
            first time provide an important insight into the function of CUEDC2
            in breast cancer proliferation.
REFERENCE   8  (bases 1 to 1100)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1100)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1100)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000262.1 and CX165866.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024040.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.50918.1,
                                           SRR1163655.367980.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369937.5/ ENSP00000358953.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-737               BC000262.1         23-759
            738-812             CX165866.1         714-788
            813-1100            BC000262.1         835-1122
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..1100
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /note="CUE domain containing 2"
                     /db_xref="GeneID:79004"
                     /db_xref="HGNC:HGNC:28352"
                     /db_xref="MIM:614142"
     exon            1..49
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            50..133
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..923
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /codon_start=1
                     /product="CUE domain-containing protein 2"
                     /protein_id="NP_076945.2"
                     /db_xref="CCDS:CCDS41566.1"
                     /db_xref="GeneID:79004"
                     /db_xref="HGNC:HGNC:28352"
                     /db_xref="MIM:614142"
                     /translation="MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGP
                     SGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSG
                     VQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCS
                     VEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQ
                     KYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYI
                     NLKPARKYRFH"
     exon            134..277
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            278..339
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            340..470
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            471..653
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            654..715
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            716..776
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1100
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /note="hexamer: AGTAAA"
     polyA_site      1100
                     /gene="CUEDC2"
                     /gene_synonym="bA18I14.5; C10orf66"
                     /note="major polyA site"
ORIGIN      
        1 gagagctgca ccgcgcggga caagtcgccg gcggcgcccg acggagcaga agagagagca
       61 tggagctgga gaggatcgtc agtgcagccc tccttgcctt tgtccagaca cacctcccgg
      121 aggccgacct cagtggcttg gatgaggtca tcttctccta tgtgcttggg gtcctggagg
      181 acctgggccc ctcgggccca tcagaggaga acttcgatat ggaggctttc actgagatga
      241 tggaggccta tgtgcctggc ttcgcccaca tccccagggg cacaataggg gacatgatgc
      301 agaagctctc agggcagctg agcgatgcca ggaacaaaga gaacctgcaa ccgcagagct
      361 ctggtgtcca aggtcaggtg cccatctccc cagagcccct gcagcggccc gaaatgctca
      421 aagaagagac taggtcttcg gctgctgctg ctgcagacac ccaagatgag gcaactggcg
      481 ctgaggagga gcttctgcca ggggtggatg tactcctgga ggtgttccct acctgttcgg
      541 tggagcaggc ccagtgggtg ctggccaaag ctcgggggga cttggaagaa gctgtgcaga
      601 tgctggtaga gggaaaggaa gaggggcctg cagcctggga gggccccaac caggacctgc
      661 ccagacgcct cagaggcccc caaaaggatg agctgaagtc cttcatcctg cagaagtaca
      721 tgatggtgga tagcgcagag gatcagaaga ttcaccggcc catggctccc aaggaggccc
      781 ccaagaagct gatccgatac atcgacaacc aggtagtgag caccaaaggg gagcgattca
      841 aagatgtgcg gaaccctgag gccgaggaga tgaaggccac atacatcaac ctcaagccag
      901 ccagaaagta ccgcttccat tgaggcactc gccggactct gcccgagcct tctaggctca
      961 gatcccagag ggatgcagga gccctatacc cctacacagg ggccccctaa ctcctgtccc
     1021 ccttctctac tcctttgctc catagtgtta acctactctc ggagctgcct ccatgggcac
     1081 agtaaaggtg gcccaaggaa
//
