LOCUS       NM_001271875            3710 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens CUE domain containing 1 (CUEDC1), transcript variant
            1, mRNA.
ACCESSION   NM_001271875 NM_017949
VERSION     NM_001271875.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3710)
  AUTHORS   Cui,Y., Song,Y., Yan,S., Cao,M., Huang,J., Jia,D., Liu,Y.,
            Zhang,S., Fan,W., Cai,L., Li,C. and Xing,Y.
  TITLE     CUEDC1 inhibits epithelial-mesenchymal transition via the
            TbetaRI/Smad signaling pathway and suppresses tumor progression in
            non-small cell lung cancer
  JOURNAL   Aging (Albany NY) 12 (20), 20047-20068 (2020)
   PUBMED   33099540
  REMARK    GeneRIF: CUEDC1 inhibits epithelial-mesenchymal transition via the
            TbetaRI/Smad signaling pathway and suppresses tumor progression in
            non-small cell lung cancer.
REFERENCE   2  (bases 1 to 3710)
  AUTHORS   Zhuang,W.C., Wu,Q.Y., Meng,F.J. and Xu,K.L.
  TITLE     [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid
            Leukemia (non-M3)]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 28 (5), 1464-1467 (2020)
   PUBMED   33067938
  REMARK    GeneRIF: [Prognostic Significance of CUEDC1 in Patients with Acute
            Myeloid Leukemia (non-M3)].
REFERENCE   3  (bases 1 to 3710)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3710)
  AUTHORS   Lopes,R., Korkmaz,G., Revilla,S.A., van Vliet,R., Nagel,R.,
            Custers,L., Kim,Y., van Breugel,P.C., Zwart,W., Moumbeini,B.,
            Manber,Z., Elkon,R. and Agami,R.
  TITLE     CUEDC1 is a primary target of ERalpha essential for the growth of
            breast cancer cells
  JOURNAL   Cancer Lett 436, 87-95 (2018)
   PUBMED   30145202
  REMARK    GeneRIF: Data inidicate CUE domain containing 1 (CUEDC1) expression
            correlates positively with estrogen receptor alpha (ERalpha) in
            breast cancer, and suggest CUEDC1 is a functional target gene of
            ERalpha and is required for breast cancer cell proliferation.
REFERENCE   5  (bases 1 to 3710)
  AUTHORS   Tomkins,J.E., Dihanich,S., Beilina,A., Ferrari,R., Ilacqua,N.,
            Cookson,M.R., Lewis,P.A. and Manzoni,C.
  TITLE     Comparative Protein Interaction Network Analysis Identifies Shared
            and Distinct Functions for the Human ROCO Proteins
  JOURNAL   Proteomics 18 (10), e1700444 (2018)
   PUBMED   29513927
REFERENCE   6  (bases 1 to 3710)
  AUTHORS   Beilina,A., Rudenko,I.N., Kaganovich,A., Civiero,L., Chau,H.,
            Kalia,S.K., Kalia,L.V., Lobbestael,E., Chia,R., Ndukwe,K., Ding,J.,
            Nalls,M.A., Olszewski,M., Hauser,D.N., Kumaran,R., Lozano,A.M.,
            Baekelandt,V., Greene,L.E., Taymans,J.M., Greggio,E. and
            Cookson,M.R.
  CONSRTM   International Parkinson's Disease Genomics Consortium; North
            American Brain Expression Consortium
  TITLE     Unbiased screen for interactors of leucine-rich repeat kinase 2
            supports a common pathway for sporadic and familial Parkinson
            disease
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2626-2631 (2014)
   PUBMED   24510904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015813.12, BC056882.1, BG475111.1, AK000746.1, AC015845.8 and
            BU732837.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001271875.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK000746.1, BC056882.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000577830.6/ ENSP00000462717.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC015813.12        23348-23436         c
            90-135              BC056882.1         1-46
            136-205             BG475111.1         2-71
            206-931             AK000746.1         422-1147
            932-932             AC015845.8         117527-117527       c
            933-1246            AK000746.1         1149-1462
            1247-1247           AC015845.8         110584-110584       c
            1248-1928           AK000746.1         1464-2144
            1929-3349           AC015845.8         99485-100905        c
            3350-3710           BU732837.1         18-378              c
FEATURES             Location/Qualifiers
     source          1..3710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..3710
                     /gene="CUEDC1"
                     /note="CUE domain containing 1"
                     /db_xref="GeneID:404093"
                     /db_xref="HGNC:HGNC:31350"
                     /db_xref="MIM:620552"
     exon            1..188
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..839
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1664
                     /gene="CUEDC1"
                     /codon_start=1
                     /product="CUE domain-containing protein 1"
                     /protein_id="NP_001258804.1"
                     /db_xref="CCDS:CCDS11599.1"
                     /db_xref="GeneID:404093"
                     /db_xref="HGNC:HGNC:31350"
                     /db_xref="MIM:620552"
                     /translation="MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRR
                     LEFNQAMDDFKTMFPNMDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDS
                     SDSEDSIPPEILERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALG
                     SGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGP
                     GPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSV
                     AVGNDFGFSSPVPGTGDANPAVSEDALFRDKLKHMGKSTRRKLFELARAFSEKTKMRK
                     SKRKHLLKHQSLGAAASTANLLDDVEGHACDEDFRGRRQEAPKVEEGLREGQ"
     exon            840..967
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1094
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1287
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1371
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1443
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1537
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1596
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1667
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..3710
                     /gene="CUEDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUEDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3349
                     /gene="CUEDC1"
                     /note="major polyA site"
     regulatory      3685..3690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUEDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3710
                     /gene="CUEDC1"
ORIGIN      
        1 gcatttctcg ccgcccgccg ctaggaagcc ggcctcgcct cactttctcc gcctccccgc
       61 gccccagccg cgccgccgcc gccgagcctg gccccgccgc caccgctgcg gattgcagcc
      121 cctcccccgc ccggcccgcg gcccggcccc tgcggcccgc gcggagcgga cgcgcgtggc
      181 gctgcccggt gggaccatcc gtgaaaccgg tgccaggatg caccgggggt gtggatgacc
      241 ggccgcccag ccccagcacg gcccggtccc gcatgccacc gccccgcgag gaccgctctc
      301 caagggctgc ctggggcccc gcgcccgtac tctcctaacc cggagctctt ggcagcccat
      361 tgctgcctgg ctacccgggg aggaggaggc gcaggagtga gctgcccgag accgcagggc
      421 aagtaagcgg ctgacggcgg aaagaccctg gggaaggggc tttgcggccg gctagaaaca
      481 ttttccccaa gcggctccgc aaaatgacca gcctgttccg ccggagcagc agcggcagcg
      541 gcgggggtgg caccgccggg gcacgcgggg gcgggggagg cacggccgcc ccccaggagc
      601 tcaacaacag ccggcctgcc cgccaggtgc gccgcctgga gttcaaccag gccatggacg
      661 acttcaagac catgttcccc aacatggatt acgacatcat cgaatgcgtg ctgcgcgcca
      721 acagcggcgc tgtggacgcc accatcgacc agctgctgca gatgaacctg gagggcggtg
      781 gcagcagcgg cggcgtctat gaggacagct ccgactcgga ggacagcatc cccccggaga
      841 tcttggaaag gactttggaa cctgatagct cggatgaaga gcccccacct gtgtactccc
      901 cgccagccta ccacatgcac gtgttcgacc ggccctaccc tctggctccc ccgactccgc
      961 ctccccgtat cgacgcgctg ggctctggag cccctacaag ccagagacgc tatcggaact
     1021 ggaacccacc actgctgggc aaccttccgg atgactttct ccgcatcctg ccccagcagc
     1081 tggacagcat acagggtaac gctgggggcc ccaagcctgg gagtggagag ggatgtccac
     1141 ctgccatggc tgggccaggg cccggagacc aggagagccg ctggaagcag tacctggagg
     1201 acgagaggat cgcgcttttc ctgcagaacg aggagttcat gaaggagctg caacggaacc
     1261 gcgacttcct cctcgctctg gagagagatc gattgaaata cgaatcccag aaatctaaat
     1321 ccagcagcgt ggctgtcgga aacgactttg gcttttcctc tcctgtccca ggaactggcg
     1381 acgccaaccc cgctgtgtct gaagatgcct tattcaggga caagctgaaa cacatgggaa
     1441 agtccacccg gaggaaactg tttgaacttg cccgagcctt ctcagagaag accaaaatga
     1501 ggaagtcaaa gaggaaacac ttgttgaagc atcagtcgct gggggctgcc gcgtcaacag
     1561 ccaacctcct ggatgatgtg gagggccacg cgtgtgatga agacttccgg ggcaggcgtc
     1621 aggaggcacc caaggtggag gaaggcctgc gagaaggaca gtaagagatg ccagcagctc
     1681 ttccttgcca gagatgatct gacccggtgg gggcagctgg aaagcaacac tggcccccag
     1741 ctgaagggcc cagctgcagc cagacagatg gtgcttgaga accgaggccc ggtgatcctc
     1801 cagccacagt ccagcccaac cactgccact ttccatggga cttagaactt cggagttgct
     1861 gccttgcaat tggaggaagg acctggggcc cctataggca gcagccaatt acagcccctt
     1921 ttgtagccag gcgttcctat ggtcaaagag tggaaatgca ggaaccaacc tccctttaaa
     1981 aaaaaaaaaa tccagaaagc agataaaagt tggaatatgg aaaagggcaa gatgaccccc
     2041 accagaggct ctttggcctg aaggtggagt ctctgcctcc gtccgttctc tatctctcct
     2101 gtcacagact ctgcctgacc ccctttcctc agctcccttc tggtccccct tcctcagctc
     2161 cctccgggca cttgtgccct tcccttccat gtcctcctgt atctcagcct tcccccgggg
     2221 ctgctggccc agcacacgag ccctgcaccc agcctgggtg ggaggtccct ggccagtccc
     2281 ccaggaactc tgaggagcta tgggctactg caaagcatct gccgactgcc ctgccccgtc
     2341 tggcctcatc aggctgctgc tgttagggat gggctcactc ccagcagctc ccggtcaccc
     2401 agcagggatg gggagggtgg ccaccctgga gctggaggac tctggggagg cagggtcttt
     2461 aatttggcag cagacaaaag ccagttctgg agtcacacca cagtaggggc tcacaggggc
     2521 tctgactccc cagctggact ggaagccctg ctgtccgagg gtgggcagcg gtgggtcctg
     2581 gagtgacccc tttgagcagg tgcagggcta aagagcaagg cggaaaggcc gccagcctgg
     2641 gtgagcgcct agggcataag ggcttgctgg gtgcccctga gaagggcggg tgatctgagg
     2701 aggagaactc tgattctagg aacgcttaca cggcactgac cactgccacg gggagggagg
     2761 ctgcccagcc cgtggccccg ccctggacat gggagcgcgc agaccttccg gagagccggg
     2821 aagcctgggc aggcacgagg cttcggcgcg gctctgggag gttgggagtg gcatccgatc
     2881 cttggccggg ccctggtggc ctccgtggcc ccaagatcac aagggcgtag cgaaggcgag
     2941 ccggcgatcg cacctcgtcc cgcccaccct gcccggactc gcaacgccga gcttggggag
     3001 ggccgggacg cgcagccgcc gccgagcgtg accaagtttg gaaacgcgcg cggggccggg
     3061 acgctggctc ggggggccct gccgaggagc ggtcgccccc tccgctgctc cccgcgccag
     3121 gcctggggcc ctggagggag gggggggggt ctccgaggag tgcctcggta ccccagctcg
     3181 agttctcgac gggtctctga gccttccccg cgccaggacc cggcgcactg tgggggaagc
     3241 cccagcccca tgtctgttga gtgttgcttt gttatttttt ttcctcctat gtgtgggttt
     3301 tttcttggag ctgtttcata ggaattcctg taataaacag ttggtgttct cttggtgctc
     3361 tgatgtggcc agcggcgtgg gctggaccct cctgctccct cctccctccc ggcctggggc
     3421 agggtttgtc cccaggagcc ccgcgtcgca tccctagggt acccctgcct tgcctggccc
     3481 attcacccgc ggcgctctcc gactgcactc tcgaggtgac acctgcggca ccgctgcacc
     3541 tcaaccttgc ggacctgccg gctgcgtcta gcgctgtcgc cttcctgttt ggcccaggac
     3601 tgtaaaccgc ttgctgtatc aggcaaggga aacaccatgg ggaaagccag tctgttgaga
     3661 aagctccaga cggccacctc cctaaataaa cagcttctgg attaaaggca
//
