LOCUS       NM_001081              11927 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens cubilin (CUBN), mRNA.
ACCESSION   NM_001081
VERSION     NM_001081.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11927)
  AUTHORS   Anatolou,D., Steiropoulos,P., Zissimopoulos,A., Chadia,K.,
            Archontogeorgis,K., Kolios,G., Manolopoulos,V.G. and Ragia,G.
  TITLE     Polymorphisms in LRP2 and CUBN genes and their association with
            serum vitamin D levels and sleep apnea
  JOURNAL   Sleep Breath 28 (2), 959-966 (2024)
   PUBMED   38008818
  REMARK    GeneRIF: Polymorphisms in LRP2 and CUBN genes and their association
            with serum vitamin D levels and sleep apnea.
REFERENCE   2  (bases 1 to 11927)
  AUTHORS   Yang,H., He,L., Gong,H., Wan,C., Ding,J., Liao,P. and Wang,X.
  TITLE     Identification of novel pathogenic variants of CUBN in patients
            with isolated proteinuria
  JOURNAL   Mol Genet Genomic Med 12 (3), e2353 (2024)
   PUBMED   38488435
  REMARK    GeneRIF: Identification of novel pathogenic variants of CUBN in
            patients with isolated proteinuria.
REFERENCE   3  (bases 1 to 11927)
  AUTHORS   Ceol,M., Gianesello,L., Trimarchi,H., Migliorini,A., Priante,G.,
            Radu,C.M., Naso,E., Angelini,A., Calo,L.A., Anglani,F. and Del
            Prete,D.
  TITLE     Human parietal epithelial cells (PECs) and proteinuria in lupus
            nephritis: a role for ClC-5, megalin, and cubilin?
  JOURNAL   J Nephrol 36 (9), 2499-2506 (2023)
   PUBMED   37594671
  REMARK    GeneRIF: Human parietal epithelial cells (PECs) and proteinuria in
            lupus nephritis: a role for ClC-5, megalin, and cubilin?
REFERENCE   4  (bases 1 to 11927)
  AUTHORS   Uglebjerg,N., Ahmadizar,F., Aly,D.M., Canadas-Garre,M., Hill,C.,
            Naber,A., Oddsson,A., Singh,S.S., Smyth,L., Tregouet,D.A.,
            Chaker,L., Ghanbari,M., Steinthorsdottir,V., Ahlqvist,E.,
            Hadjadj,S., Van Hoek,M., Kavousi,M., McKnight,A.J., Sijbrands,E.J.,
            Stefansson,K., Simons,M., Rossing,P. and Ahluwalia,T.S.
  TITLE     Four missense genetic variants in CUBN are associated with higher
            levels of eGFR in non-diabetes but not in diabetes mellitus or its
            subtypes: A genetic association study in Europeans
  JOURNAL   Front Endocrinol (Lausanne) 14, 1081741 (2023)
   PUBMED   36926036
  REMARK    GeneRIF: Four missense genetic variants in CUBN are associated with
            higher levels of eGFR in non-diabetes but not in diabetes mellitus
            or its subtypes: A genetic association study in Europeans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11927)
  AUTHORS   Gan,C., Zhou,X., Chen,D., Chi,H., Qiu,J., You,H., Chen,Y., Wang,M.,
            Yang,H., Jiang,W. and Li,Q.
  TITLE     Novel pathogenic variants in CUBN uncouple proteinuria from renal
            function
  JOURNAL   J Transl Med 20 (1), 480 (2022)
   PUBMED   36266725
  REMARK    GeneRIF: Novel pathogenic variants in CUBN uncouple proteinuria
            from renal function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11927)
  AUTHORS   Batuman,V., Verroust,P.J., Navar,G.L., Kaysen,J.H., Goda,F.O.,
            Campbell,W.C., Simon,E., Pontillon,F., Lyles,M., Bruno,J. and
            Hammond,T.G.
  TITLE     Myeloma light chains are ligands for cubilin (gp280)
  JOURNAL   Am J Physiol 275 (2), F246-F254 (1998)
   PUBMED   9691015
REFERENCE   7  (bases 1 to 11927)
  AUTHORS   Kozyraki,R., Kristiansen,M., Silahtaroglu,A., Hansen,C.,
            Jacobsen,C., Tommerup,N., Verroust,P.J. and Moestrup,S.K.
  TITLE     The human intrinsic factor-vitamin B12 receptor, cubilin: molecular
            characterization and chromosomal mapping of the gene to 10p within
            the autosomal recessive megaloblastic anemia (MGA1) region
  JOURNAL   Blood 91 (10), 3593-3600 (1998)
   PUBMED   9572993
  REMARK    Erratum:[Blood 1998 Oct 1;92(7):2608]
REFERENCE   8  (bases 1 to 11927)
  AUTHORS   Moestrup,S.K., Kozyraki,R., Kristiansen,M., Kaysen,J.H.,
            Rasmussen,H.H., Brault,D., Pontillon,F., Goda,F.O.,
            Christensen,E.I., Hammond,T.G. and Verroust,P.J.
  TITLE     The intrinsic factor-vitamin B12 receptor and target of teratogenic
            antibodies is a megalin-binding peripheral membrane protein with
            homology to developmental proteins
  JOURNAL   J Biol Chem 273 (9), 5235-5242 (1998)
   PUBMED   9478979
REFERENCE   9  (bases 1 to 11927)
  AUTHORS   Birn,H., Verroust,P.J., Nexo,E., Hager,H., Jacobsen,C.,
            Christensen,E.I. and Moestrup,S.K.
  TITLE     Characterization of an epithelial approximately 460-kDa protein
            that facilitates endocytosis of intrinsic factor-vitamin B12 and
            binds receptor-associated protein
  JOURNAL   J Biol Chem 272 (42), 26497-26504 (1997)
   PUBMED   9334227
REFERENCE   10 (bases 1 to 11927)
  AUTHORS   Bork,P. and Beckmann,G.
  TITLE     The CUB domain. A widespread module in developmentally regulated
            proteins
  JOURNAL   J Mol Biol 231 (2), 539-545 (1993)
   PUBMED   8510165
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP271329.1, AF034611.1,
            AC067747.7, BP270790.1, AL731551.9 and AL365215.23.
            
            On Aug 31, 2019 this sequence version replaced NM_001081.3.
            
            Summary: Cubilin (CUBN) acts as a receptor for intrinsic
            factor-vitamin B12 complexes. The role of receptor is supported by
            the presence of 27 CUB domains. Cubulin is located within the
            epithelium of intestine and kidney. Mutations in CUBN may play a
            role in autosomal recessive megaloblastic anemia. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034611.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377833.10/ ENSP00000367064.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               BP271329.1         7-518
            513-803             AF034611.1         493-783
            804-929             AC067747.7         59252-59377
            930-1061            AC067747.7         62354-62485
            1062-3567           AF034611.1         1042-3547
            3568-3930           BP270790.1         220-582
            3931-4678           AF034611.1         3911-4658
            4679-4741           AL731551.9         57549-57611         c
            4742-5350           AF034611.1         4722-5330
            5351-5388           AL731551.9         22300-22337         c
            5389-5901           AF034611.1         5369-5881
            5902-5972           AL731551.9         12657-12727         c
            5973-6530           AF034611.1         5953-6510
            6531-6692           AL731551.9         306-467             c
            6693-8195           AF034611.1         6673-8175
            8196-8230           AL365215.23        169829-169863       c
            8231-9888           AF034611.1         8211-9868
            9889-10078          AL365215.23        108821-109010       c
            10079-11187         AF034611.1         10059-11167
            11188-11927         AL365215.23        92457-93196         c
FEATURES             Location/Qualifiers
     source          1..11927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..11927
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /note="cubilin"
                     /db_xref="GeneID:8029"
                     /db_xref="HGNC:HGNC:2548"
                     /db_xref="MIM:602997"
     exon            1..168
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..10918
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /note="cubilin (intrinsic factor-cobalamin receptor);
                     intrinsic factor-vitamin B12 receptor; 460 kDa receptor;
                     intestinal intrinsic factor receptor"
                     /codon_start=1
                     /product="cubilin precursor"
                     /protein_id="NP_001072.2"
                     /db_xref="CCDS:CCDS7113.1"
                     /db_xref="GeneID:8029"
                     /db_xref="HGNC:HGNC:2548"
                     /db_xref="MIM:602997"
                     /translation="MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRM
                     ATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGL
                     PQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPP
                     QWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCE
                     GGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCST
                     LVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQ
                     ACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGC
                     VQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDG
                     VDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEM
                     GKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYF
                     HLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSP
                     DLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARI
                     HFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQ
                     PQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRF
                     KIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILL
                     NFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSS
                     STENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHL
                     MFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDL
                     AYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAV
                     HFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSD
                     QIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFE
                     LEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTD
                     EGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY
                     TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRR
                     EKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDF
                     DVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSI
                     NGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNF
                     TDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNR
                     GFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFE
                     LERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGG
                     FHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQ
                     LEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG
                     FQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIE
                     EIQNCYYDKLRIYDGPSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLL
                     EWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST
                     VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFT
                     SDSSVTRAGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAV
                     HFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQ
                     MFVQFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCI
                     WILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQW
                     SSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCE
                     WHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTS
                     SNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEW
                     RITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKS
                     SGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRN
                     LNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKP
                     TLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSL
                     THCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPR
                     TIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPEN
                     SRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNV
                     APGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYDNNM
                     NCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDE
                     MPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN
                     DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRP
                     PNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSN
                     GMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAG
                     TFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNIS
                     SPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSR
                     FQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRS
                     PGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLL
                     GKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTS
                     PGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSS
                     GPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS"
     exon            169..298
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..394
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..433
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..535
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..639
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..766
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..929
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1061
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1157
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1276
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1463
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1576
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1811
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1993
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2156
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2347
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2492
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2671
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2837
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3054
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3185
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3375
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3536
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3718
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3875
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..4063
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4214
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4396
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4571
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4572..4741
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4742..4901
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..5015
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5016..5126
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5255
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5256..5388
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5389..5594
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5779
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5780..5972
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5973..6170
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6171..6317
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6318..6508
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6509..6692
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6693..6867
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6868..7046
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7047..7256
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7257..7397
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7398..7579
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7580..7751
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7752..7958
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7959..8108
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8109..8230
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8231..8456
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8457..8644
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8645..8801
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8802..8951
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8952..9152
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9153..9282
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9283..9500
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9501..9709
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9710..9872
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9873..10078
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            10079..10226
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            10227..10408
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            10409..10574
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            10575..10810
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            10811..11927
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11902..11907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /note="hexamer: AATAAA"
     polyA_site      11927
                     /gene="CUBN"
                     /gene_synonym="gp280; IFCR; IGS; IGS1; MGA1"
                     /note="major polyA site"
ORIGIN      
        1 agttggttgg agtggcctca ctcttacctg ccaacctggg aggttgatga tgaacatgtc
       61 tttacctttt ctttggagtt tgcttacctt attaatattt gctgaagtaa atggcgaagc
      121 tggagaactt gagctgcaga gacaaaaaag aagcatcaat ctccaacagc ctcgaatggc
      181 tacagagaga ggaaatttgg tgtttcttac ggggtctgct caaaacattg agtttagaac
      241 cggatccctg ggaaaaatta aattaaatga tgaagatctc agtgagtgtt tacatcagat
      301 ccagaaaaac aaagaagata ttatagagtt aaaagggagt gcaattggtc tgcctcaaaa
      361 tatatctagt caaatctatc agcttaattc caagctggtg gatcttgaga gaaaattcca
      421 aggcttgcag cagactgttg acaaaaaggt ttgcagcagc aatccttgcc agaatggtgg
      481 aacctgcctc aatctgcatg attccttttt ttgtatctgt cccccacagt ggaagggtcc
      541 tctctgctca gctgatgtta acgaatgtga gatttactca ggaacaccct tgagctgcca
      601 gaatggaggc acatgtgtta atacaatggg aagttacagt tgtcactgcc cacctgagac
      661 gtacggaccc cagtgtgcat ccaaatatga cgactgtgaa gggggttctg tggcacgctg
      721 tgtccatggc atctgtgagg atttaatgcg agagcaagct ggagagccca agtacagctg
      781 cgtctgtgat gctgggtgga tgttttcacc caacagccct gcctgcacgc tggacagaga
      841 cgagtgcagc ttccagcccg ggccttgctc cacacttgtg cagtgtttca acactcaagg
      901 ctctttctac tgtggggcct gtccaacagg ctggcaaggc aatggatata tttgcgaaga
      961 tatcaatgaa tgtgagataa ataacggcgg ctgttctgtg gctccacccg ttgagtgtgt
     1021 gaatacacct gggtcttccc actgccaggc ctgtccacca gggtaccagg gtgacggaag
     1081 agtgtgcaca ctcacagaca tctgctcagt cagtaatgga ggctgccacc cagatgcctc
     1141 atgctcctca actctaggtt ccttacctct ctgcacgtgt ctcccgggtt atactggaaa
     1201 tggttatggg ccaaatggat gtgtgcagct cagtaatatt tgcctaagtc acccctgtct
     1261 aaatggacaa tgcatcgaca ctgtctctgg ttatttttgt aagtgtgact caggttggac
     1321 aggtgtcaac tgtacagaaa acatcaatga gtgtttgagc aacccctgtt tgaatggagg
     1381 aacttgtgtt gatggcgttg attctttcag ttgtgaatgc acacgtctct ggactggagc
     1441 tctctgtcag gttcctcagc aagtttgtgg agagtccctc tcaggaataa atggaagctt
     1501 cagctacagg agcccggatg ttggttatgt tcatgatgtt aactgcttct gggttatcaa
     1561 aactgaaatg ggaaaggtcc tgcgtatcac tttcactttt ttccggttag aatccatgga
     1621 caactgtcca cacgagtttc ttcaggttta tgatggagat tcctcttctg cttttcaact
     1681 tggaagattt tgtggctcca gcctccctca tgaactcctc agcagtgaca atgctctcta
     1741 ttttcatctc tattctgaac atttaagaaa tgggagaggc tttacagtaa gatgggaaac
     1801 acagcaacca gagtgtggag gtatcctgac tggtccttac ggttctatta agtctccggg
     1861 gtatcctgga aactatcccc caggaagaga ttgtgtctgg attgttgtaa ctagtcctga
     1921 cctcctggta acatttactt ttgggacctt gagcctcgag caccatgatg actgcaacaa
     1981 agattacctt gagattcgag atggtccttt gtatcaggac ccccttcttg ggaagttctg
     2041 caccactttc tctgtcccac cgctccagac tactggcccc tttgccagaa ttcacttcca
     2101 ttcagactcc cagattagtg accaaggctt ccatatcacc tacttaacat caccttcgga
     2161 tctgcgttgt ggtgggaact acacggaccc agagggtgaa ctcttcttgc ctgagttgtc
     2221 tgggcctttc actcacacca ggcaatgcgt ctatatgatg aagcagcccc agggagaaca
     2281 aatacaaatc aacttcaccc acgtggagct gcaatgccag agtgacagtt ctcagaatta
     2341 cattgaggtt cgagatggtg aaaccttact tggaaaagtc tgtggcaacg gaaccatctc
     2401 tcacattaaa tccattacta atagtgtctg gatcaggttt aaaatagatg cttctgttga
     2461 aaaagctagt ttcagagctg tttatcaagt cgcttgcggg gatgaattaa ctggagaagg
     2521 ggtcattcgc tcgccttttt ttcctaacgt gtatcctgga gaaagaacct gtaggtggac
     2581 catccaccag ccccaaagcc aagtcattct cctcaacttc actgtctttg aaattggaag
     2641 ttctgcccac tgtgaaacag attatgttga gattggtagc agttccattt tgggttctcc
     2701 tgaaaataaa aagtattgcg gtacagacat accttcattt ataacatctg tgtacaattt
     2761 tctttatgtc acattcgtga aaagttcttc tactgaaaac catggtttca tggctaagtt
     2821 cagtgctgag gatttggcat gtggagaaat tcttacagaa tcaacaggga ccattcaaag
     2881 tcctggccat ccaaatgtct acccccacgg tatcaactgt acttggcata tattagtcca
     2941 acctaatcac ctgattcatt taatgttcga aacatttcat ctggagtttc attacaattg
     3001 cacaaacgac tacttggaag tttatgacac cgactctgag acatcccttg gaagatactg
     3061 tggaaagtcg atcccgccat ctctcacaag cagtggtaac tcattgatgc tggtgtttgt
     3121 gactgactcc gacctcgctt atgaaggctt cttaataaac tatgaagcaa tcagtgcagc
     3181 aacagcatgt ttgcaagact acacagatga tttggggaca ttcacttctc caaacttccc
     3241 caataattat cccaacaact gggaatgcat ttatcggatc acagtgagaa ctggccaact
     3301 gattgcagtg cacttcacaa acttctcctt ggaggaagcc attggaaact attatacaga
     3361 ttttctggaa atcagagatg gaggctatga aaaatcacca ttgctgggaa tattctatgg
     3421 ctcaaatcta cccccaacaa tcatctctca tagtaacaaa ctatggttaa aatttaagag
     3481 tgaccaaata gacacaaggt ctggattctc agcttactgg gatgggtcat caacaggttg
     3541 cgggggtaat ctcaccactt caagcggcac gttcatatct cccaactacc cgatgcccta
     3601 ttaccacagc tctgaatgct actggtggtt gaaatctagc cacggcagcg catttgaact
     3661 ggaattcaaa gactttcact tggagcatca tccaaactgc actttagatt acctggctgt
     3721 atatgatggc ccaagtagca actctcatct gctaactcag ctttgtgggg atgagaaacc
     3781 ccctcttatt cgttctagtg gagacagcat gtttataaaa ctgaggacag atgaaggtca
     3841 gcaaggacgt ggcttcaagg ctgaataccg gcagacatgt gagaatgtgg taatagtcaa
     3901 tcaaacctat ggcatcttag agagtatagg gtatccgaat ccttattctg aaaatcagca
     3961 ttgcaactgg accatccggg caacaacagg caacactgtg aactacacat ttttagcatt
     4021 tgacttggaa catcacataa actgctccac agattattta gagctctatg atggaccacg
     4081 gcagatggga cgctactgtg gagtagacct gccccctcca gggagtacta caagctccaa
     4141 gcttcaagtg ctgctcctta cagatggggt tggccgccgt gagaaaggat ttcagatgca
     4201 gtggtttgtt tacggttgtg gtggagagct gtctggggcc acaggctcct tcagcagccc
     4261 cgggttcccc aacaggtatc caccaaacaa ggagtgtatc tggtacatta ggacggaccc
     4321 cgggagtagc attcagctca ccatccatga cttcgatgtg gagtatcatt caaggtgcaa
     4381 ctttgatgtc ttggagatct atggaggccc cgatttccac tctcccagaa tagcccaact
     4441 gtgtacccag agatcacctg agaaccccat gcaggtctcc agcactggaa atgagctagc
     4501 aattcgattc aagaccgact tgtccataaa tgggagaggc ttcaatgcgt catggcaagc
     4561 agtcactgga ggttgtggtg ggattttcca ggctcccagt ggagagattc attctccaaa
     4621 ttaccccagt ccttatagga gcaacacaga ctgttcttgg gtcattcggg ttgacagaaa
     4681 tcatcgtgtt ctcttgaact tcactgactt tgatcttgaa ccacaagact cttgtattat
     4741 ggcatacgat ggcttaagct ccacaatgtc ccgccttgcc aggacgtgtg gaagggagca
     4801 gctggctaac cccatcgtct cctcaggaaa cagcctcttc ttgagatttc agtctggccc
     4861 ttccagacag aacagaggct tccgagctca attcaggcaa gcctgcggag gccacatcct
     4921 caccagctca tttgatactg tttcctctcc acggttccct gccaattatc caaacaatca
     4981 gaactgcagc tggatcattc aagcgcaacc tccattaaat catatcaccc tctcttttac
     5041 ccactttgaa cttgaaagaa gcacaacgtg tgcacgtgac tttgtagaaa ttttggatgg
     5101 cggccacgaa gacgcgcccc tccgaggccg ttactgtggc accgacatgc cccatcctat
     5161 cacatccttc agcagcgccc tgacgctgag attcgtctct gattctagca tcagtgctgg
     5221 gggtttccac accacggtca ccgcatcagt gtcggcttgt ggtggaacgt tctacatggc
     5281 tgaaggcatc ttcaacagcc ctggctaccc agacatttat ccccctaatg tggaatgtgt
     5341 ctggaacatc gtcagttccc ctggcaaccg gctccagctg tcttttatat ctttccagtt
     5401 ggaagactct caggactgca gcagagattt tgtggagatc cgtgaaggaa atgccacggg
     5461 tcacttggtg ggacgatact gtggaaactc cttccctctc aattattctt ccatcgttgg
     5521 acataccctg tgggtcagat ttatctcaga tggttctggc agcggcacgg gcttccaggc
     5581 cacatttatg aagatatttg gcaatgataa tattgtggga actcatggga aagtcgcctc
     5641 tcctttctgg cctgaaaact acccacataa ctccaattac caatggacag taaatgtgaa
     5701 tgcatctcac gttgtccatg gtagaatctt ggagatggac atagaagaaa tacaaaactg
     5761 ctattatgac aaattaagga tctatgatgg gcctagcatt cacgcccgcc taattggagc
     5821 ttactgtggt acccagactg aatctttcag ctccactgga aattctttga catttcattt
     5881 ttactccgac tcttcaatct cagggaaggg attccttctg gagtggtttg cagtggatgc
     5941 acctgatggt gttttaccta ccattgctcc aggtgcttgt ggtggcttcc tgaggacggg
     6001 agatgcaccc gtgtttctct tctccccggg ctggcctgac agttacagta atagagtgga
     6061 ctgtacgtgg ctcatccagg ctcccgactc taccgtggaa ctcaacattc tttccctgga
     6121 cattgaatct caccgaacgt gtgcctatga tagccttgtg atacgagatg gagataataa
     6181 cttggcccag cagctagcag ttctctgtgg cagagagatc cctgggccca tccggtctac
     6241 tggagagtac atgttcatcc gcttcacctc ggactccagt gtaaccaggg caggcttcaa
     6301 tgcatccttt cacaagagct gcggtggata tttgcatgca gacagaggga tcatcacgtc
     6361 ccccaagtat ccagagactt acccatccaa cctcaactgt tcttggcacg tcctggtcca
     6421 aagtggcctg accattgctg tccattttga acagcctttc cagattccaa atggagattc
     6481 ttcttgcaac cagggggatt acttggtgct aagaaatggt cctgatatct gttctccacc
     6541 cttgggaccc cctggaggaa atggtcattt ttgtggcagt catgcttcat caactctgtt
     6601 cacctcggat aatcaaatgt ttgttcagtt tatttctgat cacagtaatg aagggcaagg
     6661 atttaaaatc aaatatgagg caaagagttt agcctgtggg ggcaacgtct acatccatga
     6721 tgctgattct gctgggtatg tgacctcccc caaccaccct cataattatc ccccgcacgc
     6781 tgattgcatt tggatcttag cggctccacc ggaaacacgc atacagctgc aatttgaaga
     6841 tcgattcgat attgaagtaa cacccaactg tacttccaac taccttgagt tgcgggatgg
     6901 agtggattcg gatgcaccaa tactttccaa attttgtggg acatctttgc ccagcagtca
     6961 gtggtcctca ggagaggtta tgtatttgag atttcgatct gacaacagcc ccacacatgt
     7021 gggattcaag gccaagtatt ctatagctca gtgtggggga agagtaccag ggcaaagtgg
     7081 tgttgttgaa agcattggac atccaacact tccatacaga gacaacttat tctgtgagtg
     7141 gcatctccag gggctctctg gacactatct caccatctct tttgaagact ttaaccttca
     7201 gaattcttct ggctgtgaaa aagacttcgt ggagatctgg gacaatcata cctctggaaa
     7261 catcttgggc agatactgtg gaaacaccat tcctgacagc atagacactt ctagcaatac
     7321 tgctgtggtc aggtttgtca cagacggctc tgtgactgcc tcaggattca gactgcgatt
     7381 tgaatccagt atggaagagt gtggtgggga tcttcagggc tctattggaa catttacttc
     7441 tcccaactac ccgaacccaa atcctcatgg ccggatctgc gagtggagaa tcactgcccc
     7501 ggagggaagg cggatcaccc taatgtttaa caacctgagg ctggccacgc atccgtcctg
     7561 caacaatgag catgtgatag tattcaatgg cattagaagt aactcacccc agctagagaa
     7621 actgtgtagt agtgtgaatg taagcaatga gattaaatct tcaggaaaca caatgaaagt
     7681 catttttttc acggatggat ccaggccata tggcggcttc actgcttcct atacctccag
     7741 tgaagatgca gtgtgtggtg ggtctcttcc aaatactcct gaaggaaact ttacttctcc
     7801 tggctatgac ggagtcagga attactcaag aaacctgaac tgcgaatgga ctctcagcaa
     7861 tccaaatcag ggaaattcat ccatttccat tcactttgaa gatttttacc tagaaagtca
     7921 ccaagactgt caatttgatg tcctcgagtt tcgagtgggt gatgctgatg ggcccctgat
     7981 gtggagactt tgtggtcctt caaagcctac attgccattg gttatacctt attctcaggt
     8041 atggattcac tttgtcacca acgaacgtgt agaacacatt ggattccatg caaagtattc
     8101 ctttacagat tgtggcggaa tacagatagg tgacagtgga gtgatcacaa gccccaacta
     8161 tccaaatgct tatgacagcc tgacccactg ctcttcgctg ttggaggccc cacaagggca
     8221 caccatcact ctcacattta gtgactttga tattgaaccc catacaactt gtgcttggga
     8281 ctctgtcact gtcaggaatg gtgggtcccc tgaatcaccc atcataggac aatactgtgg
     8341 aaattcaaac cccaggacaa tacagtcagg ttccaatcag ctggtcgtga cttttaactc
     8401 agaccattca ttgcaaggtg gtggatttta tgctacgtgg aacacacaaa ctttaggttg
     8461 tggtggaata tttcattctg ataatggtac aatcagatcc cctcactggc ctcagaattt
     8521 tcccgaaaac agcagatgtt cctggacggc cattactcac aaaagtaaac acttggagat
     8581 cagctttgac aacaacttcc taatccccag cggtgatgga caatgtcaga atagcttcgt
     8641 gaaggtgtgg gcaggaactg aggaggtgga caaagccctg ctagccactg gctgtgggaa
     8701 cgtggctccg ggtcccgtta tcacaccaag taacacattc actgccgtct tccagtctca
     8761 ggaggcacca gctcagggct tctccgcgtc ctttgttagc cgatgtggaa gtaatttcac
     8821 tggcccttca ggttacatca tttctccaaa ttacccaaaa caatatgaca acaacatgaa
     8881 ttgcacctat gtcatagagg ctaatcctct gtcagtggtc ctcttgactt ttgtgtcctt
     8941 ccacttagaa gctcgttccg ctgtgacggg aagctgtgtc aacgatggcg tgcacattat
     9001 cagaggttac agcgtcatgt ccaccccatt tgctactgtg tgtggggatg agatgccagc
     9061 tcccctcacc atcgctgggc cggttctgct taacttctac tccaacgagc aaatcacaga
     9121 cttcggattc aagttttcct ataggataat ctcctgtggt ggtgtgttca atttctcttc
     9181 tggaatcatc acaagtcctg cctattcata cgcagactac ccaaatgata tgcactgtct
     9241 gtataccatc accgttagtg acgacaaggt gatcgagctc aagttcagtg attttgatgt
     9301 ggttccctcc acctcctgct cccatgacta cctggcaatt tacgatggtg ccaataccag
     9361 cgatcccctt cttggcaaat tctgcggttc caagcgccca ccaaatgtga agagcagcaa
     9421 taatagtatg ctcctggtgt tcaagacaga ttcatttcag acagcaaaag gctggaagat
     9481 gtctttccgg cagacattgg ggcctcagca aggatgtggt ggttatctga caggctcgaa
     9541 taataccttt gcctctcctg attctgattc gaatggaatg tatgacaaga atttaaactg
     9601 tgtatggatc ataattgcac ctgtaaacaa agtaattcac ctcaccttca atacatttgc
     9661 tctggaggca gcaagtacta ggcaaagatg cctttatgat tatgtaaagt tatatgatgg
     9721 ggatagtgaa aatgcgaact tggctggaac gttttgtggt tccacagtac ctgctccttt
     9781 tatctcttct ggtaacttcc ttacggttca attcatcagt gacttaacat tagagaggga
     9841 aggatttaat gctacataca ccatcatgga catgccttgt ggtggaacat acaatgcaac
     9901 ttggacccca caaaatattt catcacccaa ttcatcagac ccagatgtcc cattttccat
     9961 ctgtacttgg gtcattgatt cccctccgca tcagcaggtc aagataactg tgtgggcatt
    10021 acagctgacc tcgcaagact gcacgcagaa ttacttacag cttcaggact caccgcaggg
    10081 tcacggaaat tcaagatttc agttctgtgg cagaaatgct tcggctgtgc cagtgtttta
    10141 ttcttctatg agtactgcaa tggtcatttt caaatctgga gttgtaaaca gaaactctag
    10201 aatgagtttc acctatcaga ttgcagattg caacagagac tatcacaagg catttggcaa
    10261 cctgagaagc cctggatggc cagataacta cgacaatgac aaggattgca ccgttactct
    10321 cacagccccc cagaaccaca ccatttccct cttttttcat tcacttggca tcgagaactc
    10381 agttgaatgc agaaacgatt tcttggaggt gagaaatgga agtaacagca attcaccatt
    10441 actgggcaag tactgtggaa ctctgctgcc aaaccctgtc ttctctcaaa ataatgaact
    10501 atacctacga tttaagagtg atagtgtaac ttctgatcgt ggatatgaaa tcatctggac
    10561 ttcatcaccc tctggatgtg gtggaactct ttatggagac agaggctcat tcaccagccc
    10621 cggctatcca ggcacatacc caaacaacac gtactgcgag tgggtccttg ttgctcctgc
    10681 tggaaggctt gtcaccatca acttctactt catcagcatt gacgatccag gagactgtgt
    10741 ccagaactat ctcacactct atgatgggcc caacgccagc tctccatcct ctggaccata
    10801 ctgcggaggc gacaccagca tagctccctt cgtggcttcc tcaaatcagg tcttcataaa
    10861 atttcatgct gattatgcac ggcgtccatc cgcattccga ttaacttggg acagctaagt
    10921 gggtaacaac tcgtgttcac tcagcacttt ccctctgcag cacgctggac agcactctgc
    10981 catcctgata catgacccct gctgatgcca cagagaataa gctgaacttg tatggttttt
    11041 caccaaacca tggatagaat caatatttgt aggccaggcg tggtggctca cccccctgta
    11101 ttctcagcac tttgggaggc cgaggcaggt tgatcacctg aggtcaggag tttgagacta
    11161 gcctggccag catggtgaaa cctcatctct ctaacaatat aataattagc caggcgtggt
    11221 ggtgggtgcc tgtaattcca gccactcgag aggctgaggc aggagaattg cttgaaccca
    11281 ggaggcagag gttgcagtga gctaagatca caccactaca ctccagcctg ggcgagacgg
    11341 caagactcca tctcaaaaaa aaaagaaaca aaaaaaacca gaatcaatat ttgtacattt
    11401 tctcgaacat agaatatagc ttctttagtc ttgagtgtgc atttcattct aatattttga
    11461 gctgaaattt aaaaaaactt tgaaagagtt ggaaatgatt atggcatatg tgacatacat
    11521 ttttaaaagt taataataat agccaggggc agtggctcat acccataatc ccagcacgct
    11581 gggaggccat gatgggagga ttgcttgaac ctaggagttt gagaccagcc tgggcaacaa
    11641 agtgagacct gatttttaca aaaaatcaaa aaattagcca ggcatggtgg catgcacccg
    11701 tggttccagc tacacaggag gttgaagcag gaggatcact tgagcccagt aggttaaggc
    11761 tgcagtgaaa ccctgtgaat taaccactgt actccagcct gggtgacaga ctgagaccct
    11821 atctcaaaaa tgacaacaag aacaacaaaa gttaatgata atatagaagc ataaatttcc
    11881 tgtgaatgtt caattacaca taataaacat tattgaattg tacacaa
//
