LOCUS       NM_001048252            1622 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cortexin 3 (CTXN3), transcript variant 1, mRNA.
ACCESSION   NM_001048252 XM_932841 XM_943671
VERSION     NM_001048252.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Sery,O., Lochman,J., Povova,J., Janout,V., Plesnik,J. and
            Balcar,V.J.
  TITLE     Association between 5q23.2-located polymorphism of CTXN3 gene
            (Cortexin 3) and schizophrenia in European-Caucasian males;
            implications for the aetiology of schizophrenia
  JOURNAL   Behav Brain Funct 11, 10 (2015)
   PUBMED   25889058
  REMARK    GeneRIF: altered expression of cortexin 3, either alone, or in
            parallel with changes in disrupted-in-schizophrenia 1, could subtly
            perturb GABAergic neurotransmission
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Chouraki,V., De Bruijn,R.F., Chapuis,J., Bis,J.C., Reitz,C.,
            Schraen,S., Ibrahim-Verbaas,C.A., Grenier-Boley,B., Delay,C.,
            Rogers,R., Demiautte,F., Mounier,A., Fitzpatrick,A.L., Berr,C.,
            Dartigues,J.F., Uitterlinden,A.G., Hofman,A., Breteler,M.,
            Becker,J.T., Lathrop,M., Schupf,N., Alperovitch,A., Mayeux,R., van
            Duijn,C.M., Buee,L., Amouyel,P., Lopez,O.L., Ikram,M.A., Tzourio,C.
            and Lambert,J.C.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     A genome-wide association meta-analysis of plasma Abeta peptides
            concentrations in the elderly
  JOURNAL   Mol Psychiatry 19 (12), 1326-1335 (2014)
   PUBMED   24535457
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Panichareon,B., Nakayama,K., Iwamoto,S., Thurakitwannakarn,W. and
            Sukhumsirichart,W.
  TITLE     Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a
            Thai population
  JOURNAL   Behav Brain Funct 8, 27 (2012)
   PUBMED   22643131
  REMARK    GeneRIF: Two single nucleotide polymophisms of the CTXN3 and
            SLC12A2 genes are associated with risk of schizophrenia in a Thai
            population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1622)
  AUTHORS   Potkin,S.G., Turner,J.A., Guffanti,G., Lakatos,A., Fallon,J.H.,
            Nguyen,D.D., Mathalon,D., Ford,J., Lauriello,J. and Macciardi,F.
  CONSRTM   FBIRN
  TITLE     A genome-wide association study of schizophrenia using brain
            activation as a quantitative phenotype
  JOURNAL   Schizophr Bull 35 (1), 96-108 (2009)
   PUBMED   19023125
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 1622)
  AUTHORS   Wang,H.T., Chang,J.W., Guo,Z. and Li,B.G.
  TITLE     In silico-initiated cloning and molecular characterization of
            cortexin 3, a novel human gene specifically expressed in the kidney
            and brain, and well conserved in vertebrates
  JOURNAL   Int J Mol Med 20 (4), 501-510 (2007)
   PUBMED   17786280
  REMARK    GeneRIF: Selective expression of CTXN3 in the kidney and brain, the
            amino acid identity to cortexin, and its high conservation among
            different species indicate that CTXN3 may be involved in a process
            specifically restricted to kidney and brain tissue function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB219764.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001048252.2.
            
            Transcript Variant: This variant (1) utilizes an alternate first
            exon. Transcript variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB219764.1, DA129300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379445.8/ ENSP00000368758.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1622              AB219764.1         39-1660
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..1622
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /note="cortexin 3"
                     /db_xref="GeneID:613212"
                     /db_xref="HGNC:HGNC:31110"
                     /db_xref="MIM:618746"
     exon            1..307
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /inference="alignment:Splign:2.1.0"
     exon            308..414
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /inference="alignment:Splign:2.1.0"
     exon            415..1622
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..759
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /note="kidney and brain-expressed protein"
                     /codon_start=1
                     /product="cortexin-3"
                     /protein_id="NP_001041717.1"
                     /db_xref="CCDS:CCDS34221.1"
                     /db_xref="GeneID:613212"
                     /db_xref="HGNC:HGNC:31110"
                     /db_xref="MIM:618746"
                     /translation="MDGGQPIPSSLVPLGNESADSSMSLEQKMTFVFVILLFIFLGIL
                     IVRCFRILLDPYRSMPTSTWADGLEGLEKGQFDHALA"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /note="hexamer: AATAAA"
     polyA_site      1622
                     /gene="CTXN3"
                     /gene_synonym="KABE"
                     /note="major polyA site"
ORIGIN      
        1 agaatcctct gaagagttgc tgaggcagaa ctgaaatcat ggctcacctc aaagaagcag
       61 cagtattggc cgttaatgat gcctcacaca gaaagacgat gctcctttaa ctcggggttt
      121 taatgggaag tttctaagcc tgaaacaaca gctttagacc tggggtgtgc catcagctgc
      181 cttgcagcta ccactgtcta ctgctttcac acagcgtggt cgggaagaat ggaaactaaa
      241 gaggcttgta actacctgta actgttccac caggaaatgg atcaagtgtt tgttcagcca
      301 gagccagtat taaaattaga ctctatttcc tgagcaccca caaatggacc tgacaaaggg
      361 aagacacaga tgtactgcgt gatgaggaaa gcctatcagg attaaaatat ggctataact
      421 cagcctctcc agagtgcagc caccatgacc tccgcagatt gatgatggaa gaaaagaaaa
      481 ccaggatatc ctgtgctctg gcttccctgg accatggatg gaggacagcc catcccctca
      541 tccctagtgc cccttgggaa cgaatcagca gattctagca tgtccctgga gcagaaaatg
      601 acatttgttt ttgtgattct gttgtttatt ttcttgggca ttctcattgt ccggtgcttc
      661 cggattcttt tggatccata tcgaagcatg ccaacctcta cctgggctga tggacttgaa
      721 ggcctggaga aagggcagtt cgaccatgcc cttgcttagg agggatggtg tgggatctcc
      781 tcctgaggag atgaagtgct ttgtgtcttg gtgaggattc cctttattta gtgttctcaa
      841 caaatcaaat ttaaacaata tttggtccca ggaccataat ccattattcc ataaatatgc
      901 agttgggtta aagacatttg aggatgttgg aaatggacac ttatataact aatccaacat
      961 aagaaggttt aaatttttat gtttgctcaa tgaatgagta ctcttaaaat tgtgtgattg
     1021 tgaaaccaag agcgttaata ctgacataga tttgccatca aacaaaacac cacctgatct
     1081 gactaaagaa taaaagacta gaaaggatct catatgaatc tggtgacaag gccaggaaga
     1141 gatttccttg ctctaattat gtctatattt gttttatttc atgggcacct atctgggtcc
     1201 tgagcagaat gaggaagatt gtgctgaatg gacccaaagt agtttcttgt tttctcccaa
     1261 agcagggagc tttgggaagc aatggaaaag cttaaaagag atgattctgt ccttggtaaa
     1321 tgtgagtgag aatagcgttt tgtttttcaa gtaaaactta attcaaaggc tacaaagttt
     1381 taaaaactat ttaccaagcc aactacatta tatgtattca tattaataac atgtgtagag
     1441 gtagctatac attacttgaa tttacacttt acacaaatga tttaaaaaat aggttgcaag
     1501 tgcagcttaa agtttttttt caatgaaaag ttaattgttt agaggagaag acttttatag
     1561 tcttcagagg aatgtgtatt tatgattgta tatagtcacc aaataaaact tttcaagaaa
     1621 ca
//
