LOCUS       NM_001145668            2704 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens cortexin 2 (CTXN2), transcript variant 1, mRNA.
ACCESSION   NM_001145668
VERSION     NM_001145668.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC066612.7 and BX537772.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001145668.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537772.1, SRR1803614.89059.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417307.3/ ENSP00000406145.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC066612.7         111570-111574
            6-827               BX537772.1         1-822
            828-2680            AC066612.7         121787-123639
            2681-2700           BX537772.1         2676-2695
            2701-2704           AC066612.7         123660-123663
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..2704
                     /gene="CTXN2"
                     /note="cortexin 2"
                     /db_xref="GeneID:399697"
                     /db_xref="HGNC:HGNC:31109"
     exon            1..189
                     /gene="CTXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..2704
                     /gene="CTXN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..492
                     /gene="CTXN2"
                     /codon_start=1
                     /product="cortexin-2"
                     /protein_id="NP_001139140.1"
                     /db_xref="CCDS:CCDS45254.1"
                     /db_xref="GeneID:399697"
                     /db_xref="HGNC:HGNC:31109"
                     /translation="MSSTYCGNSSAKMSVNEVSAFSLTLEQKTGFAFVGILCIFLGLL
                     IIRCFKILLDPYSSMPSSTWEDEVEEFDKGTFEYALA"
     regulatory      601..606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTXN2"
                     /note="hexamer: AATAAA"
     polyA_site      627
                     /gene="CTXN2"
                     /note="major polyA site"
     regulatory      2682..2687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTXN2"
                     /note="hexamer: AAGAAA"
     polyA_site      2704
                     /gene="CTXN2"
                     /note="major polyA site"
ORIGIN      
        1 gtctcaccaa cagacacaga catttacact tctaggccag gaaagcgcta accagggccc
       61 tgtgactcta cgcaggttcc agaacacgcc ttctacattt gttactgaac cgatcagcga
      121 acacagacaa acgtgccaac acttaagtct actggctgga cttcatctcc atggcaacaa
      181 gcatggaagg caaagagttg attccagaag gaactgtgaa gagccacaac aatgtgccag
      241 tgaataatga gtagtaccta ctgtggcaac tcttcagcta agatgagtgt caacgaagta
      301 tcagctttct cattgactct ggagcaaaaa actggctttg cttttgttgg gattttgtgt
      361 atcttcttgg gacttcttat tatccgatgc ttcaaaatcc tgctagaccc atatagtagc
      421 atgccttcct ctacatggga agatgaagtt gaagagtttg ataaagggac atttgaatat
      481 gcactcgcgt gagagttcca gctatatggt ttttatggtt gtgccatcgg gacacattct
      541 ggatacaatt gtaactacct tgagggtgtg ggagagaggc tcattttgtt cagtgaattc
      601 aataaacatc tgtgactaat ttcttcacca tgctgtgtaa atgataaact attgttggga
      661 ttcctcactt tcctctgttc ccacttagag gtttccaatg aatagagcat aaggatggct
      721 gccgccatgt ttaccatctt tattcttatc ttgaacaact gccttgaatt tctgcttcct
      781 ttcttgtgct aataaactgt gccaaaggca tcttgctctc tcccctctga aaagcccagg
      841 catcccctcc acattcctga ctcagacccc tttagcttta gtgagtcagg tcttaaacag
      901 agaatttagt ccaaagaata atcaaaatat tatttgtcta ataataacca taggcccaaa
      961 aggttcacag gtgaaaaaat atctcaaaaa tctaacaccc aaagcctaca agtagtcaca
     1021 ggccctaaag ctccccaaat ttcacagagc cctgaccctc ctatctcttc tgtttgtcga
     1081 atctcttgca gtaaaatccc atagcttgga atccaaacca gatctgcctc atactgatgc
     1141 tccctcccct accccttgca taaatagaat ttaaaaggga gtttccagca tgacctagtg
     1201 gaaagagtac tctaagcaga aacaaagaca gtctcagctg tgccaccagt agagctatgc
     1261 tctaatgggt aagtcatcta atctctgtga gcttcagtga agagtagtgt taacatcctt
     1321 ttcaattcta gtgccctatg aatgctacaa atgtatctga aaacccagag atctgaaatg
     1381 aatgaggatt taagatatca tgaaaagttt ttcagattag gagcctaaac tcagagattt
     1441 gaattctaat gttagcttag ccaagaacta gctttatgac ctagaaagtt acctaaaggg
     1501 aacctatatt gcacaacaag aattaagaaa cccatcctgc atgtcttcag caatattgag
     1561 agggccaatt agatataatg aatgtgaaag cattttgtaa accataaaac agtatctaaa
     1621 cataccttgc tatcaatatt tattgtcctc atcagtagca gtaatagaga ttctcaaacc
     1681 ctaagaagca atggcttagt gtaaattatt caatctctct agtatttcat tctcttcaat
     1741 tgagaaataa aaagataaaa ttatatagtt ctaaattctt tccaactaca aacttctgac
     1801 tctctatgag tcagaatgga ggaacatagc aggagataaa tacaaaaata tttatgtcct
     1861 ttgaaaacac agaactgcaa aacataccat gaaggaacaa gactaatatt accaagaggt
     1921 agcactaagt tagttacttt caatttattt gatactctta taaattcttt gagttggaga
     1981 ctactatttc cattttattt ttaatcttaa ttttgcagaa gagaaactga agctaagaga
     2041 aattaactag cttcccaagg tcaccatagc tagggaatgg ttatgttagg gattgaactt
     2101 gggcagtttg atttctgctg tatccctaga cactgtcctc aacacttcta catagcttat
     2161 aggcatggtt actgctcagg tctatggaat tccaaaacca gctgtctctg tgagattcct
     2221 tgatgctttc catctcataa tagatttaga acatatctgt tattagctat ggatcttctg
     2281 gaccaaatcc tcacctcaag gaggctctct gtaccccagt tggttcaaga gtgtaggcct
     2341 ggtacacctc atagccagtt agtaacttgg cccaagaaca ggccactggg ccaagttcaa
     2401 ctgaacatac tgaaaattgt gtgtgccagg aaactaggtc tctttgttga ccaaggcttt
     2461 taaagtacca gatgtttcat ttgtctccca gagaagacac ccaccaagac cctccatttt
     2521 gatgactaga acaaaccaag gccagatctt tatttcaaag gaagaaagac ctctacaacc
     2581 aagaaaactt tatgaaatat gagcattgtt tctggaagtt caactcccat aagcttttca
     2641 agtatattaa ctctaccata atattatttc caaatccact aaagaaaaat tctattaacc
     2701 aaaa
//
