LOCUS       NM_145232               2126 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytosolic thiouridylase subunit 1 (CTU1), mRNA.
ACCESSION   NM_145232
VERSION     NM_145232.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Van der Veen,A.G., Schorpp,K., Schlieker,C., Buti,L., Damon,J.R.,
            Spooner,E., Ploegh,H.L. and Jentsch,S.
  TITLE     Role of the ubiquitin-like protein Urm1 as a noncanonical
            lysine-directed protein modifier
  JOURNAL   Proc Natl Acad Sci U S A 108 (5), 1763-1770 (2011)
   PUBMED   21209336
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Schlieker,C.D., Van der Veen,A.G., Damon,J.R., Spooner,E. and
            Ploegh,H.L.
  TITLE     A functional proteomics approach links the ubiquitin-related
            modifier Urm1 to a tRNA modification pathway
  JOURNAL   Proc Natl Acad Sci U S A 105 (47), 18255-18260 (2008)
   PUBMED   19017811
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011473.4, BX440723.2 and AK291173.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145232.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.198025.1,
                                           SRR1163658.455268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421832.3/ ENSP00000390011.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC011473.4         108473-108491       c
            20-39               BX440723.2         1-20
            40-1498             AK291173.1         1-1459
            1499-2126           AC011473.4         97688-98315         c
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2126
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /note="cytosolic thiouridylase subunit 1"
                     /db_xref="GeneID:90353"
                     /db_xref="HGNC:HGNC:29590"
                     /db_xref="MIM:612694"
     exon            1..63
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /inference="alignment:Splign:2.1.0"
     exon            64..592
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1131
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /note="ATP binding domain 3; cancer-associated protein;
                     cancer-associated gene protein; cytoplasmic tRNA
                     adenylyltransferase 1; ATP-binding domain-containing
                     protein 3; cytosolic thiouridylase subunit 1 homolog"
                     /codon_start=1
                     /product="cytoplasmic tRNA 2-thiolation protein 1"
                     /protein_id="NP_660275.2"
                     /db_xref="CCDS:CCDS12824.1"
                     /db_xref="GeneID:90353"
                     /db_xref="HGNC:HGNC:29590"
                     /db_xref="MIM:612694"
                     /translation="MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLA
                     GRLLPPGAVVAVGASGGKDSTVLAHVLRALAPRLGISLQLVAVDEGIGGYRDAALAAV
                     RRQAARWELPLTVVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGAR
                     RVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQ
                     KEVVLYAHFRRLDYFSEECVYAPEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALA
                     PAARPPRPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPG
                     DPARPPASKAVPTF"
     exon            593..2126
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1197..1202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /note="hexamer: AATAAA"
     polyA_site      1214
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /note="major polyA site"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /note="hexamer: AATAAA"
     polyA_site      2126
                     /gene="CTU1"
                     /gene_synonym="ATPBD3; NCS6"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggc caggcttccg cgtggtgggc agtgtgggca tcccagcact gagttctgcc
       61 cgggagaagc cgacccctcc cgcaatgccc gccccgccgt gcgcctcctg ccatgctgca
      121 cgcgccgccc tccgccgtcc gctctcgggc caagcgctgt gcggtgcctg cttctgcgcc
      181 gccttcgagg ccgaggtgct gcacacggtg ctcgccggcc gcctgctgcc gcccggcgcg
      241 gtggtggccg tgggcgcctc gggcggcaag gactccacgg tgctggcgca cgtgctgcgc
      301 gcgctggcgc cgcgcctggg catctcactg cagctcgtgg ccgtcgatga gggcatcggt
      361 ggctaccggg acgcggcgtt ggcggccgtg cggcgccagg cggcgcgctg ggagctgccg
      421 ctcacggtcg tggcctacga agacctcttt gggggctgga cgatggacgc cgtggcccgc
      481 agcacagccg gctccggccg cagccgctcc tgctgcacct tctgtggagt gctgcggcgc
      541 cgggcgctgg aggaaggggc gcgccgcgtg ggagccacgc acatcgtgac aggtcacaac
      601 gccgacgaca tggcggagac cgtgctcatg aacttcctac ggggcgacgc ggggcggctg
      661 gcccggggcg ggggcctggg ctctcccggc gaggggggcg ccctgccgcg ctgccgcccg
      721 ctgcagttcg cctcgcagaa ggaggtggtg ctgtacgcgc acttccgccg cctcgactac
      781 ttctccgagg agtgcgtcta cgcgcccgag gccttccgcg gccacgcccg ggacctgctc
      841 aagcgcctgg aggcggcgcg gccgtccgcg gtgctggacc tcgtgcactc ggccgagcgc
      901 ctggcgctgg ccccggccgc gcggcccccg cgccccggcg cctgctcccg ctgtggggcg
      961 ctggccagcc gcgcgctctg ccaggcctgc gcgctcctgg acggcctgaa ccgcggccgg
     1021 ccccgcctgg ccatcggcaa gggccgccgg ggtctggacg aggaggcgac gccggggacg
     1081 cccggggatc cggcccggcc ccccgcctcc aaggccgtcc ccaccttcta gcgacttcgg
     1141 gcctcccgcc gggatctgat gccgcggggt gggggctgcc tgtaaatgac actgtgaata
     1201 aacccgttac cttacctggc cttccatgtg gggttgggaa ggagacgggg gcccattcac
     1261 ctgaaaccct gaagaagctg ggaccccaga cttcgaggtc tcagggaaga agggtctcga
     1321 actgggcttc aggctctgag ggaggagggg gctgggggac catcctaggt ctgagagagg
     1381 agagggccag gactaagcct agaagaagtg ggactgggga ccccaggcat ctgtggctga
     1441 ggaaggaggg cctggggtcg tggactcctg ggtctcaggg aggagggggc tgaacaccgt
     1501 gtgattcttg agcgagtggg gattggttgg ggacctcctg cccagggcct ctgctggttc
     1561 tgggtgcgct cagcatggtc ctgaccctcc ttgagcatca gattcctgat gtttcctgtt
     1621 tgcccgcagt ggggtaagcg gagcgtgact tgatggacac acgccattca cagccgccgt
     1681 cacgatgcct cccttccagc gcttcgtgtg tagcacgcac tgcaccctca tttcgtctcc
     1741 accacggtct cactggctgt agcctgaagt ggtaaatggc cctaagacac ccagtcggaa
     1801 ggggtcacac cgagggctcc ctccaaagct ctcgaatatc acaggtcgtg gaattggtcc
     1861 tcccccaccc atcccctctc gaatctctcc tggtatctct gtcacgggtg aggaggggtt
     1921 ggatgcgttc cccaaacctt ggactctgga ggcagggttg tgtgagcctg tcggtgactt
     1981 agcctctttc atgtcccatt tctcctatga aaatataatc agcccccttc ccccccgccc
     2041 ccccatcccc cccgcatcaa ggcaccactg ggaggaaatg gaagatcaga gaagttgagg
     2101 tgctcaataa atggtgacca cttgga
//
