LOCUS       NM_018704               5864 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens CTTNBP2 N-terminal like (CTTNBP2NL), mRNA.
ACCESSION   NM_018704
VERSION     NM_018704.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5864)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5864)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5864)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 5864)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5864)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 5864)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   7  (bases 1 to 5864)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 5864)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 5864)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 5864)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA238082.1, AL598321.1, DB236769.1, AL354760.11 and BE645464.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018704.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA834426.1, SRR1660803.227069.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271277.11/ ENSP00000271277.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA238082.1         37-45
            10-581              AL598321.1         2-573
            582-879             DB236769.1         288-585
            880-5311            AL354760.11        48976-53407
            5312-5864           BE645464.1         2-554               c
FEATURES             Location/Qualifiers
     source          1..5864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..5864
                     /gene="CTTNBP2NL"
                     /note="CTTNBP2 N-terminal like"
                     /db_xref="GeneID:55917"
                     /db_xref="HGNC:HGNC:25330"
                     /db_xref="MIM:615100"
     exon            1..59
                     /gene="CTTNBP2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            60..183
                     /gene="CTTNBP2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            184..291
                     /gene="CTTNBP2NL"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2112
                     /gene="CTTNBP2NL"
                     /codon_start=1
                     /product="CTTNBP2 N-terminal-like protein"
                     /protein_id="NP_061174.1"
                     /db_xref="CCDS:CCDS845.1"
                     /db_xref="GeneID:55917"
                     /db_xref="HGNC:HGNC:25330"
                     /db_xref="MIM:615100"
                     /translation="MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEER
                     YGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLA
                     AAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE
                     QKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLE
                     EELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKD
                     LEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTG
                     LPGPATPAYSYAKTNGHCDPEIQTTRELTAGNNVENQVPPREKSVALAQEKPVENGGC
                     PVGIETPVPMPSPLSSSGSSLSPSSTASSSLTSSPCSSPVLTKRLLGSSASSPGYQSS
                     YQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLIDNSAAKQLARNTVTQV
                     LSRFTSQQGPIKPVSPNSSPFGTDYRNLANTANPRGDTSHSPTPGKVSSPLSPLSPGI
                     KSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLTKTHSQAASLTTAEDLASSCSSNTV
                     VANGKDVELLLPTSS"
     exon            292..522
                     /gene="CTTNBP2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            523..630
                     /gene="CTTNBP2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            631..5864
                     /gene="CTTNBP2NL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4911..4916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTTNBP2NL"
                     /note="hexamer: ATTAAA"
     regulatory      4916..4921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTTNBP2NL"
                     /note="hexamer: AACAAG"
     polyA_site      4930
                     /gene="CTTNBP2NL"
                     /note="major polyA site"
     polyA_site      4946
                     /gene="CTTNBP2NL"
     regulatory      5844..5849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTTNBP2NL"
                     /note="hexamer: AATAAA"
     polyA_site      5864
                     /gene="CTTNBP2NL"
ORIGIN      
        1 agccgctgtg gatggggagt ggaggcggag gggagcggag cccggagcgt cgtggaaagc
       61 attggacaca tttccaccat gctaatggca ttttaaatat atttggcaat tttcccaatt
      121 ttttactgaa gaaaactgta agtttatact tgaggactga agtgtgactc tgccgattat
      181 caggctttca agatgaatct ggaaaaactc agcaagcctg aactcctgac actatttagt
      241 attcttgaag gagagcttga agcaagggac cttgttatag aagccttaaa ggcccaacac
      301 agagatactt tcattgaaga acgctatgga aaatataaca tcagtgatcc tttaatggct
      361 ctacagagag attttgaaac actgaaggag aaaaatgatg gcgaaaagca gccagtctgc
      421 acaaatccac tctctattct taaggttgtg atgaagcagt gcaagaacat gcaggagcgc
      481 atgctgtccc agctggctgc tgctgagagc aggcaccgaa aggtgatcct agaccttgag
      541 gaagaaaggc agcggcatgc acaggatacg gctgaaggag atgatgtcac ctacatgcta
      601 gagaaggaaa gagagaggct gactcaacag ttggaatttg aaaaatccca agtgaaaaag
      661 tttgaaaaag aacagaagaa gctctctagt cagctggaag aggagcgctc ccgccacaag
      721 cagctctcat ccatgctagt gcttgagtgc aagaaagcca ccaacaaggc agccgaggaa
      781 ggacagaagg caggagagct gagcctgaaa ttggagaagg agaagagccg ggtgagtaaa
      841 ctggaagaag agttggcagc tgagagaaag agaggcttgc agactgaggc ccaggtagag
      901 aagcagttat cagagtttga catcgaaagg gaacaactga gagcaaaact gaaccgagaa
      961 gagaaccgga ccaaaaccct gaaagaagaa atggaaagtt taaagaagat agtgaaggac
     1021 ctagaggctt cccaccagca cagtagccct aatgagcaat tgaagaaacc agtaaccgtg
     1081 tccaaaggca cagcaactga gcctctcatg ctaatgtctg tgttttgcca aacagagagt
     1141 tttccagcag aaagaaccca tgggagcaac atagccaaga tgacaaacac tgggctgcct
     1201 ggtcctgcca ctcctgctta ctcatatgca aaaaccaatg gccattgtga cccagagata
     1261 caaactacca gggagctgac tgcaggcaac aatgtagaaa accaggtgcc tccacgggaa
     1321 aaatctgtgg cattggccca agagaaacca gtggagaatg gtgggtgtcc tgtggggatt
     1381 gagactccag tcccaatgcc cagtcccctc tcttccagtg ggagctcact gtctcccagc
     1441 agcactgcct cctcctctct aacatcctct ccttgctctt cgccggtact cactaagcgt
     1501 ttattggggt catcagctag cagccctggc taccagtcat cgtaccaagt agggatcaac
     1561 caacggttcc atgcagctcg ccacaaattt cagtcccaag cagatcagga ccaacaagcc
     1621 agtggcctac agagccctcc atccagggat ttatccccca ccctcataga caactctgcc
     1681 gccaagcagc tggcccgaaa cacagtcact caggtgctct ccagattcac tagccaacaa
     1741 gggccaatca agccagtctc tcccaacagc tctccctttg gcacagacta tcgaaatcta
     1801 gccaacactg ccaatccaag aggtgacaca agccattcac ctactccagg gaaagtgtcc
     1861 agtcccctga gccccctgtc tccaggaatc aagtccccaa ccatccccag agctgagaga
     1921 ggaaaccctc cacccatccc acccaagaaa cctggcctca ccccttctcc atctgctacc
     1981 actccattga ccaaaactca ttcccaggca gcctctttga ccactgcaga agaccttgcc
     2041 agcagctgct cttccaatac tgttgtagca aatggtaagg atgttgagtt acttttgcct
     2101 accagcagct agtccctagg agggagtctc cacgtttgac attccatcag atttcgtcca
     2161 aaagctcagt cagacttctg agtcagatta tgttatttat tttgatagta gctgaaacca
     2221 tctgtataat acatttagta tatttcacca ttttgtattt ttttaagtag aaactgagta
     2281 gtttggattt ttatggctca catcttttta ctgaagccag aaaggcacct caaagatgtc
     2341 tcaagctcag cagtcaccgt catgttgtga tgaagaaagc gaatcaccag gtggtgattt
     2401 gctatctatt tgagaactag aatcactcaa cactcatttt gaattatgca gaagtggttc
     2461 atgcagattt ttattccaga tgaacatgtt ttaaaagtgc ctgaaatatg actgccatat
     2521 gaatgtgatt ctgcagcaaa aaacacaaaa tagatcattt aattacagaa aatgagatcc
     2581 tctgtgaatt ctgaatgtta aaaaccaaca ctgcttttaa tcctctttta atgttttaat
     2641 acaagctttg tgttctgaaa caaggctgca taagtagaat gggaatcctt ctaaaggtgg
     2701 gtgtgaactc accacaagct gagctttata gagcccttga gaaaccctcc tgagcactaa
     2761 gcagttgggg tgctgatttt cttgtacttt tgaaaaatta agtcactccc agtttcctgc
     2821 ataagttctt gaacagaatg aaatcacatc tccattcaaa aaatgtctca agcatctact
     2881 gttgtgtaag gaacttctga ttctgattgc tgttacttga ataggaaatg gttactcatt
     2941 ctgtataaaa gttttgcaag agaatgaatt ttttattctg taatcaaaaa gcaataactt
     3001 gaaattcact ctgtaatatt ataggtcagt cagaattata caagttttac caaattgtta
     3061 cacttattct ccaagctgcc agaacctggt atctgtatct gtaaaaccaa attaactttt
     3121 gcttaaatgg gaagtataca tatatctgta tagatacatt acccctttac atgtttaaca
     3181 tacacacact taaacacata aatactagtg tgattatatc tttggagttt gcaatatagc
     3241 ataaaggaca agtagaactg cacattaaga ttacctaccg aagcaactag atgtggctgg
     3301 gacacaatca aaggaggaat tttgtccaca ggaaggtgag gaaattccaa atgaagccta
     3361 gatcttcagt atcataaaaa ggcagagctg gccaggcaca gtggctcatg cctgtaatct
     3421 tatcactttg ggaggctgag atgggaggat ctcttgagac caggtgttca agaccagcct
     3481 catcaacata gtgagacccc atctctatta aaaaaataaa taggcagagc taaactaacc
     3541 ccagtgtcac aaaactcaac tggtcatata aatgagtgaa acaggcctct cacacaagcg
     3601 atgtaaaaca gctgggagca gtgggagctg tggcaaacta aagtgcccaa gccgcattta
     3661 aaaagggcat ctgttcagct ccatctgctt gctgcggtgc aagaatgcta aaccaggatt
     3721 accagttctt cacatttttt gaaatccaaa ttttcatgag aaacattctc atttttaaat
     3781 atcaagaagt gattttaaaa tgtttaaatg gtgctggtta aacaaacacg tctgcagctg
     3841 gatttagctt gcaagctgcc aagttgcaac ctctttcatt ctagaaactt ctgtcatttt
     3901 catcatagca agtctatgcg gacaaaagcc tccaaacttt ccaactgtgt aggccagtac
     3961 agctggcaag gttcatagaa tataatggct atccccctct gccaaataag actatccaca
     4021 acccagctca gacacagtgg ttatatgatt ttgtgtccat acaggagagg ccttggtgtc
     4081 ttcacataca ttctctgagc caacatctat ccagcagccc tgacctcctg ctataattta
     4141 agtctatttc cttttaatct aataagagtt gatagtaaaa aggcaggtga tggaaatcag
     4201 tgtataaatc acaatggagt atattggcaa ctccacagct tatagtttga taaaggcaaa
     4261 tacatgaaaa ataaaaatgc tactaatgcc ccaaggtgtc tatcaaaatg atgtaggggg
     4321 tatcttaaac tgtccaaggc aatcatgcat tgaactttat tcctatgcag agccaaaacg
     4381 aatagtgttg ataaaatagc taaactttct aaactggaga ggaggctaca gtgccagaga
     4441 gttattgtct cttttgcttt aaatggtaat cttaaaagtt gcattgtgct cttcctttgt
     4501 tttgggatag atatatatag agagagatac tataaggaag tttatttctt aggaagtgca
     4561 ctgaataatg tatttctttt acagtgtaat atgggggtgg ggatatgcga aagaaatgtg
     4621 tatttttgct agttgcctac cttctgagat aaataagcac aatcttgcaa tggatccaat
     4681 aacccagtta ggtattatag attagtattt aagtttgctg tagattgtgt gtgtgtgtgc
     4741 taagtaaaag ttccatgatt cacaatttta gtattaaccc atgttgcaaa agctgttact
     4801 ggccaacaga ttgtaatgat gtgtaccata taacacaagc attaactagg cattaacgtt
     4861 tgtaaagcca aatataccat gcagaagtct tcatttttat agcagactgc attaaaacaa
     4921 gttaaatctt gctgtttggg gggaaatagt cttgtttgta caaagtgaaa aatggcacaa
     4981 tttgggcata ttttgttggg aagagggggt ggtgtagagg gagcacttga ctgtggcttt
     5041 gacaaaacaa atgaagtcaa tgacccatcc aggttagact ccataaggaa ctaagacatt
     5101 gattttcttt agagtcttag agctggaaaa agcctttaca ataatccagt ctgtgatttt
     5161 ttaaaccttt tggtggttct ggaccttttt gagaatctta gaaaagccat ggagtttatc
     5221 cctagaaaaa tgaatatgcc tatatgcaaa atttgtttga tggcttcata ggatccaaag
     5281 accctgaagc catccatggc tcatgtattt ctgcttaaga aagcataatc ttgttctgct
     5341 ctctcatttt acaaatgatt aatgcatccc ttttcaacta ctccagcgct gttgctgctg
     5401 caatgttagc aaatgcaagc cagagagaag cacttgaaaa tcctttgatg tctaaaaaat
     5461 gttcaaatag tgtggatgtt tacatatctg aagttttcag catttaagca aattaatgat
     5521 catttcaaca aatactagca tatccggttt cccttaatag cctgtcagca gtgctgcctt
     5581 gtcaatttgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gaattcataa ggagtgcttc
     5641 tgatgcttag tccttgaaat ggaacttcaa ctgtctttca aaacactggc ttcaaaatag
     5701 gatgtgtttt cctaatgaat cagaagtggg caatgagcat tgttccacag gaataatttt
     5761 taatttaatt tctataaaac tagttgagaa atgagagcct gtccacccac catttgtgta
     5821 tcagtggcca attcattagt aaaaataaag gaggggaaag gaga
//
