LOCUS       NM_033427               5904 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cortactin binding protein 2 (CTTNBP2), transcript
            variant 1, mRNA.
ACCESSION   NM_033427
VERSION     NM_033427.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5904)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5904)
  AUTHORS   Shih,P.Y., Lee,S.P., Chen,Y.K. and Hsueh,Y.P.
  TITLE     Cortactin-binding protein 2 increases microtubule stability and
            regulates dendritic arborization
  JOURNAL   J Cell Sci 127 (Pt 16), 3521-3534 (2014)
   PUBMED   24928895
  REMARK    GeneRIF: Cttnbp2 increases microtubule stability and regulates
            dendritic arborization.
REFERENCE   3  (bases 1 to 5904)
  AUTHORS   Cobb,J., Cule,E., Moncrieffe,H., Hinks,A., Ursu,S., Patrick,F.,
            Kassoumeri,L., Flynn,E., Bulatovic,M., Wulffraat,N., van Zelst,B.,
            de Jonge,R., Bohm,M., Dolezalova,P., Hirani,S., Newman,S.,
            Whitworth,P., Southwood,T.R., De Iorio,M., Wedderburn,L.R. and
            Thomson,W.
  CONSRTM   Childhood Arthritis Response to Medication Study (CHARMS);
            Childhood Arthritis Prospective Study (CAPS); BSPAR study group
  TITLE     Genome-wide data reveal novel genes for methotrexate response in a
            large cohort of juvenile idiopathic arthritis cases
  JOURNAL   Pharmacogenomics J 14 (4), 356-364 (2014)
   PUBMED   24709693
REFERENCE   4  (bases 1 to 5904)
  AUTHORS   Zink,D., Amaral,M.D., Englmann,A., Lang,S., Clarke,L.A.,
            Rudolph,C., Alt,F., Luther,K., Braz,C., Sadoni,N., Rosenecker,J.
            and Schindelhauer,D.
  TITLE     Transcription-dependent spatial arrangements of CFTR and adjacent
            genes in human cell nuclei
  JOURNAL   J Cell Biol 166 (6), 815-825 (2004)
   PUBMED   15364959
  REMARK    GeneRIF: CORTBP2 (CTTNBP2) has a transcription-dependent spatial
            arrangement.
REFERENCE   5  (bases 1 to 5904)
  AUTHORS   Cheung,J., Petek,E., Nakabayashi,K., Tsui,L.C., Vincent,J.B. and
            Scherer,S.W.
  TITLE     Identification of the human cortactin-binding protein-2 gene from
            the autism candidate region at 7q31
  JOURNAL   Genomics 78 (1-2), 7-11 (2001)
   PUBMED   11707066
REFERENCE   6  (bases 1 to 5904)
  AUTHORS   Ohoka,Y. and Takai,Y.
  TITLE     Isolation and characterization of cortactin isoforms and a novel
            cortactin-binding protein, CBP90
  JOURNAL   Genes Cells 3 (9), 603-612 (1998)
   PUBMED   9813110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007568.1 and AC004240.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_033427.2.
            
            Summary: This gene encodes a protein with six ankyrin repeats and
            several proline-rich regions. A similar gene in rat interacts with
            a central regulator of the actin cytoskeleton. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF377960.1, BC106000.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000160373.8/ ENSP00000160373.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC007568.1         95630-95736         c
            108-215             AC007568.1         83504-83611         c
            216-440             AC007568.1         33060-33284         c
            441-2094            AC007568.1         13423-15076         c
            2095-2298           AC007568.1         6546-6749           c
            2299-2398           AC007568.1         5157-5256           c
            2399-2549           AC007568.1         2736-2886           c
            2550-2609           AC007568.1         1-60                c
            2610-2804           AC004240.1         85552-85746         c
            2805-2922           AC004240.1         75100-75217         c
            2923-3198           AC004240.1         68476-68751         c
            3199-3294           AC004240.1         65916-66011         c
            3295-3374           AC004240.1         64596-64675         c
            3375-3461           AC004240.1         54054-54140         c
            3462-3561           AC004240.1         53872-53971         c
            3562-3714           AC004240.1         43310-43462         c
            3715-3902           AC004240.1         42954-43141         c
            3903-4081           AC004240.1         36130-36308         c
            4082-4287           AC004240.1         33093-33298         c
            4288-4473           AC004240.1         32588-32773         c
            4474-4537           AC004240.1         29108-29171         c
            4538-4670           AC004240.1         27545-27677         c
            4671-4772           AC004240.1         26059-26160         c
            4773-5904           AC004240.1         18692-19823         c
FEATURES             Location/Qualifiers
     source          1..5904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..5904
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /note="cortactin binding protein 2"
                     /db_xref="GeneID:83992"
                     /db_xref="HGNC:HGNC:15679"
                     /db_xref="MIM:609772"
     exon            1..107
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..5018
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CORTBP2, C7orf8"
                     /codon_start=1
                     /product="cortactin-binding protein 2 isoform 1"
                     /protein_id="NP_219499.1"
                     /db_xref="CCDS:CCDS5774.1"
                     /db_xref="GeneID:83992"
                     /db_xref="HGNC:HGNC:15679"
                     /db_xref="MIM:609772"
                     /translation="MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRML
                     LSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKP
                     VCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARL
                     EEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKR
                     RSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK
                     PSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPSTGS
                     PLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAFPPPSANKIEENGPSTGSTP
                     DPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHSPCANTSLHPGLNPRIQAARF
                     RFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPS
                     RPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVI
                     IDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENLPKSSSPQLPPKPSIDLTVAPA
                     GCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASD
                     SLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYS
                     CEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS
                     YDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV
                     DSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGW
                     TAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKIPL
                     RISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWW
                     SLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNKAEHITVLL
                     SGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKH
                     RQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEKSS
                     LSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQ
                     QHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNS
                     CLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKR
                     QPGFGQTTAKRHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPL
                     SIVSSYNTCNKKKGESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNC
                     NRNASLSKQKSLENDLSLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADS
                     RDDLRMFDSSGNNPVLSATINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVK
                     SFLPVPRSKVTQCSQNTKRSSSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK"
     exon            108..215
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            216..440
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            441..2094
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2298
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2398
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2549
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2804
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2922
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3198
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3294
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3374
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3461
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3561
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3714
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3902
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4081
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4287
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4473
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4537
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4670
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            4671..4772
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..5904
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5882..5887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /note="hexamer: AATAAA"
     polyA_site      5904
                     /gene="CTTNBP2"
                     /gene_synonym="C7orf8; CORTBP2; Orf4"
                     /note="major polyA site"
ORIGIN      
        1 gcattcggat ccgctagagc aggaagatgg cgacggacgg cgcgagctgc gagcccgact
       61 tgtcccgggc cccggaggac gcggcggggg ccgcggcgga ggcggcgaaa aaagagtttg
      121 atgtggatac tctcagtaaa tccgagctgc ggatgctcct cagcgtgatg gaaggggagc
      181 tggaggccag agaccttgtc atcgaggccc tgcgggctcg caggaaggag gtatttatcc
      241 aggaacggta tgggagattt aatctaaatg acccgttcct ggcactccag agagactatg
      301 aagcaggtgc tggtgacaaa gagaagaagc cagtttgtac caaccccctc tccatccttg
      361 aagcagtcat ggcccactgc aagaaaatgc aagaaaggat gtccgcacag ctggctgctg
      421 ctgagagcag acaaaagaag ctggaaatgg agaagcttca gctacaagcc cttgagcaag
      481 agcacaagaa gctggctgcc cgccttgagg aagagcgtgg caagaacaag caggtggtcc
      541 tgatgctggt caaagagtgc aagcagctct caggcaaagt catagaggag gcccagaagc
      601 tcgaagacgt aatggccaaa ctggaagagg aaaagaaaaa gacgaatgaa ttagaagagg
      661 aactctccgc tgagaaacga agaagcacag aaatggaagc tcagatggaa aaacaactct
      721 ctgagtttga cactgagcgg gaacagcttc gtgccaagct gaaccgggaa gaagcacaca
      781 ccactgacct caaagaggag atagacaaga tgaggaaaat gattgagcaa ctgaaaaggg
      841 gaagtgacag caaaccaagc ctctctcttc cacggaagac aaaagatagg cgtttggttt
      901 ccatatctgt gggaacagaa ggaactgtga caaggtctgt tgcatgccag acagacctag
      961 tgacagaaaa tgctgaccac atgaaaaagt tgcctttaac catgcctgta aaaccttcca
     1021 cagggagtcc cctagtttct gcaaatgcaa aagggagcgt gtgcaccagt gccaccatgg
     1081 ccagaccagg tattgacagg caggcttcct atggtgactt gattggcgct tctgtacccg
     1141 ctttcccacc tccaagtgca aacaaaattg aggaaaatgg accaagcact ggctcaacac
     1201 cagatccaac cagtagcaca cccccacttc ccagtaacgc tgcccctccc accgctcaaa
     1261 caccaggcat agctcctcag aactcgcaag ctccacctat gcacagttta cattcaccat
     1321 gtgccaacac ctctttgcat ccaggtctaa acccacgaat ccaagcagct agatttagat
     1381 ttcagggcaa tgctaacgac ccagaccaaa atggaaatac tacccaaagt cctccgtcaa
     1441 gagatgtctc gcctacaagt cgtgacaacc tagtggccaa acaactagct cggaatactg
     1501 tgacccaagc actgtcaaga tttacaagcc ctcaagcagg tgctccctca aggcctggag
     1561 tgcccccaac aggggatgtt ggcacccacc ctccagttgg tcggaccagt ttaaagactc
     1621 atggtgtagc acgagttgac agaggaaatc ctcctcctat ccctccaaaa aagccagggc
     1681 tctcccaaac tccttctcca ccacaccccc aactcaaggt tattatagac agcagcaggg
     1741 cctcgaacac aggggccaaa gttgataaca aaactgtggc ttcgactcct tccagtttgc
     1801 cacaagggaa cagggtgatc aatgaggaga accttcctaa gtcatcctcc cctcagctgc
     1861 caccaaaacc atccatagat ttaactgtgg cacctgcagg ctgtgccgtt tcagccctgg
     1921 ccacgtctca ggtgggtgcc tggcctgctg caacccccgg actgaaccaa cctgcatgtt
     1981 cagacagttc ccttgtcatt cctaccacca ttgccttttg ctcttccata aaccccgtta
     2041 gtgcctcatc ctgtagacca ggtgcctcag acagcctcct ggtaacagca tcaggctggt
     2101 caccctccct aacccctttg ctaatgagtg gtggtcctgc ccccctggct ggcaggccca
     2161 cccttcttca gcaagctgct gcccagggaa atgtcacttt attatcaatg ctgcttaatg
     2221 aagaaggact ggacattaat tactcctgtg aagatggcca ttctgccttg tattctgctg
     2281 ctaagaatgg acatacagac tgtgtgagat tgctgctgag tgcagaagcc caagtcaatg
     2341 ctgctgataa aaatggcttc acacccttgt gtgctgcagc tgctcaggga catttcgagt
     2401 gtgtagaatt attaatttca tatgatgcta acattaatca tgctgctgat ggaggacaga
     2461 cacctctata cctggcctgt aaaaatggaa ataaagaatg tattaaactc ttgttggaag
     2521 ctggaaccaa tcgaagtgta aaaaccacag atggctggac accagttcac gcagctgtgg
     2581 acactggtaa tgtggacagc ctcaagcttc ttatgtacca tagaatacca gctcatggaa
     2641 attctttcaa tgaggaggag tccgagtcaa gtgtctttga cttggatgga ggagaagaga
     2701 gtcctgaagg catatccaag cctgttgttc ctgcagacct cattaaccac gccaacagag
     2761 aaggctggac tgctgcccac attgctgctt ccaaaggttt taagaactgc ctagaaatct
     2821 tgtgtaggca cggagggctt gagccagaaa ggagagacaa gtgcaatcgg actgtgcatg
     2881 atgttgccac tgatgactgc aagcatttgc tggagaatct gaatgctctt aaaataccct
     2941 taaggatttc agtgggtgag attgaaccaa gcaactatgg ttctgatgac ttggaatgtg
     3001 aaaacacaat atgtgcttta aatatccgca aacagacatc atgggatgat ttttcaaaag
     3061 cagtgagtca agctctgaca aatcatttcc aggcaatctc ttctgatgga tggtggagtc
     3121 tggaagacgt gacttgcaat aacaccactg attccaacat cggcctcagt gcaagaagca
     3181 tacgatccat cacgctagga aatgtgccgt ggtcagtggg tcagagcttc gcgcagtccc
     3241 cgtgggactt tatgaggaag aataaggcag agcacatcac tgtgcttttg tcaggtcctc
     3301 aagaaggctg tctcagtagt gtgacttatg cctccatgat ccctctccag atgatgcaga
     3361 actacctcag gctggttgag caatatcata atgtcatttt ccacggccca gaaggaagct
     3421 tgcaagacta catagtacat cagcttgcac tctgcctgaa gcacagacaa atggctgcag
     3481 gattctcctg tgaaatagtg agagctgaag tagatgctgg tttttccaag gaacagctac
     3541 tagacctgtt cattagtagc gcttgtctga tcccagtgaa acaatctccc agtaagaaga
     3601 aaatcatcat cattttagaa aatttagaaa aatcttcact gtcggagtta ttgagggact
     3661 ttttggcacc tcttgaaaat cgcagcactg aaagcccctg cactttccaa aaaggaaatg
     3721 gactgtccga atgttattac tttcatgaga actgctttct gatgggaacc atcgccaagg
     3781 cctgtctcca gggctccgac ttgctggtgc agcagcattt ccgctgggtg cagctgcggt
     3841 gggatggcga gcccatgcaa ggactgctgc agaggttctt acgaaggaaa gttgtgaata
     3901 agttcaaagg tcaggcgccc tccccctgcg atcctgtgtg caagattgtc gactgggctc
     3961 tgtccgtctg gcgtcagctt aactcctgcc tggcccgctt gggcacacct gaagcacttc
     4021 ttggaccaaa atatttcctg tcttgtcctg tagttcctgg gcatgcccaa gtgacagtga
     4081 agtggatgtc taagctgtgg aatggcgtca tcgcacccag agttcaagaa gcaatattgt
     4141 caagagcctc tgtgaaaaga caacctggct ttgggcagac aactgctaaa agacacccta
     4201 gccaaggaca gcaggctgtg gtcaaagctg ctctcagcat cttgctaaat aaagctgtac
     4261 tgcatggctg tcccctcccc agagcagagc tagaccagca tacagctgat ttcaaaggag
     4321 gaagtttccc tttatccata gtttccagtt ataacacttg taacaagaag aaaggagaga
     4381 gtggtgcctg gagaaaggtg aacaccagtc ctcgcaggaa gtctggccgc ttctctttac
     4441 ccacctggaa taagccagac ctaagcactg aaggtatgaa aaataagact atatcacagc
     4501 tgaattgtaa caggaatgct tctctgtcaa aacaaaagtc tttagagaat gatctatcac
     4561 tgacgttgaa tttggatcag agactctctc tgggttcaga tgacgaagca gatcttgtca
     4621 aggaacttca gagcatgtgc tccagcaagt ctgagtctga tatcagcaag attgctgatt
     4681 ccagggatga tttaaggatg tttgatagtt ctggaaacaa ccctgtactt tcagcaacta
     4741 ttaataatct gagaatgcca gtgtcacaaa aggaggtcag tcctctcagc agccatcaaa
     4801 ctactgaatg cagcaacagt aaatcaaaga ctgagttggg tgtttcaaga gttaaatctt
     4861 ttcttcctgt tcctagaagt aaagtcaccc agtgttccca gaacaccaaa agaagcagca
     4921 gcagcagtaa tacaaggcaa atagaaatca acaacaactc aaaagaagtg aattggaact
     4981 tacacaaaaa tgaacaccta gaaaaaccta acaaataggc ctgcctacaa tattctcatt
     5041 attaacttcc tctatttcac acagaaacca aggacaacaa gatacaaata cctttaaatt
     5101 gataaaatgt tttcactgta atataaatta tgagtgcggg accactattc aatttttttt
     5161 tgtaaagaat gtatttataa ccaacatttt gttgcttttt tttttaattc tgtaggattg
     5221 aacttcaata ccaggaagtt atgccaactt ttcaagtagt tttataatag aaaaattgta
     5281 atagttttaa tcaagatgtt caggggtatt aaaacagaac tgtgtactgt atatctgtat
     5341 atatgtatat atgtatgtat atttaaggaa gtccagaaat catactgcat acatgctaca
     5401 aaaaagtagc aaaaaagtac aaagttggct tagataactt gtaccgtttt aaatggagat
     5461 cataatttta tgttcacttg atggggaatg actagaatgg ggcaataaca aatcatttct
     5521 aaacagttat tttccattaa aagccatatt aagtattttg cttgttaaat tctagtttta
     5581 tgttttaaat ctcttagtgg ttacattgcc atttggtagc atcatgtata tatttatgct
     5641 tataagtttg cattatgact cctgtaaaat atgaaattat aatgcaataa aagtgttatc
     5701 tttcttacaa aagttttgta cctaagtgga tatagataac tgcataaatg aataaattca
     5761 gaattaactc cttcaatatt tctagtagca caactgataa tattgatatt ttctacaaat
     5821 gttacttcta aaattacaga caaaattact tacacaattc agttaagatg ctttgacact
     5881 gaataaaata ttgatttcat gaaa
//
