LOCUS       NM_001336               1502 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens cathepsin Z (CTSZ), mRNA.
ACCESSION   NM_001336
VERSION     NM_001336.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Liu,L., Feng,X., Fan,C., Kong,D., Feng,X., Sun,C., Xu,Y., Li,B.,
            Jiang,Y. and Zheng,C.
  TITLE     PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of
            multiple myeloma cells
  JOURNAL   FASEB J 38 (16), e70024 (2024)
   PUBMED   39190024
  REMARK    GeneRIF: PDCD4 interacting with PIK3CB and CTSZ promotes the
            apoptosis of multiple myeloma cells.
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Ulrich,A., Wu,Y., Draisma,H., Wharton,J., Swietlik,E.M., Cebola,I.,
            Vasilaki,E., Balkhiyarova,Z., Jarvelin,M.R., Auvinen,J.,
            Herzig,K.H., Coghlan,J.G., Lordan,J., Church,C., Howard,L.S.,
            Pepke-Zaba,J., Toshner,M., Wort,S.J., Kiely,D.G., Condliffe,R.,
            Lawrie,A., Graf,S., Morrell,N.W., Wilkins,M.R., Prokopenko,I. and
            Rhodes,C.J.
  TITLE     Blood DNA methylation profiling identifies cathepsin Z
            dysregulation in pulmonary arterial hypertension
  JOURNAL   Nat Commun 15 (1), 330 (2024)
   PUBMED   38184627
  REMARK    GeneRIF: Blood DNA methylation profiling identifies cathepsin Z
            dysregulation in pulmonary arterial hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Malovitski,K., Sarig,O., Feller,Y., Bergson,S., Assaf,S.,
            Mohamad,J., Pavlovsky,M., Giladi,M. and Sprecher,E.
  TITLE     Defective cathepsin Z affects EGFR expression and causes autosomal
            dominant palmoplantar keratoderma
  JOURNAL   Br J Dermatol 189 (3), 302-311 (2023)
   PUBMED   37210216
  REMARK    GeneRIF: Defective cathepsin Z affects EGFR expression and causes
            autosomal dominant palmoplantar keratoderma.
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Jiang,Y., Huang,Y., Ma,G., Liu,T., Li,Q., Wu,H. and Li,J.
  TITLE     Granulomatous rosacea in Chinese patients:
            Clinical-histopathological analysis and pathogenesis exploration
  JOURNAL   J Dermatol 50 (7), 856-868 (2023)
   PUBMED   37020415
  REMARK    GeneRIF: Granulomatous rosacea in Chinese patients:
            Clinical-histopathological analysis and pathogenesis exploration.
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Majc,B., Habic,A., Novak,M., Rotter,A., Porcnik,A., Mlakar,J.,
            Zupunski,V., Pecar Fonovic,U., Knez,D., Zidar,N., Gobec,S., Kos,J.,
            Lah Turnsek,T., Pislar,A. and Breznik,B.
  TITLE     Upregulation of Cathepsin X in Glioblastoma: Interplay with
            gamma-Enolase and the Effects of Selective Cathepsin X Inhibitors
  JOURNAL   Int J Mol Sci 23 (3), 1784 (2022)
   PUBMED   35163706
  REMARK    GeneRIF: Upregulation of Cathepsin X in Glioblastoma: Interplay
            with gamma-Enolase and the Effects of Selective Cathepsin X
            Inhibitors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Sivaraman,J., Nagler,D.K., Zhang,R., Menard,R. and Cygler,M.
  TITLE     Crystal structure of human procathepsin X: a cysteine protease with
            the proregion covalently linked to the active site cysteine
  JOURNAL   J Mol Biol 295 (4), 939-951 (2000)
   PUBMED   10656802
REFERENCE   7  (bases 1 to 1502)
  AUTHORS   Pungercar,J., Viyjak,A., Ivanovski,G. and Krizaj,I.
  TITLE     Tissue expression and immunolocalization of a novel human cathepsin
            P
  JOURNAL   Pflugers Arch 439 (3 Suppl), R119-R121 (2000)
   PUBMED   10653163
REFERENCE   8  (bases 1 to 1502)
  AUTHORS   Pungercar,J. and Ivanovski,G.
  TITLE     Identification and molecular cloning of cathepsin P, a novel human
            putative cysteine protease of the papain family
  JOURNAL   Pflugers Arch 439 (3 Suppl), R116-R118 (2000)
   PUBMED   10653162
REFERENCE   9  (bases 1 to 1502)
  AUTHORS   Nagler,D.K. and Menard,R.
  TITLE     Human cathepsin X: a novel cysteine protease of the papain family
            with a very short proregion and unique insertions
  JOURNAL   FEBS Lett 434 (1-2), 135-139 (1998)
   PUBMED   9738465
REFERENCE   10 (bases 1 to 1502)
  AUTHORS   Santamaria,I., Velasco,G., Pendas,A.M., Fueyo,A. and Lopez-Otin,C.
  TITLE     Cathepsin Z, a novel human cysteine proteinase with a short
            propeptide domain and a unique chromosomal location
  JOURNAL   J Biol Chem 273 (27), 16816-16823 (1998)
   PUBMED   9642240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109840.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001336.3.
            
            Summary: The protein encoded by this gene is a lysosomal cysteine
            proteinase and member of the peptidase C1 family. It exhibits both
            carboxy-monopeptidase and carboxy-dipeptidase activities. The
            encoded protein has also been known as cathepsin X and cathepsin P.
            This gene is expressed ubiquitously in cancer cell lines and
            primary tumors and, like other members of this family, may be
            involved in tumorigenesis. [provided by RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.203888.1, AF136273.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217131.6/ ENSP00000217131.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AL109840.24        104413-104681       c
            270-433             AL109840.24        103749-103912       c
            434-613             AL109840.24        98892-99071         c
            614-764             AL109840.24        95030-95180         c
            765-927             AL109840.24        94066-94228         c
            928-1502            AL109840.24        92612-93186         c
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..1502
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /note="cathepsin Z"
                     /db_xref="GeneID:1522"
                     /db_xref="HGNC:HGNC:2547"
                     /db_xref="MIM:603169"
     exon            1..269
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1038
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /EC_number="3.4.18.1"
                     /note="preprocathepsin P; cathepsin X; cathepsin P;
                     cathepsin Y; cathepsin B2; cathepsin IV; cathepsin Z1;
                     carboxypeptidase LB; lysosomal carboxypeptidase B;
                     cysteine-type carboxypeptidase"
                     /codon_start=1
                     /product="cathepsin Z preproprotein"
                     /protein_id="NP_001327.2"
                     /db_xref="CCDS:CCDS13474.1"
                     /db_xref="GeneID:1522"
                     /db_xref="HGNC:HGNC:2547"
                     /db_xref="MIM:603169"
                     /translation="MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAP
                     LGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMA
                     DRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAK
                     DQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMA
                     TERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIV
                     TSTYKDGKGARYNLAIEEHCTFGDPIV"
     exon            270..433
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /inference="alignment:Splign:2.1.0"
     exon            434..613
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /inference="alignment:Splign:2.1.0"
     exon            614..764
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /inference="alignment:Splign:2.1.0"
     exon            765..927
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1502
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /note="hexamer: AATAAA"
     polyA_site      1502
                     /gene="CTSZ"
                     /gene_synonym="CTSX"
                     /note="major polyA site"
ORIGIN      
        1 aaagtgcggg gtcggccggg tgctgggccg aggccgaggc cggggcggga tccagagcgg
       61 gagccggcgc gggatctggg actcggagcg ggatccggag cgggacccag gagccggcgc
      121 ggggccatgg cgaggcgcgg gccagggtgg cggccgcttc tgctgctcgt gctgctggcg
      181 ggcgcggcgc agggcggcct ctacttccgc cggggacaga cctgctaccg gcctctgcgg
      241 ggggacgggc tggctccgct ggggcgcagc acataccccc ggcctcatga gtacctgtcc
      301 ccagcggatc tgcccaagag ctgggactgg cgcaatgtgg atggtgtcaa ctatgccagc
      361 atcacccgga accagcacat cccccaatac tgcggctcct gctgggccca cgccagcacc
      421 agcgctatgg cggatcggat caacatcaag aggaagggag cgtggccctc caccctcctg
      481 tccgtgcaga acgtcatcga ctgcggtaac gctggctcct gtgaaggggg taatgacctg
      541 tccgtgtggg actacgccca ccagcacggc atccctgacg agacctgcaa caactaccag
      601 gccaaggacc aggagtgtga caagtttaac caatgtggga catgcaatga attcaaagag
      661 tgccacgcca tccggaacta caccctctgg agggtgggag actacggctc cctctctggg
      721 agggagaaga tgatggcaga aatctatgca aatggtccca tcagctgtgg aataatggca
      781 acagaaagac tggctaacta caccggaggc atctatgccg aataccagga caccacatat
      841 ataaaccatg tcgtttctgt ggctgggtgg ggcatcagtg atgggactga gtactggatt
      901 gtccggaatt catggggtga accatggggc gagagaggct ggctgaggat cgtgaccagc
      961 acctataagg atgggaaggg cgccagatac aaccttgcca tcgaggagca ctgtacattt
     1021 ggggacccca tcgtttaagg ccatgtcact agaagcgcag tttaagaaaa ggcatggtga
     1081 cccatgacca gaggggatcc tatggttatg tgtgccaggc tggctggcag gaactggggt
     1141 ggctatcaat attggatggc gaggacagcg tggcactggc tgcgagtgtt cctgagagtt
     1201 gaaagtggga tgacttatga cacttgcaca gcatggctct gcctcacaat gatgcagtca
     1261 gccacctggt gaagaagtga cctgcgacac aggaaacgat gggacctcag tcttcttcag
     1321 cagaggactt gatattttgt atttggcaac tgtgggcaat aatatggcat ttaagaggtg
     1381 aaagagttca gacttatcac cattcttatg tcactttaga atcaagggtg ggggagggag
     1441 ggagggagtt ggcagtttca aatcgcccaa gtgatgaata aagtatctgg ctctgcacga
     1501 ga
//
