LOCUS       NM_001335               1272 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cathepsin W (CTSW), mRNA.
ACCESSION   NM_001335
VERSION     NM_001335.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1272)
  AUTHORS   Gunther,S.C., Martinez-Romero,C., Sempere Borau,M., Pham,C.T.N.,
            Garcia-Sastre,A. and Stertz,S.
  TITLE     Proteomic Identification of Potential Target Proteins of Cathepsin
            W for Its Development as a Drug Target for Influenza
  JOURNAL   Microbiol Spectr 10 (4), e0092122 (2022)
   PUBMED   35867415
  REMARK    GeneRIF: Proteomic Identification of Potential Target Proteins of
            Cathepsin W for Its Development as a Drug Target for Influenza.
REFERENCE   2  (bases 1 to 1272)
  AUTHORS   Edinger,T.O., Pohl,M.O., Yanguez,E. and Stertz,S.
  TITLE     Cathepsin W Is Required for Escape of Influenza A Virus from Late
            Endosomes
  JOURNAL   mBio 6 (3), e00297 (2015)
   PUBMED   26060270
  REMARK    GeneRIF: These results establish CtsW as an important host factor
            for entry of influenza A virus into target cells and suggest that
            CtsW could be a promising target for the development of future
            antiviral drugs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1272)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1272)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 1272)
  AUTHORS   Raab,A.K., Monkemuller,K., Kandulski,A., Weber,E., Malfertheiner,P.
            and Wex,T.
  TITLE     Expression pattern of cathepsin W isoforms in peripheral blood and
            gastroesophageal mucosa of patients with gastroesophageal reflux
            disease
  JOURNAL   Biol Chem 392 (12), 1167-1172 (2011)
   PUBMED   22050231
  REMARK    GeneRIF: The predominant expression of wildtype form by
            infiltrating immune cells was confirmed in 116 patients with
            gastroesophageal reflux disease and 27 reflux-negative individuals
            demonstrating that cathepsin W expression is not altered in this
            disease.
REFERENCE   6  (bases 1 to 1272)
  AUTHORS   Brinkworth,R.I., Tort,J.F., Brindley,P.J. and Dalton,J.P.
  TITLE     Phylogenetic relationships and theoretical model of human cathepsin
            W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes
  JOURNAL   Int J Biochem Cell Biol 32 (3), 373-384 (2000)
   PUBMED   10716634
REFERENCE   7  (bases 1 to 1272)
  AUTHORS   Wex,T., Levy,B., Wex,H. and Bromme,D.
  TITLE     Human cathepsins F and W: A new subgroup of cathepsins
  JOURNAL   Biochem Biophys Res Commun 259 (2), 401-407 (1999)
   PUBMED   10362521
REFERENCE   8  (bases 1 to 1272)
  AUTHORS   Brown,J., Matutes,E., Singleton,A., Price,C., Molgaard,H.,
            Buttle,D. and Enver,T.
  TITLE     Lymphopain, a cytotoxic T and natural killer cell-associated
            cysteine proteinase
  JOURNAL   Leukemia 12 (11), 1771-1781 (1998)
   PUBMED   9823953
REFERENCE   9  (bases 1 to 1272)
  AUTHORS   Wex,T., Levy,B., Smeekens,S.P., Ansorge,S., Desnick,R.J. and
            Bromme,D.
  TITLE     Genomic structure, chromosomal localization, and expression of
            human cathepsin W
  JOURNAL   Biochem Biophys Res Commun 248 (2), 255-261 (1998)
   PUBMED   9675123
REFERENCE   10 (bases 1 to 1272)
  AUTHORS   Linnevers,C., Smeekens,S.P. and Bromme,D.
  TITLE     Human cathepsin W, a putative cysteine protease predominantly
            expressed in CD8+ T-lymphocytes
  JOURNAL   FEBS Lett 405 (3), 253-259 (1997)
   PUBMED   9108299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001201.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001335.3.
            
            Summary: The protein encoded by this gene, a member of the
            peptidase C1 family, is a cysteine proteinase that may have a
            specific function in the mechanism or regulation of T-cell
            cytolytic activity. The encoded protein is found associated with
            the membrane inside the endoplasmic reticulum of natural killer and
            cytotoxic T-cells. Expression of this gene is up-regulated by
            interleukin-2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035637.1, BC048255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307886.8/ ENSP00000311300.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AP001201.7         14978-15082
            106-190             AP001201.7         15343-15427
            191-304             AP001201.7         16548-16661
            305-459             AP001201.7         17316-17470
            460-556             AP001201.7         17571-17667
            557-637             AP001201.7         17750-17830
            638-763             AP001201.7         17920-18045
            764-828             AP001201.7         18210-18274
            829-1038            AP001201.7         18356-18565
            1039-1272           AP001201.7         18649-18882
FEATURES             Location/Qualifiers
     source          1..1272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1272
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /note="cathepsin W"
                     /db_xref="GeneID:1521"
                     /db_xref="HGNC:HGNC:2546"
                     /db_xref="MIM:602364"
     exon            1..105
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1149
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /note="lymphopain"
                     /codon_start=1
                     /product="cathepsin W preproprotein"
                     /protein_id="NP_001326.3"
                     /db_xref="CCDS:CCDS8117.1"
                     /db_xref="GeneID:1521"
                     /db_xref="HGNC:HGNC:2546"
                     /db_xref="MIM:602364"
                     /translation="MALTAHPSCLLALLVAGLAQGIRGPLRAQDLGPQPLELKEAFKL
                     FQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQL
                     YGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAG
                     NIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQ
                     GKVRAHRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGV
                     IKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWG
                     AQWGEKGYFRLHRGSNTCGITKFPLTARVQKPDMKPRVSCPP"
     exon            106..190
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            191..304
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            305..459
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            460..556
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            557..637
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            638..763
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            764..828
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1038
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1272
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1250..1255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /note="hexamer: AATAAA"
     polyA_site      1272
                     /gene="CTSW"
                     /gene_synonym="LYPN"
                     /note="major polyA site"
ORIGIN      
        1 actccagact gcaccggcat ggcactgact gcccacccct cctgcctcct ggccctgttg
       61 gtggcaggcc tagcccaagg catcagaggc ccccttaggg cccaggacct aggtccccag
      121 ccgctagagc tgaaagaggc cttcaagttg ttccagatcc agttcaaccg gagttacctg
      181 agcccagaag agcatgctca ccgcctggac atctttgccc acaacctggc ccaggctcag
      241 aggctgcagg aggaggactt gggcacagct gagtttgggg tgactccatt cagtgacctc
      301 acagaggagg agtttggcca gctctatggc tatcggaggg cagctggagg ggtccccagc
      361 atgggcagag aaataaggtc tgaagagcca gaggagtcag tacctttcag ctgtgactgg
      421 cggaaggtgg ccagcgccat ctcacccatc aaggaccaga aaaactgcaa ctgctgctgg
      481 gccatggcag cggcaggcaa catagagacc ctgtggcgca tcagtttctg ggattttgtg
      541 gatgtctccg tgcaggaact gctggactgt ggccgctgtg gggatggctg ccacggtggc
      601 ttcgtctggg acgcgttcat aactgtcctc aacaacagcg gcctggccag tgaaaaggac
      661 tacccgttcc agggcaaagt cagagcccac aggtgccacc ccaagaagta ccagaaggtg
      721 gcctggatcc aggacttcat catgctgcag aacaacgagc acagaattgc gcagtacctg
      781 gccacttatg gccccatcac cgtgaccatc aacatgaagc cccttcagct ataccggaaa
      841 ggtgtgatca aggccacacc caccacctgt gacccccagc ttgtggacca ctctgtcctg
      901 ctggtgggtt ttggcagcgt caagtcagag gaggggatat gggcagagac agtctcatcg
      961 cagtctcagc ctcagcctcc acaccccacc ccatactgga tcctgaagaa ctcctggggg
     1021 gcccaatggg gagagaaggg ctatttccgg ctgcaccgag ggagcaatac ctgtggcatc
     1081 accaagttcc cgctcactgc ccgtgtgcag aaaccggata tgaagccccg agtctcctgc
     1141 cctccctgaa cccacctggc cccctcagct ctgtcctgtt aggccaactg cctccttgcc
     1201 agccccaccc ccaggttttt gcccatcctc ccaatctcaa tacagcctga ataaaccaag
     1261 acaagacctc tg
//
