LOCUS       NM_001333               4359 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cathepsin V (CTSV), transcript variant 1, mRNA.
ACCESSION   NM_001333
VERSION     NM_001333.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4359)
  AUTHORS   Liu,J., Zhang,W., Wang,Z., Wang,Y., Li,T., Wang,Y., Ding,J. and
            Ning,B.
  TITLE     Cathepsin V is correlated with the prognosis and tumor
            microenvironment in liver cancer
  JOURNAL   Mol Carcinog 63 (3), 400-416 (2024)
   PUBMED   38051285
  REMARK    GeneRIF: Cathepsin V is correlated with the prognosis and tumor
            microenvironment in liver cancer.
REFERENCE   2  (bases 1 to 4359)
  AUTHORS   Lecaille,F., Chazeirat,T., Saidi,A. and Lalmanach,G.
  TITLE     Cathepsin V: Molecular characteristics and significance in health
            and disease
  JOURNAL   Mol Aspects Med 88, 101086 (2022)
   PUBMED   35305807
  REMARK    GeneRIF: Cathepsin V: Molecular characteristics and significance in
            health and disease.
            Review article
REFERENCE   3  (bases 1 to 4359)
  AUTHORS   Xia,Y., Ge,M., Xia,L., Shan,G. and Qian,H.
  TITLE     CTSV (cathepsin V) promotes bladder cancer progression by
            increasing NF-kappaB activity
  JOURNAL   Bioengineered 13 (4), 10180-10190 (2022)
   PUBMED   35443863
  REMARK    GeneRIF: CTSV (cathepsin V) promotes bladder cancer progression by
            increasing NF-kappaB activity.
REFERENCE   4  (bases 1 to 4359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4359)
  AUTHORS   Sereesongsaeng,N., McDowell,S.H., Burrows,J.F., Scott,C.J. and
            Burden,R.E.
  TITLE     Cathepsin V suppresses GATA3 protein expression in luminal A breast
            cancer
  JOURNAL   Breast Cancer Res 22 (1), 139 (2020)
   PUBMED   33298139
  REMARK    GeneRIF: Cathepsin V suppresses GATA3 protein expression in luminal
            A breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4359)
  AUTHORS   Somoza,J.R., Zhan,H., Bowman,K.K., Yu,L., Mortara,K.D.,
            Palmer,J.T., Clark,J.M. and McGrath,M.E.
  TITLE     Crystal structure of human cathepsin V
  JOURNAL   Biochemistry 39 (41), 12543-12551 (2000)
   PUBMED   11027133
  REMARK    Erratum:[Biochemistry 2001 Apr 3;40(13):4200]
REFERENCE   7  (bases 1 to 4359)
  AUTHORS   Itoh,R., Kawamoto,S., Adachi,W., Kinoshita,S. and Okubo,K.
  TITLE     Genomic organization and chromosomal localization of the human
            cathepsin L2 gene
  JOURNAL   DNA Res 6 (2), 137-140 (1999)
   PUBMED   10382972
REFERENCE   8  (bases 1 to 4359)
  AUTHORS   Bromme,D., Li,Z., Barnes,M. and Mehler,E.
  TITLE     Human cathepsin V functional expression, tissue distribution,
            electrostatic surface potential, enzymatic characterization, and
            chromosomal localization
  JOURNAL   Biochemistry 38 (8), 2377-2385 (1999)
   PUBMED   10029531
REFERENCE   9  (bases 1 to 4359)
  AUTHORS   Adachi,W., Kawamoto,S., Ohno,I., Nishida,K., Kinoshita,S.,
            Matsubara,K. and Okubo,K.
  TITLE     Isolation and characterization of human cathepsin V: a major
            proteinase in corneal epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 39 (10), 1789-1796 (1998)
   PUBMED   9727401
REFERENCE   10 (bases 1 to 4359)
  AUTHORS   Santamaria,I., Velasco,G., Cazorla,M., Fueyo,A., Campo,E. and
            Lopez-Otin,C.
  TITLE     Cathepsin L2, a novel human cysteine proteinase produced by breast
            and colorectal carcinomas
  JOURNAL   Cancer Res 58 (8), 1624-1630 (1998)
   PUBMED   9563472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358641.1, AL445670.19 and
            AW444458.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001333.3.
            
            Summary: The protein encoded by this gene, a member of the
            peptidase C1 family, is a lysosomal cysteine proteinase that may
            play an important role in corneal physiology. This gene is
            expressed in colorectal and breast carcinomas but not in normal
            colon, mammary gland, or peritumoral tissues, suggesting a possible
            role for this gene in tumor processes. Alternatively spliced
            variants, encoding the same protein, have been identified.
            [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.197982.1,
                                           SRR1660803.125959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259470.6/ ENSP00000259470.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1192              AY358641.1         169-1360
            1193-4349           AL445670.19        45216-48372         c
            4350-4359           AW444458.1         16-25               c
FEATURES             Location/Qualifiers
     source          1..4359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..4359
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /note="cathepsin V"
                     /db_xref="GeneID:1515"
                     /db_xref="HGNC:HGNC:2538"
                     /db_xref="MIM:603308"
     exon            1..72
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     exon            73..208
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1087
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /EC_number="3.4.22.43"
                     /note="cathepsin U; cathepsin L2, preproprotein"
                     /codon_start=1
                     /product="cathepsin L2 preproprotein"
                     /protein_id="NP_001324.2"
                     /db_xref="CCDS:CCDS6723.1"
                     /db_xref="GeneID:1515"
                     /db_xref="HGNC:HGNC:2538"
                     /db_xref="MIM:603308"
                     /translation="MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANE
                     EGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRK
                     GKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVS
                     LSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENS
                     VANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLD
                     HGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
                     "
     exon            209..331
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     exon            332..478
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     exon            479..703
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     exon            704..869
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     exon            870..987
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     exon            988..4359
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /note="hexamer: AATAAA"
     polyA_site      1381
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /note="major polyA site"
     polyA_site      3525
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
     regulatory      3914..3919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /note="hexamer: AACAAA"
     polyA_site      3933
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
     regulatory      4336..4341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
                     /note="hexamer: AGTAAA"
     polyA_site      4359
                     /gene="CTSV"
                     /gene_synonym="CATL2; CTSL2; CTSU"
ORIGIN      
        1 accagaccgc ggacgtctgt aatctcagag gcttgtttgc tgagggtgcc tgcgcagctg
       61 cgacggctgc tggttttgaa acatgaatct ttcgctcgtc ctggctgcct tttgcttggg
      121 aatagcctcc gctgttccaa aatttgacca aaatttggat acaaagtggt accagtggaa
      181 ggcaacacac agaagattat atggcgcgaa tgaagaagga tggaggagag cagtgtggga
      241 aaagaatatg aaaatgattg aactgcacaa tggggaatac agccaaggga aacatggctt
      301 cacaatggcc atgaatgctt ttggtgacat gaccaatgaa gaattcaggc agatgatggg
      361 ttgctttcga aaccagaaat tcaggaaggg gaaagtgttc cgtgagcctc tgtttcttga
      421 tcttcccaaa tctgtggatt ggagaaagaa aggctacgtg acgccagtga agaatcagaa
      481 acagtgtggt tcttgttggg cttttagtgc gactggtgct cttgaaggac agatgttccg
      541 gaaaactggg aaacttgtct cactgagcga gcagaatctg gtggactgtt cgcgtcctca
      601 aggcaatcag ggctgcaatg gtggcttcat ggctagggcc ttccagtatg tcaaggagaa
      661 cggaggcctg gactctgagg aatcctatcc atatgtagca gtggatgaaa tctgtaagta
      721 cagacctgag aattctgttg ctaatgacac tggcttcaca gtggtcgcac ctggaaagga
      781 gaaggccctg atgaaagcag tcgcaactgt ggggcccatc tccgttgcta tggatgcagg
      841 ccattcgtcc ttccagttct acaaatcagg catttatttt gaaccagact gcagcagcaa
      901 aaacctggat catggtgttc tggtggttgg ctacggcttt gaaggagcaa attcgaataa
      961 cagcaagtat tggctcgtca aaaacagctg gggtccagaa tggggctcga atggctatgt
     1021 aaaaatagcc aaagacaaga acaaccactg tggaatcgcc acagcagcca gctaccccaa
     1081 tgtgtgagct gatggatggt gaggaggaag gacttaagga cagcatgtct ggggaaattt
     1141 tatcttgaaa ctgaccaaac gcttattgtg taagataaac cagttgaatc attgaggatc
     1201 caagttgaga ttttaattct gtgacatttt tacaagggta aaatgttacc actactttaa
     1261 ttattgttat acacagcttt atgatatcaa agactcattg cttaattcta agacttttga
     1321 attttcattt tttaaaaaga tgtacaaaac agtttgaaat aaattttaat tcgtatataa
     1381 aggtgggcct ttttttaatg cattggcttt ttgtgtagtc aggaaatata attaagctct
     1441 gaaataataa cttcatgtgc caatggtatg ttaggagaaa gatgctagca gaaagctggc
     1501 ttcctggctc ttgagtagtt ataaaaatac agactttata tcagctgccc agttactgtg
     1561 tgttacccaa ctcctgaatc taccaaaatt tgataaacaa tttggaagga caaacctaca
     1621 tttttttttt ttatgagacg gagtctctct cactctgtca ccaaggctgg agtgcagtag
     1681 tgtgatctca gctcactgca acctctgcct cccgggttta agcaattctc tgcctcagcc
     1741 tcccgagtag ctgggattac aggcgcgtgc caccacgcct agtgtatttt tagtagagag
     1801 agggtttcac catcttggcc aggctggtct tgaactctcg acctcgtgat ccacctgcct
     1861 cagcctccca aagtgttggg attacagatg tgagccactg cgcccagccc ctaaattgtt
     1921 ttagtaaaga agaaagcagt tgacttttta gaaaaggaaa tgtcttcttc ctttgacaca
     1981 taacctcaag atggttaggt tacgtgataa aaagtgaagc tgcttgttac tggagcctct
     2041 ctgaattgct ggtgaccact ttgcagtctg aggaagacgc aggtgcaagt aagttaccaa
     2101 gggtattttg ttttcattcc aagtctctga tgacatattc cacctagctc ttctagaaaa
     2161 gcttatttgt taactagtgt tagcaaaaat aaatggtgtg gttaacaaat ctcaggcatt
     2221 tgacagtagc tggagaaatt tgttcaaggt ccacaagaga tgaggctggg ctacaaaaag
     2281 aggcctctgg ccgaagatgg ataagagatc acaagtgaaa ggtcagaagt cactaggcca
     2341 gactctggct acctaatccc tgaattaaaa ataaactcaa aatgggggga aaaaggctaa
     2401 gcatatagtt acacaggtag taaatacaaa taaaacgata tttttgcata tttaaaatac
     2461 tggaagaaag tacaccaaac ttgtgggtga attatgggtg gttatttaac tcgtttagtg
     2521 aaaagcatgt atttttatga gcaggagaaa atagtaaaga tatacccaca ttctgcaggc
     2581 taaaggagag ccctgtgtgt gttttaaaag cccatgtttc cagtcaaata aaaaattacc
     2641 ggggatgagc tggtgaaatt taatcgaaag gtgatccatt gtgaatgcaa tgggagggaa
     2701 ggggcatgtg ggactgtgta tcccaaaaac cctttgatag cctatgtcca cagccatctc
     2761 tggaaaatcc agtctaccat attcagtctt gagttttctc tgagaaagga ttccttcgtc
     2821 tttgcagcag caggctaagt tggtactctc cacagattct tggaacaaca acccaggctc
     2881 taaggaaaca tctaggcact aaattgaatg aaagagtgat ggctttttat tcaaataaaa
     2941 aaatttcaaa tctgtcaaaa cagcacccct cggaaaacta aaatagagat atttcaagat
     3001 tttataattt tcaaagacct ttgaaatatt ttaaacttgt gaaaagttac aaacctgatg
     3061 tgttgtctaa aagcgttttt caaacaagcc agtagacttg aaaaatctag tctgaagcac
     3121 agacttaacc aatatttgct ggggatatgc ccccaaatct ggccataaac aaaatctctg
     3181 cagtactgtg acaggttcat gatggccatg acgccatgct gaaggtttac cggaatgaga
     3241 gcaaggaaca cctggaccac ccagggcggg aaaacggctt aaaggcgttc ctaaactaca
     3301 aacaatagca tgagcgatct gtgccttaag gacatgttcc tgctgcagat aactagccag
     3361 accccatgcc tttgtttcgt ttgggaagga atacttttag ttaatctata atctatagaa
     3421 acaatgttta tcactggctt gctgtcaata aacatgggta aatctctgtt cggggctctc
     3481 agctctgaaa gctgtgagtc ccctgatttc ccactctgca tgctatattt ctgggtgtgt
     3541 gtctttaatt tctctagcgc ctctgggtta gggtctccat gaccaagctg gtctcggcaa
     3601 atatttccta tactcgaaca tctaaattgt ttgttttctt acttgaattg caaaggaagt
     3661 aaggaagggt gagatagaaa tcactgagca tattaagagg gaggagtttg ctgatgtggg
     3721 agtgtagtta tgacacttgg gcatcatact agaggctatg gacttagcaa taaggaaaca
     3781 tccactcagc cctatgtgtg gttcatgtgt atgttttgcc tatgaaagtt gaaactgttt
     3841 tctaaatgtt atttcctttt gtaactgata aaatttctaa aaagcaaaga agaaactttt
     3901 ctgtattaaa aataacaaac attagtaaat gtatatatac agtcatgtgt tgcttaatga
     3961 tggggataca ttctgagaaa tgtgtcttgg gtgatttcat cgtgacgtga acatcataga
     4021 gtacactgac acaaacctag atggtatagc ctattacaca cctaggctat atggtacagc
     4081 ctgttgctcc taagctacgc acctgtgcaa cacatcactg tgctgagtac tgtacacagt
     4141 tgtaacacag tggtaagtat tcgtgtatct gaacagaaaa gtacagtaaa aatataggat
     4201 cataatttta tgggaccact atcatatatg cagtcactga ccaaaacatc acacagcaca
     4261 tgacttgtgt gtatggatat ctcaattgta aacaatttca caaatgttca ttatctcttt
     4321 ttaagtaagt taataagtaa aactattact aagctgcaa
//
